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Perbedaan Model Pembelajaran Kooperatif Tipe NHT dan Model Pembelajaran Konvensional Pada Hasil Belajar Materi Garis Dan Sudut Susilowati, Heni; Rembet, T.A.S.; Pangemanan, A.
JSME MIPA UNIMA Vol 1, No 4 (2013): Matematika
Publisher : JSME MIPA UNIMA

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Abstract

Rendahnya partisipasi siswa dalam kegiatan pembelajaran matematika sehingga perlu pemilihan model pembelajaran yang sesuai dengan tujuan kurikulum dan potensi peserta didik oleh karena itu saya ingin meneliti model pembelajaran kooperatif tipe NHT dengan model pembelajaran konvensional yang bertujuan untuk mengetahui perbedaan hasil belajar siswa yang diajarkan dengan menggunakan model pembelajaran kooperatif tipe NHT dengan siswa yang diajarkan dengan model pembelajaran konvensional. Populasi yang diambil adalah seluruh siswa kelas VII SMP Negeri 3 Manado, sedangkan sampel terpilih 2 kelas yang homogen yaitu kelas VIIi sebagai kelas eksperimen dan VIIj sebagai kelas kontrol. Kelas eksperimen terdiri dari 25 orang siswa sedangkan kelas kontrol terdiri dari 25 siswa. Data diambil dan dikumpulkan dari tes hasil belajar siswa. Pada analisis deskriptif rata-rata hasil belajar siswa pada kelas yang diajarkan dengan model pembelajaran kooperatif tipe NHT adalah 72,04 sedangkan rata-rata hasil belajar siswa yang diajarkan dengan menggunakan model pembelajaran konvensional adalah 59,12. Sedangkan pada analisis inferensial yaitu dengan menggunakan uji perbedaan dua rata-rata pada kriteria H0 diterima jika thitung ≤ ttabel pada taraf signifikan α=0,05, menunjukan nilai thitung = 2,95 > ttabel = 1,677. Hal ini menunjukkan bahwa tidak cukup bukti untuk menerima H0 dan menolak H1. Berdasarkan hasil penelitian disimpulkan bahwa terdapat perbedaan hasil belajar siswa yang diajarkan dengan model pembelajaran kooperatif tipe NHT dan model pembelajaran konvensional. Hal ini terlihat dari rata-rata hasil belajar siswa yang diajarkan dengan model pembelajaran kooperatif tipe NHT lebih tinggi dari hasil belajar siswa yang diajarkan dengan model pembelajaran konvensional. Kata kunci: NHT, Garis dan Sudut, Hasil Belajar Siswa
Cyclosporine A and FK506 as Potent Inhibitors of Streptococcus intermedius Intermedilysin-Induced NFAT-1 Activation Susilowati, Heni; Okamura, Hirohiko; Hirota, Katsuhiko; Yoshida, Kaya; Tabata, Atsushi; Nagamune, Hideaki; Haneji, Tatsuji; Miyake, Yoichiro
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Research Gateway

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Abstract

Cyclosporine A (CsA) and tacrolimus (FK506), a member of calcineurin inhibitors, inhibit inflammation process as part of immune response. Nuclear activated T cells subfamily NFAT1 is a trascription factor responsible for the regulation of immune response genes. Streptococcus intermedius, an oral commensal bacterium, has been shown to strongly associate with liver abscess.  The S. intermedius strains produce intermedilysin (ILY), which is responsible for the bacterial virulence. Cyclosporine A and FK506 have been widely used to control NFAT activation in most of cell types, however the ability of CsA and FK506 to inhibit ILY-induced NFAT1 activation remains to be investigated. The aim of this study was to investigate the effect of  CsA and FK506 on NFAT1 activation caused by ILY. Human cholangiocellular cell line HuCCT1 was stimulated with various concentrations of ILY. The cell and nuclear morphological change was observed by microscopy analysis. The NFAT1 nuclear translocation that indicates its activation was detected by immunocytochemistry. The inhibitory effect of CsA and FK506 was tested after 30 min application before ILY treatment by using immunofluorescence microscope. The results showed cell and nuclear shrinkage in ILY-treated cells. The NFAT1 was translocated to the nuclei in HuCCT1 cells, and observed in dose dependent manner.  Cyclosporine A and FK506 inhibited ILY-induced NFAT1 nuclear translocation.  In conclusion, CsA and FK506 may act as potent inflammation control agents in S. intermedius ILY-infected cells.
EFEKTIFITAS MINYAK ATSIRI LENGKUAS TERHADAP PRODUKSI NITRIT OKSIDA MAKROFAG MENCIT Tandelilin, Regina T. C.; Susilowati, Heni; Hasniatuti, Tetiana
Journal of Dentistry Indonesia Vol 10, No 2 (2003): AUGUST
Publisher : Faculty of Dentistry, University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.596 KB) | DOI: 10.14693/jdi.v10i3.447

