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Journal : Pharmacology and Clinical Pharmacy Research

Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.767 KB) | DOI: 10.15416/pcpr.v1i2.15201

Abstract

The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol
Antibacterial Activity of Polygonum pulchrum Blume Ethanol Extract on Staphylococcus aureus and Escherichia coli Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.919 KB)

Abstract

The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique
Antimitotic Activity of Cayratia trifolia Ethanol Extract on Zygote Cells of Tripneustes gratilla Feriadi, Eva; Wahyuni, Wahyuni; Yusuf, Muhammad I.
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.767 KB) | DOI: 10.15416/pcpr.v1i2.15205

Abstract

Cancer is a devastating disease characterized by abnormal cell growth. Due to several safety issues associated with current cancer treatment, identification of new strategies for cancer therapy is considered necessary. Natural substances in plants m and fruits have the potentials to be developed as anticancer drugs. One of them is Cayratia trifolia (C. trifolia). This study was aimed to determine the cytotoxic activity of stem and leaf ethanol extract of C. trifolia against zygote cells of sea urchin or Tripneustes gratilla (T. gratilla). Extraction of stem and leaf of C. trifolia was conducted using maceration method in ethanol solvent. Thin layer chromatography was performed to screen phytochemicals contained in the extract. Zygoteof T. gratilla was used to conduct antimitotic activity test. We found that stem and leaf ethanol extract had IC50 of 169.82 μg/ml and 208.92 μg/ml, respectively. In comparison with positivecontrol of vincristine which had IC50 value of 3.23x10-3 μg/ml (very strong category), this extract showed moderate antimitotic activity. In conclusion, C. trifolia is potential to be developed as anticancer treatment.Keywords: cancer, Cayratia trifolia, antimitotic
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.058 KB) | DOI: 10.15416/pcpr.v2i2.15210

Abstract

The potential toxicity effect presents in the medicinal plants is important to be identified forthe safety assurance. Accute toxicity study is an initial step in the drug safety assurance test.Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves,and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). Thisstudy used brine shrimp lethality test (BSLT) method. The total number of larvae used ineach concentrations in three times replications was 330 larvae. Each group was given consecutivelyroots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants withvariation concentrations 12.5 μg/ml, 25 μg/ml, 50 μg/ml, 100 μg/ml, 125 μg/ml, 250 μg/ml, 500 μg/ml, 1000 μg/ml, 2000 μg/ml, and 4000 μg/ml. The number of dead larvae after24 hours treatment were calculated to obtain the mortality percentages and to determine theLC50 value, which were determined by probit analysis using MiniTab application version17.1.0. Ethanol extract of P. pulchrum roots and stems resulted LC50 values of 933.08 μg/mland 919.58 μg/ml, respectively. While the LC50 values of leaves and flowers extracts were2207.06 μg/ml and 1081.90 μg/ml, respectively. In conclusion, P. pulchrum Blume roots andstems were classified as toxic according to BLST method, while leaves and flowers were not.Keywords: acute toxicity, brine shrimp lethality test, Polygonum pulchrum Blume
Antibacterial Activity of Polygonum pulchrum Blume Ethanol Extract on Staphylococcus aureus and Escherichia coli Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 3, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.919 KB) | DOI: 10.15416/pcpr.v3i2.18097

Abstract

The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique
Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.767 KB) | DOI: 10.15416/pcpr.v1i2.15201

Abstract

The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol
Antimitotic Activity of Cayratia trifolia Ethanol Extract on Zygote Cells of Tripneustes gratilla Feriadi, Eva; Wahyuni, Wahyuni; Yusuf, Muhammad I.
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v1i2.15205

Abstract

Cancer is a devastating disease characterized by abnormal cell growth. Due to several safety issues associated with current cancer treatment, identification of new strategies for cancer therapy is considered necessary. Natural substances in plants m and fruits have the potentials to be developed as anticancer drugs. One of them is Cayratia trifolia (C. trifolia). This study was aimed to determine the cytotoxic activity of stem and leaf ethanol extract of C. trifolia against zygote cells of sea urchin or Tripneustes gratilla (T. gratilla). Extraction of stem and leaf of C. trifolia was conducted using maceration method in ethanol solvent. Thin layer chromatography was performed to screen phytochemicals contained in the extract. Zygoteof T. gratilla was used to conduct antimitotic activity test. We found that stem and leaf ethanol extract had IC50 of 169.82 ?g/ml and 208.92 ?g/ml, respectively. In comparison with positivecontrol of vincristine which had IC50 value of 3.23x10-3 ?g/ml (very strong category), this extract showed moderate antimitotic activity. In conclusion, C. trifolia is potential to be developed as anticancer treatment.Keywords: cancer, Cayratia trifolia, antimitotic
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.058 KB) | DOI: 10.15416/pcpr.v2i2.15210

