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Journal : Jurnal Ilmiah Manuntung

OPTIMASI CAMPURAN PATI JAGUNG DAN AVICEL PH 101 SEBAGAI BAHAN PENGHANCUR PADA TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH Saryanti, Dwi; Ismawati, Heny; Setiawan, Iwan
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Bitter melon fruit (Momordica charantia L.) can be used as traditionally to reduce blood sugar levels. Avicel PH 101 and corn starch are efficacious as fillers, disintegration excipient and binders. The combination of Avicel PH 101 with corn starch is expected to be able accelerate the tablet disintegration time of tablet. This research was aimed to get the optimum formula tablets of  bitter melon extract tablets using combination of corn starch and avicel PH 101. Bitter melon extract was formulated in tablet with wet granulation method. Bitter melon extract was obtained by maceration with ethanol 70% as solvent. Tablet formula based on the Simplex Lattice Desaign method uses Design Expert software version 11 with parameters that are used weight uniformity, hardness, friability and disintegration time. The results obtained from the simplex lattice design compared with the results of testing using the SPSS 18 program using the One Sample T-Test with a confidence level of 95%. The result  of this research indicate bitter melon extract was made by tablets with wet granulation method with a combination of Avicel PH 101and corn starch, a formula with a ratio of 51% : 49% selected as the optimum formula with weight uniformity, hardness, friability and disintegration time meeting the requirements.   Keywords : bitter melon extract, tablets, corn starch, avicel PH 101, simplex lattice design  
Co-Authors Abdussamad . Achmad Fuad Achmad Hidayatno Adi Septian Putra Atmaja, Adi Septian Putra Adian Fatchur Rochim Aditya Bakti Priahutama Afrilianto, muhammad Agung Nugroho Agus Sukarto Wismogroho, Agus Sukarto Ahmad Asmedi, Ahmad Ahmad Shafi Mukhaitir Ahmad Thoriq, Ahmad ahmad yani Akbar, Padillah Al-Anshory, Umair Alfa Pradipta, Alfa Ambarwati, Levia Hasvi Andreas Handojo Andrey Wicaksono, Andrey Andrian Kristianto Andrie Al Kausar Anita Yuliyanti Anne Charina Ardyono Priyadi Ariani, Nofi Risa Arif Satria Arifudin Idrus Aris Sugianto, Aris Aris Triwiyatno Arrasyid, Riko Arsyahadij, Miftahuddin Aryati, Yosephine Vania Prima Ashari, Ayu Aisyah At., Mulyadi Atiek Iriany Azis Wisnu Widhi Nugraha, Azis Wisnu Azis Wisnu Widhi Nugraha, Azis Wisnu Widhi B Devina Puspasari bagja waluya, bagja Basari, M. Aziz Bobby Rachmat Saefudin, Bobby Rachmat Budi Setiyono Camalin, Maudia Colin R Trainor Darjat Darjat Darmanto Darmanto David Setiawan, David Dede Rohmat Dede Sugandi Dian Agista Dian Masita Dewi Dianto, Ryan Dista Yoel Tadeus Djedi S. Widarto, Djedi S. Dwi Lesmana Eddy Gaffar Zulkarnain, Eddy Gaffar Eduward Tigor Elly Rasmikayati, Elly Endang Bidayani, Endang Ernowo Ernowo Fadlin Idrus Fajar Wisnu Aribowo Faruk, Mujaddid Feti Fahmimroah, Feti Fifi Swandari Franklin Franklin Friska, Yuliana H, Puput Wahyu Habibi, Muhammad Irfan Hariri, Azka Harlina, Raesa Harsono Harsono Haryadi Permana Hastuti - Sekolah Tinggi Ilmu Kesehatan Nasional Surakarta, Diah Dwi Hastuti, Diah Dwi Hendri Donnel Heni Kusdarwati Hepi Hapsari Hill. Gendoet Hartono Imam Santoso Indira, Diah Insani, Fitrah Rahmah Irkham, Irkham Ismawati, Heny Isnan Fauzan Akrom Ivan Aris Panoyo, Ivan Aris Juliana, Venti Jusagemal Aria EL Justinus Andjarwirawan Kausar, Andrie Al Keith Martin Kukuh Priyangga Laras Dwi Kawuri Lili Somantri Lintjewas, Lediyantje Lisye Setiagustina Luwandi Suhartono M Charlotte Benstead Maria Teodora Ping, Maria Teodora Martina Nainggolan Mauridhi Hery Purnomo Mochammad Facta Moetamar Moetamar Muhammad Fairuz Luthfa Muhammad Farchani Rosyid Muhammad Fathul Faris Muhammad Riyadi Muhammad Supono Kurniawan Munawar Agus Riyadi Mutia Dewi Yuniati Noor Yudhi Noviyanto, Alfian Nugroho, Muhammad Arief Nur Syamsiyah Nurul Taufiqu Rochman Paundralingga, Angsoka Yorintha Phil J Benstead Prabowo Tjitropranoto Pradana, Byan Bagas Pradana, Muhammad Ivan Prasetyo, Agus Budi Prestian Rindho S. Raf Drijvers Rahmawati, Dyana Rano Gusman Namara raudatul jannah Rika Arliza, Rika Riva Amrulloh Rizkiyana, Shella Rizky Mulya Sampurno Roron Wicaksono Hadi Saputri, Inderi Mira Saryanti, Dwi Setiyawidi Setiyawidi, Setiyawidi Sigit Purwanto Silalahi, Indra Pribady Sinaga, Bosker SIska Rasiska, SIska Sorikhi Sorikhi, Sorikhi Sri Fatimah Sri Indarto SUDARSONO SUDARSONO Sudjadi Sudjadi SUHARYANTO SUHARYANTO Sukmandaru Prihatmoko Sumardi Sumardi Sumardjo Sumardjo Supriatin, Hj. Ukilah Surya Wisnurahutama Suryani . Syafri Kamsul Arif Taniady, Vicky Tarya J Sugarda Tejo Sukmadi Teuku Winnetou Thinni Nurul Rochmah Thoyyibah, Ita Tri Bagus Susilo Tri Wiyoko Trias Andromeda Tunjung Dwi Madyanto urai salam Wahyudi Wahyudi Wahyuni, Lies widya astuti Wisnu Ari Adi Yoga Handoko Agustin, Yoga Handoko Yuli Christyono Yulia Yulia Yuslinar, Asep Yusuf Dewantoro, Yusuf Zabib Bashori