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Pola Distribusi Imunoekspresi P63 pada Hiperplasia Prostat sebagai Indikator Keganasan K., Surjadi; J.M., Tanwir; S.H., Bethy; Suryanti, Sri
Jurnal Kedokteran Maranatha Vol 6, No 1 (2006)
Publisher : Universitas Kristen Maranatha

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yang disebabkan oleh pertumbuhan berlebihan dari epitel dan jaringan fibromuskuler dari transition zone dan daerah periurethral. BPH sangat sering terjadi, beberapa peneliti melaporkan bahwa BPH mempunyai risiko lebih besar untuk menjadi karsinoma, tetapi peneliti-peneliti lain menyatakan tidak ada kenaikan risiko untuk menjadi karsinoma.Lesi-lesi prakarsinoma dapat berbentuk PIN (Prostatic Intraepithelial Neoplasia) atau Hiperplasia Adenomatosa Atipik, tetapi jarang dilaporkan pada pemeriksaan histopatologi biopsi prostat dan prostatektomi, sehingga kita tidak dapat memprediksi hiperplasia prostat tersebut, apakah suatu BPH biasa atau ada indikasi keganasan.Telah dilakukan penelitian pada 30 blok parafin hiperplasia prostat dan 30 blok parafin adenokarsinoma prostat yang diperoleh dari bagian Patologi Anatomi FKUP/RSHS Bandung dan dilakukan pulasan imunohistokimia dengan anti-P63. Ditentukan persentase imunoekspresi P63 pada asini-asini hiperplasia prostat dan adenokarsinoma prostat. Perbandingan imunoekspresi P63 pada hiperplasia prostat dengan adenokarsinoma prostat dianalisis secara statistik menggunakan metode ROC (Receiver Operating Characteristic curve).Dari hasil perhitungan statistik pada persentase imunoekspresi P63 pada asini-asini hiperplasia prostat dan adenokarsinoma prostat, diperoleh cut off (titik potong) yaitu batas persentase imunoekspresi P63 untuk memprediksi apakah suatu hiperplasia prostat akan berubah menuju ke arah adenokarsinoma prostat atau tidak. Persentase jumlah asini yang imunoreaktif continuous, incontinuous dan tidak imunoreaktif dapat digunakan sebagai indikator untuk memprediksi keganasan pada hiperplasia prostat, tetapi yang lebih baik digunakan adalah persentase asini yang continuous, yaitu 0,07 ; bila kita mempunyai sediaan hiperplasia prostat baru dari biopsi dan imunoreaktivitas asini terhadap anti-P63 < 7%, hiperplasia prostat tersebut diprediksi mengarah ke adenokarsinoma prostat. Bila imunoreaktivitas asini terhadap anti-P63 > 7%, hiperplasia prostat tersebut belum mengarah ke adenokarsinoma prostat
Characteristics of Renal Cell Carcinoma in Dr. Hasan Sadikin General Hospital Bandung, 2010–2014 Putra, Dicky Suryana; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Background: Data characteristics for renal cell carcinoma are mostly derived from developed countries. However, data from developing countries, specifically in Indonesia have not been fully described. This study aimed at describing renal cell carcinoma (RCC) characteristics based on age, gender, and histopathology type in Dr. Hasan Sadikin General Hospital Bandung.Methods: This was a descriptive study conducted in August–October 2015. The data were collected from histopathology medical records of patients who had been diagnosed with RCC at Department of Pathology Anatomy Dr. Hasan Sadikin General Hospital Bandung, from 2010 to 2014. Total sampling was used as sampling method. Only RCC records that had complete variables; which were age, gender, and histopathological type; included in this study.Results: There were 25 cases of renal cell carcinoma discovered in this study, 17 cases discovered in men and 8 cases discovered in women. The histopathology type found in this study was clear cell renal cell carcinoma (12 cases), papillary renal cell carcinoma (8 cases), chromophobe renal cell carcinoma (3 cases), and carcinoma of the collecting ducts of bellini (2 cases). There were no cases found below the age range 2–29 years old and above the age range 70–79 years old.Conclusions: Men have higher incidence than women with the ratio of 2:1. Peak incidence is found on the age range 50–59 years old. The most common histopathology type is clear cell renal cel carcinoma.[AMJ.2016;3(4):644–8] DOI: 10.15850/amj.v3n4.953
KEBUTUHAN AIR, EFISIENSI PENGGUNAAN AIR DAN KETAHANAN KEKERINGAN KULTIVAR KEDELAI (Water Use, Water Use Efficiency and Drought Tolerance of Soybean Cultivars) Suryanti, Sri; Indradewa, Didik; Sudira, Putu; Widada, Jaka
Jurnal Agritech Vol 35, No 01 (2015)
Publisher : Jurnal Agritech