Abstract

Based on the content of the galangals essential oil which can be used as antimicroorganism, analgesic, and antiseptic characterize with inhibiting and estructing microorgnism life process, it is predicted that there is a possibility of essential oil can be use for anti-inflammatory agent. Nitric-oxie (NO) is an unstable gas produced by cell such as macrophage and has the function as antimicroorganism. The aim of this study was to investigate whther essential oil of galangal components has an effect to the macrophage NO production, which stimulated by LPS E. coli.The both curative and preventive analysis using ANOVA showed that the NO productions differences were significant (p<0,01). The study showed that the NO levels produced by marine macrophages induced by LPS E. coli were suppressed by essential oil in a dose dependent fashion, suggesting antiinflammatory activities. Curatively, increased doses of the essential oil resulted in increased its anti-inflammatory functions. Five micro liter of the essential oil was preventively the most concentration as anti inflammation.
Ekspresi COX-2 dan Jumlah Neutrofil Fase Inflamasi pada Proses Penyembuhan Luka Setelah Pemberian Sistemik Ekstrak Etanolik Rosela (Hibiscus sabdariffa) (studi in vivo pada Tikus Wistar) Kusumastuti, Endah; Handajani, Juni; Susilowati, Heni
Majalah Kedokteran Gigi Indonesia Vol 21, No 1 (2014)
Publisher : Majalah Kedokteran Gigi Indonesia

