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Levels of Adiponectin and Soluble Tumor Necrosis Factor-α Receptor 2 (sNFαR2) in Obese Males with or without Fatty Liver

The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Background: Increased lipolysis in obese patients will cause elevated free-fatty acid level leading to insulin resistance. There are varied inflammatory cytokines (sTNFαR2) and anti-inflammatory cytokines (adiponectin) in obese patients, with and without fatty liver (FL). The aim of this study was to determine sTNFαR2 and adiponectin levels in obese patients with and without fatty liver. Method: This study was an observational study with cross-sectional approach, which was conducted between September 2008 and August 2009. The patients were 94 obese male with waist circumference ≥ 90 cm based on criteria of the International Diabetes Federation. Fatty liver was detected by ultrasonography; while adiponectin and sTNFαR2 levels in blood were analyzed by using ELISA Method and blood examination at the clinical laboratory. Results: Levels of adiponectin and sTNFαR2 were different between obese patients with and without FL. The adiponectin level was 3.10 ± 1.14 in patients with FL and was 3.52 ± 1.07 in patients without FL; while the sTNFαR2 were 23.92 ± 6.00 (FL) and 20.61 ± 5.29 (without FL). In patients with low adiponectin level (< 3.33 µ g/L) and high sTNFαR2 level (> 21.78 pg/dL), there was relatively higher occurrence of fatty liver compared to the other patients. Conclusion: Obese patients with fatty liver have higher sTNFαR2 level than patients without fatty liver. Moreover, obese patients with fatty liver have lower adiponectin level compared to patients without fatty liver. Patients with low adiponectin level and high sTNFαR2 level have higher incidence of fatty liver than subjects with high adiponectin level and low sTNFαR2 level. Keywords: adiponectin, soluble tumor necrosis factor α receptor 2 (sTNFαR2), obese, fatty liver

MIXED CODE IN NOVEL HANUM DAN RANGGA FAITH & THE CITY HANUM SALSABILA RAIS WORKS

Journal of English Language and Literature (JELL) Vol 4 No 01 (2019): JELL STIBA IEC
Publisher : STIBA IEC JAKARTA

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Abstract

The purpose of this study is to describe the code mixing in the novel Hanum and Rangga faith & the city by Hanum Salsabila Rais. In this study, researchers used qualitative research with content analysis research method (content analysis), in qualitative research of language and literature,  researchers used documentation for the technique of collecting data because the data is novel by Hanum & Rangga. From the results of the research obtained that one kind of code mixing is idiom. In the novels "Hanum and Rangga" a word insertion or idiom is found. This study is expected to add to the study in the field of sociolinguistics which examines the language used in the conversations of characters in novel literary works.

Metabolic Syndrome (MetS) and Nonalcoholic Steatohepatitis (NASH): Study of biochemical markers Free Fatty Acid (FFA), Total Antioxidant Status (TAOS), Adiponectin, Transforming Growth Factor (TGF-beta1), in occurence of NASH

The Indonesian Biomedical Journal Vol 1, No 1 (2009)
Publisher : The Prodia Education and Research Institute (PERI)

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Abstract

BACKGROUND: The prevalence of metabolic syndrome (MetS) in USA and Makassar are 22% and 23.7%. The prevalence of Non Alcoholic Steatosis Hepatosis (NASH) in MetS has not been reported. Study in Non-alcoholic Fatty Liver Disease (NAFLD) is 25–90 % in obesity patients. In NASH, there is accumulation of lipid in hepatocyte (raised free fatty acid level), raised stress oxidative (decreased total antioxidant status), raised of inflammation process (decreased adiponectin) and hepatic fibrotic process (raised TGF β1). The aim of this study is to investigate the correlation of free fatty acid, total antioxidant status, adiponectin and TGF-β1 with the occurrence of NASH.METHODS: This was a case control study in man aged ≥30 years old. Metabolic syndrome (MetS) was defined by IDF categories. NASH was defined as fatty liver plus raised type IV collagen level ≥140 ng/ml and Alanine Transferase (ALT) level 1.5x upper normal limit.RESULT: The samples consisted of 8 MetS subjects, 11 MetS subjects with fatty liver and 2 MetS subjects with suspect NASH. Low level of adiponectin and high level free fatty acid led to progression from Fatty Liver (FL) to NASH. Level of total antioxidant and Level of TGF-β1 were relatively steady in NASH.CONCLUSION: The level of Free Fatty acid in subjects with MetS-FL was higher than in subjects with MetS, but was lower than in subjects with MetS-NASH. No difference in total antioxidants status level was observed among all groups. Level of adiponectin decreased in subjects with MetS-FL and MetS-NASH compared with subjects with MetS only. The level of TGF-β1 increased in subjects with MetS-FL more than in subjects with MetS only, and was steady low in subjects with MetS-NASH.KEYWORDS: metabolic syndrome, NASH, free fatty acid, total antioxidant status, adiponectin, transforming growth factor β1

