Lack of Atherosclerotic Lesion Progression on Severe Hyperlipidemic Rabbits

HAYATI Journal of Biosciences Vol 16, No 2 (2009): June 2009
Publisher : Bogor Agricultural University, Indonesia

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In human, coronary heart disease causes by severe pathological atherosclerosis. In this study, we established animal model to study atherosclerosis caused by hyperlipidemia. This study therefore was undertaken to define the effect of increasing atherosclerosis risk factor, include body weight as well as age, cholesterol concentration and dietary fat in rabbit chow, and time of treatment. Male New Zealand White rabbits were divided into 4 groups; Group I and III were consisted of 2 months rabbit were fed with standard rabbit chow. To introduce atherosclerosis, the chow for Group II was contained 0.25% cholesterol and 5% palm oil; whereas the chow for group IV was contained 0.5% cholesterol and 5% coconut oil to induce higher atherosclerotic lesion. Results showed that group II and IV developed hyperlipidemia. However, aortic cholesterol concentration in those groups did not different significantly (P > 0.05). We suggest that low carbohydrate composition in diet, 50% lower compared to the previous researches, was able to increase high-density lipoprotein (HDL) concentration. This study demonstrated the complex interactions between low carbohydrate diet and cholesterol metabolism and the dramatic effects of reducing atherosclerosis risk factor; however, even though hyperlipidemic condition was achieved, total plasma cholesterol HDL ratio was maintained low. Key words: atherosclerosis, hyperlipidemia, rabbit, low carbohydrate diet

Beberapa Faktor Yang Berhubungan Dengan Fungsi Tiroid Pada Pasangan Usia Subur (PUS) di Kecamatan Kersana Kabupaten Brebes


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Background  : Pesticide exposure on women who live in agricultural areas can cause health problems such as disruption of thyroid function. Pesticides can inhibit the binding of iodine by the body. Hypothyroidism can cause disturbances in female reproductive system, including disorders of puberty and menstruation, pre menstrual syndrome, sexual disfunction, birth defects and low birth weight infant. Goiter are usually be found in mountainous or highland areas but now mostly found in the lowlands. This is probably due to the exposure to heavy metals such as Pb, the use of hormonal contraceptives, and consumption of thiocyanate.  The purpose of this study was to identify some factors associated with thyroid function on child bearing age woman in  Kersana Subdistrict,  district of Brebes Method  : It was an observational research using cross-sectional design. Research was conducted in 4 villages namely Kemukten, Limbangan, Sutamaja and Kubangpari Kersana Brebes District. The subjects were 87 women. Data obtained from TSH, FT4 serum, Pb in blood, kholinesterase in blood, urinary iodine excretion, thiocyanate, measurement of nutritional status, the interview to find out the type of contraception used by couples. Data were analyzed using chi square test. Result  : The results showed that there was no correlation between levels of kholinesterase, Pb in blood, urinary iodine excretion, urinary thiocyanate, the type of contraception, age and BMI with thyroid function on child bearing age woman in Sub district of Kersana. There was no association between exposure of pesticides and Hypothyroid cases occured in Kersana Sub district. It was recomended that women of childbearing need to reduce the adverse impacts of pesticides by using personal protective equipment in agricultural activities and improve health and clean living, and  health department should monitor and regular inspection for kholinesterase levels in women of childbearing age who live in agricultural areas. Keywords : Pesticides expose, thyroid disfunction, child bearing age woman.

Hubungan Kadar Timah Hitam (Pb) Dalam Darah Dengan Profil Darah Studi Pada Petugas Pengujian Emisi Gas Buang Dinas Perhubungan Kabupaten Purbalingga dan Banjarnegara


