Articles

Found 6 Documents
Search

PREPARASI TARGET PADAT TELURIUM UNTUK PEMBUATAN RADIOISOTOP 123I Sarwono, Daya Agung; Amiruddin, Cahyana; Widyaningrum, Triani; Triyanto, Triyanto
Jurnal Radioisotop dan Radiofarmaka Vol 15, No 2 (2012): JURNAL PRR 2012
Publisher : Jurnal Radioisotop dan Radiofarmaka

Show Abstract | Original Source | Check in Google Scholar | Full PDF (4307.536 KB)

Abstract

ABSTRAKPREPARASI TARGET PADAT TELURIUM UNTUK PEMBUATAN RADIOISOTOP 1231.Radioisotop lodium-123 (1231)da~at digunakan sebagai bahan sediaan radiofarmaka untuk pencitraan denganalat SPECT. Hal ini disebabkan 231 memancarkan sinar gamma dengan energi 159 keY dengan waktu paro(t1/2) 13,2 jam. Radioisotop 123 1 dapat dibuat dari bahan sasaran berupa lapisan tipis target padat telurium(Te), kemudian, diradiasi menggunakan siklotron. Salah satu teknologi untuk pembuatan lapisan tipis targetpadat Te adalah elektroplating. Untuk pembuatan lapisan tipis target padat telurium secara elekroplatingpada keping Cu diperlukan lapisan logam sebagai interface. Hal ini disebabkan logam telurium tidak dapatmenempel secara langsung pada keping Cu. Bahan yang dapat dipakai sebagai interface adalah logam nikelsebagai lapisan perekat antara keping Cu dengan target telurium. Tujuan dari kegiatan ini adalah untukmencari kondisi yang optimal elektroplating nikel dalam keping Cu dan elektroplating telurium dalamkeping Cu yang telah dilapisi nikel. Elektroplating nikel dilakukan pada variasi kuat arus dalam suasanaasam (pH 4) dan suasana basa (pH 10) sedangkan elektroplating telurium dilakukan dengan variasi kuat arusdalam suasana basa (pH 10). Dari hasil kegiatan diperoleh bahwa elektroplating nikel pada kuat arus 200 mAdalam suasana asam (pH 4) memberikan hasil yang optimal dengan efisiensi sebesar 88,86%. Elektroplatingtelurium pada kuat arus 100 mA pada suasana basa (pH 10) memberikan hasil yang optimal. Teluriummelekat kuat pada keping Cu yang telah dilapisi nikel dengan hasil yang halus dan rata serta efisiensiterbesar 56,97 %.Kata kunci : lodium-123, target padat telurium, elektroplating.ABSTRACTPREPARATION OF TELLURIUM SOLID TARGET FOR 1231 RADIOISOTOPEPRODUCTION. Radioisotope of iodine-123 (1231) can be used in a radiopharmaceutical preparation forSPECT imaging. 1231emits positron, gamma rays 159 keY with half-life 13.2 hour. Radioisotope 1231 can bemade by cyclotron irradiation from a thin layer of tellurium (Te) solid targets. One of the methods forpreparation of thin layers of solid targets Te is electroplating. A thin layer of solid material is required on theCu metal surface as an interface, since the tellurium can not be attached directly to the Cu. Materials that canbe used as an interface is nickel metal, as an adhesive layer between Cu and tellurium. The purpose of thisexperiments is to fmd the optimal conditions in the nickel electroplating on Cu and tellurium electroplatingon Cu surface coated with nickel. Nickel electroplating was performed in acid (pH 4) and alkaline (pH10) with electric current variation. Electroplating of tellurium was performed on current variation underalkaline (pH 10). The results showed that nickel with currents of 200 mA under acidic (pH 4) providedoptimal results with an efficiency of 88.86%. Tellurium electroplating with 100 mA of electric current inalkaline conditions (pH 10) provided optimal results. Tellurium is strongly attached to the Cu coated withnickel. The electroplated Te is smooth and flat with the greatest efficiency of 56.97%.Key-words: lodine-123, tellurium solid target, electroplating
Sintesis Poli N-Isopropilakrilamida (PNIPA)/Polityrosin (PTYR) Interpenetrating Polymer Networks (IPNs) Bertanda Iodium-125 Saptiama, Indra; Herlina, Herlina; Sarmini, Endang; Karyadi, Karyadi; Abidin, Abidin; Widyaningrum, Triani; Awaludin, Rohadi
Jurnal Kimia dan Kemasan Vol. 36 No. 2 Oktober 2014
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Original Source | Check in Google Scholar | Full PDF (663.835 KB)

