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Journal : INDONESIAN JOURNAL OF PHARMACY

THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) wahyuningsih, iis -; Sugiyanto, Sugiyanto; Yuswanto, Ag.; Martien, Ronny
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (699.486 KB) | DOI: 10.14499/indonesianjpharm28iss2pp112

Abstract

Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation  could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation
Effect of Soybean-based Food Supplement on Insulin and Glucose Levels in Type 2 Diabetes Mellitus Patients Purwoko, Akhmad Edy; Astuti, Indwiani; Asdie, Ahmad Husain; Sugiyanto, Sugiyanto
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm30iss3pp208

Abstract

Introduction: Indonesia is one of ten countries with the largest diabetic populations in the world. Giving soy supplements to people with diabetes can reduce blood glucose levels significantly. However, no studies have shown a reduction back to normal glucose levels. This study aimed to determine the increase of insulin levels and blood glucose suppression in glucose tolerance tests after supplementation of soy in patients with type 2 diabetes. Sequencing the gene of GLP-1 (37 amino acid). This experimental research was a randomized, treatment controlled; open clinical trial study conducted by comparing the control group treated with soybean supplement products containing 18g protein and placebo. Seventy-six treatment subjects with type 2 diabetes were recruited from Muhammadiyah Gamping Hospital and PERSADIA gymnastics group according to the inclusion and exclusion criteria and then grouped randomly in the supplement treatment and placebo groups. Blood sampling was drawn at 8 hours fasting, 2 hours after supplement administration and 2 hours after administration of 75g glucose for measuring blood insulin and glucose level. Blood insulin level 2 hours after supplement administration (mean±SEM) increased 5.3±0.8µIU/ml (n=37) while placebo decreased 0.9±0.4µIU/ml (n=39) which was statistically significantly different (p<0.05). Blood glucose levels increased in the glucose tolerance tests, while the supplement group was 130.0±11.5mg/dl (n=37) lower than the placebo 146.7±8.2mg/dl (n=39) (p>0.05). Gene sequencing shows a nucleotide variation of GLP-1 (37 amino acid) in Javanese T2DM Giving Soybean supplements containing 18g protein increased blood insulin levels and suppressed blood glucose levels in glucose tolerance tests.
Co-Authors Abdul Gofir Abdurrachman, Abdurachman Achmad Santosa, Achmad Adi, Alik Sus Adibatul Mustaanah Adji Nur Mohammad Ag. Yuswanto Agung Nugroho Setiawan, Agung Nugroho Agus Kristiyanto Agus Miftakus Surur, Agus Miftakus Agus Zainal Arifin Agustin, Ika Kristina Dewi Agustina Shinta Ahmad Husain Asdie Akhmad Edy Purwoko, Akhmad Edy Al Jamil, Abu Hasan Alif Fauziah Sari, Alif Fauziah Andita, Frizal Didin Mardyansyah Anggi Febriani, Anggi Ani