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Background : Fuel oil in Indonesia is still using of leaded gasoline, so that 70% of Pb from the burning will be emitted to the air. The official exhaust emission testing have a high risk, exposure to which continue to cause health problems, one of which is a disorder of the blood profile. The purpose of this study was to analysis the relationship between blood lead and blood profiles in exhaust emissions testing officer department of Transportation District Purbalingga and Banjarnegara. Methods : This research method was an observational analytic research with a cross sectional study design.Subjects were official exhaust emission testing with the inclusion criteria.Variables examined in this study are blood lead and blood profiles in the official exhaust emission testing. Data was collected through interviews, observation and measurement. Analysis of data using univariate analysis, bivariate analysis with spearman rank correlation. Results : The study found the average lead was 13.362 µg/dl, which means it was under the toxic threshold (40 ug/dl) and the average of blood profiles consisting of hemoglobin, erythrocytes, leukocytes, platelets, hematocrit was 15.737 ug/dl; 5.210.106/ml; 8.0723.103 / ml; 220.06.103/ml; 45.383%, 87.31 fl; 30.297pg; 34.685 fl. Bivariate analysis showed that there was a relationship between blood lead and blood profile (erythrocytes and hematocrit ), with  p-value and sequentially rho 0.018; 0.397 and 0.039; 0.35 (p-value <0.05). Conclusions : The conclusion of this study, although the value level of blood lead below the threshold toxic but are at risk in blood profile (decrease the number of erythrocytes and hematocrit levels) so that there is need for an appeal to the official testing of exhaust emissions in order to use Personal Protective Equipment (PPE) like a respirator, to reduce customs cigarette consumption, routine doing check-ups, increase the consumption of foods containing iron and vitamin C as well as expand the ventilation in the testing room, install exhaust and greenery around the testing room exhaust emissions. Keywords: blood lead, blood profiles, the official exhaust emission testing

Faktor Risiko Lingkungandan Kebiasaan Penduduk Berhubungan Dengan Kejadian Filariasis di Distrik Windesi Kabupaten Kepulauan Yapen Provinsi Papua


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Background : Regency of Kepulauan Yapen through Finger Blood Survey in 2006 was established as a filariasis endemic region. In 2007 started the implementation of mass treatment was held once a year for 5 years. Based on the survey of microfilaria at January 2010, the microfilaria ratewas 2.06%, where the largest number of people was in the District Windesi. Method : The study was an analytic survey with a case control approach. Population was resident in the village of Saruman and Windesi. The determination of the cases and control was done trough screening tests and found 10 cases of Wuchereria bancrofti.The ratio 1: 2, then the number of samples was 30, which was matched by age, sex and type of work. Result : The results were characteristics of filariasis patients, 30% in ≤ 20 year age group (≥ 15 years) and 21-30 years, 50% as farmers, 70% low income level (<Rp. 500,000) and 60% low level education (elementary school). Physical environmental conditions (average temperature of 26.75 0C, humidity of 83.61%, and 275.5 mm of rainfall and wind speed 4.07 knots). Chemical environmental conditions had the average pH of 6.69 and 1.14% salinity.There was significant correlation between presences of a pool of water with the incidence of filariasis.There was not significant correlation between presencesof aquatic plants, habits of using musquito net, hanging clothes, outside the house at night, and conduct environmental management with the incidence of filariasis. The dominant risk factor are existence of forest/bush  (p value: 0.027, OR: 9.727; 95% CI: 1.290 to 73.333) and completeness of clothing when tappingof sago (p value: 0.045, OR: 7.327; 95 % CI: 1.048 to 51.213). Someone who lived in a house close to bushes/forest and has a habit of not using fully clothed when tapping of sago, the probability of suffering from filariasis of 79.43%. Keywords : filariasis, environmental risks, habit, Saruman, Windesi

Dampak Program Bina Keluarga Balita (BKB) Terhadap Tumbuh Kembang Anak Balita 6-24 Bulan (The Impact Of Bina Keluarga Balita (BKB) Program To The Growth Development Of Toddler 6-24 Months)

Pustaka Kesehatan Vol 2, No 1 (2014)
Publisher : Pustaka Kesehatan

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The growth development is two difference phenomenons, but it is related and difficult to separated, that is growth and development. Bina Keluarga Balita (BKB) Program is one of the Keluarga Berencana (KB) program which purpose is to increase the knowledge and skills of parents and other family members to build the growth development of toddler by their ages. The aim of this study is to analyze the impact of Bina Keluarga Balita (BKB) program to the growth development toddler 6-24 months in the working area of Sumbersari subdistrict of Jember. The research type was observational analytic with cohort approaches. The samples about 130 toddlers (65 toddlers who family is participate and not participate on BKB) taken by Proportional Random Sampling. Based on Chi-Square results of statistical tests, it’s known that the difference of parenting nutrition, love pattern, teach pattern, and growth development between toddler 6-24 months who family is participate and not participate on BKB with the Sig or p = 0.0001 (p<α).   Keywords: Bina Keluarga Balita Program, Growth Development Of Toddler, 6-24 Months


