Ali Sungkar
Indonesian journal of obstetrics and gynecology
Articles
12
Documents
IL-10 Serum Concentration was Observed Higher in Threatened Preterm Labor

Indonesian Journal of Obstetrics and Gynecology Vol. 34. No. 4. October 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

Objective: To determine the serum concentration of Th-1 and Th-2 cytokine in threatened preterm labor compared to that in normal pregnancy.Method: The design was analytical cross-sectional, comparing the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor and 29 normal pregnant women. The cytokine concentration was measured with ELISA. T test and Mann-Whitney U test was used for statistical analysis.Results: The mean concentration of TNF-α and IL-2 in both groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor (PTL) group was observed higher than that observed in the normal pregnancy group (p = 0.001). Compared to normal pregnancy group, the TNF-α to IL-10 ratio in the PTL group was observed lower (p = 0.009). Both groups did not show any difference in the IL-2 to IL-10 ratio (p = 0.057).Conclusion: The IL-10 serum concentration was increased in threatened preterm labor. There was no difference observed in the Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as compared to normal pregnancy.[Indones J Obstet Gynecol 2010; 34-4: 191-4]Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokinesTujuan: Untuk menilai kadar sitokin Th-1 dan Th-2 dalam serum perempuan hamil dengan ancaman persalinan preterm dan dibandingkan dengan kadar tersebut pada perempuan hamil normal.Metode: Kajian potong lintang, yang membandingkan kadar TNF-α, IL-2, IL-10, nisbah TNF-α dengan IL-10 dan nisbah IL-2 dengan IL-10, pada 29 subjek penelitian perempuan hamil dengan ancaman persalinan preterm dan pada 29 perempuan hamil normal. Kadar sitokin diukur dengan teknik ELISA. Uji statistik dilakukan dengan menggunakan uji T dan uji Mann-Whitney.Hasil: Tidak dijumpai perbedaan yang bermakna dari rerata TNF-α dan IL-2 dari kedua grup (p = 0,188 dan p = 0,493). Konsentrasi median dari IL-10 serum perempuan hamil dengan ancaman preterm dijumpai lebih tinggi dibandingkan dengan kadar tersebut pada kehamilan normal. (p = 0,001). Dibandingkan dengan kehamilan normal, maka kehamilan dengan ancaman persalinan preterm menunjukkan nisbah TNF-α dengan IL-10 yang lebih rendah. Tidak terdapat perbedaan pada nisbah IL-2 dan IL-10 antara kedua grup.Kesimpulan: Kehamilan dengan ancaman persalinan preterm menunjukkan kadar IL-10 yang lebih tinggi dibandingkan dengan kehamilan normal. Tidak terdapat perbedaan nisbah sitokin Th-1 dan Th-2 pada kedua group.[Maj Obstet Ginekol Indones 2010; 34-4: 191-4]Kata kunci: IL-10, persalinan preterm, sitokin Th-1 dan Th-2

The use of B-Lynch Technique and Lasso-Budiman Technique to Control Postpartum Hemorrhage in Uterine Atony