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Water use (WU) and water use efficiency (WUE) provides a simple methods of assessing whether yield is affected by water supply.Drought tolerance cultivars havestable yield under drought. The objective of this study was to asses water use, water use efficiency, and drought tolerance of soybean cultivars. The 18 × 4 factorial experiment was set in a completely randomized design with three replications during May to October 2012 at the Tridharma Research Station Faculty of Agriculture, Gadjah Mada University at altitute 110 m dpl. Eighteen soybean cultivars were assigned as the first factor and four level watering intervals i.e. 1days, 2 days, 4 days and 8 days until field capasity were assigned asthe second factor. Data were recorded for water use at 15 days until 56 days after planting andwater use efficiency at 56 days after planting. Data for stress index andstress susceptibility index  were calculated at 84 days after planting. Results indicated that Grobogan and Galunggung were identified as drought tolerance cultivars with water use values rangedfrom  4.87 to 4.98 mm and water use efficiency value 5.16 gram/mm. Burangrang, Kaba, Argomulyo, Panderman, Baluran, Ijen,  Petek, Malabar were identified as medium drought tolerance cultivars with water use values ranged from 3.98 to 6.14 mm and water use efficiency values ranged from 3.69 to 5.51 gram/mm. Sibayak, Tanggamus, Anjasmoro, Wilis, Garut, Gepak, Sinabung, and Seulawah were identified as sensitive cultivars with water use values ranged from  5.37 to 5.95 mm and water use efficiency values ranged from 3.49 to 5.60 gram/mm. Keywords: Water use, water use efficiency, drought tolerance, soybean cultivars ABSTRAKKebutuhan air dan efisiensi penggunaan air merupakan cara sederhana untuk mengetahui apakah hasil tanaman dipengaruhi oleh pasokan air. Tanaman tahan kering mengalami penurunan hasil lebih rendah ketika terjadi cekaman kekeringan. Penelitian ini dilakukan untuk mengetahui kebutuhan air tanaman, efisiensi penggunaan air dan variasi ketahanan kultivar kedelai terhadap cekaman kekeringan. Rancangan percobaan yang digunakan adalah rancangan acak lengkap (RAL) faktorial 18 x 4 dengan tiga ulangan. Penelitian dilaksanakan pada bulan Mei sampai Oktober 2012 di Kebun Tridharma  Fakultas Pertanian Universitas Gadjah Mada dengan ketinggian tempat 110 m dpl. Faktor pertama adalah kultivar kedelai terdiri atas 18 kultivar dan faktor kedua adalah interval penyiraman terdiri atas 4 taraf yaitu penyiraman 1 hari, 2 hari, 4 hari dan 8 hari sekali sampai kapasitas lapangan. Pengamatan kebutuhan air dilakukan mulai umur 15 hari sampai 56 hari setelah tanam dan efisiensi penggunaan air dilakukan pada umur 56 hari setelah tanam. Perhitungan indeks cekaman dan indeks sensitivitas cekaman dilakukan pada umur 84 hari setelah tanam. Hasil penelitian menunjukkan bahwa kultivar Grobogan dan Galunggung tahan terhadap cekaman kekeringan dengankebutuhan air antara  4,87 sampai 4,98 mm dan efisiensi penggunaan air 5,16gram/mm. Kultivar Burangrang, Kaba, Argomulyo, Panderman, Ijen, Baluran, Petek, dan Malabar merupakan kultivar yang agak tahan terhadap cekaman kekeringan dengan kebutuhan air antara 3,98 sampai 6,14 mm dan efisiensi penggunaan air antara  3,69 sampai  5,51gram/mm. Kultivar Sibayak, Tanggamus, Anjasmoro, Wilis, Garut, Gepak Kuning, Sinabung, dan Seulawah merupakan kultivar yang tidak tahan terhadap cekaman kekeringan dengan kebutuhan air antara  5,37 sampai 5,95 mm dan efisiensi penggunaan air antara  3,49 sampai 5,60 gram/mm.Kata kunci: Kebutuhan air, efisiensi penggunaan air, ketahanan kekeringan, kultivar kedelai
Korelasi Ekspresi VEGF dan Densitas Mikrovesel Dengan Respons Radioterapi Adenokarsinoma Serviks Wibisono, Fennisia; Suryanti, Sri; Hernowo, Bethy S
JAMBI MEDICAL JOURNAL Vol 2, No 2 (2014): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

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ABSTRACT Background: Most of cervical carcinoma patients, including cervical adenocarcinoma comes at an advanced stage and thus radiotherapy is one of the modality treatment. The success of radiotherapy depends on several prognostic factors such as the performance, staging, histopathology of tumor, presence of organ dysfunction and cellular biology marker such as VEGF. Activation singaling pathway Vascular Endothelial Growth Factor (VEGF) can induce radioresistance on cervical adenocarcinoma. Activation angiogenesis mediated by VEGF can be counted from microvessel density (MVD). Counting MVD use imunohistochemical CD34 on endothelial cells form capiller of blood vessel in peritumoral. The aim of this study was to determine correlation between immunohistochemistry VEGF dan MVD with neoadjuvant radiotherapy response cervical