Serat Acitya Vol 1, No 2 (2012): Masyarakat, Bisnis dan Lingkungan
Publisher : UNTAG Semarang

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Usaha kecil dan Menengah / UKM merupakan tumpuan utama pemerintah dalam menciptakan lapangan kerja baru terutama setelah krisis ekonomi yang terjadi beberapa tahun terakhir. Usaha kecil dan usaha rumah tangga di Indonesia memainkan peranan penting menyerap tenaga kerja. Perusahaan mebel di klaten semakin berkembang dan tumbuh pesat seiring dengan permintaan yang meningkat. Tujuan penelitian dalam jangka panjang dapat menciptakan tenaga kerja yang lebih baik/berkualitas, dengan meningkatkan ketrampilan dari proses belajar,  sehingga  melahirkan ide-ide kreatif membuat produk yang inovatif, akhirnya meningkatkan kinerja pemasaran. Hasil penelitian dapat disimpulkan : Orientasi pembelajaran generatif antara lain pembelajaran berdasar pengalaman,  cukup mampu memiliki pengalaman dari orang lain, dari karyawan, dari pelanggan, melihat pameran ; sedang mampu mengatasi resiko, antara lain cukup mampu mengatasi resiko dalam membuat produk, mencari bahan yang berkualitas, dengan meningkatkan ketrampilan, dengan mengatur keuangan yang benar ; kemudian meningkatkan ketrampilan antara lain cukup mampu : meningkatkan ketrampilan berasal dari sesama karyawan, berasal dari pelathan, dengan memberi tanggung jawab penuh pada karyawan, dengan  cara mendatangkan tenaga ahli, dengan melatih karyawan oleh karyawan yang lebih  senior, Kinerja Pemasaran terdiri dari indikator peningkatan volume penjualan disebabkan karena : permintaan mebel bertambah, pelayanan yang lebih baik, banyaknya variasi harga, sedsang pertumbuhan pelanggan meningkat karena : masyarakat semakin menyenangi mebel, mebel menarik dipandang,  mebel awet penggunaanya, kemudian jumlah pelanggan meningkat karena : mengadakan pameran, melakukan promosi, memberi discount, dan memberi hadiah

Faktor Lingkungan dan Praktik Masyarakat Berkaitan Dengan Kejadian Filariasis di Kabupaten Semarang

Publisher : Master of Environmental Health Study Program, Faculry of Public Health, Faculty of Public

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Latar belakang: Perkembangan suatu penyakit infeksi di suatu daerah tergantung pada terdapatnya manusia yang rentan dan kondisi lingkungan yang sesuai bagi kehidupan mikroorganisme penyebab penyakit, salah satunya adalah penyakit filariasis (kaki gajah). Penyakit filariasis disebabkan oleh infeksi cacing filaria yang ditularkan oleh gigitan nyamuk. Kementrian Kesehatan menetapkan Kabupaten Semarang sebagai daerah endemis filariasis tahun 2015 menyusul beberapa daerah di Provinsi Jawa Tengah yang lebih awal sudah  menjadi endemis.Metode : Penelitian ini adalah penelitian observasional deskriptif dengan sampel sebanyak 45 orang yang dipilih dengan metode purposive sampling dan tersebar dalam wilayah kerja 6 puskesmas di Kabupaten Semarang. Variabel yang diteliti meliputi faktor lingkungan dan praktik masyarakat. Analisis data dilakukan secara deskriptif.Hasil : Nyamuk hasil survei entomologi  yang berhasil diidentifikasi terdiri dari  spesies Culex quinquefasciatus 83,5% dan Aedes aegypti 16,5% serta hasil bedah tidak ditemukan nyamuk yang positif mengandung larva mikrofilaria. Responden yang ditemukan breeding place di sekitar rumahnya sebanyak 64,4% dan 35, % tidak ditemukan breeding place. responden yang ditemukan resting place di sekitar rumahnya sebanyak 60 % dan 40% tidak ditemukan resting place. sebanyak 26,7% responden melakukan praktik keluar rumah pada malam hari dan 73,3% tidak melakukan praktik keluar rumah.Simpulan : Hasil survey entomologi didominasi nyamuk spesies Culex quinquefasciatus dan tidak ditemukan larva filaria saat pembedahan nyamuk, sekitar rumah responden masih banyak ditemukan breeding place dan resting place. Sebagian besar responden tidak  keluar pada malam hari. ABSTRACT Title: Environmental and Practice Factor  Related to Filariasis Incidence in Semarang RegencyBackground: The spreading of infectious disease in an area depends on the presence of susceptible humans and suitable environmental conditions for  the microorganisms that cause disease to live, one of which is filariasis (elephantiasis). Filariasis is caused by infectious filarial worm that are transmitted through mosquitos. The Ministry of Health (MoH) stipulated Semarang Regency as one of filariasis endemic areas in 2015, following other several areas in Central Java Province that have become endemic earlier.Methods : This research is a descriptive observational research, with 45 respondents had been observed as a sample. They were selected by purposive sampling method spread in 6 work areas of public health centers (Puskesmas) in Semarang Regency. Finger blood examination and mosquitoes dissesction ware conducted to determne mosquitoe species and infected status. Data was analyzed descriptively.Results : An entomological survey identified two species of mosquitos, consisted of 83.5% was Culex quinquefasciatus and 16.5% was Aedes aegypti. Moreover no mosquitoes were found that positively contained microfilariae larvae. Result from the observation showed 64.4% of respondents’ house were detected a breeding place, and 35% were not detected. Respondents’ house that were detected resting place  as much as 60%, and 40% were not. Meanwhile, 26.7% of respondents were practicing outside house at night, and 73.3% were not.Conclusion : The entomological survey results were dominated by mosquitoes from Culex quinquefasciatus species and did not find filaria larvae during mosquito surgery. However, there were still many breeding places and resting places around the respondents’ house. Most of respondents did not leave at night.

Determinant Factors of Work-Related Complaints

International Journal of Public Health Science (IJPHS) Vol 7, No 1: March 2018
Publisher : Institute of Advanced Engineering and Science

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Home-based workers of Footwear industries in Semarang Regency are all womans. The employment status of home-based workers usually unrecognized or unregulated by the employer or their itermediaries so that they did not paid close attention about HWBs’s working condition. They often work on inadequate working environment such as poor ventilation system, bad lighting, humid working space (damp wall and floor), and also poor layout of furnitures and work equipments. That condition exaberated by lack of HWBs’s knowledge and awareness regarding their health and safety at work. In addition HBWs often with little to none education, work on long extended working hours and working under intensive labor.This research was aimed to determine the relationship between respondent characteristics, medical history, and use of PPE with work-related complaints on home workers of shoe industry in Semarang regency. This was an observational analytic study using cross sectional approach. Population in this study was 80 home workers of shoe industry in Semarang regency. The samples are 66 home workers were taken using stratified random sampling method. Data were analyzed using frequency distribution and Chi-Square test. The results of this study showed that there were some variables that have significant association with work-related complaints (p≤ 0.05) including, length of work, duration of work, personal protective equipment (PPE). While the variables of age, body mass index (BMI), and medical history did not show significant association with work-related complaints (p> 0.05). Multivariate analysis using logistic regression showed the duration of work had the most powerful influence to the work-related complaints. The conclusion of this study was important for home workers to maintain health condition by doing exercise to avoid work-related complaints. Home workers that have long duration of work should increase the use of PPE such as masks and gloves.

Determinan Kejadian Anak Balita Gizi Buruk dan Gizi Kurang Usia 6-24 Bulan Pada Keluarga Non Miskin di Wilayah Kerja Puskesmas Rogotrunan Kecamatan Lumajang Kabupaten Lumajang