Abstract

Saat ini perkembangan polimer telah semakin maju, berbagai aplikasi polimer telah dikembangkan baik di sektor energi, pangan maupun kesehatan. PNIPA/PTYR IPNs bertanda iodium-125 dapat dimanfaatkan sebagai sumber terapi kanker. PNIPA/PTYR merupakan polimer peka temperatur. Tujuan dari penelitian ini adalah sintesis PNIPA/PTYR IPNs bertanda iodium-125. Polityrosin ditandai dengan iodium-125 kemudian secara simultan direaksikan dengan monomer N-isopropilakrilamida melalui polimerisasi radikal bebas dengan inisiator amonium persulfat (APS) dan tetrametiletilenediamin (TEMED) untuk memperoleh PNIPA/PTYR IPNs bertanda iodium-125. Kemurnian radiokimia PNIPA/PTYR IPNs bertanda iodium-125 diukur dengan krom atografi lapis tipis (KLT) dengan fasa gerak 2 propanol: 1 butanol: 0,2 M NH4OH. Selain Itu, stabilitas PNIPA/PTYR IPNs bertanda iodium-125 diuji pada media air. PNIPA/PTYR IPNs telah berhasil ditandai dengan iodium-125 dengan rendemen penandaan sebesar 37,6 ± 4,2 % (n = 3). Hasil pengamatan visual, ditunjukkan bahwa polimer mengalami perubahan sifat pada temperatur 32 oC sampai dengan 34°C. Hasil H-NMR hanya menunjukkan spektrum dari polimer PNIPA. Berdasarkan pemeriksaan KLT, kemurnian radiokimia PNIPA/PTYR IPNs bertanda iodium-125 adalah 95,93%. Pengujian stabilitas polimer bertanda iodum-125 pada media air pada T = 37°C selama 2 minggu menunjukkan bahwa iodium-125 yang masih tertahan pada polimer adalah 71,3 ± 6,2 %. 
Stability of Silver Nanoparticles as Imaging Materials Sholikhah, Umi Nur; Pujiyanto, Anung; Lestari, Enny; Sarmini, Endang; Widyaningrum, Triani; Kadarisman, Kadarisman; Triyanto, Triyanto; Puspitasari, Putri
The Journal of Pure and Applied Chemistry Research Vol 5, No 3 (2016)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Original Source | Check in Google Scholar | Full PDF (655.071 KB)

Abstract

Determining the stability of silver nanoparticles is a very important process. It was associated with unwanted metal charge and materials properties. Therefore, we studied to synthesis and stability of silver nanoparticles (AgNPs). The synthesis was performed by reduction method used sodium borohydride (NaBH4). Silver nitrate solution 0.0005 M in 1 mL was reduced using 1 mL 0.002 M of NaBH4. Then a 40.0 mL of polyvinylpyrrolidone 0.3% and 20 mL of 1.5 N NaCl was added to the mixture. Characterization of silver nanoparticles is undertaken using spectrophotometer UV-Vis, transmission electron microscopy, particle size analyzer and zeta potential. The stability of products is observed for 5 times using spectrophotometer UV-Vis. The product was characterized by determining its surface plasmon resonance (SPR) of AgNPs and the result was obtained at 403 nm. The size of AgNPs was 20 nm using tomography emission microscopy analysis and the particle size distribution give 5.8 nm. The dielectric charge was 53 mV. The stable AgNPs showed no significant SPR shift at 402±0.89 nm wavelength during 5 days observation. Based on the size and stability, it was suitable for imaging materials.
KARAKTERISTIK PEMISAHAN RADIOLUTESIUM-177/177mLu DAN RADIOITERBIUM-169/175Yb PADA KOLOM RESIN LN-EICHROM Widyaningrum, Triani; Triyanto, Mr; Sarmini, Endang; Sholikhah, Umi Nur; Soenarjo, Sunarhadijoso
Jurnal Sains dan Teknologi Nuklir Indonesia Vol 16, No 1 (2015): Februari 2015
Publisher : BATAN

Show Abstract | Original Source | Check in Google Scholar | Full PDF (472.61 KB)

