Articles

Found 7 Documents
Search

Aspek Patobiologis pada Penyakit Trofoblas Gestasional Wargasetia, Teresa L.; Nataprawira, Heda M. D.; Shahib, M. Nurhalim
Jurnal Kedokteran Maranatha Vol 10, No 2 (2011)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penyakit trofoblas gestasional (PTG) mencakup mola hidatidosa (komplit dan parsial) dan tumor trofoblas gestasional (mola invasif, koriokarsinoma, placental site trophoblastic tumor, dan epithelioid trophoblastic tumour). Para ahli mempelajari kelainan perkembangan sel-sel trofoblas pada berbagai lesi trofoblastik PTG termasuk exaggerated placental site dan placental site nodule melalui gambaran morfologis, sitogenetik, imunofenotip, dan profil ekspresi gen. Upaya tersebut dilakukan untuk memahami patogenesis tumor trofoblas gestasional yang belum dipahami secara jelas, serta pengembangan diagnosis patologis dan molekuler dari berbagai tipe tumor trofoblas, pencarian petanda-petanda genetik untuk prognosis, dan penentuan target-target terapi potensial bagi bentuk metastatis dari PTG yang resisten terhadap pengobatan konvensional. Ketertarikan yang besar untuk mengetahui patogenesis PTG belumlah cukup bagi kemajuan penanganan PTG tanpa disertai ketekunan untuk mendapatkan petanda kanker yang tidak hanya diduga berperan dalam penyakit ini, namun dibutuhkan tahapan panjang dalam pencarian dan validasi petanda-petanda kanker untuk diagnostik, prognostik, dan target terapi.Kata kunci: penyakit trofoblas gestasional, mola hidatidosa, koriokarsinoma, placental sitetrophoblastic tumor, sitotrofoblas, sinsitiotrofoblas.
Free Radicals Scavenger Potency of Betel Leaves (Piper betel L.) Extract and Various Fractions Widowati, Wahyu; Wargasetia, Teresa L.; Khiong, Khie; Mozef, Tjandrawati; Soeng, Sylvia; Risdian, Chandra
Jurnal Kedokteran Maranatha Vol 10, No 1 (2010)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The imbalance between free radicals and antioxidants in the biology system can cause various diseases. Betel leaves (Piper betel L.), parts of a medicinal plant, are popularly used as a herbal remedy for diseases, but the scientific basis especially of their antioxidant properties remains unknown. To evaluate free radicals scavenger activity of ethanol extract and various fractions (hexane, ethyl acetate, butanol and water fraction), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and hydroperoxide (H2O2) scavenging activity were determined. To determine the DPPH and H2O2 scavenging activity, betel leaves extract and fractions were prepared in 10 concentrations. The result of this research showed that betel leaves extract and fractions had higher H2O2 scavenger and lower DPPH scavenger activities than gallic acid. The highest DPPH scavenging activity with Inhibitory Concentration (IC50) was found in gallic acid 0.732 μg/mL, ethyl acetate fraction 3.156 μg/mL, and ethanol extract 5.489 μg/mL. The highest H2O2 scavenging activity with IC50 was found in butanol fraction 0.223 μg/mL, gallic acid 0.597 μg/mL, and ethyl acetate fraction 0.783 μg/mL. In conclusion, betel leaves extract and fractions were potential free radicals scavenger; they could be potential candidates to inhibit oxidative stress. Gallic acid and ethyl acetate fraction were the highest free radicals scavenger both in DPPH and H2O2 free radical scavenging activity.Keywords: free radical, betel leaves, DPPH, H2O2, antioxidant
Nilai-nilai Etika Kedokteran Wargasetia, Teresa L.
Majalah Komunikasi Maranatha Vol 9, No 7 (2000)
Publisher : Majalah Komunikasi Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Profesi dokter adalah profesi yang mulia, penuh tantangan dan menuntut loyalitas yang tinggi. Profesi ini sedemikian penting dan dihargai karena dapat berkaitan dengan kesetamatan nyawa seseorang. Dalam menjalankan profesinya, seorang dokter acap kali diperhadapkan pada masalah etika dan sistem nilai yang memerlukan pertimbangan dan pemikiran yang mendalam. Sejalan dengan kemajuan di bidang teknologi maka teknologi kedokteranpun berkembang pesat. Ilmu dan teknologi kedokteran yang terus dikembangkan manusia di seluruh penjuru dunia dimaksudkan untuk meningkatkan kesejahteraan umat manusia, namun di balik itu bermunculan masalah-masalah etika yang perlu dipertimbangkan. Tulisan ini mencoba memunculkan beberapa masalah etika yang ada seputar pekerjaan seorang dokter.
Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Permadi, Achmad R.; Ratnawati, Hana; Wargasetia, Teresa L.
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients characteristics, prevalence 
The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Wargasetia, Teresa L.
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy
The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Wargasetia, Teresa L.
Journal of Medicine & Health Vol 1 No 3 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.723 KB) | DOI: 10.28932/jmh.v1i3.523

Abstract

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy
Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Permadi, Achmad R.; Ratnawati, Hana; Wargasetia, Teresa L.
Journal of Medicine & Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.433 KB) | DOI: 10.28932/jmh.v1i4.531

Abstract

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence