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Journal : Medula

Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan

Medula Vol 4, No 1 (2016)
Publisher : Medula

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Abstract

This research was carried out to determine the content of secondary metabolites contained in the ethanol extract of bitter melon (Momordica charantia L.) and antipyretic and antiinflammatory effects on mice. Bitter melon extract obtained by maceration method using ethanol 96%. Bitter melo ethanol extract was made in three variations of dose 50 mg / KgBW, 150 mg / KgBW, and 250 mg / KgBW. The content of secondary metabolites determined phytochemical Skrining by TLC (thin layer chromatography) with specific reagent. Antipyretic effect performed by vaccine DPT (Diphtheria Pertussis Tetanus) as inducers of fever and Parasetamol 500 mg as a positive control and antiinflammatory effect using the method of edema artificial on the soles of the mice foot with carrageenan 2% as an aphrodisiac edema and Diclofenac Sodium 50 mg as a positive control. Subjects used is a white male mice were given intraperitoneally (i.p). Analysis of the data using ANOVA statistical analysis and continued with LSD Post Hoc test. Phytochemical screening results showed that ethanol extract of bitter melon contains alkaloids, tannins, flavonoids, saponins, and triterpenoids. The results indicated that ethanol extract of bitter melon at dose of 150 mg/KgBW has antipyretic effect with total temperature decrease 1,1oC and anti-inflammatory effects with the largest of inflammation inhibition percent by 68.57%. One way ANOVA analysis signify a probability value (p) < 0.05 with 95 % of confidence level that indicate a significant influence of ethanol extract of bitter melon to its antipyretic and antiinflammatory effects on male mice.Keywords : Antipyretic, Anti-inflammatory, Momordica charantia, Bitter melon

Co-Authors A P, I Nyoman Nugraha Abdullah, Dahliana Abu Bakar Afriani, Miskah Ahmad Ridhay Alfyano, Aexsa Amirullah Amirullah Andayani Andayani Andi Parenrengi Andriani, Rina Anggraini Anggraini Anika, Mutia Annawaty Annawaty, Annawaty Anwar Umar Ardyana, Della Arianto, Asnandar Ariastika, Dian Arief, Tita Rahayu Armin, La Ode Arsa Wahyu Nugrahani Arsyad, Usman ASMAN SADINO, ASMAN Asrul Sani Astuti Wijayanti, Astuti B. Yuliadi Bafadal, Mentarry Baru Sadarun, Baru Benny, Faichal Budirman Bachtiar Darsono Darsono Dwi Hilda Putri Emilia Emilia Fahri Fahri Fauziyyah, Afifah Feriadi, Eva Fredricka, Jhoanne Fristiohady, Adryan Halik, Tian Amalia Harahap, Milna Chairunnisa Hartono Hartono Hasratuddin Hasratuddin Herri Mahyar Hidayat Hidayat Hidayat, Alfa Manarul Hidayati, Siti Aisyah Himawan, Noni Inayah Inayah Indalifiany, Astrid Indrayana, Sofyan Irmawanty, Irmawanty Islamiah, Nurul Isnaini Herawati, Isnaini Istiqomah, Widya Izwita Dewi Jamaluddin . Kasmawati, Henny Ketut Sofjan Firdausi, Ketut Sofjan Khaeruddin Khaeruddin Kurniawan, Dedy Hendra Lestari Sukarniati, Lestari Lilis Martutik Mahidin Mahidin Mahmudah, Zakiyatul Malaka, Muhammad Hajrul Malik, Fadhliyah Masdul, Muhammad Rizal Matandung, Karla Kembongallo Mohammad, Habsah Muhammad Fadli Muhammad Ilyas Yusuf Muhammad Irfan Muhammad, Tengku Sifzizul Tengku Mukarramah Mukarramah, Mukarramah Munar Munar Musa, Najiah Muwakhidah, Muwakhidah Nasution, Rina Mahyurni Ningsi, Andryani Ningsih, Andryani Normawati Normawati, Normawati Nur Illiyyin Akib Nurakhirawati Nurakhirawati Nurjaman, Jajang Nurlaela Rauf Nurlina Ibrahim Nuryamin Nuryamin, Nuryamin Parawansah Parawansah, Parawansah Poko, Feny Rizkia Rahayu, Gustin Sari Margiani Rahmanpiu, Rahmanpiu Rahmayani, Nur Rini Hamsidi, Rini Ristiyanto Ristiyanto Roland Alexander Barkey, Roland Alexander Rosmiati Rosmiati Rustam HN, Muhammad Sabrianto Aswad, Sabrianto sadimantara, muhammad syukri Safa’at, Rachmat Sahidin Sahidin Sahidin, Idin Saktiani, Dwi Nur Satria Bijaksana Siregar, Khoirotun Najihah Soma, Andang Suryana Sri Wahyuni Supriati, Yulia Suriana Suriana Surjono Surjono Suryani Suryani Sutji Rochaminah Suwarjo Suwarjo Taufiq Taufiq Totok Budi Santoso Umar Dani, Ali Winda Irwanti, Winda Wirawan, Reza Ashari Yusuf, Muhammad I. Zubaydah, Wa Ode Sitti