Interferensi Morfologi dalam Karangan Narasi Mahasiswa Thailand Semester IV Pendidikan Bahasa dan Sastra Indonesia FKIP Universitas Muhammadiyah Tangerang

Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Vol 1 No 1 (2018): Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing
Publisher : LP4MK STKIP PGRI Lubuklinggau

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Abstract

Tujuan penelitian ini untuk mendeskripsikan bentuk-bentuk interferensi morfologi bahasa Melayu Thailand terhadap bahasa Indonesia dalam karangan narasi mahasiswa Thailand semester 4 yang menempuh pendidikan Strata 1 Program Studi Pendidikan Bahasa dan Sastra Indonesia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Muhammadiyah Tangerang. Untuk menemukan interferensi morfologi dalam karangan narasi, peneliti menggunakan metode deskriptif kualitatif, dan dianalisis dengan metode analisis isi. Teknik pengumpulan data menggunakan teknik dokumentasi berupa hasil karangan narasi tujuh mahasiswa Thailand, dari data yang diperoleh peneliti menganalisis bentuk-bentuk interferensi dari bentuk afiksasi, reduplikasi, dan pemajemukan dalam bahasa Indonesia. Teknik analisis data dengan langkah-langkah: teknik analisis isi dimulai dengan menentukan masalah penelitian, kategorisasi, interpretasi, dan kesimpulan. Berdasarkan hasil penelitian terdapat interferensi pada karangan narasi mahasiswa Thailand semester IV PBSI FKIP Universitas Muhammadiyah Tangerang. Di dalam karangan yang mahasiswa buat, terlihat  mahasiswa  masih menggunakan bahasa Melayu dalam berkomunikasi secara lisan maupun tulisan.  Temuan penelitian ini, juga menunjukkan  bahwa banyaknya kata yang terinterferensi pada bentuk afiksasi kategori prefiks, sufiks, kombinasi afiks, konfiks, reduplikasi, dan komposisis sedangkan pada afiks kategori infiks tidak terdapat interferensi. Bentuk yang sering terinterferensi adalah pada bentuk afikasisi kategori prefiks, konfiks, dan komposisi dari ke enam karangan mahasiswa. Kata kunci: interferensi morfologi, karangan narasi, mahasiswa Thailand    Abstract The objective of this research was to describe the forms of morphological interference of Thai Malay to Indonesian in the narrative of Thai students of the 4th semester who studied in Strata 1 Indonesian Language and Literature Education Study Program, Faculty of Teacher Training and Education, Muhammadiyah Tangerang University. To find morphological interference in narrative essay, the researcher uses qualitative descriptive method, and analyzed by content analysis method. Data collection techniques used documentation techniques in the form of a narrative of seven Thai students, from data obtained by researchers analyzing the forms of interference from the form of affixation, reduplication, and compounding in the Indonesian language. Data analysis techniques with steps: content analysis techniques begin by determining research problems, categorization, interpretation, and conclusions. Based on the result of the research, there is interference on student narration of Thailand semester IV PBSI FKIP, Muhammadiyah Tangerang University. In the essay that the students make, it is seen that students still use Malay language in communicating orally and in writing. The findings of this study also show that the number of interferenced words in the form of affixation of categories of prefixes, suffixes, affix combinations, confix, reduplication and compositions whereas in the affix of the infix category there is no interference. Frequently interfered forms are in the form of affiliation categories of prefixes, confixes, and compositions of the six student compositions. Keywords: morphological interference, narrative essay, Thai college students