adenocarcinoma. Methods: This study was an observational study, cross-sectional and correlational analysis. Samples was collected by total sampling with amount 32 samples block parafin from Departement Anatomical Pathology General Hospital Dr. Hasan Sadikin Bandung and treated with complete neoadjuvant radiotherapy from Januari 2007 until December 2013. Immunohistochemical examination of VEGF and CD34 for counting MVD was done on all sample block parafin. Result: There was a strong correlation between microvessel density (MVD) with neoadjuvant radiotherapy response in cervical adenocarcinoma (p = 0.000). In this study MVD above 30 correlate with poor neoadjuvant radiotherapy response in cervical adenocarcinoma. Conclusion: Examination MVD recommended for cervical adenocarcinoma patient before radiation treatment.   Keyword : Cervical Adenocarcinoma, CD34, Neoadjuvant Radiotherapy, VEGF
ANALYSIS OF IMMUNOEXPRESSION OF ESTROGEN RECEPTOR BETA AND EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON TESTICULAR SEMINOMAS NONRECURRENCE AND RECURRENCE Ridwan, Antonius Janes; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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The most common malignancy of testis is seminoma with prognosis that is not always good because of high recurrence rate and death cases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a glycoprotein adhesion molecules which plays a role in tumor cell invasion and metastasis as evidenced by immunohistochemistry method in several types of tumor cells and tissue that shows the correlation to the clinical progessivity.This study was conducted by observational descriptive analytics with each seven cases of seminoma nonrecurrences and recurrences diagnosed histopathologically from Dr.Hasan Sadikin Hospital, Advent Hospital and St.Borromeus Hospital in Bandung. This study shows that immunoexpression of estrogen receptor beta is not higher in testicular seminoma recurrence compared with nonreccurence. There was no higher imunoexpression of EMMPRIN receptor on testicular seminoma recurrence compared with nonrecurrence; besides, there was no relationship between immunoexspression of estrogen receptor beta and EMMPRIN in testicular seminoma nonrecurrence and recurrence.In conclusion, immunoexpression estrogen receptor beta expressed in all testicular seminoma, so that the patient could be given an alternative therapy and immunoexspression EMMPRIN, cannot be used to predict a recurrence in patients with seminoma who has received complete therapy.                                                        Keywords: EMMPRIN, Estrogen Receptor Beta, Seminoma Testis nonrecurrence and recurrence
Five Years Facts of Bladder Cancer at West Java’s Top Referral Hospital, in Indonesia Perix, Vivien Kate; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Bladder cancer is the second most common genitourinary cancer and its incidence is rising 15% annually in Indonesia. Smoking is the leading risk factor of bladder cancer and two thirds of men in Indonesia smokes. This study was conducted to describe the characteristics of bladder cancer based on sex, age and histopathology type in  West Java’s Top Referral Hospital, Indonesia. Methods: This study was a descriptive study conducted during theperiod of September to November 2015 using 372 histopathological medical records of patients who had primary and secondary bladder cancer at the Pathology Department, Dr. Hasan Sadikin General Hospital Bandung from January 2010 to December 2014. Data were collected using total sampling method based on the characteristics of age, sex histopathology type, and staging of bladder cancer.Results: Out of the 372 cases, 298 cases were male and 38 cases were female with a male to female ratio of 7.8:1. The age group with the highest incidence was the 50–59 years old group. Infiltrating urothelial carcinoma was the most common histopathology type (71.1%) in primary cancers, 66.1% of cases was muscle invasive while 33.9% was non muscle invasive. Staging pT1 had the most number of cases. The most common site of origin for secondary neoplasm was cervix with adenocarcinoma as the most common histopathology type. Conclusions: Bladder cancer is more common in male than female and peaks at the sixth decade of life. Infiltrating urothelial carcinoma is the most common histopathology type. [AMJ.2017;4(1):94–9] DOI: 10.15850/amj.v4n1.1028
ANALYSIS OF IMMUNOEXPRESSION OF ESTROGEN RECEPTOR BETA AND EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON TESTICULAR SEMINOMAS NONRECURRENCE AND RECURRENCE Ridwan, Antonius Janes; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S
