Tanti Azizah Sujono
Fakultas Farmasi Universitas Muhammadiyah Surakarta, Surakarta, Indonesia

Published : 14 Documents
Articles

Found 14 Documents
Search

PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Sujono, Tanti Azizah; Patimah, Raudatul; Yuliani, Ratna
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI Sujono, Tanti Azizah; Hidayah, Ullya Nur Wahyu; Sulaiman, T.N. Saifullah
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pegagan (Centella asiatica L. Urban) contain saponin asiaticoside, which is a structural protein. The compound plays a role in the wound healing process by the formation of collagen. This research was conducted to determine the effect of wound healing of burns on New Zealand male rabbits using gel extract of Pegagan (Centella asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling agent. This research was an experimental with the same subject design, using � ve male New Zealand rabbits to test the wound healing of burns, and the backs of each rabbit were divided into six treatment i.e : positive control (Bioplasenton), negative control (no treatment), control HPMC base (no extract), and three formula with herbal extracts of Centella asiatica with a concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was applied to the back of rabbits with the use ± 0.3 grams once daily until the wound diameter equal to zero or until healed. The data was analyzed by one way anava with a 95% confidence level. The result showed that of the gelling agent HPMC concentration effect on the increased the viscosity, and decreased the spreadability and the burn wound healing time is a longer. Gel herb pegagan extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of 8% (17,60±1,14 days) most effectively heal burns compared to the concentration of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).Keywords: Centella asiatica L. Urban, gel, hydroxypropyl methylcellulose, burns.
Inhibition Test of Noni Fruit Extract (Morinda citrifolia) toward Fungal Isolates that Cause Dandruff Ambarwati, Ambarwati; Sujono, Tanti Azizah; Sintowati, Retno
Prosiding Seminar Biologi Vol 12, No 1 (2015): Seminar Nasional XII Pendidikan Biologi
Publisher : Prodi Pendidikan Biologi FKIP UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (11.277 KB)

Abstract

Dandruff  is  the most head skin problem. If it does not treatment as possible as, dandruff can cause hair drop off. Dandruff  is  caused by microorganism, especially fungal. Noni (Morinda citrifolia) fruit has an activity as antifungal. The aim of this research was to know the inhibition effect of Noni extract toward fungal isolates that can cause dandruff. This research was exploration research. The steps in this research included : (1). Isolation microorganism from dandruff on Potatos Dextro Agar media by Spread plate methode. (2). Purification was done to get a pure fungi isolate by streak plate methode. (3). Made Noni extract. (4). Inhibition test of Noni extract toward fungal isolates by paper disc methode. Based on this research, there were 18 fungal isolates from the purification. Three isolates was knowen as kapang and 15 isolates as yeast. Noni extract could inhibit the grow of 14 fungal isolates with diameter of inhibition zone about 10 until 35 mm. Seven isolates could be blocked with strong category (the diameter of inhibition zone ≥ 25 mm), namely : J4 (30 mm), J5 (35 mm), J8 and J16 (26 mm), J13 (33 mm), J14 (25 mm),  and J18 (28 mm). The conclusion of this  research is Noni fruit extract can be used as an alternative medicine to treatment dandruff. Keywords: Noni fruit extract, antifungal, dandruff
THE PROTECTIVE EFFECT OF SARANG SEMUT (Myrmecodia tuberose) TUBERS INFUSION ON GENTAMICIN-PIROXICAM INDUCED NEPHROTOXICITY IN RATS Sujono, Tanti Azizah
INDONESIAN JOURNAL OF PHARMACY Vol 25 No 2, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (832.497 KB) | DOI: 10.14499/indonesianjpharm25iss2pp91