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Abstract

Inflamasi merupakan respon alami tubuh terhadap adanya kerusakan jaringan. Salah satu medikamen untuk mengatasi inflamasi adalah antiinflamasi non steroid (AINS). Penggunaan AINS mempunyai beberapa efek samping dan dalam beberapa hal penggunaan tanaman obat dinilai lebih aman. Rosela merupakan salah satu tanaman obat yang mempunyai potensi sebagai antiinflamasi. Penelitian ini bertujuan untuk mengetahui efek pemberian sistemik ekstrak etanolik rosela terhadap ekspresi COX-2 dan jumlah neutrofil fase inflamasi pada proses penyembuhan luka. Bunga rosela didapatkan dari perkebunan di Dusun Bulusari Desa Pojok Kecamatan Tarokan Kabupaten Kediri Jawa Timur. Pembuatan ekstrak rosela dilakukan di LPPT unit I UGM Yogjakarta dengan cara perkolasi. Tikus putih galur Wistar sebanyak 36 ekor diberi perlukaan dengan punch biopsi ɵ 3 mm pada mukosa bukal. Subjek dibagi menjadi 3 kelompok, masing-masing kelompok 12 ekor tikus. Pembagian kelompok terdiri dari kontrol negatif (saline), kontrol positif (ibuprofen 20 mg/kg BB) dan perlakuan (ekstrak rosela 500 mg/kg BB). Pemberian minum sesuai kelompoknya sehari sekali selama 4 hari. Pada hari ke-1, ke-2, ke-3 dan ke-4 tikus dikorbankan lalu jaringan mukosa yang mengalami perlukaan dibuat preparat histologis. Pewarnaan Hematoksilin Eosin (HE) dilakukan untuk mengamati jumlah neutrofil. Ekspresi COX-2 diamati pada preparat dengan pewarnaan imunohistokimia menggunakan rabbit polyclonal antibody COX-2 (Lab Vision, USA). Jumlah neutrofil dan ekspresi COX-2 dihitung di bawah mikroskop cahaya lalu data dianalisi menggunakan ANAVA dan LSD. Hasil penelitian menunjukkan bahwa ekspresi COX-2 dan jumlah neutrofil lebih rendah pada kelompok perlakuan dibanding kontrol. Pengamatan klinis pada hari ke-4 juga tampak luka seluruh subjek telah menutup sempurna setelah pemberian minum rosela. Disimpulkan bahwa ekstrak etanolik rosela mempunyai kemampuan menghambat ekspresi COX-2 dan menurunkan jumlah neutrofil sehingga dapat digunakan sebagai bahan anti-inflamasi. ABSTRACT: Expression of COX-2 and The Number of Neutrophil in Inflammation stage of Wound Healing Process after Systemic Administration of Ethanolic Extract Rosela. Inflammation is an initial stage of body’s natural response to tissue damage.The use  empirically plants often used for traditional medicine because it is easily found in the community and fewer side effects. Flavanoid presence of roselle (Hibiscus sabdariffa) is thought to have anti inflammatory effects. This study aimed to know the effect of systemic administration of Roselle ethanolic extract toward COX-2 expression and neutrophils number in the inflammatory phase of wound healing processes. Roselle was obtained from plantations in Bulusari hamlet, Tarokan, Kediri, EastJava. Making roselle extract was performed in LPPT unit 1 UGM Yogyakarta by percolation ways. Wistar rats were given a total of 36 injuries with ɵ 3 mm punch biopsy of the buccal mucosa. Subjects were divided into three groups, each group of 12 rats. The division consists of the negative control group (saline), positive control (ibuprofen 20 mg/kg) and treatment (roselle extract 500 mg/kg). Giving drink suitable group once daily for four days. On day 1, the 2nd, 3rd and fourth rats were sacrificed, and mucosal tissue injury was made histological preparat. Hematoxylin eosin staining (HE) was performed to observe the number of neutrophils. COX-2 expression was found in preparations for immunohistochemical staining using rabbit polyclonal COX-2 antibody (Lab Vision, USA). The number of neutrophils and expression of COX-2 is calculated under a light microscope data were analyzed using Two-way ANOVA and LSD. The results showed that the expression of COX-2 and neutrophil number were least in the treatment group compared to the control. Clinical observation on day four also appears around the wound has completely closed the subject after administration of roselle drink. It was concluded that the ethanolic extract of roselle can inhibit COX-2 expression and decrease the number of neutrophils that can be used as an anti-inflammatory ingredient. 
Ekspresi Caspase-3 pada Sel Epitel Rongga Mulut (Kb Cell Line) setelah Paparan Ekstrak Kopi Hutomo, Suryani; Suryanto, Yanti Ivana; Susilowati, Heni; Rudolf Phym, Agustinus; Maheswara, Devi Chretella
Majalah Kedokteran Gigi Indonesia Vol 21, No 2 (2014)
Publisher : Majalah Kedokteran Gigi Indonesia

