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Journal : Atom Indonesia Journal

Separation of Radiocopper 64/67Cu from the Matrix of Neutron-Irradiated Natural Zinc Applicable for 64Cu Production

Atom Indonesia Vol 38, No 1 (2012): April 2012
Publisher : PPIKSN-BATAN

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Abstract

Radioisotope 64Cu is a promising radiometallic-isotope for molecular-targeted-radiopharmaceuticals. Having a half-life of 12.70 hours and emitting β+-radiation (Eβ+ = 0.6531 MeV) as well as β-ray (Eβ- = 0.5787 MeV), it is widely used in the form of biomedical-substrate-radiopharmaceutical for positron emission tomography (PET) diagnosis and simultaneously for targeted radiotherapy of cancer. The potential needs on the availability of 64Cu-labeled pharmaceuticals for domestic nuclear medicine hospitals lead to a necessity for the local production of carrier-free 64Cu using BATAN’s G.A. Siwabessy reactor because of the technical and economical constraints in the production using BATAN’s cyclotron. The presented work is accordingly to study whether the radioisotope 64Cu can be produced and separated from the matrix of post-neutron-irradiated-natural zinc. This study is expected can be further improved and implemented in production technology of carrier-free 64Cu based on 64Zn (n,p) 64Cu nuclear reaction exploiting the fast neutron fraction among the major thermal fraction due to unavailability of fast-neutron-irradiation facility in the BATAN’s G.A. Siwabessy reactor. The solution of post-neutron-irradiated-natural zinc in 1M acetic acid was loaded into Chelex-100 cation exchanger resin column to pass out the Zn/Zn* fraction whereas the Cu* fraction which remained in the column was then eluted out from the column by using 1.5 M HCl and loaded into the second column containing Dowex-1X8 anion exchanger resin. The second column was then eluted with 0.5 M HCl. The collected eluate was expected to be zinc-free Cu* fraction. It was observed from the half-life and the γ-spectrometric analysis that radioactive copper-64Cu containing 67Cu was produced by neutron activation on the natural Zn-foil target and can be separated from the target matrix by the presented two-steps-column-chromatographic separation technique. The radioactivity measurement showed that wrapping the Zn target with cadmium foil increased the activity of radioactive copper and, thus, the Cu*/Zn*-ratio.Received: 28 June 2011; Revised: 21 February 2012; Accepted: 24 February 2012

Co-Authors A. Isnansetyo, A. A.E.T.H. Wahyuni Abdul Muthalib Abidin Abidin Agus Cahyono Agus Nursalim, Agus Agustiar, Devie Ahmad, Hariyatunnisa ALIM ISNANSETYO Ambariyanto , Andriansyah, Rico Andrianus Andrianus, Andrianus Anik Rahmawati, Anik Anshor, Arrini Shabrina Anung Pujiyanto Ardiyawan, Ardiyawan Arief Taslihan Arief, Ahmad Fikri Astri Charolina Azmi, Azmi Azmi, Ulya Zakaria Basri, Novysa Basuki, Umar Beniarso, Mundin Cahyana Amiruddin Darfioes Basir Daya Agung Sarwono Desrina Desrina Desty Ratna Permatasari, Desty Ratna Dian Indriani Dini Siswani Mulia Dini, Tria Ayu Drajad Sarwo Seto, Drajad Sarwo Duranta D. Kembaren, Duranta D. Dwiningtyas, Ratih E. Sarmini Edi Irawan Eko Sugiarto, Eko Endang Sarmini Enny Lestari Erik, Mohamad Erni Martani Ervia Yudiati FAJAR SETIAWAN Fatimah Azzahrah Fatmawati, Harlinda Finny Fitry Yani Fitriani Fitriani H. Syakuri, H. Habib Adjie Hambali Hambali Hartono Hartono Henny Ekana Ch. Henny Ekana Chrisnawati Herlina Herlina Hotnida Junita Situmeang Imamudin, Kurniasih INDAH ISTIQOMAH Irfan D. Prijambada Islami, Hidayatul Iswidiarti, Sri JAKA WIDADA K. H. Nitimulyo, K. H. Kadarisman Kadarisman Kamiso H. N., Kamiso H. KAMISO HANDOYO NITIMULYO KH, Abdul Aziz Kundharu Saddhono Kurniasih Kurniasih LANGKAH SEMBIRING Lantip Diat Prasojo Lestari, Fajar Sumi Lili Sholichah, Lili Manik, Astri Marita Mardi Mardi Mardiyana Mardiyana Maria Ulfahmi, Cut Gesti Mayang Pitaloka MIFTAKHUL JANNAH Mirwa, Tetty Muh. Ibnan Syarif, Muh. Ibnan Muhammad Murdjani Muhammad Zainuddin Muhammmad Murdjani, Muhammmad Mujiyono Mujiyono Murti, Fahriza Murwantoko Murwantoko Namastra Probosunu Nina Yuliana Nirmalasari Idha Wijaya Noer Kasanah, Noer Nur Fadhilah Nur Rokhmat Nursyirwani Nursyirwani Pratiwinindya, Ratih Ayu Prayogo, Sugeng Putri Puspitasari R Sudradjat, R Rachmansyah Rachmansyah Raden Bagus Sugio Sumanta Ratna Puspita, Ratna REZA Adi ADI PRADANA Risca Damayanti, Risca Risnawati, Ririn Riyadi Riyadi Rukayah Rukayah S. Soenarjo Sabillah, Masayu Selly Sahli, Zamahsjari Salu, Vega Ricky SANTI NURBAITI Sebastian Margino Sesung, Rusdiyanto Setyaningrum, Ikha Sulis Setyobudi Setyobudi Shanie, Arsan Shatrie, Dikry N Shatrie, Dikry Novel Siti Amirah Budiastuti Sri Hartati Sri Iswidayati Sri Rejeki Sriyono Sriyono Subagiyo Subagiyo Suharno Suharno Suherman Suherman Sumarwati Sumarwati Sunarhadijoso Soenarjo Sunarto Sunarto Suparti Suparti Sutarman Sutarman Sutrisno sutrisno Suyono Suyono syakir syakir Syarif, Muh Ibnan Tanjung, Dailami Tjetjep Rohendi Rohidi, Tjetjep Rohendi Totok Sumaryanto Florentinus, Totok Sumaryanto Totok Sumaryanto, Totok Triani Widyaningrum Udi Utomo Umi Nur Sholikhah W. Asmara W.Y. Rahman Wadiyo Wadiyo, Wadiyo Widaningtyas H, Adoniati Meyria Wijaya, Dhimayu Ichtiara Wilis Ari Ari Setyati1,2, Wilis Ari Wilis Ari Setyati Windi Amelia, Windi Wira Rahman Wira Y. Rahman Wisnu Nurcahyo Wulandari, Tita Yudha Trinoegraha Adiputra Yulius Docang Casessar Yuniarti, Ivana