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Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat

Pustaka Kesehatan Vol 3, No 1 (2015)
Publisher : Pustaka Kesehatan

Show Abstract | Original Source | Check in Google Scholar | Full PDF (212.085 KB)

Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.

Efek Angiogenesis Beraprost terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi (Angiogenesis Effect of Beraprost on the Cardiac Histopathology of Hypertensive Wistar Rat)

Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (1912.411 KB)

Abstract

Hypertension is a state where there is an increase of blood pressure above normal threshold,120/80 mmHg. The phatophysiology of hypertension involves the changes of vascular structure. Therefore, the beraprost drug was created. It is a vasodilator and antitrombolytic which is able to induce angiogenesis. The study aimed to investigate the effect of Beraprost on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Beraprost 100mcg/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with Beraprost from 180 mmHg to 143 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of Beraprost. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 16.637.29 compared to 7.45 1.21 in control group. It can be concluded that Beraprost had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, Beraprost, vascular structure, angiogenesis.

Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat

Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (212.085 KB)

Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.

Hubungan Kadar SGOT dengan Kadar Leukosit pada Pasien NSTEMI di ICCU RSD dr. Soebandi Jember (Correlation between SGOT Level and Leukocytes in NSTEMI Patients at ICCU dr. Soebandi Hospital, Jember)

Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (250.454 KB)

Abstract

Acute Coronary Syndrome (ACS) is a syndrome that occurs because of blockage of the coronary artery causing clinical symptoms due to unfulfilled oxygen supply. Atherosclerosis is suspected as the main cause of ACS. Inflammation is one pathophysiology of atherosclerosis characterized by leukocytosis. NSTEMI is one spectrum of ACS that diagnosed by anamnesis, ECG, and cardiac marker such as troponin. SGOT is also released into the circulation when there is myocardial damage. Studies has reported that SGOT increased from the normal range during a myocardial infarction. The purpose of this study was to determine the relationship between levels of SGOT and leukocytes in patients with NSTEMI. The sample included 10 patients with NSTEMI in July-December 2016 from ICCU RSD dr. Soebandi Jember. The data was collected from medical record. The result showed that the average of SGOT increased from the normal range, while the average levels of leukocytes were in normal range. Pearson correlation test showed that there was no significant relationship between the two variables with p=0.083>0.05. In conclusion, there was no relationship between the levels of SGOT and leukocytes in patients with NSTEMI at ICCU RSD dr. Soebandi Jember.   Keywords: NSTEMI, SGOT, Leukocyte  

