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Journal : Pharmaceutical Sciences and Research (PSR)

Toksisitas Ekstrak Etanol Mangifera foetida L. Sebagai Pengkelat Besi Ditinjau dari LD50 dan Komponen Sel Darah

Pharmaceutical Sciences and Research (PSR) Vol 2, No 3 (2015)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Ethanolic extract of bacang mango leaves (Mangifera foetida L.) was reported could decrease blood iron concentration of iron overloaded-Sprague dawley rats. The aim of this experiment was to determine acute toxicity (LD50) value of ethanolic extract of M. foetida by weil method and its effect to blood component. This study was conducted by employing a complete random design using 25 male and 25 female mice of DDY strain which was divided into 5 groups. The first until fourth group were administered by the aquadest suspension of ethanolic extract of M. foetida with dose variation, orally. The fifth group was control group that administered by aquadest only. The LD50 was determined by the total of death on all group. LD50 value of the extract showed no death in the biggest doses (13.013 g/kg). The examination was continued with measured blood count (erythrocytes, trombocytes, leukocytes, and haemoglobin concentration). It was shown that the extract at dose 1.626; 3.253; 6.506 and 13.013 g/kg unchanged the blood count measurement. It is concluded that Mangifera foetida L. leaf was not toxic, but could not change the blood count measurement.  

Co-Authors Abidin, Faris Adelina Hasyim Agistiana, Seruni Akhirmen Akhirmen Anastasya, Lidwina Anita Rahmawati Anjarsari, Dwi Indah Ari Estuningtyas, Ari Arif Widiyatmoko, Arif Ashari, . Atni Prawati Bakar, Abdoel Bakhtaruddin Nst. Cahya Mulat, Trimaya Calista Siagian, Irma Denah Suswati Deniswaty, . Desi Areva Dewi Kurniati Dewi, Arum Kusnila Didik Prasetyoko Endang Ernawati Endarwati, Susiani Fadly Azhar Fahmi Medias, Fahmi Fatchurohman, Fatchurohman Feriadi Feriadi, Feriadi Haeriah, . Halida . Hamdani . Hariani, Lilik Sri Hasan, Sholeh Hasmin Tamsah, Hasmin Hermi Yanzi Heru Pramono HJ Freisleben, HJ Isa Akhlis Kalanjati, Woro Wulandari Kamaluddin, Muhammad Totong Katrin Katrin Komara, Adi Kumar, Abdul Malik Laksmi Widajanti Linda Masniary Lubis Lulus Irawati, Lulus M. Syukri Mamik Sarwendah Mangiliwati Winardi, Mangiliwati Melda Agarina Mujiatun, . Mulawarman Mulawarman Munaris Munaris Munstermann, Susanne Mun’im, Abdul Nanik Setiyawati, Nanik Nugraha, I Ketut Destian Nugraismia, Wilda Nur Annis Hidayati, Nur Annis Nurhayati Damiri Nurliza Nurliza Ochi Marshella Febriani Parisa, Nita Perryanis, Perryanis Prastanti, Hestu Puji Harto Putri, Rahmah Dianti Qurotaayunina, Yasmin Rahmat Hidayat Rahmiati Rahmiati Raja Muhammad Amin Ramdhani, Eka Putra Rani Mega Putri Ridwan Affandi rini hazriani Rosalina, Linda Santi Purna Sari Sentosa Ginting Silitonga, Risma Juniarti Paulina Sinanto, Agus Siti Fatimah Pradigdo Soni Kurniawan Sri Ayem, Sri Sri Lestari Sriyanto, . Subagyo, Tutut Suciati Sudarisman Sulistiono, nFN Sumartono, Fareza Ferdyna Nanda Suprapto Suprapto Suyanto Suyanto Taupik Rahman Tedi Rusman Tomo Djudin Tri Karyono Tri Noor Aziza Triyanto Pristiwaluyo Wahyu Ardianto Werdiningsih, Sri Werner R. Murhadi Widuri, Anggita Yatim Lailun Ni’mah Yaya Sukaya Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Zaenuddin, Nuryani