MARINGAN DIAPARI LUMBAN TOBING
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Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients KURNIA, IIN; SIREGAR, BUDININGSIH; SOETOPO, SETIAWAN; RAMLI, IRWAN; KURJANA, TJAHYA; ANDRIONO, .; TOBING, MARINGAN DIAPARI LUMBAN; SURYAWATHI, BETHY; KISNANTO, TEJA; TETRIANA, DEVITA
HAYATI Journal of Biosciences Vol 21, No 4 (2014): Desember 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1416.842 KB) | DOI: 10.4308/hjb.21.4.173-179

Abstract

Akt is a protein that is associated with cell proliferation and is expressed at high levels in cancer cells. Some research indicates it may play a role in increasing the resistance of cancer cells to chemotherapy treatment. P53 is a tumor suppressor protein that influences the cell cycle and apoptosis. The purpose of this study was to examine the relationship between the expression of Akt and p53 in cancerous tissue before chemoradiation treatment, and the clinical response to treatment of cervical cancer patients. Twenty microscopic tissue samples were taken from cervical cancer biopsies obtained from patients before cancer treatment. The tissue samples were stained with p53 and Akt antibodies via immunohistochemistry technique, to measure expression of both proteins. After completion of chemoradiotherapy, patients’ clinical response to treatment was determined using the pelvic control method. Our results revealed no correlation between expression of Akt and p53 index (P = 0.74) as well as between p53 Index and chemoradiotherapy clinical response (P=0.29). There was significant correlation between expression of Akt and cervical cancer chemoradiotherapy response (P = 0.03). There was no correlation found between p53 index and chemoradiotherapy clinical response (P = 0.29). High expression of Akt may related with high cell proliferation and resistance to chemoradiotherapy.
Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients KURNIA, IIN; SIREGAR, BUDININGSIH; SOETOPO, SETIAWAN; RAMLI, IRWAN; KURJANA, TJAHYA; ANDRIONO, .; TOBING, MARINGAN DIAPARI LUMBAN; SURYAWATHI, BETHY; KISNANTO, TEJA; TETRIANA, DEVITA
HAYATI Journal of Biosciences Vol 21, No 4 (2014): December 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1416.842 KB) | DOI: 10.4308/hjb.21.4.173