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Abstract

Kopi adalah minuman yang biasa dikonsumsi oleh masyarakat sehari-hari. Telah diketahui bahwa kopi mengandung kafein seperti yang terdapat juga pada teh dan coklat. Kandungan terbanyak kafein terdapat pada kopi. Kafein mempunyai struktur kimia 1, 3, 7- trimethylxanthine dan merupakan derivat xanthine. Senyawa ini dapat menginduksi kematian sel yang mengarah pada apoptosis, namun mekanisme yang terlibat belum diketahui dengan jelas. Tingginya konsumsi kopi di dunia yang selalu meningkat mengindikasikan perlunya dilakukan penelitian untuk mengetahui efek kafein pada epitel rongga mulut yang berkontak langsung dengan kafein. Penelitian terdahulu melaporkan bahwa ekstrak kopi menyebabkan kerusakan sel yang sebagian besar mengarah pada apoptosis, tetapi mekanismenya belum jelas. Tujuan penelitian ini adalah untuk menganalisis mekanisme kematian sel KB yang diinduksi oleh kafein melalui aktivasi caspase-3. Sel KB sebagai model epitel oral (5x10⁴sel) dikultur dalam DMEM menggunakan 24 wells microplate selama 24 jam sebelum perlakuan. Sel selanjutnya dipapar dengan kafein dengan konsentrasi 100 µg/ml, 200 µg/ml, 400 µg/ml dan diinkubasi selama 24 dan 48 jam dalam DMEM. Doxorubicin (0,5625 µg/ml) digunakan sebagai kontrol positif induksi apoptosis. Teknik imunositokimia terhadap caspase-3 dilakukan pada sel setelah dipapar kafein untuk mengamati adanya ekspresi caspase-3 sebagai ciri apoptosis. Identifikasi caspase-3 dilakukan menggunakan mikroskop fase kontras. Ekspresi protein caspase-3 terdeteksi pada sitoplasma sel KB. Hasil penelitian ini menunjukkan adanya ekspresi caspase-3 aktif yang ditandai dengan warna cokelat dengan intensitas kuat pada sitoplasma sebagian besar sel setelah dipapar kafein dengan konsentrasi 100 μg/ml dan 200 µg/ml selama 24 jam. Disimpulkan bahwa ekstrak kopi menyebabkan apoptosis sel KB melalui jalur aktivasi caspase-3. ABSTRACT: The Expression of Caspase-3 in Oral Cavity (Kb Cell Line) after Exposure to Coffee Extract. People widely consume coffee in daily meals. It is known there is caffeine found in coffee like it is found in tea and chocolate. Caffeine is found in the greatest amount of coffee. This 1, 3, 7- trimethyl xanthine substance is a derivate of xanthine that is consumed by almost all people in the world. This substance could induce cell death that mainly is apoptosis, but how the mechanism has not been clearly understood. Considering that coffee is widely consumed in the whole world, it is necessary to conduct an experiment to find any possible effect of caffeine to oral epitel that make direct exposure to caffeine. This experiment is targeted to analyze the mechanism of cell death which caused by caffeine through activation of caspase-3. KB cells as oral epithelial model (5x1044 sel) were cultured in DMEM using 24 well microplate for 24 hours before treatment. Then caffeine was given with concentration of 100 µg/ml, 200 µg/ml and 400 µg/ml. Cells were then incubated for 24 and 48 hours period in DMEM. Doxorubicin (0,5625 µg/ml) was used as a positive control of apoptosis induction. Immunocytochemistry technique was then done to observe any caspase three expression as a marker for apoptosis. Identification of active caspase-3 was then done using contrast phase microscope. The results showed expression of caspase-3 in KB cells cytoplasm which observed as high intensity of brown colored molecules in cell cytoplasm after 100 μg/ml and 200 µg/ml caffeine exposure in 24 hours. It was concluded that coffee extract induce KB cells apoptosis through caspase-3 activation mechanism.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PER ANTARA SAHAM YANG TERCATAT DALAM INDEX SYARIAH DAN SAHAM BIASA (Studi pada Perusahaan Non Keuangan di Bursa Efek Indonesia 2006 -2008) Ratnaningrum, Ratnaningrum; Susilowati, Heni
Benefit: Jurnal Manajemen dan Bisnis Benefit : Kumpulan Makalah Diskusi Dosen FE UMS Volume 14 No 1 Juni 2010
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.004 KB) | DOI: 10.23917/benefit.v14i1.1317

Abstract

Price Earning ratio (PER) shows how much investors are willing to pay per rupiah of reported profit. Since a high PER shows that investor think that the firm has good growth opportunity, so factors determining of PER become very important means to investors in making investment decisions.This study examined the influence of current ratio, debt to equity ratio, return on equity, net profit margin, dividend payout ratio, and inventory turn over  on PER between stock listed in syariah index and common stock of non financial companies in the Indonesia  Stock Exchange (IDX). Samples used in this study consisted on 38 companies listed in IDX and 10 of them listed in Jakarta Islamic Index (JII). The data was analized using regression model and Chow test. The result showed  return on equity has negative influence on the join  PER. This coefficient was contrary with the expectation. This might due to the fact that the PER could increase because of  decreasing of the profit but not from the increasing of the stock price. Other result is a difference of the regression coefficient between stock listed in syariah index and common stock. 
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PER ANTARA SAHAM YANG TERCATAT DALAM INDEX SYARIAH DAN SAHAM BIASA (Studi pada Perusahaan Non Keuangan di Bursa Efek Indonesia 2006 -2008) Ratnaningrum, Ratnaningrum; Susilowati, Heni
Benefit Volume 14 No 1 Juni 2010
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.004 KB)