Abstract

Kidney is very important organ for blood filtration. Impaired renal function often results in chronic kidney disease. Sarang semut (Myrmecodia tuberosa) is traditionally used to cure various diseases. This research was conducted to determine the effect of sarang semut infusion in nephrotoxicity rats models by gentamicin-piroxicam. Thirty male Wistar rats were divided into 6 groups. Group I as normal control (CMC Na was treated orally for 7 days), group II was treated sarang semut infusion dose of 1g/kgBW orally for 7 days, group III as nephrotoxic control was injected by gentamicin 100mg/kgBW intraperitoneally and piroxicam 3.6mg/kgBW orally daily for 7 days and group IV until VI were rats simultaneously treated with sarang semut infusion at the dose of 1, 2, and 4g/kgBW, respectively and induced by gentamicin-piroxicam daily for 7 days. Parameters of kidney function such as serum creatinine and blood urea nitrogen (BUN) levels were measured on day 0 and 7 using spectrophotometer. The rats were then sacrificed, kidneys tissue were removed for examination of renal index and kidney histology. These results showed that sarang semut tubers infusion at the dose of 1, 2, and 4g/kgBW reduced BUN and creatinine levels on induced-nephrotoxic rats. Creatinine level was reduced significantly to 1.76±0.13; 0.86±0.15; 0.60±0.07mg/dL, respectively. The creatinine level of nephrotoxic control was 5.16±0.27mg/dL. BU level decreased significantly to 55.66±6.22; 18.49±2.61; 16.81±1.24mg/dL, respectively. Meanwhile the BUN level of nephrotoxic control was 276.65±50.52mg/dL. Rat histological profile of the three doses tratment showed improvement in renal cell after administration of sarang semut infusion for 7 days. 
PELATIHAN PEMERIKSAAN TAJAM PENGLIHATAN PADA SISWA KELAS 5 SD GEDONGAN I, COLOMADU, KARANGANYAR Sutrisna, Em; Hanwar, Dedi; Indrayudha, Peni; Sujono, Tanti Azizah
WARTA WARTA Volume 10, Nomor 1, Maret 2007
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/warta.v10i1.3210

Abstract

Seeing is crucial aspect in life includes in the field of education. Ifit is not cured the reduction of  sharpness of seeing/visus can affect thestudent ability to study. This action is done to detect  this reduction early.Therefore, the eyes will not be getting worse. The research is done bytraining and demonstrating how to check visus. The location of the researchis SD Gedongan I, Gedongan, Colomadu, Karanganayar. The 31 studentsare checked. The result is that there are 3 students have visus with miop.All the students can participate in this research well.
Aktivitas Antihiperurisemia Ekstrak Etanol Kulit Buah Rambutan (Nephelium lappaceum L.) dan Jeruk Manis (Citrus Sinensis L. Osbeck) pada Mencit Jantan Galur SWISS Sujono, Tanti Azizah; Muhtadi, Muhtadi; Sativa, Wieke Rachma
Jurnal Penelitian Sains Teknologi Volume 13, No. 1, April 2012
Publisher : Muhammadiyah University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kulit buah rambutan dan jeruk manis mengandung senyawa yangdiduga dapat berperan sebagai antihiperurisemia seperti asam galat,kaempferol, luteolin, hesperidin dan rutin. Namun belum ada penelitianmengenai potensi antihiperurisemia kulit buah rambutan dan jerukmanis. Tujuan dari penelitian ini untuk mengetahui pengaruh dariekstrak etanol kulit buah rambutan dan jeruk manis pada mencit jantangalur swiss yang telah diinduksi dengan kalium oksonat secaraintraperitoneal. Pengujian efek ekstrak etanol kulit buah rambutan danjeruk manis dilakukan secara eksperimental dengan rancangan post testcontrol group design menggunakan Empat puluh ekor mencit jantandibagi dalam 8 kelompok yaitu kelompok kontrol positif (allopurinoldosis 10 mg/kgBB), kontrol negatif (CMC Na 0,5%), tiga kelompokperlakuan masing-masing diberikan ekstrak etanol kulit buah rambutandosis 125; 250 dan 500 mg/kgBB dan tiga kelompok perlakuan lainnyamasing-masing diberikan ekstrak etanol kulit buah jeruk manis dosis125; 250 dan 500 mg/kgBB. Konsentrasi asam urat serum dianalisisdengan metode enzimatis TBHBA pada panjang gelombang 546 nm.Hasil penelitian menunjukkan bahwa ekstrak etanol kulit buahrambutan dan jeruk manis memiliki pengaruh dalam menurunkankadar asam urat serum mencit jantan galur Swiss yang telah dibuathiperurisemia dengan diinduksi potassium oxonate.
UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN TUMBUHAN SALA (CYNOMETRA RAMIFLORA LINN.) DENGAN PARAMETER KIMIA URIN DAN HISTOPATOLOGI ORGAN GINJAL PADA TIKUS GALUR WISTAR -, Haryoto; Suhendi, Andi; W, Eka Prasnaparamita; Sujono, Tanti Azizah; -, Muhtadi
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.584 KB)