Journal of Medicine & Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.175 KB) | DOI: 10.28932/jmh.v1i2.507

Abstract

The most common malignancy of testis is seminoma with prognosis that is not always good because of high recurrence rate and death cases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a glycoprotein adhesion molecules which plays a role in tumor cell invasion and metastasis as evidenced by immunohistochemistry method in several types of tumor cells and tissue that shows the correlation to the clinical progessivity.This study was conducted by observational descriptive analytics with each seven cases of seminoma nonrecurrences and recurrences diagnosed histopathologically from Dr.Hasan Sadikin Hospital, Advent Hospital and St.Borromeus Hospital in Bandung. This study shows that immunoexpression of estrogen receptor beta is not higher in testicular seminoma recurrence compared with nonreccurence. There was no higher imunoexpression of EMMPRIN receptor on testicular seminoma recurrence compared with nonrecurrence; besides, there was no relationship between immunoexspression of estrogen receptor beta and EMMPRIN in testicular seminoma nonrecurrence and recurrence.In conclusion, immunoexpression estrogen receptor beta expressed in all testicular seminoma, so that the patient could be given an alternative therapy and immunoexspression EMMPRIN, cannot be used to predict a recurrence in patients with seminoma who has received complete therapy.                                                        Keywords: EMMPRIN, Estrogen Receptor Beta, Seminoma Testis nonrecurrence and recurrence
THE EFFECT OF USING RING THEORY MOBILE APPLICATION ON STUDENT INVOLVEMENT AND REASONING ABILITY Suryanti, Sri; Sutaji, Deni
Journal on Mathematics Education Online First
Publisher : Department of Doctoral Program on Mathematics Education, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22342/jme.12.2.5398.%p

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This study aims to determine the influence of the use of ring theory mobile application on student involvement in learning and the students reasoning ability. The subject of research is sixth-semester students who take the subject of Ring Theory that is 30 people. The research instrument used is observation sheet, student involvement questionnaire, and test questions to know students reasoning ability. The research method used is descriptive quantitative to know the involvement of students, while to know the effect on students reasoning ability used independent sample t-test with SPSS 15.0. The results showed that the use of ring theory mobile application caused a very positive engagement, from the overall indicator of student involvement in learning, gets an average score  4.74 (score range 1-5). Also, there was a significant influence of the use of ring theory mobile application on students reasoning ability, which is 0.721
The Distribution of Meningioma in Dr. Hasan Sadikin General Hospital Bandung Period 2010–2013 Gunadi, Stephanie Victoria; Suryanti, Sri; Yohana, Raden
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v5n3.1062

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Background: In neurological diseases, brain tumor is the second leading cause of death after stroke, of which the most common types of brain tumor is meningioma. There are many factors affect the prognosis of meningioma patient, including age, gender, location, and histopathological type of tumor. This study aimed to explore the distribution of meningioma based on age, gender, location of the tumor, and its histopathological type during the period of 2010–2013 in Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was a quantitative descriptive study and data were collected from medical records of Department of Pathology between January 2010-December 2013. Age, gender, location, and histopathological type of meningioma were acquired. Results: There were 277 eligible cases of meningioma with an average number of cases per year were 69 cases. The ratio of men to women was 1:6.4.  Meningioma was most commonly found in the age group 41­50 years (38.9%), and mostly located in convexity (55.96%). The most common histopathological type of meningioma was meningotheliomatous meningioma (70%).Conclusions: The frequency of meningioma is 6 times higher in women, predominantly around the age of 50 years old. Meningioma is most commonly found in convexity, and meningotheliomatous meningioma is the most common histopathological type.   
