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Journal : Jurnal Kedokteran Brawijaya

PENGARUH PEMBERIAN DIET TINGGI KALSIUM TERHADAP PENURUNAN BERAT BADAN PADA Rattus novergicus galur wistar

Jurnal Kedokteran Brawijaya Vol 22, No 2 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

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Abstract

ABSTRACT Calcium diet has an important role in energy metabolism regulation especially intracellular Ca2+ which is the key tarrange the metabolism of adiposity fat and triasilgliserol save. When intracellular Ca2+ increase it makes the stimulatioof gen lipogenic and lipogenesis also forcing of lipolysis and finally increasing the fat fitting and increasing adiposity. Thlow level of calcium absorbtion increases the production of calsitirol which could stimulate adiposity Ca2+ influx and thconcequance is the increase of adiposity, so it needs high calcium diet to delay lipogenesis increase of lipolysis, lipioksidaxion, to reduce fat adiposity and weight. The research used  pretest – postest control group design. Trial animawere male rat of Rattus novergicus strain wistar. The research consisted of 2 phases. The first phase was increasing thrat weight by giving normal diet with calcium of 0,4% for all kinds of rats for 4 weeks. The second phase by giving calciumdiet with different doses that is  group A as control group (0,4% Ca as normal diet), group B 0,8% Ca (Ca as normal diet +0,4% Ca as CaCO3), group C 1,2% Ca (Ca as normal diet + 0,8% Ca as CaCO3) and  group D 1,6% Ca(Ca as normadiet + 1,2% Ca as CaCO3) for 4 weeks. To find out the difference of calcium diet it used statistical test Oneway Anova

PENGHAMBATAN AKTIFASI NFκ κκ κB OLEH CAPE (CAFFEIC ACID PHENETHYL ESTER), KOMPONEN AKTIF MADU LEBAH (HONEYBEE HIVES),PADA HUVEC’S (HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS) YANG DIPAPAR LDL TEROKSIDASI

Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Original Source | Check in Google Scholar

Abstract

The high prevalence of cardiovascular morbidity and  mortality caused by complication of atherosclerosisneeds an optimal effort to prevent the atherosclerosis progression and complication. Atherogenesis is a chronicinflammatory process which could be prevented via the inhibitionof NFκB, a known key transcription factor involved in inflammatory process. An active component of honeybee hives, CAPE (Caffeic Acid Phenethyl Ester), is believed to inhibit inflammatory process via the inhibition of NFκB activation. However, it remains uncertain whetherCAPE inhibits NFκB activation in endothelial cells. This study therefore was aimed to examine the molecular mechanism of CAPE mediated NFκB inactivation in OxLDL-treated HUVEC’s. Immunohistochemistry using p50 antibody was applied to detectthe migration of NFκB (p50-p65 complex) from inactive form in cytoplasmto active form in nucleus.

PENGARUH PEMBERIAN DIET TINGGI KALSIUM TERHADAP PENURUNAN BERAT BADAN PADA Rattus novergicus galur wistar

Jurnal Kedokteran Brawijaya Vol 22, No 2 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Original Source | Check in Google Scholar

Abstract

ABSTRACT Calcium diet has an important role in energy metabolism regulation especially intracellular Ca2+ which is the key tarrange the metabolism of adiposity fat and triasilgliserol save. When intracellular Ca2+ increase it makes the stimulatioof gen lipogenic and lipogenesis also forcing of lipolysis and finally increasing the fat fitting and increasing adiposity. Thlow level of calcium absorbtion increases the production of calsitirol which could stimulate adiposity Ca2+ influx and thconcequance is the increase of adiposity, so it needs high calcium diet to delay lipogenesis increase of lipolysis, lipioksidaxion, to reduce fat adiposity and weight. The research used  pretest – postest control group design. Trial animawere male rat of Rattus novergicus strain wistar. The research consisted of 2 phases. The first phase was increasing thrat weight by giving normal diet with calcium of 0,4% for all kinds of rats for 4 weeks. The second phase by giving calciumdiet with different doses that is  group A as control group (0,4% Ca as normal diet), group B 0,8% Ca (Ca as normal diet +0,4% Ca as CaCO3), group C 1,2% Ca (Ca as normal diet + 0,8% Ca as CaCO3) and  group D 1,6% Ca(Ca as normadiet + 1,2% Ca as CaCO3) for 4 weeks. To find out the difference of calcium diet it used statistical test Oneway Anova