Abstract

The potential toxicity effect presents in the medicinal plants is important to be identified forthe safety assurance. Accute toxicity study is an initial step in the drug safety assurance test.Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves,and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). Thisstudy used brine shrimp lethality test (BSLT) method. The total number of larvae used ineach concentrations in three times replications was 330 larvae. Each group was given consecutivelyroots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants withvariation concentrations 12.5 ?g/ml, 25 ?g/ml, 50 ?g/ml, 100 ?g/ml, 125 ?g/ml, 250 ?g/ml, 500 ?g/ml, 1000 ?g/ml, 2000 ?g/ml, and 4000 ?g/ml. The number of dead larvae after24 hours treatment were calculated to obtain the mortality percentages and to determine theLC50 value, which were determined by probit analysis using MiniTab application version17.1.0. Ethanol extract of P. pulchrum roots and stems resulted LC50 values of 933.08 ?g/mland 919.58 ?g/ml, respectively. While the LC50 values of leaves and flowers extracts were2207.06 ?g/ml and 1081.90 ?g/ml, respectively. In conclusion, P. pulchrum Blume roots andstems were classified as toxic according to BLST method, while leaves and flowers were not.Keywords: acute toxicity, brine shrimp lethality test, Polygonum pulchrum Blume
Anti-Inflammatory Activity of Marine Sponge Aaptos sp. to the Plasma Interleukin-1β Level in Wistar Male Rats Fristiyohadi, Adryan; Wahyuni, Wahyuni; Kalimin, Wa OIL.; Permana, La OMJ.; Saripuddin, Saripuddin; Sahidin, Idin
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.584 KB) | DOI: 10.15416/pcpr.v4i2.24269

