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All Journal Journal of Tropical Life Science e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences
Muhammad Ali Shodikin
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Library & Information Science

Published : 5 Documents
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 1 
Correlation between Serum Ferritin and Cardiac Troponin I in Major Beta Thalassemia Children Shodikin, Muhammad Ali; Suwarniaty, Renny; Nugroho, Susanto
Journal of Tropical Life Science Vol 6, No 1 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.575 KB) | DOI: 10.11594/jtls.06.01.03

Abstract

Background: Major beta thalassemia (MBT) is a hereditary disease which synthesis defect on beta chains of haemoglobin, it is cause red blood cell destruction and the symptoms of anemia. Red blood cells destruction, frequent blood transfusion and low adherence to routine use of iron chelator were cause iron accumulation in the heart, liver and endocrine organs. Accumulation of iron in the myocard can lead acute myocardial infarction. One of cardiac markers that had been used for the diagnosis of myocardial infarction was cardiac troponin I (cTnI). The aim of this research is find correlation between serum ferritin levels and cTnI in MBT children.Methods: A descriptive analytic research was conducted using a cross sectional design. The subjects were divided into 2 groups, the MBT group and the control group. In both groups perform laboratory examination to checks the serum ferritin and cTnI levels. Data were analyzed using t-test and Pearson correlation test.Result: Eleven children in the MBT group and 11 children in the control group were involved in this study. In the MBT group, the mean of serum ferritin and cTnI levels were 4292.5 μg/L and 0.22 ng/mL respectively. In the control group, the mean of serum ferritin and cTnI levels were 136.2 μg/L and 0.20 ng/mL respectively. The mean of serum ferritin levels in MBT group was higher than control, statistically significant (p= 0,0004 ). The mean of serum cTnI in MBT group was higher than control, statistically not significant (p= 0,82). In MBT group, there was a weak corellation between serum ferritin and cTnI levels (r = 0,34). Keywords: Major beta thalassemia, children, ferritin, cTnI
Risk Factor Analysis of Dengue Shock Syndrome Occuring to Children in RSD dr. Soebandi Jember Regency Salsabila, Oessi; Shodikin, Muhammad Ali; Rachmawati, Dwita Aryadina
Journal of Agromedicine and Medical Sciences Vol 3, No 1 (2017)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengue Shock Syndrome is a medical emergency situation caused by shocking DHF. Some factors that can influence the DSS. The purpose of this research know some risk factors that might cause DSS. Those are age, nutritional status, gender, and amount of platelet and hematocrit. This research was retrospective case control doing in dr. Soebandi Hospital Jember. The sample were divided into 2 groups. Those were DSS (case group) and non-DSS group (control group). Data analysis was done by Chi-Square test using SPSS 21 version. These were 136 patients which were divided into 94 patients of control group and 42 patients of case group. In this research, there were p-value for ages, nutritional status, gender, amount of platelet and hematocrit on each 0,450; 0,490; 0,198; 0,001; 0,007 respectively. In this search, it could be concluded that age, nutritional status, and gender were not significantly related to DSS case although amount of platelet and hematocrit were significantly related to DSS case.Keywords:dengue shock syndrome, age, nutritional status, gender, hematocrit, platelet.
The Correlation between HIV/AIDS Positive Pregnant Mother with Infant APGAR Score in RSD dr. Soebandi Jember Purwaningsih, Nurlaila Ayu; Shodikin, Muhammad Ali; Abrori, Cholis
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Medical Faculty of Jember University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6781