Abstract

Tumbuhan Sala (Cynometra ramiflorra Linn.) merupakan salah satu tumbuhan mangrove, yang memiliki beberapa manfaat antara lain antioksidan, antihiperglikemia, dan antiinflamasi. Uji toksisitas subkronis digunakan untuk mengetahui toksisitas suatu senyawa yang dilakukan selama 90 hari. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan ekstrak etanol daun Sala terhadap parameter kimia urin dan histopatologi ginjal. Penelitian ini merupakan penelitian eksperimental dengan rancangan Post Test Controlled Group Design, yaitu melihat perubahan yang terjadi pada tikus setelah diberi perlakuan. Sampel penelitian terdiri dari 20 ekor tikus putih jantan yang dibagi 4 kelompok dosis perlakuan. Kelompok pertama merupakan kelompok kontrol yang diberi CMC-Na (Sodium Carboxy Methyl Cellulose), kelompok kedua, ketiga, dan keempat diberi ekstrak etanol daun Sala dengan dosis 500, 1000, dan 1500 mg/kgBB. Parameter yang diamati yaitu kimia urin dan histopatologi ginjal. Parameter kimia urin dievaluasi menggunakan urin tampungan pagi hari pada hari ke-0, 45, dan 90 menggunakan reagen strip. Hasil parameter kimia urin tikus untuk kelompok kontrol dan perlakuan selama 90 hari memberikan pengaruh pada parameter protein, glukosa, keton, bilirubin, urobilinogen terhadap fungsi ginjal, namun tidak mempengaruhi pH dan nitrit. Hasil histopatologi menunjukkan terjadinya peradangan pada ginjal tikus yang diberi ekstrak etanol daun Sala dengan dosis 1000 dan 1500 mg/kgBB.Kata kunci: Cynometra ramiflora Linn., toksisitas subkronis, kimia urin
Antifungal Activity of Streptomyces Isolate Associated with The Rhizosphere of Belulang Grass (Eleusine indica) AMBARWATI, AMBARWATI; SUJONO, TANTI AZIZAH; SEMBIRING, LANGKAH; WAHYUONO, SUBAGUS
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.721 KB)

Abstract

The appearing of various new infection diseases and resistantly pathogenic microorganism to old antibiotic, have motivated another antibiotic discovery from bacteria, fungus and Actinomycetes. Nowadays, some researchers are being focused on Actinomycetes, that is indicated as the bacteria which produces the biggest number of antibiotics. About 45,6% of 8.000 antimicrobia were produced by Streptomyces. The aims of this research were to isolate and identify of Streptomyces from rhizosphere of belulang grass (Eleusine indica) that potentially as antibiotic producer. This research was exploration research. From this research, 33 isolates from rhizosphere of belulang grass (Eleusine indica) were found, 17 isolates potentially as antifungal producer. Eight isolates could inhibit only one of test fungal, seven isolates could impede the growth of two test fungal and one isolate (RRR67) could inhibit the growth of three test fungal, namely Trichophyton mentagrophytes, Aspergilus fumigatus and Candida albicans. Based on SEM result, it could be known that the spore morphology and the ornament of the spore chain surface, one isolate (RRR67) was identified as Streptomyces. From the research, it could be concluded that 17 isolates from the rhizosphere of belulang grass (Eleusine indica) potentially produce antifungal which is need for infection medicine treatment.
Kombinasi Ekstrak Daun Pandan Wangi ( Pandanus amaryllifolius Roxb.) dan Buah Mengkudu (Morinda citrifolia) sebagai Antifungi terhadap Jamur Penyebab Ketombe AMBARWATI, AMBARWATI; SUJONO, TANTI AZIZAH; SINTOWATI, RETNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.429 KB)

Abstract

Ketombe adalah masalah kulit kepala yang menyebabkan gatal dan rambut rontok. Hal ini disebabkan oleh mikroorganisme, terutama jamur. Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) dan buah Mengkudu (Morinda citrifolia) diketahui memiliki efek antijamur. Tujuan dari penelitian ini adalah untuk mengetahui kombinasi ekstrak etil asetat 96% daun pandan wangi dan ekstrak etanol 96% buah mengkudu yang dapat menghambat jamur yang diisolasi dari ketombe. Jamur diisolasi dari sampel ketombe pada PDA (Potatoes Dextro Agar) dan dimurnikan. Berdasarkan penelitian, diketahui kepadatan jamurnya adalah 9,2x10???? koloni / gram. Dimurnikan dari 17 jenis isolat jamur pada sampel ketombe. Uji penghambatan EPW:EP (1:1) menunjukkan bahwa 82,4% isolat jamur dihambat, diameter zona penghambatan berkisar antara 15-35 mm. Ada tiga jenis jamur: Aspergillus sp, Paecylomyces varotii, Candida sp (non albicans) dan 1 isolat adalah ragi. Senyawa aktif ekstrak daun pandan: fenol (9,42% b/b) dan fl avonoid (4,39% b/b), sedangkan pada ekstrak buah mengkudu: alkaloid (1,97% b/b), fenol (12,50% b/b) dan fl avonoid (8,61% b/b). Dapat disimpulkan bahwa kombinasi ekstrak daun pandan wangi dan buah mengkudu berpotensi digunakan sebagai shampo anti ketombe.