Hubungan Imunoekspresi Epidermal Growth Factor Receptor (EGFR) dengan Stadium Dukes pada Karsinoma Kolorektal Ariyanni, Fenny; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S
Majalah Patologi Indonesia Vol 24 No 1 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAK Latar belakang Epidermal growth factor receptor (EGFR) berperan dalam patogenesis dan progresivitas karsinoma kolorektal. Stadium Dukes menunjukkan luas penyebaran tumor dan digunakan sebagai pedoman terapi. Pada stadium Dukes A tumor masih terbatas pada tunika submukosa, stadium Dukes B tumor sudah menembus tunika muskularis dan stadium Dukes C sudah bermetastasis ke kelenjar getah bening. Penggunaan kemoterapi adjuvan pada stadium Dukes B masih kontroversi sehingga hanya diberikan pada stadium Dukes B yang high risk. Diperlukan penanda molekuler yang dapat menunjukkan tumor yang agresif. Pada penelitian ini akan diteliti hubungan imunoekspresi EGFR dengan stadium Dukes pada karsinoma kolorektal. EGFR diharapkan dapat digunakan menjadi penanda karsinoma kolorektal yang agresif. Metode Pewarnaan imunohistokimia EGFR dilakukan terhadap 45 blok parafin karsinoma kolorektal yang dilakukan kolektomi (masing-masing stadium Dukes A, B, C 15 kasus). Hasilnya dihubungkan dengan stadium Dukes. Hasil Pada stadium Dukes A sebanyak 2 kasus (13%) menunjukkan imunoekspresi positif dan stadium Dukes B sebanyak 8 kasus (53%) menunjukkan imunoekspresi positif dan pada stadium Dukes C sebanyak 11 kasus (73%) menunjukkan imunoekspresi positif. Imunoekspresi EGFR secara statistik (p=0.004, uji Chi-Square) lebih sering ditemukan pada stadium Dukes C. EGFR berperan penting dalam diferensiasi dan proliferasi sel. Pada sel normal pengaktifan sinyal EGFR menyebabkan proliferasi sel, migrasi, metastasis, penghindaran apoptosis dan angiogenesis. Kesimpulan Imunoekspresi EGFR lebih sering ditemukan pada stadium Dukes C dibanding Dukes A dan B. Kata kunci: EGFR, imunoekspresi, karsinoma kolorektal, stadium Dukes. ABSTRACT Background Epidermal growth factor receptor immunoexpression may clarify the effects of the pathogenesis and determine the prognosis of colorectal carcinoma (CRC). Dukes’ stage explained the extension of the tumor. Dukes’ stage A was defined as malignant tumour in which growth extends into the submucosa, but not into the muscle coat; Dukes’ stage B was defined as the tumour growth extends into the muscle coat; and Dukes’ stage C was defined as the presence of lymph node metastases. Adjuvant chemotherapy in Dukes’ stage B is controversial, which only given to high-risk Dukes’ stage B. Hence, we need to identify high-risk Dukes’ stage B. This research will study association EGFR clone H11 and CRC Dukes’ stage. Methods Immunohistochemistry was performed in paraffin-embedded specimens of 45 cases colorectal carcinoma (each Dukes’ stage A, B, C was 15 cases) for the assesment of clone H11 EGFR expression. The results were correlated with colorectal carcinoma Dukes’ stage. Results At Dukes’ stage A there were 2 cases (13%) showed positive immunoexpression and Dukes’ stage B there were 8 cases (53%) showed positive immunoexpression and Dukes’ stage C there were 11 cases (73%) showed positive immunoexpression. clone H11. EGFR clone H11 immunoexpression (p=0.004, Chi-Square test) was significantly more frequent in Dukes’ stage C. EGFR play an important role in cell differentiation and proliferation. The activation of EGFR signaling would lead to cell proliferation, migration, metastasis, evasion of apoptosis or angiogenesis. Conclusion EGFR immunoexpression was more frequent in colorectal carcinoma Dukes’ stage C explain clearly that EGFR play important role in pathogenesis colorectal carcinoma. Key words: colorectal carcinoma, Dukes’ stage, EGFR, immunoexpression.