Bagus Komang Satriyasa
Department of Pharmacology, Medical School, Udayana University Denpasar-Bali

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FRACTIONS OF THE HEXANE EXTRACT OF YOUNG CARICA PAPAYA SEEDS CAN INHIBIT SPERMATOGENESIS IN MALE MICE MORE THAN FRACTION OF THE METHANOL EXTRACT OF YOUNG CARICA PAPAYA SEEDS Satriyasa, Bagus Komang
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 1 Maret 2008
Publisher : Udayana University

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Fraction of hexane extract contains glycosides and triterpenoids, which isassumed to have an anti fertility ingredient, so it can be used as a male contraceptive,although the mechanism of action is not yet clear.This study used the pre-test and post-test control group design, using 30 malemice of balb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped byrandom into 3 groups each consisting of 10 male mice. One control group (P0 = controlgroup) was given double distilled water, and two treatment groups (P1 = treatment group)was given fraction of the hexane extract of young Carica papaya seed 20 mg/20gram/day,P2 = treatment group) was given fraction of the methanol extract of young Carica papayaseed 20 mg/20 gram/day). After 36 days of treatment, evaluation of the testis and blood,of the male mice was conducted.Data were analysed by normality test of Kolmogorov Smirnov Goodness of Fit,homogeneity test, and Anova test. This study showed that cells of spermatogonia A,primary pakhiten spermatocyte, spermatid, and Sertoli cells, decreased significantly (p <0,05) but Leydig cells and testosterone were not decreased significantly (p > 0,05).It is concluded that fraction of hexane extract of carica papaya seeds can decreasethe mean number of cells spermatogonia A, spermatocyte of primary pakhiten, spermatid,Sertoli, and Leydig cells and the level of testosterone hormone better than fraction ofmethanol extract of young Carica papaya seeds.
FRAKSI HEKSAN EKSTRAK BIJI PEPAYA MUDA DAPAT MENGHAMBAT PROSES SPERMATOGENESIS MENCIT JANTAN LEBIH BESAR DARIPADA FRAKSI METANOL EKSTRAK BIJI PAPAYA MUDA Satriyasa, Bagus Komang
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 2 Mei 2008
Publisher : Udayana University

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Fraksi ekstrak heksan mengandung dua golongan zat aktif yang bersifat antifertilitas yaitu golongan steroid dan golongan triterpenoid yang diperkirakan bersifat antifertilitas, walupun mekanisme kerjanya belum jelas. Rancangan penelitian yang digunakan ialah ‘’ Pre-test post-test control group design’’. Penelitian ini memakai 30 ekor mencit jantan strain balb C , umur sekitar 12 minggu dengan berat 20-22 gram, kemudian dikelompokkan secara random menjadi 3 kelompok yang masing-masing terdiri dari 10 ekor. Satu kelompok kontrol (P0 = yang diberikan aquabides), dan dua kelompok perlakuan (P1 = kelompok perlakuan yang diberikan fraksi heksan ekstrak 20 mg/20 gram/hari, P2 = kelompok perlakuan yang diberikan fraksi ekstrak metanol 20 mg/20 gram/hari). Setelah 36 hari perlakuan lalu dilakukan pemeriksaan testis dan darah mencit. Data yang diperoleh dianalisis secara statistik dengan menggunakan uji normalitas Kolmogorov Smirnov Goodnees of Fit test, uji homogenitas, dan uji anova. Didapatkan hasil bahwa fraksi heksan ekstrak maupun metanol dapat menurunkan jumlah sel spermatogonia A, sel spermatosit primer pakhiten, sel spermatid, dan sel Sertoli secara sangat bermakna (p < 0,01), sedangkan jumlah sel Leydig dan kadar hormon testosteron menurun tidak bermakna (p > 0,05). Dari hasil penelitian ini dapat disimpulkan bahwa fraksi heksan ekstrak biji pepaya dapat menurunkan jumlah rata-rata sel spermatogonia A, spermatosit primer pakiten, spermatid, sel Sertoli, sel Leydig dan kadar hormon testosteron lebih besar dari pada fraksi metanol ekstrak biji pepaya muda.
Fraksi Heksan dan Fraksi Metanol Ekstrak Biji Pepaya Muda Menghambat Spermatogonia Mencit (Mus Musculus) Jantan Satriyasa, Bagus Komang; I Pangkahila2, Wimpie
Jurnal Veteriner Vol 11, No 1 (2010)
Publisher : Jurnal Veteriner