PENGHAMBATAN AKTIFASI NFκ κκ κB OLEH CAPE (CAFFEIC ACID PHENETHYL ESTER), KOMPONEN AKTIF MADU LEBAH (HONEYBEE HIVES),PADA HUVEC’S (HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS) YANG DIPAPAR LDL TEROKSIDASI

Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Original Source | Check in Google Scholar

Abstract

The high prevalence of cardiovascular morbidity and  mortality caused by complication of atherosclerosisneeds an optimal effort to prevent the atherosclerosis progression and complication. Atherogenesis is a chronicinflammatory process which could be prevented via the inhibitionof NFκB, a known key transcription factor involved in inflammatory process. An active component of honeybee hives, CAPE (Caffeic Acid Phenethyl Ester), is believed to inhibit inflammatory process via the inhibition of NFκB activation. However, it remains uncertain whetherCAPE inhibits NFκB activation in endothelial cells. This study therefore was aimed to examine the molecular mechanism of CAPE mediated NFκB inactivation in OxLDL-treated HUVEC’s. Immunohistochemistry using p50 antibody was applied to detectthe migration of NFκB (p50-p65 complex) from inactive form in cytoplasmto active form in nucleus.

Co-Authors Abdul Ghofur Abdul Hakim Abu Bakar, Kosasih Ali Achdia Supriadidjaja Achdia Supriadidjaya, Achdia Adianto, Dwi Priyo Aditia Wardana, Aditia Aditiawardana Aditiawardana, Aditiawardana Aditya Kurniawan Admiasri, Admiasri Agung Sosiawan, Agung Agus Irianto Agus Maman Abadi Agus Ridwan Ahmad Faizal Ahmad Zakarsyi Aji, Nusa Suindrata Akhmad Rifai Alakhyar, Alakhyar Ali Agus Andriansyah, Rian Anggoro Tri Mursito Anindya Putri Permatasari, Anindya Putri Anita Yuliyanti Anthoni Sulthan Harahap, Anthoni Sulthan Ardityo R Ardhany, Ardityo R Ardyanto, Wisnu Aris Slamet Widodo, Aris Slamet Aristia, Firda Artaria Tjempakasari, Artaria Asih Kurniawati Bahri, Muadin Wasis Saeful Bambang Priadi Bangsawan, Merah Bela Yunita, Bela Bima, Ahmad Fadhil Chandra Irwanadi Mohani, Chandra Irwanadi Chandra Irwanadi, Chandra chieko Hamada, chieko Darmawan Setijanto, Darmawan Dea, Yolanda Dinarka Dedek Kusvianti Dewi, Evita Dewi, Rafiqa Dhonny, Chusniati Diana Wibowo, Diana Dini Dinarty, Dini Djanggan Sargowo DJOKO PRIJONO Djoko Santoso Dwi Ertiningsih Dwi Hanto Dwi Sarbini Dwidjono Hadi Darwanto edy susanto Edy Waliyo Efi Toding Tondok Endah Kusuma Rastini Endang Caturini Sulistyowati Erlangga, Bagus D. Evan P. Ramdan Fahrurrozi Fahrurrozi Fajar Wahyono Faradila, Annisa Fatma Hetami Febbiyanti, Tri Rappani FETRINA OKTAVIA Fora, Rony HR Frederikus Dian Indrastomo, Frederikus Dian Ganjar Samudro Ghaitsa, Ghaitsa