Indonesian Journal of Obstetrics and Gynecology Vol. 34. No. 4. October 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the use of B-Lynch Technique and Lasso Budiman Technique as conservative way to control post partum hemorrhage due to uterine atony.Method: The cross-sectional retrospective study in Department of Obstetrics and Gynecology, Tangerang General Hospital, Banten, year 2005 - 2008 and Department of Obstetrics and Gynecology, Wonosobo General Hospital, Central Java, year 2003 - 2008. Results: Total 38 post partum hemorrhage cases managed conservatively using B-Lynch technique and Lasso-Budiman technique. Twenty-six cases were done at Wonosobo General Hospital using B-Lynch technique, with 1 failure case and hysterectomy was done with good result. No complications has been reported for the rest 25 successful cases. Twelve cases were done at Tangerang General Hospital, using Lasso-Budiman technique, 1 failure reported, continue to hysterectomy. Among 11 successful cases, 2 complications were found. Ssecondary amenorrhea after performing Lasso-Budiman technique due to uterine sinechia were reported.Conclusion: The B-Lynch technique and Lasso-Budiman technique, both are simple, easy, and effective to control post partum hemorrhage due to uterine atony. If failed, hysterectomy is the last choice. These techniques are also effective methods to conserve uterus and fertility.[Indones J Obstet Gynecol 2010; 34-4: 195-8]Keywords: postpartum hemorrhage, conservative methode, BLynch technique, Lasso-Budiman techniqueTujuan: Melakukan evaluasi penggunaan teknik B-Lynch dan teknik Lasso-Budiman sebagai cara konservatif untuk penanganan perdarahan pascapersalinan yang disebabkan oleh atonia uteri.Metode: Studi potong-lintang retrospektif, di Departemen Obstetri dan Ginekologi, RSU Tangerang, Banten pada tahun 2005 - 2008 dan Departemen Obstetri dan Ginekologi, RSU. Wonosobo Jawa Tengah pada tahun 2003 - 2008. Hasil: Terdapat total 38 kasus perdarahan persalinan yang dilakukan penanganan menggunakan teknik B-Lynch dan teknik Lasso-Budiman. Sebanyak, 26 kasus dikerjakan di Rumah Sakit Umum Wonosobo Jawa Tengah dengan menggunakan teknik BLynch dan ditemukan 1 kasus kegagalan, yang berakhir dengan histerektomi. Komplikasi tidak ditemukan pada 21 kasus yang berhasil. Terdapat 12 kasus dikerjakan di Rumah Sakit Umum Tangerang, Banten, de-ngan menggunakan teknik Lasso-Budiman. Ditemukan 1 kasus ke-gagalan yang berakhir dengan histerektomi dan dari 11 kasus yang berhasil, ditemukan 2 kasus mengalami komplikasi, amenorea se-kunder pascatindakan yang disebabkan oleh sinekia uterus.Kesimpulan: Teknik B-Lynch dan teknik Lasso-Budiman, keduanya merupakan teknik yang aman, sederhana, mudah, dan efektif untuk menghentikan perdarahan pascapersalinan yang disebabkan oleh atonia uteri. Bila terjadi kegagalan, histerektomi adalah pilihan terakhir. Kedua teknik tersebut juga merupakan metode yang efektif untuk mempertahankan uterus dan fertilitas.[Maj Obstet Ginekol Indones 2010; 34-4: 195-8] Kata kunci: perdarahan pascapersalinan, metode konservatif, teknik B-Lynch, teknik Lasso-Budiman

The Identification of Placental Alpha Micro Globulin-1 (Amnisure®) as a Method to Identify Rupture of Membrane

Indonesian Journal of Obstetrics and Gynecology Vol. 36. No 1. January 2012
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

AbstractObjective: We aimed to do a study in the use of the identification of Placental Alpha Micro Globulin-1 or PAMG-1, in the form of Amnisure ® test, as a method to diagnose rupture of membrane (ROM), compared with other conventional method (direct visualization and nitrazine test).Method: We used a cross-sectional design. Every pregnant woman who came to our hospital with gestational age of 14 to 42 weeks complaining of membrane rupture was recruited. Sterile speculum examination and nitrazine test was performed for every patient. Amnisure ® was utilized, using vaginal swab from posterior fornices. Data analysis was performed with SPSS version 17. Results: We recruited 20 patients to join our study. Mean age, parity and gestational age was 28.5 years, parity one and 35.5 ± 3.4 weeks of gestation. Amnisure® test was positive in 14 patients. With nitrazine as standard for ROM diagnosis, the sensitivity for Amnisure® was 85% and the specificity was 83.3%. The positive predictivevalue was 92.3% and negative predictive value was 71.4%.Conclusion: For every positive vaginal pooling, nitrazine and Amnisure ® will be tested positive. Several studies using Amnisure® have shown similar results. Role of Amnisure® seemed evident in cases of uncertainty such as chronic ROM and severe oligohydramnios due to ROM. Positive results in presence of intact membranes which suggested micro-perforations of the membrane still need further research. Much still needed to be done before implementing Amnisure® in our country, especially in the matter of cost effectiveness.[Indones J Obstet Gynecol 2012; 36-1:20-3]Keywords: amnisure®, PAMG-1, ROM

Vitamin D Supplementation to Reduce the Risk of Preeclampsia: Is It True?

Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

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Associations of maternal body composition and nutritional intake with fat content of Indonesian mothers’ breast milk

Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

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Abstract

Background Breast milk is the best sole food for infants in their first six months of life. Breast milk fat content accounts for the largest part of infants’ energy and may be influenced by many factors, including maternal factors, which may vary in different settings. So far, there has been no published data about the breast milk fat content of Indonesian mothers, including whether it is affected by their body composition or nutritional intake.Objective To investigate breast milk fat content of Indonesian mothers and its associations with maternal body composition and nutritional intake. Method This cross-sectional study was conducted at Budi Kemuliaan Mothers’ and Children’s Hospital. Breast milk specimens were collected from 48 nursing mothers, centrifuged, and tested by creamatocrit for fat content. A 24-hour food recall was performed to evaluate maternal macronutrient intake. Maternal body composition was evaluated by bioelectric impedance analysis. Univariable correlations between breast milk fat content and either energy and macronutrient intake were assessed using the Spearman rho test.Results All nursing mothers had breast milk fat content within clinically normal range [mean 59.4 (SD 15.9) g/L]. There was no significant correlation between milk fat content and maternal body fat (r = -0.03, P=0.840), total body water (r = 0.09 P=0.509), or muscle mass (r = 0.08, P=0.577). Milk fat content seemed to weakly correlated with maternal fat intake, although it was not statistically significant (r = 0.27, P=0.065).Conclusion Breast milk fat content at one-month post delivery appears not associated with with maternal body composition. It seems to weakly correlate with maternal fat intake but findings need to be confirmed in larger studies with adjustment for confounding variables. 