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To avoid population booming, family planning program should be maintained in which menand woman have the same rights and obligations. However in execution of family planning the roleof men is still low. Studies about contraception in men are limited. Male contraception that isknown in society are condom and vasectomy. In the recent few years in particular, researcheshave been refocused on investigating traditional plants as anti fertility. In use researches manyplants have been studied, including papaya seed. Some researches on herbal anti fertility propertiesof papaya seed have been carried out including those on the active compounds of anti fertility, onapprolaki-lakite dosage of extract of carica papaya seed by animal experiments. Hexane fraction ofunripe papaya seed extract contains glycosides, alkaloid and triterpenoids, which is assumed hasan antifertility effect, so it can be used as a male contraceptive, although the mechanism of actionis not yet clear. Research is conducted at Animal Laboratory Unit Department of PharmacologyFaculty of Medicine University of Udayana, and Laboratorium Patologi Balai Penyidikan danPengujian Veterian (BPPV) Wilayah VI Denpasar Direktorat Jenderal Peternakan, DepartmentPertanian. This study used the pre-test and post-test control group design, using 30 male mice ofbalb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped by random into 3 groupseach consisting of 10 male mice. One control group (P0 = control group) was given double distilledwater, and two treatment groups (P1 = treatment group) was given fraction of the hexane extractof young Carica papaya seed 20 mg/20gram Body wieght/day, (P2 = treatment group) was givenfraction of the methanol extract of young Carica papaya seed 20 mg/20 gram/day). After 36 days oftreatment, evaluation of the testis, of the male mice was conducted. Data were analysed by normalitytest of Shapiro-will, homogeneity test, and Anova test. This study showed that cells of spermatogoniaA decreased significantly (p < 0,01). It is concluded that hexan fraction and methanol fraction ofunripe carica papaya seeds extract can decrease spermatogonia A cell of male mice (mus musculus).
PENGGUNAAN KLINIK TRAM ADOL Satriyasa, Bagus Komang
Majalah Kedokteran Udayana Vol 32, No 111 (2001): Majalah Kedokteran Udayana
Publisher : Majalah Kedokteran Udayana

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Menghilangkan rasa nyeri yang hehat masih menjadi masalah sampai sekarang. Morfin merupakan obat analgetik golongan opioid yang sangat baik untuk mengatasi nyeri berat yang akut maupun yang kronis. Tapi pemakaian morfin yang lama bisa menyebabkan terjadinya addiksi, ketergantungan fisik dan banyak disalah gunakan tramadol sebagai analgetik golongan opioid yang baru sangat bermanfaat untuk mengatasi nyeri berat yang akut maupun kronis. Bahkan WHO merekombinasikan tramadol aman dan efisien jika dipakai untuk mengatasi nyeri pada kanker. Efek ketergantungannya sangat minimal dan jarang disalah gunakan, juga jarang dilaporkan adanya efek samping yang serius, sehingga penggunaannya di klinik makin meningkat. Dosis yang dianjurkan 50-100 mg setiap 4-6 jam, atau di berikan secara regular terutama pada nyeri yang kronis. Pemberian tramadol dengan dosis terapi dapat ditoleransi dengan baik oleh tubuh, efek samping yang hanya timbul berupa : pusing, mual, mulut kering, muntah, sakit kepala, mengantuk, berkeringat dan konstipasi.Kata kunci : Tramadol, penggunaan klinik; analgelik opioid.ABSTRACTTreating severe pain still poses a problem for most physicians until now. Morphine is an opioid analgesic that is effective for a variety of acute and chronic pains. Long use of morphine induces addiction, physiologic dependence, and abuse. Tramadol is a new opioid analgesic which has been used for acute and chronic pain. This drug c an be recommended as a safe and efficient drug, according to the Word Health Organization guidelines, for cancer pain management. The potential abuse or addiction seem minimal, and serious complications have not been reported, which makes tramadol one of the most interesting agent for clinical use. The recommended dosage is 50-100 mg every 4-6 hours , regular administration isadvisible, particularly for chronic pain. The tolerability profile of tramadol is well defined, adverse effects being dizziness, nausea, sedation, dry mouth, sweating, vomiting, headache and constipation.Keywords : Tramadol, clinical use; opioid analgesic.
NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT Wirantari, Ni Putu; Jawi, I Made; Satriyasa, Bagus Komang
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : E-Jurnal Medika Udayana