Gusti Ayu Kade Sutariati Gusti Gina Permata Sari, Gusti Gina Hardina, dini Hasan, Husni Hendra Grandis Hendro Pramono I Gde Sukadana I Nengah Tanu K Ichiyu Shou, Ichiyu Ichrom Nahzi, Muhammad Yanuar Idris HM Noor, Idris HM Iflah, Dinie Muthia Imam Sujadi Imran, Al Ichlas Indratiningsih Indratiningsih, Indratiningsih Irawan Wisnu Wardhana Irmawati Irmawati Jamhari Jamhari Jangkung Handoyo Mulyo Joko Sukoyo Kafaah Estancia komalaningrat, devi ayu Kunimi Maeda, Kunimi Kuswanhadi Kuswanhadi, Kuswanhadi Laifa Rahmawati, Laifa Lasse, David Aroschi Lies Mira Yusiati Luthfi, Muhammad Jafar M Thaha, M M. Ulum Gani Marasabessy, Muhammad Irfan Maria Ulfa Putri Yoeshinda Melisa Melisa Merdeko Utomo, Verry Hendarto Mimien Henie Irawati Al-Muhdar, Mimien Henie Irawati Mitsumine Fukui, Mitsumine MOCHAMAD YUSUF MOCHAMMAD THAHA Moh. Yogiantoro, Moh. Mohamad Amin Mohammad Saifur Rohman MUHAMAD SYUKUR Muhammad Ja’far Luthfi, Muhammad Ja’far Muhammad Syukur Muhammad Yoga Arie Yunanto, Muhammad Yoga Muharam, Syamsul Rizal Muhibin, Sohib Muhammad Mukhamad Romli Muntasir, Adib Murhan, Al Mu’awanah, Frida Rosidatul Naimatun Munawaroh, Naimatun Nandang Kosasih Ananda Ngadenin Ngadenin Ninda Sahriyani Noormantama, Hidan Normalita, Normalita Nugraha, Bayu Setya Aji Nukhan Wicaksono Pribadi, Nukhan Wicaksono Nunuk Mardiana, Nunuk Nur'afifah, Martha Marshynta Prabowo, Catur Hadi pranawa pranawa, pranawa Pratiwi, Galuh Ayu Puspita, Ariati Dina R.F, Rony Haendra Rina Rina Riyadi Riyadi Rizal Fahmi Bachtiar, Rizal Fahmi Rizki Hadi, Rizki Rosihan Adhani, Rosihan Rusdian Noor Dermawan, Rusdian Noor Ryanti W. Savitri Samsubar Saleh Sari, Dia Novita Satoshi Horikoshi, Satoshi SATRIYAS ILYAS Siburian, Theresia Siti Lestari soewanto soewanto, soewanto Solihin Solihin SRI HENDRASTUTI HIDAYAT Subanar Subanar Subari Subari SUDARSONO SUDARSONO SUDIRMAN YAHYA SUMADI SUMADI Sumardino Sumardino Sunarso Sunarso Suparno, Nano Surya Putra, Ahmad Romadhoni Suryandari, Retno SURYO WIYONO Susanti Mugi Lestari Sutrisno sutrisno Syaidatul Rosidah Tanu, Lenny Octaviani Teguh Budiharjo, Teguh Theresia Ika Purwantiningsih Titi A W Titiek Siti Yuliani Toni Kus Indratno, Toni Kus Tri P Asmarawati, Tri P Tridjoko Wisnu Murti Triyani, Devi Umaeza, Agus Wahyudi W. Parnadi Wahyuni, Dina Warijan Warijan Waslaluddin Waslaluddin Wayan Tunas Artama Weni Willia WENNY PUTRI NILAMSARI, WENNY PUTRI Widianto, Eri Widodo, Hermawan Setyo Willy Hermawan, Willy Winarno Winarno Wiwik Utami Wiwik Wijaningsih, Wiwik Yasim, Ahmad Yasuhiko Tomino, Yasuhiko Yuni Suranindyah, Yuni Yuntara, Rendi YUSNITA YUSNITA Yuwantono, Naufal Zakia, Rahma zumaroh, siti