IKESMA Vol 6, No 2 (2010)
Publisher : FKM - UNEJ

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This research is a qualitative study that analyzed the determinant factor is the occurrence of malnutrition  among children under the age of 6-24 months of non-poor families in the working area Rogotrunan District Health Center Lumajang, Lumajang.  The target of this research is the mother of a toddler, who has a child under five with poor nutrition or malnutrition 6-24 months of age on non-poor families as much as 8 informants. The samples taken by purposive. The results showed that characteristics of children under five who became the subject of research is mostly women. Although the nutritional status of all children under five in this study were malnourished and underweight but their weight at birth was normal, all born with a weight > 2500 grams. Spacing of all children under five with a brother or sister is more than 2 years, and nearly all children under five was the second child. The characteristics of mothers, the average education level is high, and most are workers. The level of nutrition knowledge of mothers is enough. Based on the informant in-depth interview study that parenting becomes a major determinant, although the level of higher education and high levels of maternal knowledge but in terms of child care that is the practice of exclusive breastfeeding and complementary breastfeeding is really not done well. In terms of time less than the maximum care and parenting than mothers who tend to be left to the maid or grandmother for informants who worked without any special attention by the mother also helped support the occurrence of malnutrition and undernourishment among the children. Key words:  malnourished, underweight, non-poor family


IKESMA Vol 6, No 1 (2010)
Publisher : FKM - UNEJ

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This study intended to discuss the correlation between food consumption (energy, carbohydrate, protein and fat) and nutritional status of 2-5 years old children of poor family. This observational-analytical study is implemented by involving 83 samples taken by proportional random sampling. The result showed that 75% of the children were in good nutritional status. All respondents’ families had income below regional minimum income standard. Furthermore, 69.9% of mothers were elementary school graduates, and 86.8% of mothers had little knowledge of nutrition. Respondents’ consumption degree was also low; 58% suffered from energy deficit, 94% suffered from carbohydrate deficit, 67% good protein consuming, and 71% good fat consuming. The analysis showed that there was a correlation between energy and fat consumption degree and nutritional status, and there was no correlation between carbohydrate and protein consumption degree and nutritional status. Keywords: food consumption, nutritional status, poor family

Co-Authors Andri Wahyuni Anjasmara, Ira Mutiara Barodji Barodji Bina Ikawati Budi Bowo Leksono, Budi Bowo Budiyono Budiyono DEDY DURYADI SOLIHIN DEWI APRI ASTUTI Dianawati, Ika Dicka Indo Putri Priyono, Dicka Indo Putri DIMAS ANDRIANTO DONDIN SAJUTHI Dorce Mengkidi, Dorce Eddi Suhaedi, Eddi Elfian Zulkarnain, Elfian Elvi Sunarsih, Elvi Erfan Priyambodo Estri Irawati, Estri Farida Wahyu Ningtyas Farida Wahyu Ningtyias, Farida Wahyu Farikhun Asror, Farikhun Faruda Wahyu Ningtyias, Faruda Wahyu Fitria Dewi Sri Rahayuningati, Fitria Dewi Sri HASIM DANURI Ika Murni Saputri, Ika Murni Lailiyah, Putri Istik Larasti Yogantari, Larasti LATIFAH KOSIM DARUSMAN Leersia Yusi Ratnawati Lita Dwi Listyowati, Lita Dwi Maulidah, Wiwin Barokhatul Mursid Raharjo Mutasir Mutasir, Mutasir Ninna Rohmawati, Ninna Nur Endah Wahyuningsih Nurjazuli Nurjazuli Onny Setiani Pujiono Pujiono Purnomo, Joko Rahanyamtel, Robo Ratih Hafsari Purwindah Ratnasari Kusumawati Rizky Amaliyah, Rizky Rosi Marta Wahyuningrum, Rosi Marta Sagita, Qoni Mulia Santi, Nevi Ruliyana Sari, Rita K Sariningtyas, Eka Rosita Widya Saudin Yuniarno Semuel Franklyn Yawan, Semuel Franklyn Siti Fitriatun, Siti Siti Thomas Zulaikhah Sri Sugiyatmi Sri Winarsih Suhartono Suhartono Sujari Sujari, Sujari Supriyono Asfawi Taher, Achmad Teguh Budi Prijanto, Teguh Budi Thohirun Thohirun, Thohirun Titiek Praptini, Titiek Tri Ardyati Tri Choiratul Aminah, Tri Choiratul Tri Joko Triwahyuni, Wulan Yigibalom, Nofi Yuliani Setyaningsih Yulius Sarungu Paiting Yusniar Hanani D., Yusniar Zeta Rina Pujiastuti, Zeta Rina