Levels of Adiponectin and Soluble Tumor Necrosis Factor-α Receptor 2 (sNFαR2) in Obese Males with or without Fatty Liver

The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Background: Increased lipolysis in obese patients will cause elevated free-fatty acid level leading to insulin resistance. There are varied inflammatory cytokines (sTNFαR2) and anti-inflammatory cytokines (adiponectin) in obese patients, with and without fatty liver (FL). The aim of this study was to determine sTNFαR2 and adiponectin levels in obese patients with and without fatty liver. Method: This study was an observational study with cross-sectional approach, which was conducted between September 2008 and August 2009. The patients were 94 obese male with waist circumference ≥ 90 cm based on criteria of the International Diabetes Federation. Fatty liver was detected by ultrasonography; while adiponectin and sTNFαR2 levels in blood were analyzed by using ELISA Method and blood examination at the clinical laboratory. Results: Levels of adiponectin and sTNFαR2 were different between obese patients with and without FL. The adiponectin level was 3.10 ± 1.14 in patients with FL and was 3.52 ± 1.07 in patients without FL; while the sTNFαR2 were 23.92 ± 6.00 (FL) and 20.61 ± 5.29 (without FL). In patients with low adiponectin level (< 3.33 µ g/L) and high sTNFαR2 level (> 21.78 pg/dL), there was relatively higher occurrence of fatty liver compared to the other patients. Conclusion: Obese patients with fatty liver have higher sTNFαR2 level than patients without fatty liver. Moreover, obese patients with fatty liver have lower adiponectin level compared to patients without fatty liver. Patients with low adiponectin level and high sTNFαR2 level have higher incidence of fatty liver than subjects with high adiponectin level and low sTNFαR2 level. Keywords: adiponectin, soluble tumor necrosis factor α receptor 2 (sTNFαR2), obese, fatty liver

Hubungan Obesitas dan Hipertrigliseridemia dengan Risiko Perlemakan Hati pada Pasien di Makassar

Indonesian Journal of Clinical Pharmacy Vol 1, No 4 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Perlemakan hati terjadi akibat lipolisis berlebihan dari jaringan lemak dan peningkatan suplai asam lemak bebas ke hati. Derajat keparahan perlemakan hati berkorelasi dengan peningkatan berat badan. Penelitian ini bertujuan untuk menemukan hubungan antara obesitas, trigliserida, obesitas dan hipertrigliseridemia terhadap risiko terjadinya perlemakan hati. Penelitian cross sectional menggunakan data retrospektif yang diambil dari pasien check up di Laboratorium Klinik Prodia Makassar selama tahun 2006. Diagnosis perlemakan hati melalui pemeriksaan ultrasonografi, obesitas ditentukan dari indeks massa tubuh, dan trigliserida diukur dengan metode enzimatik kolorimetri. Dari 204 pasien check up, 67 pasien (32,8%) mengalami perlemakan hati. Pada pasien dengan perlemakan hati sebanyak 95,5% mengalami obesitas, 67,2% hipertrigliseridemia, dan 32,8% trigliserida normal. Terdapat hubungan bermakna antara obesitas (risiko relatif (RR)=18,7; 95% C.I 5,6–62,4; p=0,001), obesitas disertai hipertrigliseridemia (RR=5,1; 95% C.I 2,7–9,5; p<0,001) dengan perlemakan hati. Didapatkan hubungan bermakna antara perlemakan hati dengan obesitas. Trigliserida tidak berhubungan langsung tetapi hipertrigliseridemia disertai obesitas berhubungan bermakna dengan kejadian perlemakan.Kata kunci: Obesitas, trigliserida, hipertrigliseridemia, perlemakan hati Relationship between Obesity and Hypertriglyceridemia on Fatty Liver in Patients at MakassarAbstractFatty liver is caused by a failure of normal hepatic fat metabolism due to a dysfunction of either within the hepatocytes. The degree of fatty liver is correlating to the increase of body weight. The aim of this study is to investigate any specific relationship between fatty liver and obesity as well as hypertriglyceridemia.This is a cross sectional study by using the retrospective data which is obtained from medical check up at Prodia clinical laboratory during 2006, fatty liver is diagnosed by using ultrasonography,obesity on body mass index (BMI), and triglyceride level by enzymatic colorimetric method.In 204 subjects of medical check up subjects were analyzed. Fatty liver has been found in 67 subjects (32.8%),95.5% of subjects with obesity, 32.8 subjects with normal triglyceride and 67.2% subjects with hypertriglyceridemia. There are significant relationship of obesity (relative risk(RR)=18.7; 95% C.I 5.6–62.4;p=0.001), obesity and hypertrigliseridemia (RR=5.1; 95% C.I 2.7–9.5; p<0.001) with fatty liver. Thereare a significant relationship of fatty liver and as well as obesity. Triglyceride is not contributing directlyto fatty liver but hypertriglyceridemia with obesity have significant relationship with fatty liver.Key words: Obesity, triglyceride, hypertriglyceridemia, fatty liver

