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Journal : Medula

Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan Parawansah, Parawansah; Wahyuni, Wahyuni; Mahmudah, Zakiyatul
Medula Vol 4, No 1 (2016)
Publisher : Medula

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Abstract

This research was carried out to determine the content of secondary metabolites contained in the ethanol extract of bitter melon (Momordica charantia L.) and antipyretic and antiinflammatory effects on mice. Bitter melon extract obtained by maceration method using ethanol 96%. Bitter melo ethanol extract was made in three variations of dose 50 mg / KgBW, 150 mg / KgBW, and 250 mg / KgBW. The content of secondary metabolites determined phytochemical Skrining by TLC (thin layer chromatography) with specific reagent. Antipyretic effect performed by vaccine DPT (Diphtheria Pertussis Tetanus) as inducers of fever and Parasetamol 500 mg as a positive control and antiinflammatory effect using the method of edema artificial on the soles of the mice foot with carrageenan 2% as an aphrodisiac edema and Diclofenac Sodium 50 mg as a positive control. Subjects used is a white male mice were given intraperitoneally (i.p). Analysis of the data using ANOVA statistical analysis and continued with LSD Post Hoc test. Phytochemical screening results showed that ethanol extract of bitter melon contains alkaloids, tannins, flavonoids, saponins, and triterpenoids. The results indicated that ethanol extract of bitter melon at dose of 150 mg/KgBW has antipyretic effect with total temperature decrease 1,1oC and anti-inflammatory effects with the largest of inflammation inhibition percent by 68.57%. One way ANOVA analysis signify a probability value (p) < 0.05 with 95 % of confidence level that indicate a significant influence of ethanol extract of bitter melon to its antipyretic and antiinflammatory effects on male mice.Keywords : Antipyretic, Anti-inflammatory, Momordica charantia, Bitter melon
Co-Authors A P, I Nyoman Nugraha Abdullah, Dahliana Abu Bakar Adrianus Adrianus, Adrianus Adryan, Fristiohady Afriani, Miskah Ahmad Ridhay Alam, Ilham Kudratul Alfyano, Aexsa Aliah, Ahmad Irsyad Amirullah Amirullah Andayani Andayani Andi Parenrengi Andriani, Rina Andriani, Rina Anggraini Anggraini Anika, Mutia Annawaty Annawaty, Annawaty Anwar Umar Anwar, Zakariya Apriliani, Apriliani Ardyana, Della Arianto, Asnandar Arianto, Asnandar Ariastika, Dian Arief, I. I. Arief, Tita Rahayu Armin, La Ode Arsa Wahyu Nugrahani Arsyad, Usman ASMAN SADINO, ASMAN Asrul Sani Astuti Wijayanti, Astuti B. Yuliadi Bafadal, Mentarry Baru Sadarun, Baru Benny Rusli, Benny Benny, Faichal Budirman Bachtiar Damanhuri Daud, Damanhuri Darsono Darsono Desiana Trisnawati Tobigo, Desiana Trisnawati Dj, MUHAMMAD ZUHRI Dwi Hilda Putri Dwi Kesuma Sari Dwi Shintia, Ulan Emilia Emilia Eva Dolorosa Fahri Fahri Fauziyyah, Afifah Feriadi, Eva Feriadi, Eva Fredricka, Jhoanne Fristiohady, Adryan Fristiohady, Adryan Fristiyohadi, Adryan hajrawati, Hajrawati Halik, Tian Amalia Harahap, Milna Chairunnisa Hartono Hartono Hasratuddin Hasratuddin Herri Mahyar Hidayat Hidayat Hidayat, Alfa Manarul Hidayati, Siti Aisyah Himawan, Noni I Sahidin Imelda Imelda Imran Imran Inayah Inayah Indalifiany, Astrid Indalifiany, Astrid Indrayana, Sofyan Irawati Mei Widiastuti Irmawanty, Irmawanty Islamiah, Nurul Ismartoyo Ismartoyo Isnaini Herawati, Isnaini Istiqomah, Widya Izwita Dewi Jabbar, Asriullah Jamaluddin . Jesi Alexander Alim Kalimin, Wa OIL. Kardi, Ipa Sari Kasmawati, Henny Ketut Sofjan Firdausi, Ketut Sofjan Khaeruddin Khaeruddin Kurniawan, Dedy Hendra Lestari Sukarniati, Lestari Lestari, Indri Lilis Martutik Limbongan, Amelia A Lubis, Adryan Fristiohady M., Fadliah Mahidin Mahidin Mahmudah, Zakiyatul Malaka, Muh Hajrul Malaka, Muhammad Hajrul Malik, Fadhliyah Malik, Fadhliyah Masdul, Muhammad Rizal Matandung, Karla Kembongallo Mirda, Mirda Mohammad, Habsah Muhammad Fadli Muhammad Ilyas Yusuf Muhammad Irfan Muhammad, Tengku Sifzizul Tengku Mukarramah Mukarramah, Mukarramah Munar Munar Musa, Najiah Muwakhidah, Muwakhidah Nasution, Rina Mahyurni Ningsi, Andryani Ningsih, Andryani Normawati Normawati, Normawati Nur Illiyyin Akib Nurahmi, Nurahmi Nurakhirawati Nurakhirawati Nuralifah Nuralifah, Nuralifah Nurjaman, Jajang Nurjannah Bachri, Nurjannah Nurjunitar, Annita Vury Nurlaela Rauf Nurlina Ibrahim Nuryamin Nuryamin, Nuryamin Parawansah Parawansah, Parawansah Permana, La OMJ. Poko, Feny Rizkia Purba, Fika Yuliza Purnama, La Ode Muhammad Julian Rahayu, Gustin Sari Margiani Rahmanpiu, Rahmanpiu Rahmayani, Nur Rina Sri Widayati Rini Hamsidi, Rini Ristiyanto Ristiyanto Roland Alexander Barkey, Roland Alexander Rosmiati Rosmiati Rustam HN, Muhammad Sabrianto Aswad, Sabrianto sadimantara, muhammad syukri Safa’at, Rachmat Sahidin Sahidin Sahidin, Idin Sahidin, Idin Saktiani, Dwi Nur Salsabila, Syefira Saripuddin, Saripuddin Satria Bijaksana silvitasari, ika Siregar, Khoirotun Najihah Sitanggang, Andri Sahata Soma, Andang Suryana Sri Wahyuni Supriati, Yulia Suriana Suriana Surjono Surjono Suryani Suryani Sutji Rochaminah Suwarjo Suwarjo Syafariani, R Fenny Taufiq Taufiq Totok Budi Santoso Umar Dani, Ali Wanialisa, Mery Winda Irwanti, Winda Wirawan, Reza Ashari Yusuf, Muhammad I. Yusuf, Muhammad I. Zubaydah, Wa Ode Siti Zubaydah, Wa Ode Sitti