Abstract

Human Immunodeficiency Virus (HIV) is a virus that decreased immunity and a set symptoms of diseases called Acquired Immune Deficiency Syndrome (AIDS). One of the major risk factors for HIV transmission is perinatal transmission about 2.8% during pregnancy, delivery, and postpartum. HIV positive mothers have a potential to give birth infants with low APGAR. APGAR Score was used as a reference to determine asphyxia in the first and fifth minutes of life. The purpose of this research were to determine the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score and to determine the other factors that affect the infant APGAR Score in RSD dr. Soebandi Jember. This research used observational analytic survey method with cross sectional design using medical record of HIV positive and negative pregnant women from August 2014-July 2017 in RSD dr. Soebandi Jember as a subject that qualify the inclusion and exclusion criteria. This research used case group sampling technique by total sampling and control group by simple random sampling each 52 samples. Test result of the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score using Chi-Square test obtained p value=1.000 (OR=1.13) that means there was no significant correlation. Test result of the correlation between the other factors that affect infant APGAR Score concluded that there were no significant correlation. Keywords: pregnant mother, HIV/AIDS, APGAR Score, infant
Titer Widal pada Populasi Sehat di Universitas Jember (Widal Titre among Healthy Population in University of Jember) Suryani, Dissa Yulianita; Shodikin, Muhammad Ali; Astuti, Ida Srisurani Wiji
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.292 KB) | DOI: 10.19184/pk.v6i2.7611

Abstract

  Enteric fever is endemic in developing countries including Indonesia. Widal test in a single serum sample is commonly used as laboratory diagnosis especially where culture facilities are not available. Examination of the single Widal test in endemic countries such as Indonesia, will give less accurate results with the large number of false-positive or false-negative. One of false-positive results is single Widal interpretation of test in endemic areas where the majority of the healthy population had contact or infected previously, and showed a positive result of Widal test. Widal titre examination in healthy population both men and women have not been investigated in Jember. So the aim of this study was to determine Widal titres among apparently healthy population in Jember University. In this cross-sectional study, blood samples were collected as much as 3 mL from healthy men (n=47) and women (n=47) and were analyzed for the presence of Salmonella antibodies by carrying out the Widal slide agglutination test. The data was analyzed using SPSS version 23 descriptively. The result showed that the most frequent antibody titres of O, H, AO, AH, BO, and BH antigens were 1/320 (37,2%), 1/320 (38,2%), 1/320 (86,1%), 1/320 (67,0%), 1/320 (77,7%) and 1/40 (27,7%) respectively in healthy population. In conclusion, antibody titre of AO dominated the most positive results in healthy population.   Keywords: Widal test, healthy population, Indonesia  
Antioxidant Effect of Kenitu leaf Etanol Extract (Chrysophyllum Cainito L.) on Wistar Rat Induced Cyclophosphamid Pramudito, Ekvan Danang Setya; Efendi, Erfan; Shodikin, Muhammad Ali
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Medical Faculty of Jember University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6837

Abstract

Recently, cancer is  globally the second highest cause of death with a total death about 8.8 million in 2015. There are some  therapy of cancer, one of them  by using cyclophosphamid chemotherapy, but this regimen has side effects of bone marrow depression through its active metabolite of 4 hydroxy cyclophpsphamid and increase ROS which will  effect on serum MDA elevation. Increased MDA serum can be prevented by giving an antioxidant or plants that have various antioxidants, such as kenitu  leaves. The aim of this study was to determine the effect of antioxidants in  kenitu leaves (Chrysophyllum cainito L.)) extract  to MDA serum leves of  cyclophosphamid-induced mice. This study used quasi experimental method with post test only controlled group  design by using 1 normal control group, 1 negative control group (cyclophosphamid), and 5 treatment groups (dose of extract 50mg/kgBW; 100mg/kgBW; 200mg/kgBW; 400mg/kgBB; and 800mg / kgBW). The results of the treatment group dose 100mg/kgBB showed the  average of MDA serum levels was 1.94 μg/mL which is the highest decrease in this study. The result of Kendall Tau correlation test showed the effect of kenitu leaves extract to MDA serum level had p = 0.013 and correlation coefficient = 0.431.   Keywords: kenitu leaf etanol extract, cyclophosphamid, MDA serum     
Co-Authors Cholis Abrori, Cholis Dwita Aryadina Rachmawati, Dwita Aryadina Erfan Efendi Ida Srisurani Wiji Astuti, Ida Srisurani Wiji Nurlaila Ayu Purwaningsih, Nurlaila Ayu Oessi Salsabila, Oessi Pramudito, Ekvan Danang Setya Renny Suwarniaty, Renny Suryani, Dissa Yulianita Susanto Nugroho