Farida Tabri
Dept, of Dermato-Venereology, Hasanuddin Medical Faculty, Makassar

Published : 5 Documents
Articles

Found 5 Documents
Search

COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB)

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB) | DOI: 10.20473/ijtid.v4i4.220

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
EVALUATION OF ANTI PCL-1 ANTIBODY TITER IN A GROUP OF HEALTHY SCHOOL CHILDREN WHO LIVE IN LEPROSY ENDEMIC AREA FROM 2007–2010 putri, rachmah diana; amiruddin, M. dali; tabri, farida; Adriaty, Dinar; Wahyuni, ratna; iswahyudi, iswahyudi; agusni, indropo; izumi, shinzo
Indonesian Journal of Tropical and Infectious Disease Vol 1, No 3 (2010)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.13 KB) | DOI: 10.20473/ijtid.v1i3.2184

Abstract

The “Iceberg phenomene” has been used to explain this situation which indicate that these new leprosy cases is originated from Subclinical Leprosy. Fifty eight healthy school children who live in Jeneponto Regency, a leprosy endemic area in South Sulawesi were recruited. The first examination was performed in 2007 and sera samples were kept in deep freeze refrigerator. In 2010 these children were re-examined for clinical leprosy and sera were collected again. ELISA study was performed simultaneously to these 58 pairs of sera (2007 & 2010) for measuring the titer of IgM anti PGL-1 antibody (ELISA) and the level 605u/ml was regarded as cut off value. After three years evaluation, none of these children showed any clinical signs of leprosy, but 20 of 22 ( 90.9%) children were remained sero-positive and only 2 (9.1%) became sero-negatives. In other sites, 5 children that previously sero-negatives became sero-positives after 3 years. Eight of 10 (80%) children who showed sero (+) with high titer (>1.000u/ml) in 2007, were also remained in high titer. The mean titer of 2007 was 627.8 u/ml, and after3 years became 723.9 u/ml (p<0.05). Although there is no progression from Subclinical to Manifest Leprosy cases among these children, the number of sero (+) cases were increased and the mean titer of IgM anti PGL-1 antibody was significantly increased.. The majority who previously showed high anti PGL-1 antibody titer, remained in high level. This study support the “iceberg phenomene” theory in Leprosy.
Infeksi Cacing Tidak Berpengaruh terhadap Kadar Transforming Growth Factor (TGF)-β dan Kejadian Dermatitis Atopik pada Anak Mukhasin, Nadiah Soleman; Wahyuni, Sitti; Ilyas, Faridha S; Amin, Safruddin; Satriono, R; Tabri, Farida
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2015.028.03.10

Abstract

Infeksi cacing melalui kemampuannya memacu proliferasi sel T regulator dilaporkan dapat mempengaruhi manifestasi klinik dari alergi. Selain Interleukin (IL)-10, Transforming Growth Factor (TGF)-β merupakan sitokin yang di lepaskan oleh sel T regulator. Penelitian ini bertujuan untuk melihat pengaruh infeksi cacing terhadap kejadian dermatitis atopik (DA) melalui TGF-β. Penelitian ini dilakukan di beberapa rumah sakit pendidikan Fakultas Kedokteran Universitas Hasanuddin. Dermatitis atopik (DA) didiagnosis dengan menggunakan kriteria William, ada dan beratnya infeksi cacing diperiksa dengan metode Kato Katz dan kadar TGF-β serum diukur menggunakan metode ELISA.  Sebanyak 80 anak usia 2-7 tahun berpartisipasi pada penelitian ini. Partisipan dibagi menjadi kelompok DA (30 anak) dan non-DA (50 anak). Persentasi infeksi cacing adalah 21,2% (17/80) dengan intensitas infeksi yang ringan. Infeksi cacing tidak mempengaruhi kadar TGF-β, demikian juga infeksi cacing serta kadar TGF-β tidak mempengaruhi kejadian DA. Penelitian ini menyimpulkan bahwa infeksi cacing dengan intensitas ringan tidak mempengaruhi kadar TGF-β maupun kejadian DA pada anak di Makassar.Kata Kunci: Dermatitis atopik, infeksicacing, TGF-β
The efectiveness of narrowband ultraviolet B (NB-UVB) in Vitiligo Management and its Association with Thyroid Stimulating Hormone (TSH) level in Indonesian population Tabri, Farida
Journal of Dentomaxillofacial Science Vol 3, No 3 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.931 KB) | DOI: 10.15562/jdmfs.v3i3.843

Abstract

Objective: Vitiligo is an autoimmune disease marked by the presence of hypopigmented macules due to the reduction in the number and function of melanocytes. Besides its adverse cosmetic effect, vitiligo is also associated with other autoimmune diseases such as thyroid disorders. Ultraviolet irradiation, especially narrowband ultraviolet B (NB-UVB), has been widely used in treating vitiligo despite the unclear mechanism. However, such studies in Indonesian population are very limited. This study aims to examine the efficacy of NB-UVB in vitiligo treatment and its effect of thyroid function in Indonesian population.Material and Methods: Twenty-two vitiligo patients aged 4-54 years old were treated three times weekly with NB-UVB. The minimal erythema dose (MED) was determined and an initial dose of 50% MED dose was commenced three times per week. The dose was increased gradually while assessing for the treatment response. The change in depigmentation rate, vitiligo area severity index (VASI), and the level of thyroid stimulating hormone (TSH) were assessed before and after therapy using Wilcoxon test.Results: Depigmentation rate and VASI score were found to decrease after treatment, although the change was not statistically siginificant. Two patients showed an decrease in depigmentation rate of more than 75%. The TSH level significantly decreased after treatment (p&gt;0.05). The most common side effect found was the combination between erythema, soreness, and pruritus.Conclusion: Our study shows that NB-UVB therapy results in improved depigmentation, VASI score and a reduced TSH level in vitiligo patients.