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Hypertension is a silent killer because it causes complications in vital organs unwitting patients. Beta blockers are generally a choice of safe and effective drugs for initial treatment of hypertension. However, the current hypertension treatment guidelines said beta blockers were not suitable use as first-line therapy because of complications caused. On the use of atenolol found an increased incidence of cardiovascular death of 24%, 14% and cardiac complications 23% cerebrovascular complications. Nebivolol is a third-generation beta-blocker that is highly selective for ?1-adrenergic receptors and has the ability as a direct vasodilator was able to stimulate the activity of endothelial L-arginin/nitric oxide synthase, is expected nebivolol can reduce blood pressure so can achieve blood pressure that expected.
MULTI-INFARCT DEMENTIA Diandra Sari, Ayu; Ratep, Nyoman; Satriyasa, Bagus Komang
E-Jurnal Udayana Medica vol 1no1 2013
Publisher : E-Jurnal Udayana Medica

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Dementia is a cognitive functional deficits that causes memory impairment with symptoms such as: aphasia, agnosia, apraxia or a disturbance in executive functioning (the ability to plan, sequence, and organize) that interferes with social, occupational, or interpersonal skills. Most of dementia among older people in Asia, especially Indonesia is Vascular dementia. Most of vascular dementia among older people in Indonesia is multi-infarct dementia (MID). Multi-infarct dementia (MID) is a disorder involving deterioration in mental function caused by changes or damage to the brain tissues from lack of oxygen as a result of multiple blood clots throughout the brain. Risk factor for MID include a history of: Hardening of arteries (arthrosclerosis), high blood pressure (hypertension), smoking, and stroke. In MID, disruption of blood flow leads to damaged brain tissue. For diagnose the patient with MID, the most important thing we must do is anamnesis. From anamnesis, we can get history of sufficient exposure, Onset of symptoms, checking sign and doing tests, and also ask whether the patient has risks factors about MID or not. There is no known definitive treatment for MID. Treatment is based on control of symptoms. Other treatments may be advised based on the individual condition.
THE CORRELATION OF TRANSAMINASES AND LIVER DISEASES Alfian Juatmadja, Bastianus; Sutirta Yasa, I Wayan Putu; Rasmika dewi, DAP; Satriyasa, Bagus Komang
E-Jurnal Udayana Medica vol 1no1 2013
Publisher : E-Jurnal Udayana Medica

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The symptoms of liver diseases are very diverging, from the mild one till the severe one. Sometimes we may find that severe heart disorders but the symptoms are too less. We need some tools to make a good diagnosis. We can not only use a good anamnesis, but also have to use good physical examination and the other support test. Transaminase also called aminotransferase. This aminotransferase catalyzes the transfer of the amino group (?NH2) of an amino acid to a carbonyl compound. The liver contains specific transaminases for the transfer of an amino group from glutamic acid to ?-keto acids that correspond to most of the other amino acids. Other transaminases catalyze reactions in which an amino group is transferred from glutamic acid to other compounds. Transamination is one of the principal mechanisms for the formation of necessary amino acids in the metabolism of proteins. Transaminase as a sign to cell damage may divided into Serum Glutamic Oxalocetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), and Lactic Dehydrogenase (LDH). Gamma GT and alkali fosfatase correlate with cholestasis. Cholinestrase correlate with liver synthesis capacity.
IMMUNOPATHOGENESIS OF DENGUE SHOCK SYNDROME Sawenda, Karta; Sutirta Yasa, I Wayan Putu; Rasmika Dewi, DAP; Satriyasa, Bagus Komang
E-Jurnal Udayana Medica vol 1no1 2013
Publisher : E-Jurnal Udayana Medica