Abstract

Price Earning ratio (PER) shows how much investors are willing to pay per rupiah of reported profit. Since a high PER shows that investor think that the firm has good growth opportunity, so factors determining of PER become very important means to investors in making investment decisions.This study examined the influence of current ratio, debt to equity ratio, return on equity, net profit margin, dividend payout ratio, and inventory turn over  on PER between stock listed in syariah index and common stock of non financial companies in the Indonesia  Stock Exchange (IDX). Samples used in this study consisted on 38 companies listed in IDX and 10 of them listed in Jakarta Islamic Index (JII). The data was analized using regression model and Chow test. The result showed  return on equity has negative influence on the join  PER. This coefficient was contrary with the expectation. This might due to the fact that the PER could increase because of  decreasing of the profit but not from the increasing of the stock price. Other result is a difference of the regression coefficient between stock listed in syariah index and common stock. 
Micronucleus frequency of the buccal epithelial cells on pesticide-exposed female farmers in Dieng village, Central Java Yudasari, Innayati Oktiana; Susilowati, Heni; Jonarta, Alma Linggar
The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

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Abstract

Pesticide is a toxic material used to eradicate physical intruder of crop, including pests, diseases, or weeds. Long-term exposure of pesticide to human body may give genotoxic effects at cellular level, as its substances are chemically bond with the components of DNA triggering the damage of DNA and chromosomes. Micronucleus, additional nucleus on the cells, presents as a result of the termination of the chemical bonds of DNA. The aim of this study was to investigate the frequency of micronuclei of buccal epithelial cells on pesticide-exposed female farmers in Dieng Village, Central Java. This research was conducted on 36 female villagers of Dieng Plateau. The first group consisted of 18 subjects who had regularly and directly exposed by pesticides due to their job as farmers. The control group consisted of 18 subjects were unexposed to pesticides. Buccal epithelium cells of all subjects was collected by swabing the right and left buccal mucosa using cytobrush, fixed and stained using Feulgen-Rossenbeck method. The micronuclei frequency was counted per 1000 epithelial cells. Data was analyzed using Independent Sample t-test. The statistical analysis showed a significant difference between exposed and unexposed groups (p= 0,01). It is concluded that there was an increase in the micronucleus frequency of buccal epithelial cells on pesticide-exposed female farmers in Dieng Village. Moreover, direct long-term exposure of pesticides may harm and damage the human body cells at the gene level.
Ekspresi Caspase-3 pada Sel Epitel Rongga Mulut (Kb Cell Line) setelah Paparan Ekstrak Kopi Hutomo, Suryani; Suryanto, Yanti Ivana; Susilowati, Heni; Rudolf Phym, Agustinus; Maheswara, Devi Chretella
Majalah Kedokteran Gigi Indonesia Vol 21, No 2 (2014): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.8739