Rusilowati Anisa Anisa Annisa Eki Mulyati, Annisa Eki Anwar, M. Choiroel Anwar, Muhammad Choiroel Aprilia Cheni Hermawati Aprilia, Anisatul Khoir Ardianto Wibowo Ariansyah, Arisman Arief Nurrochmad Arifin Arifin Arinda Puspitaningtyas Aris Santjaka Ariyani Eka Wardani, Ariyani Eka Ary Kurniati Asia Refina Asim Asim, Asim Awaluddin Awaluddin Awanda, Ifan Ba’tradiansar, Muhammad Badrun Kartowagiran Baharuddin Risyak Baskoro Adi Prayitno Budi Naini Mindyarto, Budi Naini Cahyono, Edi Dwi Candra Junianto, Candra Candra, Alexander Candrawati, Yunita Christine Patramurti, Christine Cut Rohani Bitai, Cut Rohani Danang Soeko Rahardjo, Danang Soeko Darsono Darsono Dartini Dartini, Dartini Deasti Nurmaguphita, Deasti Denny Saputra DESI NATALIA, DESI Dewi Agustina Dewi Liesnoor Setyowati Dewi, Ayu Trisna Diartama, Anak Agung Aris Diffah Hanim Dinar Tri Palupi Djoko Santoso Dona Prayogo, Dona Donny Kristanto Mulyantoro Dwi Setyawan Dyah Ardan Pratiwi Edo Himawan Edy Meiyanto Een Yayah Haenilah Eflita Yohana Emi Murniati, Emi Endang Sri Sunarsih Endriatmo Soetarto Ernila Indah Febrika, Ernila Indah Faisal Amri Faisal Nurrohman, Faisal Fangohoi, Latarus Farida Hayati fatimah Fatimah Fatimah, Fatimah Fatoni, Rismi Febriana, Tya Nur Firdaus, Harish Fitri Akhyar, Fitri Fitria Akhyar Garyas Praja Siswadi Gatot Murti Wibowo, Gatot Murti Gito Sugiyanto Godham Eko Saputro, Godham Eko Gunawan, Dea Ayu Permata Hafidhoh, Nisa’ul Harianto, Fajar Hary Budieny HERMANTO SIREGAR Hermawan Widi Laksono Herpratiwi Herpratiwi Hertanto, Dedy Heru Trisikwanto, Heru Hervina, Norenda Okta Hidayatullah, R.H Hindriani, Dita Husman, Husman Iis Wahyuningsih Ika Kartika Ilahi, Bogy Restu Imam Arahman, Imam Imam Budiarjo, Imam Imam Santosa Inayati Inayati Indrastono Dwi Atmono, Indrastono Dwi Indwiani Astuti Insanistyo, Bayu Irfandi Irfandi, Irfandi Ito, Yonathan Jailani Jailani Jamari Jamari Jeffri Ardiyanto, Jeffri Jehma, Rosana Joga Dharma Setiawan Joko Purwanto Joko Waluyo Jupiter Sitorus Pane Kartika Septianingrum, Kartika Kartono Kartono Kayan Swastika Keppi Sukesi Khumaedi Khumaedi, Khumaedi Kiyatno Kiyatno Kurniawati, Ary Kusumaningsih, Indriati Kusumo, Fajar Adi Lanny Sunarjo, Lanny Leny Latifah Lina Aryati Lintje Setyawati Maurits, Lintje Setyawati Liya Umaroh, Liya Loliyana Loliyana Lubis, Novitasari Lukman Hakim M. E. Winarno, M. E. M. Rifqi Rokhman Ma’rifatun, RR Laila Made Elisa Deviyanti, Made Elisa Mae Sri Hartati, Mae Sri Maesaroh Ulfa, Maesaroh Maharani, Annisa Mahmudyan Nuriil Fahmi Maman Surahman Mangku Purnomo Mardiah Suci Hardianti Marjono Marjono Marsum Marsum, Marsum Maryati Maryati Melysa, Oktia Moh. Toifur Mohammad Badaruddin Mohammad Yudhi Widyatmoko Mosik Mosik, Mosik Muchammad Abrori, Muchammad Muchsin Doewes Muhammad Donny Kusumo N. Muhammad Dwi Prayoga Muhammad Dzulfikar Muhammad Erri Kurniawan Muhammad Heru Firmansyah, Muhammad Heru Muhammad Wakhid Musthofa, Muhammad Wakhid Musoli, Musoli