Co-Authors AB Susanto Achmad Widodo Adi Priyo Wicaksono, Adi Priyo Agung Chandra Prasetya Agung Nugroho Setiawan, Agung Nugroho Agus Indarjo Agus Sulistiyo Agus Suyanto Agus Syafrudin Agus Triyanto Ahmad Syaify, Ahmad Aini Moeljono, Aini AL. Supartinah, AL. Andika Bagus Setiawan, Andika Bagus Andri Wahyu Septo Putra Anifatur Nurjannah, Anifatur Arbiyanti, Yossi Norma Arfian, Finty Ari Anshori, Ari Ari Suwondo Arief Suseno, Arief Arif Syaifuddin Arifin Budi Putro, Arifin Budi Arinianzah, Aldo Rizqi Aris Wijayanti Arista, Desi Arlien Siswanti Arnefia Mei Yusnida Asfan Muqtadir, Asfan Astuti, Anjar Ave Gierdo Alfaseno, Ave Gierdo Baliyan I, Baliyan Bambang Nugraha, Bambang Basuki Basuki Bayu Surarso Budi Setiawan Chrisna A Suryono Chrisna Adhi Suryono Cicilia Artitin Cynthia Damayanti Dadang Sukandar Dayyana, Surya Desi Sandra Sari Desie Dwi Wisudanti, Desie Dwi Dewi Agustina Dewi Sulistyaningrum Dhidik Prastiyanto Diana Layla Dimas Putra Anugrah, Dimas Putra Djoko Adi Widodo Donny Prasetyo Santoso, Donny Prasetyo Drajat Martianto Dwi Puji Adiana, Dwi Puji Edi Wibowo Edi Wibowo Kushartono Edy Junaidi Eka Miftakhul Jannah, Eka Miftakhul Eko Supraptono Emi Agustina, Emi Endah Setiyaningrum Endang Sri Susilo ENNY SUSWATI Ervia Yudiati Evi Setiawati Fatekurohman, Mohamat fatimah Fatimah Febriana Tirta Kirana, Febriana Tirta Fitri Mahardika Sari Frida Fallo Gatot Murti Wibowo, Gatot Murti Gatot Yulianto Gentur Handoyo Gigih Budhiawan Gunawan Widi Santosa Hadi Endrawati Harindra W Pradhana, Harindra W Harindra Wisnu Pradhana Haryati Haryati Hayat Maulana Heri Sugito Heri Sutanto Hernita Kusuma Wardani Hery Sulistyo JNS, Hery Sulistyo Hery Widijanto Hidayat, Syarief Thaufik Hilmi Trian Setyawan Indhana Sudiharto, Indhana Indri Trifiantari Irianiwati Irianiwati Irwani Irwani Isa Nurnusanto, Isa Isnaini Isnaini Ivan Nurizal Sakti Izah, Luluk Lailatul Jatmiko Endro Suseno Jauhari Syamsiyah Joko Winarno Juniyanto, Dimas Kamasita, Systriana Esi Kartini Sinaga Kesawa Sudarsih Khanif Pramusinto, Khanif Kharis, Muhamad Kusworo Adi Kusworowulan, Suryati Kwartarini Murdiastuti, Kwartarini Laela Meitasari, Laela Laska, Yulinda Lukman Hakim Mahda Veronika Maisi, Sri Malau, Rotua Mardiyono Mardiyono Margo Utomo Marsetyawan HNES, Marsetyawan Mediawati, Saskia Mefi Priba Sari, Mefi Priba Melo, Gabriella Imanuella Melyana Nurul Widyawati Menur Wahyu Pangestika, Menur Wahyu Mohamad Nadhif, Mohamad Muh. Yusuf Muhammad Arif Prasetyo Muhammad Arsyad Suyuti Muhammad Izzuddin Shofar Muhammad Zainuri Mujiyo Mujiyo Mulyanto Mulyanto Munarso Munarso Muthoifin Muthoifin, Muthoifin N. Euis Sutaningsih, N. Euis Nailatul Ilmi Nasronudin Nasronudin Niharul Annas Nirwani Soenardjo Nourobby Aulada, Nourobby Oky Dwi Nurhayati Oky Yuripa Pradana P. H, Aditya Praptiwi Praptiwi Prasetyo Nugroho Raden Ario Radini Sinta, Radini Ragil Saputra Rahayu Sapta S Rahmat Gernowo Rakhmat Syaefullah Ramadhan, Hazbina Fauqi Rani Gamawati, Rani Ratna Dwi Meilani, Ratna Dwi Retno Handayani Retno Hartati Ria Amitasari Ria Azizah Rieneke L Sela, Rieneke L Rini Riyanti Robby Eko Christanto Rudhi Pri, Rudhi Rudhi Pribadi Rusdi, Muh Sangkertadi Sangkertadi Satryo Adi Wibowo, Satryo Adi Setyaningsih, Erni Sharfina Sharfina, Sharfina Siti Fatimah Muis Soeharyo Hadisaputro Sri Budi Barunawati, Sri Budi Sri Huning Anwariningsih Sri Kusumastuti, Sri Sri Sedjati Sri Sukamta Sudadi Sudadi Sudibyo Sudibyo Sugeng Purbawanto Sugiyanto Sugiyanto Sukarnen Sukarnen, Sukarnen Sulistyo Warjono, Sulistyo Sumarno Sumarno Sumaryo Sumaryo Suntoro Suntoro Supriyanto Supriyanto Supriyati Supriyati Suroyo Suroyo Suwarto Suwarto Tatyantoro Andrasto Tika Retnowati Tri Saputra, Tri Valentino, Nico Vifaldi Agti, Vifaldi Vincensius Gunawan Wahyu Fredi Santoso Wahyu Setia Budi Widyatmani Sih Dewi Wilis Ari Setyati Yosafat Hermawan Trinugraha, Yosafat Hermawan Yudha Nurdian, Yudha Yuli Hermansyah, Yuli Yuningtyastuti, Gita Surya