MANTRA STRUCTURE OF BANTEN AND ITS IMPLICATION IN LITERARY LEARNING

Jurnal Gramatika Vol 4, No 1 (2018)
Publisher : STKIP PGRI Sumatera Barat

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Abstract

 Agus Sulaeman, Zainal Rafli, Aceng RahmatTangerang  Muhammadiyah  University, Banten Indonesia.Jakarta State University, Jakarta Indonesiasultanwahyu13@gmail.com.The purpose of this study is to describe the mantra of Tangerang community at Banten regency.The method in this study uses a qualitative approach with ethnography method. Ethnography method is one of qualitative research strategies in which researcher investigates a cultural group of a natural environment in a long period through primary data collection. The data in this research is in the form of old poetry (mantra) which got from 29respondents from 29 districts in Tanggerang regency. To analyze the data, the researcher used domain analysis, taxonomic analysis, and component analysis. From the research results obtained that the data are in the form of elementary constructive structures such as rhyme, diction,imagyand language figurative. The results of this study can be utilized for literary materials especially in literary studies.

Pengaruh Penggunaan Model Pembelajaran Examples Non-Examples terhadap Hasil Belajar Menulis Teks Berita pada Siswa Kelas VIII SMPN 14 Kota Tangerang

Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Vol 1 No 2 (2018): Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing
Publisher : LP4MK STKIP PGRI Lubuklinggau

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Abstract

Tujuan penelitian ini untuk  mengetahui pengaruh penggunaan model examples non examples pada siswa kelas VII SMPN 14 Kota Tangerang. Metode yang digunakan dalam penelitian ini adalah metode quasi eksperimen dengan melakukan pretes dan postes dua kelompok. Jenis metode penelitian eksperimen ini menggunakan disain penelitian Nonequivalent Control Group Design. Dimana kelas eksperimen yang diberi perlakuan dan kelas kontrol tidak diberi perlakuan. Nonequivalent Control Group Design ini hampir sama dengan pretest dan postest kontrol group desain, hanya pada desain ini kelompok eksperimen maupun kontrol tidak dipilih secara random. Teknik pengumpulan data menggunakan tes. Teknik analisis data dimulai dari uji normalitas, uji homogenitas, dan dilanjutkan uji hipotesis. Terdapat perbedaan hasil belajar menulis teks berita antara siswa yang diberi model pembelajaran examples non-examples dengan siswa yang tidak diberi model pembelajaran examples non-examples dan dibuktikan dengan hasil pengujian hipotesis yaitu pretes pada kelas kontrol dan eksperimen Ho diterima H1 ditolak, dapat disimpulkan bahwa thitung lebih kecil ttabel ( 0,42 lebih kecil 2,0022 ) maka pada pretes tidak memiliki perbedaan hasil belajar yang signifikan, dan hasil hipotesis postes pada kelas kontrol dan kelas eksperimen yaitu H1 diterima Ho ditolak karena thitung lebih besar ttabel = 3,05 lebih besar 2,0022. Maka dapat dinyatakan bahwa pemberian postes pada kelas kontrol yang tidak mendapatkan perlakukan dan kelas eksperimen mendapatkan perlakuan dengan menggunakan model pembelajaran examples non-examples menunjukkan perbedaan hasil belajar yang sangat signifikan.

Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae

Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

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Abstract

Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme activity and lipid peroxidation. This study was conducted by 2 methods including assay of HMG CoA reductase inhibition and lipid peroxidation test. The study was performed by in vitro method, using 20% rat liver homogenate. The inhibition of HMG CoA reductase enzyme was done by reacting liver homogenate, HMG CoA substrate, which added the Zingiberaceae extract compared with simvastatin as standard drug. The absorbance of the mixture was measured by a Microlab 300 spectrophotometer at a 340 nm wavelength. Lipid peroxidation assay was induced by the FeSO4.7H2O solution. The absorbance value measured using a spectrophotometer at a 532 nm wavelength. Lipid peroxidation inhibition was characterized by absorbance of the test extract, compared with the control group. The obtained data was calculated as percent of inhibition and was used to calculate IC50 extract test. The results showed that the 10 ethanolic extracts of Zingiberaceae rhizomes have activity as enzyme inhibitor HMG-CoA reductase with IC50 value range 65.8±4.1 – 203.3±15.2 ppm, and inhibition of lipid peroxidation with IC50 value range 13.5±5.0 – 219.6±4.3 ppm. This study can be concluded that the Zingiberaceae rhizomes have potential role as antihyperlipidemic agents through inhibition of HMG CoA reductase enzyme activity and preventing lipid peroxidation.

POTENSI RIMPANG BANGLE HANTU (Zingiber ottensii Val.) SEBAGAI ANTIHIPERGLIKEMIA PADA MODEL HEWAN DIABETES YANG DIINDUKSI FRUKTOSA

JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indon
Publisher : Sekolah Tinggi Farmasi Bandung

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Abstract

Latar belakang : Diabetes melitus (DM) dicirikan dengan intoleransi glukosa yang menghasilkan terjadinya hiperglikemia dan gangguan dalam metabolisme lipid dan protein. DM tipe 2 adalah jenis DM yang paling sering dijumpai dan pada umumnya diawali oleh gangguan fungsi insulin (resistensi insulin) yang mana selain dapat meningkatkan kadar glukosa darah juga dapat meningkatkan kadar trigliserida. Penelitian ini dilakukan untuk mengetahui aktivitas ekstrak bangle hantu (Zingiber ottensii Val.) sebagai antihiperglikemia dan dosis efektif ekstrak rimpang bangle hantu (Zingiber ottensii Val.) yang dapat menurunkan kadar glukosa darah pada model hewan yang diinduksi fruktosa Metode            : Penelitian ini menggunakan desain true experimental in vivo pada hewan coba tikus yang diinduksi dengan fruktosa dan propiltiourasil (PTU). Hewan coba dibagi menjadi 6 kelompok (n = 6), yaitu kelompok normal, kelompok pembanding, kelompok induksi dan 3 kelompok ekstrak dengan dosis 50 mg/kg BB, 100 mg/kg BB dan 150 mg/kg BB. Hasil : Terjadi penurunan kadar glukosa darah tikus selama test toleransi glukosa yang dilakukan pada hari ke 8, 15, dan 22 serta kadar trigliserida yang diuji pada hari ke 22. Kesimpulan : Ekstrak rimpang bangle hantu (Zingiber ottensii Val.)  memiliki potensi sebagai antihiperglikemia terhadap model hewan diabetes yang diinduksi fruktosa dan memiliki aktivitas maksimal sebagai antihiperglikemia secara in vivo pada dosis 100 mg/kg BB.