Abstract

Kopi adalah minuman yang biasa dikonsumsi oleh masyarakat sehari-hari. Telah diketahui bahwa kopi mengandung kafein seperti yang terdapat juga pada teh dan coklat. Kandungan terbanyak kafein terdapat pada kopi. Kafein mempunyai struktur kimia 1, 3, 7- trimethylxanthine dan merupakan derivat xanthine. Senyawa ini dapat menginduksi kematian sel yang mengarah pada apoptosis, namun mekanisme yang terlibat belum diketahui dengan jelas. Tingginyakonsumsi kopi di dunia yang selalu meningkat mengindikasikan perlunya dilakukan penelitian untuk mengetahui efek kafein pada epitel rongga mulut yang berkontak langsung dengan kafein. Penelitian terdahulu melaporkan bahwaekstrak kopi menyebabkan kerusakan sel yang sebagian besar mengarah pada apoptosis, tetapi mekanismenya belum jelas. Tujuan penelitian ini adalah untuk menganalisis mekanisme kematian sel KB yang diinduksi oleh kafein melaluiaktivasi caspase-3. Sel KB sebagai model epitel oral (5x10⁴ sel) dikultur dalam DMEM menggunakan 24 wells microplate selama 24 jam sebelum perlakuan. Sel selanjutnya dipapar dengan kafein dengan konsentrasi 100 μg/ml, 200 μg/ml, 400 μg/ml dan diinkubasi selama 24 dan 48 jam dalam DMEM. Doxorubicin (0,5625 μg/ml) digunakan sebagai kontrol positif induksi apoptosis. Teknik imunositokimia terhadap caspase-3 dilakukan pada sel setelah dipapar kafeinuntuk mengamati adanya ekspresi caspase-3 sebagai ciri apoptosis. Identifikasi caspase-3 dilakukan menggunakan mikroskop fase kontras. Ekspresi protein caspase-3 terdeteksi pada sitoplasma sel KB. Hasil penelitian ini menunjukkanadanya ekspresi caspase-3 aktif yang ditandai dengan warna cokelat dengan intensitas kuat pada sitoplasma sebagian besar sel setelah dipapar kafein dengan konsentrasi 100 μg/ml dan 200 μg/ml selama 24 jam. Disimpulkan bahwa ekstrak kopi menyebabkan apoptosis sel KB melalui jalur aktivasi caspase-3. ABSTRACT: The Expression of Caspase-3 in Oral Cavity (Kb Cell Line) after Exposure to Coffee Extract. People widely consume coffee in daily meals. It is known there is caffeine found in coffee like it is found in tea and chocolate.Caffeine is found in the greatest amount of coffee. This 1, 3, 7- trimethyl xanthine substance is a derivate of xanthine that is consumed by almost all people in the world. This substance could induce cell death that mainly is apoptosis, but how the mechanism has not been clearly understood. Considering that coffee is widely consumed in the whole world, it is necessary to conduct an experiment to find any possible effect of caffeine to oral epitel that make direct exposure to caffeine. This experiment is targeted to analyze the mechanism of cell death which caused by caffeine through activation of caspase-3. KB cells as oral epithelial model (5x10⁴ sel) were cultured in DMEM using 24 well microplate for 24 hours before treatment. Then caffeine was given with concentration of 100 μg/ml, 200 μg/ml and 400 μg/ml. Cells were then incubated for 24 and 48 hours period in DMEM. Doxorubicin (0,5625 μg/ml) was used as a positive control of apoptosis induction. Immunocytochemistry technique was then done to observe any caspase three expression as amarker for apoptosis. Identification of active caspase-3 was then done using contrast phase microscope. The results showed expression of caspase-3 in KB cells cytoplasm which observed as high intensity of brown colored molecules incell cytoplasm after 100 μg/ml and 200 μg/ml caffeine exposure in 24 hours. It was concluded that coffee extract induce KB cells apoptosis through caspase-3 activation mechanism.
UJI HAMBATAN TUMORIGENESIS SARI BUAH MERAH (PANDANUS CONOIDEUS LAM.) TERHADAP TIKUS PUTIH BETINA YANG DIINDUKSI 7,12 DIMETILBENZ(a)ANTRASEN (DMBA) Munim, Abdul; Andrajati, Retnosari; Susilowati, Heni
Pharmaceutical Sciences and Research (PSR) Vol 3, No 3 (2006)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (68.036 KB) | DOI: 10.7454/psr.v3i3.3407

Abstract

Red fruit (Pandanus conoideous Lam.) has been known by public as a medicine for any kind of diseases, among of them is for cancer. To determine the carcinogenesis inhibition effect of red fruit extract , we have examined the effect on 7,12- dimethylbenz[a]anthrasene (DMBA)-induced rat lungs cancer model in female Sprague-Dawley rats. The extract was tested at 0.21 ml/200 g bw; 0.43 ml/200 g bw and 0.88 ml/ 200 g bw. The experiment was terminated at day 120. Lung histology was used to evaluate carcinogenesis inhibition. The result showed that the extract at 0.21 ml/200g bw improved lung carcinogenesis inhibition than other dose. Key words : red fruit extract, DMBA, lung cancer, Pandanus conoideus