Abstract

Inflammation is the response of the body to injury and infection characterized by swelling, heat, pain, and redness. This study aimed to investigate the anti-inflammatory effect of Aaptos sp. ethanolic extract to plasma interleukin (IL)-1? level of Wistar male rats. Aaptos sp. was macerated with 96% ethanol for 3 x 24 hours. Inflammation was induced with administration of 1% carrageenan intraplantarly. Animals were divided into 5 treatment groups, i.e., positive control  (diclofenac sodium 3598 ppm); Aaptos sp extract 50 ppm; Aaptos sp extract 100 ppm Aaptos sp extract 200 ppm; and negative control (0.5% Na CMC). After 1 hour, blood was collected and assayed using enzyme-linked immunosorbent assay (ELISA) kit. The results showed that plasma IL-1? levels of animals were decreased by Aaptos sp ethanolic extract. The administration of 50 ppm of extract showed no significant difference (p>0.05)  in IL-1? level in first and second hour measurement, but indicated a statistically significant decrease after three hour (p<0.05). The administration of 100 ppm of extract showed no significant difference (p>0.05) in every hour. Significant reduction was observed in the administration of 200 ppm of extract, but the elevation of IL-1? levels was also observed at third hour measurement. In conclusion, ethanolic extract of Aaptos sp. had anti-inflammatory activity and its effective dose was 50 ppm.   
Co-Authors A P, I Nyoman Nugraha Abdullah, Dahliana Abu Bakar Adrianus Adrianus, Adrianus Adryan, Fristiohady Afriani, Miskah Alam, Ilham Kudratul Alfyano, Aexsa Aliah, Ahmad Irsyad Amirullah Amirullah Andayani Andayani Andi Parenrengi Andriani, Rina Andriani, Rina Anggraini Anggraini Anika, Mutia Annawaty Annawaty, Annawaty Anwar Umar Anwar, Zakariya Apriliani, Apriliani Ardyana, Della Arianto, Asnandar Arianto, Asnandar Ariastika, Dian Arief, I. I. Arief, Tita Rahayu Armin, La Ode Arsa Wahyu Nugrahani Arsyad, Usman ASMAN SADINO, ASMAN Asrul Sani Astuti Wijayanti, Astuti B. Yuliadi Bafadal, Mentarry Baru Sadarun, Baru Benny Rusli, Benny Benny, Faichal Budirman Bachtiar Damanhuri Daud, Damanhuri Darsono Darsono Desiana Trisnawati Tobigo, Desiana Trisnawati Dj, MUHAMMAD ZUHRI Dwi Hilda Putri Dwi Kesuma Sari Dwi Shintia, Ulan Emilia Emilia Eva Dolorosa Fahri Fahri Fauziyyah, Afifah Feriadi, Eva Feriadi, Eva Fredricka, Jhoanne Fristiohady, Adryan Fristiohady, Adryan Fristiyohadi, Adryan hajrawati, Hajrawati Halik, Tian Amalia Harahap, Milna Chairunnisa Hartono Hartono Hasratuddin Hasratuddin Herri Mahyar Hidayat Hidayat Hidayat, Alfa Manarul Hidayati, Siti Aisyah Himawan, Noni I Sahidin Imelda Imelda Imran Imran Inayah Inayah Indalifiany, Astrid Indalifiany, Astrid Indrayana, Sofyan Irawati Mei Widiastuti Irmawanty, Irmawanty Islamiah, Nurul Ismartoyo Ismartoyo Isnaini Herawati, Isnaini Istiqomah, Widya Izwita Dewi Jabbar, Asriullah Jamaluddin . Jesi Alexander Alim Kalimin, Wa OIL. Kardi, Ipa Sari Kasmawati, Henny Ketut Sofjan Firdausi, Ketut Sofjan Khaeruddin Khaeruddin Kurniawan, Dedy Hendra Lestari Sukarniati, Lestari Lestari, Indri Lilis Martutik Limbongan, Amelia A Lubis, Adryan Fristiohady M., Fadliah Mahidin Mahidin Mahmudah, Zakiyatul Malaka, Muh Hajrul Malaka, Muhammad Hajrul Malik, Fadhliyah Malik, Fadhliyah Masdul, Muhammad Rizal Matandung, Karla Kembongallo Mirda, Mirda Mohammad, Habsah Muhammad Fadli Muhammad Ilyas Yusuf Muhammad Irfan Muhammad, Tengku Sifzizul Tengku Mukarramah Mukarramah, Mukarramah Munar Munar Musa, Najiah Muwakhidah, Muwakhidah Nasution, Rina Mahyurni Ningsi, Andryani Ningsih, Andryani Normawati Normawati, Normawati Nur Illiyyin Akib Nurahmi, Nurahmi Nuralifah Nuralifah, Nuralifah Nurjaman, Jajang Nurjannah Bachri, Nurjannah Nurjunitar, Annita Vury Nurlaela Rauf Nurlina Ibrahim Nuryamin Nuryamin, Nuryamin Parawansah Parawansah, Parawansah Permana, La OMJ. Poko, Feny Rizkia Purba, Fika Yuliza Purnama, La Ode Muhammad Julian Rahayu, Gustin Sari Margiani Rahmanpiu, Rahmanpiu Rahmayani, Nur Rina Sri Widayati Rini Hamsidi, Rini Ristiyanto Ristiyanto Roland Alexander Barkey, Roland Alexander Rosmiati Rosmiati Rustam HN, Muhammad Sabrianto Aswad, Sabrianto sadimantara, muhammad syukri Safa’at, Rachmat Sahidin Sahidin Sahidin, Idin Sahidin, Idin Saktiani, Dwi Nur Salsabila, Syefira Saripuddin, Saripuddin Satria Bijaksana silvitasari, ika Siregar, Khoirotun Najihah Sitanggang, Andri Sahata Soma, Andang Suryana Sri Wahyuni Supriati, Yulia Suriana Suriana Surjono Surjono Suryani Suryani Sutji Rochaminah Suwarjo Suwarjo Syafariani, R Fenny Taufiq Taufiq Totok Budi Santoso Umar Dani, Ali Wanialisa, Mery Winda Irwanti, Winda Wirawan, Reza Ashari Yusuf, Muhammad I. Yusuf, Muhammad I. Zubaydah, Wa Ode Siti Zubaydah, Wa Ode Sitti