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Journal : Borneo Journal of Pharmacy

Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Zubaydah, Wa Ode Sitti; Wahyuni, Wahyuni; Sahidin, Sahidin; Halik, Tian Amalia; Andriani, Rina; Indalifiany, Astrid; Fristiohady, Adryan
Borneo Journal of Pharmacy Vol 2 No 1 (2019): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity Fristiohady, Adryan; Zubaydah, Wa Ode Siti; Wahyuni, Wahyuni; Mirda, Mirda; Saripuddin, Saripuddin; Andriani, Rina; Purnama, La Ode Muhammad Julian; Sahidin, Sahidin
Borneo Journal of Pharmacy Vol 2 No 2 (2019): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.868

Abstract

The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.
Co-Authors A P, I Nyoman Nugraha Abdullah, Dahliana Abu Bakar Adrianus Adrianus, Adrianus Adryan, Fristiohady Afriani, Miskah Ahmad Ridhay Alam, Ilham Kudratul Alfyano, Aexsa Aliah, Ahmad Irsyad Amirullah Amirullah Andayani Andayani Andi Parenrengi Andriani, Rina Andriani, Rina Anggraini Anggraini Anika, Mutia Annawaty Annawaty, Annawaty Anwar Umar Anwar, Zakariya Apriliani, Apriliani Ardyana, Della Arianto, Asnandar Arianto, Asnandar Ariastika, Dian Arief, I. I. Arief, Tita Rahayu Armin, La Ode Arsa Wahyu Nugrahani Arsyad, Usman ASMAN SADINO, ASMAN Asrul Sani Astuti Wijayanti, Astuti B. Yuliadi Bafadal, Mentarry Baru Sadarun, Baru Benny Rusli, Benny Benny, Faichal Budirman Bachtiar Damanhuri Daud, Damanhuri Darsono Darsono Desiana Trisnawati Tobigo, Desiana Trisnawati Dj, MUHAMMAD ZUHRI Dwi Hilda Putri Dwi Kesuma Sari Dwi Shintia, Ulan Emilia Emilia Eva Dolorosa Fahri Fahri Fauziyyah, Afifah Feriadi, Eva Feriadi, Eva Fredricka, Jhoanne Fristiohady, Adryan Fristiohady, Adryan Fristiyohadi, Adryan hajrawati, Hajrawati Halik, Tian Amalia Harahap, Milna Chairunnisa Hartono Hartono Hasratuddin Hasratuddin Herri Mahyar Hidayat Hidayat Hidayat, Alfa Manarul Hidayati, Siti Aisyah Himawan, Noni I Sahidin Imelda Imelda Imran Imran Inayah Inayah Indalifiany, Astrid Indalifiany, Astrid Indrayana, Sofyan Irawati Mei Widiastuti Irmawanty, Irmawanty Islamiah, Nurul Ismartoyo Ismartoyo Isnaini Herawati, Isnaini Istiqomah, Widya Izwita Dewi Jabbar, Asriullah Jamaluddin . Jesi Alexander Alim Kalimin, Wa OIL. Kardi, Ipa Sari Kasmawati, Henny Ketut Sofjan Firdausi, Ketut Sofjan Khaeruddin Khaeruddin Kurniawan, Dedy Hendra Lestari Sukarniati, Lestari Lestari, Indri Lilis Martutik Limbongan, Amelia A Lubis, Adryan Fristiohady M., Fadliah Mahidin Mahidin Mahmudah, Zakiyatul Malaka, Muh Hajrul Malaka, Muhammad Hajrul Malik, Fadhliyah Malik, Fadhliyah Masdul, Muhammad Rizal Matandung, Karla Kembongallo Mirda, Mirda Mohammad, Habsah Muhammad Fadli Muhammad Ilyas Yusuf Muhammad Irfan Muhammad, Tengku Sifzizul Tengku Mukarramah Mukarramah, Mukarramah Munar Munar Musa, Najiah Muwakhidah, Muwakhidah Nasution, Rina Mahyurni Ningsi, Andryani Ningsih, Andryani Normawati Normawati, Normawati Nur Illiyyin Akib Nurahmi, Nurahmi Nurakhirawati Nurakhirawati Nuralifah Nuralifah, Nuralifah Nurjaman, Jajang Nurjannah Bachri, Nurjannah Nurjunitar, Annita Vury Nurlaela Rauf Nurlina Ibrahim Nuryamin Nuryamin, Nuryamin Parawansah Parawansah, Parawansah Permana, La OMJ. Poko, Feny Rizkia Purba, Fika Yuliza Purnama, La Ode Muhammad Julian Rahayu, Gustin Sari Margiani Rahmanpiu, Rahmanpiu Rahmayani, Nur Rina Sri Widayati Rini Hamsidi, Rini Ristiyanto Ristiyanto Roland Alexander Barkey, Roland Alexander Rosmiati Rosmiati Rustam HN, Muhammad Sabrianto Aswad, Sabrianto sadimantara, muhammad syukri Safa’at, Rachmat Sahidin Sahidin Sahidin, Idin Sahidin, Idin Saktiani, Dwi Nur Salsabila, Syefira Saripuddin, Saripuddin Satria Bijaksana silvitasari, ika Siregar, Khoirotun Najihah Sitanggang, Andri Sahata Soma, Andang Suryana Sri Wahyuni Supriati, Yulia Suriana Suriana Surjono Surjono Suryani Suryani Sutji Rochaminah Suwarjo Suwarjo Syafariani, R Fenny Taufiq Taufiq Totok Budi Santoso Umar Dani, Ali Wanialisa, Mery Winda Irwanti, Winda Wirawan, Reza Ashari Yusuf, Muhammad I. Yusuf, Muhammad I. Zubaydah, Wa Ode Siti Zubaydah, Wa Ode Sitti