Preterm Delivery and the Psychological Burden on Parents

Indonesian Journal of Obstetrics and Gynecology Vol. 3. No. 1 January 2015
Publisher : Indonesian Journal of Obstetrics and Gynecology

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High preterm birth at Cipto Mangunkusumo Hospital as a national referral hospital in Indonesia

Medical Journal of Indonesia Vol 26, No 3 (2017): September
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Background: Preterm birth is the leading direct that causes neonatal death. Indonesia was listed as one of the countries with the greatest number of preterm birth in 2010. This study aims to identify the prevalence and the potential risk factors of preterm birth among women underwent delivery in Cipto Mangunkusumo Hospital, an Indonesian national reference hospital.Methods: This retrospective cohort study involved 2,612 women who delivered between January and December 2013. Any clinical data which related to the potential risk factors and outcomes were recorded. The data were managed using chi-square for bivariate analysis and t-test or Mann-Whitney for numerical data followed by multiple logistic regression for multivariate analysis in SPSS version 20.0.Results: Preterm birth affected 1,020 of 2,616 pregnancies (38.5%). Non-booked patients increased nearly twice risk for preterm delivery (OR 1.89, 95% CI 1.37–2.61). While women with singleton pregnancy (OR 0.17, 95% CI 0.12–0.25), head presentation (OR 0.75, 95% CI 0.63–0.89), and regular ANC (OR 0.67, 95% CI 0.54–0.84) had lower risk for preterm birth. Apgar score, birthweight, and mode of delivery were significantly different between the pre-term group and the full-term group.Conclusion: Prevalence of preterm birth in Cipto Mangunkusumo Hospital was approximately 2.5 times higher compared to the national number. Several factors reducing preterm birth rate include singleton pregnancy, head presentation, and regular ANC.

The effect of Bifidobacterium animalis lactis HNO19 supplementation among pregnant and lactating women on interleukin-8 level in breast milk and infant’s gut mucosal integrity

Medical Journal of Indonesia Vol 26, No 3 (2017): September
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Background: Newborn’s gut mucosal is not fully developed, therefore infants are prone to diarrhea. Probiotic supplementation is known to induce the gut mucosal maturity. This study aimed to identify whether probiotics supplementation among pregnant women since the third trimester would increase the infant’s gut mucosal integrity.Methods: A double-blind, randomized clinical trial was conducted to understand the potential effect of probiotic supplementation on the level of probiotics and IL-8 in breastmilk, urine IFABP, faecal α-1-antytripsin (AAT) and calprotectin in infant’s at birth (V0) and three-months old (V3). A single strain of Bifidobacterium lactis animalis HNO19 (known as DR10) was used since it was not the resident bacteria. The study was held at Budi Kemuliaan Hospital and its satellite clinics from December 2014 to December 2015.Results: About 14% (5/35) and 20% (7/35) of the subjects had DR10 in the breastmilk’s colostrum and at the age of 3-months. The median values of IL-8 in the probiotic group vs the placebo group at V0 and V3 were 2810,1 pg/mL vs 1516.4 pg/mL (p=0.327) and 173.2 pg/mL vs 132.7 pg/mL (p=0.211) respectively. IFABP level 211.7 ng/mL vs 842.5 ng/mL (p=0.243) and 25.3 ng/mL vs 25.1 ng/mL (p=0.466); AAT 136.2 mg/dL vs 148.1 mg/dL (p=0.466) and 24 mg/mL vs 29.72 mg/mL (p=0.545); Calprotectin 746.8 ng/mL vs 4645.2 ng/mL (p=0.233) and 378.6 ng/mL vs 391.3 ng/mL (p=0.888).Conclusion: Probiotic DR10 given to pregnant women since the 3rd trimester can be found in colostrum and 3-months breastmilk. However, it did not affect the level of other probiotics or IL-8 and the gut mucosal integrity.

Preterm Delivery and the Psychological Burden on Parents

Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 1, January 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

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Vitamin D Supplementation to Reduce the Risk of Preeclampsia: Is It True?

Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

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