Muzdalifa, Muzdalifa Nanang Fakhrur Rozi Nanang Sugiarto Nastiti, Fajar Tri Nendyah Roestijawati Neri, Chindi Aran Nila Oktaviani Nina Salamah Nizar Rahman Aprilitama, Nizar Rahman Nopembereni, Eti Dewi Nugraha, Faryan Nunuk Aries Nurulita Nur Pinandoyo Nur Rohman Nuraeni Nuraeni Nuraini, Tumang Nuroniyah, Rifatun Nurul Maziyyah, Nurul Oni Bagus Januarto, Oni Bagus P.W, Agnes Intan Pande Made Udiyani Pangandosan, Annisa Parmasari, Megawati Partoso Hadi, Partoso Praditha Edu Ar-Rasyid Pratama, Andika Priya Pratiwi, Hasih Prawastyorini, Ardina Nilam Pri Iswati Utami Priantoro, Win Priyono Priyono Pujianto, Dian Purwati, Endah Purwati, Magdalena Yuli Raharjo, Komplit Rahayu, Anggi Andriani Rahman, Faisal Adam Rahmat Putra Perdana Rahmawati, Hesti Dwi Ramadaniawan, Nizamuddin Nur Rasyid Rasyid, Rasyid Retno Palupi Yonni Siwi, Retno Palupi Yonni Retnosari, Dewi Reza Safitri Rifky Ismail Rinci Kembang Hapsari, Rinci Kembang Rini Indrati, Rini Rini Rahma Dianti, Rini Rahma Risna Endah Budiati Risqhe Rumsi, Risqhe Riswandi Riswandi Riswanti Rini Riyanto M. Taruna Rizky Tegar Wicaksono Agami Rochmiyati Rochmiyati Rokhayah, Fajar Ronny Martien Rosmansyah, Ridho Sabir Sabir Saktyianto Ajinugroho Sapta Kunta Purnama Saraswati, Suci Sari, Fitri Ropita Satria Waskita Eka Paksi, Satria Satria Waskita Eka Paksi, Satria Waskita Eka Sebtika, Astrid Nanda SEPTI WULANDARI Sholihah, Ana Putri Silvani, Amalia Silvani, Daffanny Aida Silvia Yulita Ratih Singgih Prihadi Siswandari Siswandari, Siswandari Siti Khanafiyah Siti Romlah Soeadgihardo Siswantoro Sofi'ah, Saifuli Sri Eko Wahyuni Sri Handayani Sri Kuntjoro Sri Purnami, Sri Sri Sangkawati Sri Sangkawati Sachro Sri Sangkawati Sachro, Sri SRI UTAMI ADY Sriyana Sriyana Sucipto, Barep Sudarto, Untung Sudarwati, Ida Sudibyo Martono Sudiyono Sudiyono Sugeng Wahono Sugianto Sugianto Sugihartiono, Tono sugihartono, Tono Sugiman Sugiman Suhardi Suhardi Sujatmoko, Sujatmoko Sumantri Sumantri Sumardi Sumardi Sumarjono, Sumarjono Sumiyani, Ririn Sunandarti, Hermi Supriyadi Supriyadi Supriyana Supriyana, Supriyana Suryono Suryono Suseno Darsono Susy Suswaty Sutisyana, Ari Syafrial Syafrial Syaifuddin Latif Tarigan, Emiliana Tesa Eranti Putri Thaqibul Fikri Niyartama Tia Nur Meilinda, Tia Nur Tono Wibowo Tony Prahasto Topo Suhartoyo, Topo Tri Murti Andayani Triasmono, Haris Kukuh Trisandy, Memo Triyudho, Ramos Tutuk Indriyani, Tutuk Uchi, Atika Yana Ukhtinasari, Febri vita, Septika Usde wahyuningsih, iis - Wasiilati, Anifa Wati, Setiana Wicaksono, Pararto Widha Sunarno Widhy Hayuhardhika Nugraha Putra Widi Hidayati, Widi Wlnarto, F. Eko Wlsmo Y.I. Wicaksono Yandi Purbangsa Yasin Yusup Yayuk Yuliati Yenni Sri Utami, Yenni Sri Yenny Puspitasari Yopi Harwinanda A, Yopi Harwinanda Yudha Satria Yudi Ari Adi, Yudi Ari Yunitasari, Yessyca Yuswanto, Ag Yuwana, Rizkia Wira Zabdillah, Mohammad Zulmi Fairuz Zaenal Kusuma Zaenal Zaenal, Zaenal Zukhronah, Etik Zulhelmi Zulhelmi, Zulhelmi