Abstract

ABSTRAK KARAKTERISTIK PEMISAHAN RADIOLUTESIUM- 177/177mLu DAN RADIOITERBIUM-169/175Yb PADA KOLOM RESIN LN-EICHROM. Radiolutesium-177Lu keradioaktifan jenis tinggi merupakan salah satu radiolantanida yang banyak digunakan untuk menangani berbagai kasus kanker, namun di Indonesia penggunaan radiofarmaka bertanda 177Lu belum dapat dijanjikan karena teknik produksi radioisotop primernya belum dikuasai. Prospek produksi 177Lu melalui reaksi inti 176Yb (n,g) 177Yb* à 177Lu* + β– dipelajari melalui metode pemisahan matrik 177/177mLu-169/175Yb/176Yb dalam sistem kromatografi kolom resin LN-Eichrom. Profil fraksinasi dan karakteristik pemisahan dipelajari dengan pemeriksaan keradioaktifan dan analisis spektro-metri-g terhadap hasil elusi larutan sasaran pasca iradiasi. Bahan sasaran digunakan 176Yb2O3 alam dan 176Lu2O3 diperkaya. Hasil penelitian menunjukkan bahwa radiolutesium-177/177mLu dapat dipisahkan dari matrik radioiterbium-169/175Yb/natYb melalui sistem kromatografi kolom dengan fase diam resin LN-Eichrom dan fase gerak larutan HNO3, dengan konsentrasi antara 1,5 – 4 M untuk mendapatkan pemisahan yang efektif, selektif dan kuantitatif. Reaksi inti 176Yb(n,g) 177Yb* à 177Lu + β– merupakan model reaksi inti yang perlu dipertimbangkan walau-pun harus melibatkan tahapan pemisahan produk 177Lu dari matrik sasaran Yb pasca iradiasi. Prosedur pemisahan yang dilakukan masih perlu diperbaiki melalui pemilihan jenis dan konsentrasi fase gerak pengelusi yang lebih tepat. ABSTRACT SEPARATION CHARACTERISTIC OF RADIOLUTETIUM-177/177mLu AND RADIOY-TTERBIUM-169/175Yb ON LN-EICHROM RESIN COLUMN. High specific activity radiolutetium-177Lu is one of radiolanthanides that is widely used to handle variety of cancer cases, but in Indonesia the use of 177Lu-labeled-radiopharmaceutical can not be promised yet as the primary radioisotope production techniques have not been mastered.  The  prospect of 177Lu production based on the nuclear reaction of 176Yb (n,g) 177Yb * ® 177Lu * + β– in the BATAN’s G.A. Siwabessy reactor was learned through the separation characteristics of 177/177mLu-169/175Yb /176Yb process matrices in the LN-Eichrom resin column chromatography. The separation and fractionation profiles were characterized by radioactivity measurement as well as g-spectrometric analysis of the eluting post-irradiated target solution. The target materials used were natural 176Yb2O3 and enriched 176Lu2O3. The results showed that radiolutetium-177/177mLu can be separated from the radioiterbium-169/175Yb/natYb matrix by column chromatography system with a stationary phase of LN-Eichrom resin using HNO3 solution as the mobile phase, but the concentration of HNO3 used is a critical variable, between 1.5 - 4 M, to obtain an effective separation selectively and quantitatively. The nuclear reaction of 176Yb (n,g) 177Yb* ® 177Lu + β– using natural Yb2O3 is considered to be better, although it must involve 177Lu product separation stage from the post-irradiated natural Yb target matrix. The presented separation procedure still needs to be improved through the selection of the type and the concentration of the mobile phase used to gain more appropriate elution solvent.
Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch Rahman, Wira Y.; Sarmini, Endang; Herlina, Herlina; Abidin, Abidin; Triyanto, Triyanto; Hambali, Hambali; Sriyono, Sriyono; Widyaningrum, Triani
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 1, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Original Source | Check in Google Scholar | Full PDF (508.919 KB)

Abstract

Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumours. Currently, keloid is treated by a conventional method e.g.by applying the bulk of 32P radioisotope directly on keloid area. However, this method is considered inefficient and less secure. The purpose of this research is to obtain a technology for preparing of 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with particle size of <1 μm.  These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily. Characterization of the prepared Cr32PO4colloids gave a yield of 97,8% with particle size of greater than > 1μm.  Further study needs to be performed in due time in order to have Cr32PO4 colloids with a suitable particle size.Key words: keloid, chromic phosphate colloid, skin patch, condensation, oxidation-reduction reaction
Studi Awal Pembuatan Koloid Kromik Fosfat Bertanda Radioisotop 32P Sebagai Bahan Pembuatan Skin Patch Rahman, Wira Y.; Sarmini, Endang; Herlina, Herlina; Hambali, Hambali; Abidin, Abidin; Triyanto, Triyanto; Sriyono, Sriyono; Widyaningrum, Triani
Prosiding Seminar Nasional Teknik Kimia "Kejuangan" 2019: PROSIDING SNTKK 2019
Publisher : Prosiding Seminar Nasional Teknik Kimia "Kejuangan"

Show Abstract | Original Source | Check in Google Scholar | Full PDF (227.568 KB)

Abstract

Keloids are skin disorders or benign tumors that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumors. Currently, keloid is treated by a conventional method e.g. by applying the bulk of 32P radioisotope directly on keloid area and this method is considered inefficient and less secure. The purpose of this research is to obtain technology for preparing of a 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with a particle size of <1 μm.  These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily.  Characterization of the prepared Cr32PO4 colloids gave a yield of 97,8%. Geometric standard deviation (sg) of colloidal particles amounted to 163.7 nm shaped poly-disperse.  Further study needs to be performed in due time in order to have Cr32PO4 colloids with suitable particle size.