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Dengue is the most important emerging tropical viral disease of humans in the world today. It is estimated that there are between 50 and 100 million cases of dengue fever (DF) and about 500.000 cases of dengue haemorrhagic fever (DHF) each year which require hospitalization. Persons of all ages can be infected and develop dengue fever. However, children younger than 15 years typically present with only a nonspecific self-limited febrile illness. Untreated dengue hemorrhagic fever mostly likely progresses to dengue shock syndrome which is defined as dengue fever with signs of circulatory failure. The prognosis depends on prevention or early recognition and treatment with case fatality rate is as high as 12% to 14% once shock has set in. Management of dengue fever requires rest, oral fluids to compensate for losses via diarrhoea or vomiting, antipyretics and analgesics. Patients who present with shock may require central venous pressure monitoring. An arterial line may be required in unstable patients for the assessment of blood gases, electrolytes, and coagulation profile to help identify patients needing ventilatory support.
The influence of granting ngor eggplant (solanium indicum) extract inhibiting of spermatogenesis in mice (mus musculus) Suarjana, Nyoman; Karmaya, I Nyoman Mangku; Satriyasa, Bagus Komang; Pangkahila, J. Alex; Astuti, Ni Putu Widya
International journal of health sciences Vol 1 No 2: August 2017
Publisher : Universidad Tecnica de Manabi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.807 KB) | DOI: 10.21744/ijhs.v1i2.35

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The study about contraceptive for adult especially for men that the numbers were limited, so needed the ingredients contraceptive is derived from a plant. One of the plants that potentially becomes contraceptive is ngor eggplant because contains antifertility substances. The research has been done about granting of ngor eggplant extract inhibiting spermatogenesis in mice. The design of research used random post-test control group design by one group control, three groups by treatment and six times doing treatment again. (T0 = control group, T1 = granting extract 15%, T2 = granting extract 20%, T3 = granting extract 25%). This treatment has been done in 36 days. The result of this research showed the granting ngor eggplant extract to T1 could reduce the number of cells spermatocyte primary pakhiten and cells spermatids 7 & 19 by meaningful (P<0,05). In T2 and T3 could reduce the number spermatogonia A cells, spermatocyte primary pakhiten cells and spermatids 7 & 19 cells (P<0,05).
KARAKTERISTIK PENDERITA HIPERTENSI YANG DIRAWAT INAP DI RUMAH SAKIT UMUM PUSAT SANGLAH TAHUN 2013 Mahendra Sugiarta, I Gede Restu; Satriyasa, Bagus Komang
E-Jurnal Medika Udayana vol 4 no 11(2015):e-jurnal medika udayana
Publisher : E-Jurnal Medika Udayana

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Hipertensi merupakan penyakit yang sering disebut sebagai the silent killer karena pada awalnya tidak menunjukkan gejala. Berdasarkan Survei Pendahuluan di Rumah Sakit Umum Pusat (RSUP) Sanglah tahun 2014, tercatat 44 pasien menderita hipertensi di ruang Instalasi Rawat Inap (IRNA) B, C, dan D RSUP Sanglah pada tahun 2013. Penelitian ini bertujuan untuk mengetahui karakteristik penderita hipertensi yang meliputi proporsi penderita hipertensi (berdasarkan umur, jenis kelamin, keluhan utama, derajat hipertensi, komplikasi, dan keadaan keluar) dan lama rawatan rerata penderita hipertensi. Penelitian ini merupakan penelitian deskriptif dengan metode studi survei observasional. Penelitian ini dilaksanakan di Instalasi Rekam Medis RSUP Sanglah pada bulan April 2014 hingga bulan Juli 2014 dengan data yang digunakan adalah data sekunder yang diperoleh dari catatan rekam medis pasien di RSUP Sanglah. Sampel penelitian berjumlah 44 orang dari bagian IRNA B, C, dan D di RSUP Sanglah dengan menggunakan time-series data serta dari total sampling pada survei pendahuluan di RSUP Sanglah tahun 2014. Distribusi proporsi penderita hipertensi tertinggi terdapat pada umur 45 s/d 64 tahun (63,6%), berdasarkan jenis kelamin terdapat pada lelaki (56,8%), berdasarkan keluhan utama terdapat pada sakit kepala (34,1%), berdasarkan derajat hipertensi terdapat pada Hipertensi Stadium 3 (63,6%), berdasarkan status komplikasi terdapat pada Tanpa Komplikasi (52,3%), serta berdasarkan keadaan keluar terdapat pada Membaik (100%). Lama rawatan rerata penderita hipertensi adalah 7,52 hari.