Abstract

Akt is a protein that is associated with cell proliferation and is expressed at high levels in cancer cells. Some research indicates it may play a role in increasing the resistance of cancer cells to chemotherapy treatment. P53 is a tumor suppressor protein that influences the cell cycle and apoptosis. The purpose of this study was to examine the relationship between the expression of Akt and p53 in cancerous tissue before chemoradiation treatment, and the clinical response to treatment of cervical cancer patients. Twenty microscopic tissue samples were taken from cervical cancer biopsies obtained from patients before cancer treatment. The tissue samples were stained with p53 and Akt antibodies via immunohistochemistry technique, to measure expression of both proteins. After completion of chemoradiotherapy, patients? clinical response to treatment was determined using the pelvic control method. Our results revealed no correlation between expression of Akt and p53 index (P = 0.74) as well as between p53 Index and chemoradiotherapy clinical response (P=0.29). There was significant correlation between expression of Akt and cervical cancer chemoradiotherapy response (P = 0.03). There was no correlation found between p53 index and chemoradiotherapy clinical response (P = 0.29). High expression of Akt may related with high cell proliferation and resistance to chemoradiotherapy.
Hubungan antara Ekspresi Ki-67 dan Kaspase-3 dengan Respons Kemoterapi Neoajuvan pada Pasien Karsinoma Serviks Stadium IB2 dan IIA2 di Rumah Sakit Dr. Hasan Sadikin, Bandung MAHAYASA, I MADE WIDYALAKSANA; TOBING, MARINGAN DIAPARI LUMBAN; HARSONO, ALI BUDI
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTCervical carcinoma is the second ranks cancer in women in developing countries. This study was a retrospective cohortstudy of the relationship between the role of Ki-67 expression and caspase-3 on tumor shrinkage response in cervical carcinoma stage IB2 and IIA2. A total of 41 cases have been done NACT with Cisplatin, Vincristine and Bleomycin. All samples showed expression in immunohistochemical staining for Ki-67 and caspase-3. Meanwhile, Pearson correlation analysis found no correlation between the expression levels of Ki-67 and caspase-3 with a diminution oftumor mass (p>0.05). While the correlation between the ratio of Ki-67 expression and caspase-3 with a significant diminution of tumor mass is obtained p 0.042, R-0.319, means that the higher the Ki-67 expression levels compared caspase-3 expression level then the response of the tumor mass size reduction will be better.ABSTRAKKarsinoma serviks merupakan kanker kedua terbanyak pada wanita di negara berkembang. Penelitian ini merupakan penelitian kohort retrospektif yang mempelajari hubungan antara peran ekspresi Ki-67 dan kaspase-3 terhadap respons pengecilan tumor pada karsinoma serviks stadium IB2 dan IIA2. Sebanyak 41 kasus telah dilakukan KTNA dengan Cisplatin, Vincristin, dan Bleomycin (PVB).Hasil penelitian menunjukkan seluruh sampel ekspresi pada pewarnaan imunohistokimia untuk Ki-67 dan kaspase-3. Sedangkan analisis korelasi Pearson tidak didapatkan korelasi antara tingkat ekspresi ki-67 dan kaspase-3 dengan pengecilan massa tumor dan nilai p>0,05. Sedangkan korelasi antara rasio ekspresi Ki-67 dan kaspase-3 dengan pengecilan massa tumor didapatkan bermakna dengan nilai p = 0,042 (p<0,05), R-0,319. Artinya, semakin tinggi proliferasi (tingkat ekspresi Ki-67) dibandingkan dengan apoptosis (tingkat ekspresi kaspase-3) maka respons pengecilan tumor akan semakin baik pada karsinoma serviks stadium IB2 dan IIA2
Perbandingan Fungsi Berkemih pada 3 Hari dan 5 Hari Katerisasi Urin Pascaoperasi Histerektomi Radikal pada Wanita Penderita Keganasan Serviks Stadium Awal Novianti, Astri; Purwara, Benny Hasan; Hidayat, Yudi Mulyana; Krisnadi, Sofie Rifayani; Tobing, Maringan Diapari Lumban; Armawan, Edwin
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 2 September 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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Abstract

AbstrakTujuan: Menganalisis perbandingan fungsi berkemih pada pemakaian kateter urin selama 3 hari dan 5 hari pasca operasi histerektomi radikal.Metode: Non-inferiority randomized controlled trial. Subjek penelitian adalah penderita kanker serviks di Rumah Sakit Hasan Sadikin Bandung yang dilakukan operasi histerektomi radikal. Dilakukan penilaian fungsi berkemih dan kejadian infeksi saluran kemih sebelum dan setelah operasi hari ke−3 (kelompok intervensi) dan hari ke−5 (kelompok kontrol). Hasil: Pascaoperasi terjadi penurunan fungsi sensorik 8,5% pada kelompok intervensi dan 13,5% pada kelompok kontrol dan penurunan fungsi motorik 87,5% pada kelompok intervensi dan 150% pada kelompok kontrol. Kejadian infeksi saluran kemih meningkat 6,7% pada kelompok kontrol. Kesimpulan: Penggunaan kateter urin selama 3 hari pasca histerektomi radikal tidak lebih buruk dari 5 hari dan dapat digunakan sebagai manajemen pada penderita kanker serviks pasca histerektomi radikal. Kata kunci: Disfungsi berkemih pasca histerektomi radikal, kateter 3 dan 5 hari pasca histerektomi radikal, infeksi saluran kemih.AbstractObjective: To compare the urinary function after radical hysterectomy  with catheter usage for 3 days and 5 days. Method: A non-inferiority randomized controlled trial. Subjects were women diagnosed with cervical cancer that underwent radical hysterectomy in Hasan Sadikin Hospital Bandung. The study conducted by comparing urinary function and urinary tract infection in 3 days catheterization and 5 days catheterization after radical hysterectomy. Result: Post operation, there was decreased 8,5% sensory function in intervention group and 13,5% in control group and decreased 87,5% motoric function in intervention group and 150% in control group. The urinary tract infection increased about 6,7% in control group. Conclusion:3-days urethral catheterization following radical hysterectomy is non inferior to 5 days urethral catheterization and could be used for management of women with early stage cervical cancer after radical hysterectomy. Key  words: Urinary dysfunction after radical hysterectomy, 3 and 5 days catheterization after radical hysterectomy, urinary tract infection