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Sensitivity and Specificity of Troponin T and I for Diagnosis of Acute Myocardial Infarction Samsu, Nur; Sargowo, Djanggan
Journal of the Indonesian Medical Association Vol. 57 No. 10 October 2007
Publisher : Journal of the Indonesian Medical Association

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Abstract

Acute coronary syndrome (ACS) encompasses unstable angina and acute myocardial infarction (AMI). Differentiating ACS from non-cardiac chest pain is a diagnostic challenge. The diagnosis of AMI requires at least two of the following: ischemic symptoms, electrocardiogram (ECG) changes, and serum cardiac marker elevation. However, only 22% of ACS patient present with typical chest pain further more predictive value of the ECG varies markedly. Approximately, AMI is diagnosed in 10% of patients with normal ECG findings and only 41% with “frankly abnormal” ECG findings. Aspartate transaminase, lactate dehydrogenase (LDH), LDH subforms and Creatine kinase (CK) have low sensitivity and specificity for cardiac injury. CK-MB is much more cardiac specific than CK alone, but CK-MB cannot detect minor cardiac injury; its peak level does not predict infarct size and not useful as late markers of recent AMI. Cardiac troponin (cTnT and cTnI) are the preferred markers because of its sensitivity and specificity. They can detect microinfarction, will remain elevated up to two weeks after symptom onset (useful as late markers of recent AMI) and helpful in risk stratification of ACS. Raised troponin levels are associated with increased risks of death and development of AMI and showed greater treatment benefit with LMWH, IIb/IIIa antagonists and revascularization. Increased risk is related quantitatively to the serum troponin level. Generally, troponin T or I is the most sensitive determinant of ACS.Keywords: Acute Coronary Syndrome, Cardiac Marker, Troponin
Profil Kejadian Bakteriuria Asimtomatik serta Faktor-Faktor yang Terkait dengan Kejadian Bakteriuria Asimtomatik pada Ibu Hamil di Puskesmas Janti Kota Malang Zahroh, Fatimatuz; Roebijoso, Jack; Samsu, Nur
Majalah Kesehatan FKUB Vol 1, No 4 (2014)
Publisher : Faculty of Medicine Universitas Brawijaya

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Abstract

Infeksi saluran kemih (ISK) adalah infeksi yang paling umum dijumpai selama kehamilan. Bakteriuria asimtomatik didefinisikan sebagai bakteriuria yang terdiri dari ≥ 105 colony forming unit per milliliter (cfu/mL) dengan satu jenis bakteri pada urin pancaran tengah serta tidak terdapat tanda dan gejala infeksi simptomatik. Sebanyak 25 % dari bakteriuria asimtomatik yang tidak diobati dapat menyebabkan infeksi simptomatik akut selama kehamilan. Tujuan penelitian  ini untuk mengetahui profil ibu hamil yang menderita bakteriuria asimtomatik serta faktor-faktor sosial ekonomi yang terkait dengannya. Desain penelitian menggunakan cross sectional. Penelitian ini dilakukan di Puskesmas Janti, Malang. Subjek adalah 43 orang ibu hamil dengan 13 orang  menderita bakteriuria asimtomatik. Hasil penelitian ini menunjukkan bahwa prevalensi bakteriuria asimtomatik pada ibu hamil adalah 30,2 %. Proporsi bakteriuria asimtomatik relatif tinggi pada ibu hamil berusia 20-29 tahun (69,2 %), nullipara (76,9 %), trimester II (61,5 %),  ibu hamil dengan pendapatan rendah sebesar (61,5 %), serta aktivitas seksual tinggi sebesar (61,5 %). Hasil analisis bivariat menunjukkan adanya  hubungan yang bermakna antara nullipara (rasio prevalensi = 3,833, Cl 95 % = 1,223-12,017; p = 0,008) dan aktivitas seksual tinggi (rasio prevalensi = 3,314, Cl 95 % 1,324-8,295; p = 0,008) dengan terjadinya bakteriuria asimtomatik pada ibu hamil. Berdasarkan hasil penelitian, petugas kesehatan disarankan untuk melakukan penyaringan mengenai paritas dan aktivitas seksual ibu hamil saat kunjungan pertama pemeriksaan antenatal care (ANC). Kata kunci : Aktivitas seksual, Bakteriuria asimtomatik, Ibu hamil, Nullipara.
Role of Antibody Anti-AGE in the Expression of Nephrin and RAGE on Primary Glomerulus Cell Exposed with AGE Salam, Rudy; Lyrawati, Diana; Samsu, Nur
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

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Abstract

Upregulation of nephrin expression occurs at the early stage of nephropathy and decrease in the period 6 months on hyperglycaemic condition. Nephrin is associated with the initial stage of the loss of the permeability barrier in diabetic nephropathy. Interaction AGE-RAGE increases angiotensin II on Renin Angiotensin-Aldosterone System (RAAS) and activation of protein kinase c (PKC) which induce alterations in nephrin mRNA expression. Alterations of nephrin expression induces transformation of slit membrane structure and the permeability changes at the glomerular filtration barrier. Anti-AGE vaccination once may cause the changes of nephrin and RAGE expression and can prevent progression of diabetic nephropathy. This study used primary glomerulus cell culture obtained from renal of Wistar mice aged 3 months, weighting 200-300 grams that consist of negative control group that exposed to BSA 100 µg/ml, positive control group that exposed to AGE-BSA 100 µg/ml, treatment group 1 that exposed to polyclonal anti-AGE 5 µg/ml and AGE-BSA 100 µg/ml and treatment group 2 that exposed to monoclonal antibody anti-CML 5 µg/ml and AGE-BSA 100 µg/ml. Paired t-test with a 0.05 level of confidence results showed that there were significant differences in level of RAGE expression among experimental groups with control groups. Administration of polyclonal antibody decreased RAGE expression among negative control (p=0.188). but not in positive control (p=0.000). In contrast to monoclonal anti-AGE antibody, RAGE expression did not differ significantly compared to negative control but significant than positive control. Administration of monoclonal anti-AGE antibody inhibited increasing of nephrin expression compared to negative and positive control (p=0.73; 0.125). In conclusion, this study suggested that administration of polyclonal and monoclonal anti-AGE antibody could inhibit increasing of RAGE and nephrin expression in glomerulus primary culture that exposed to AGE which is expected to prevent the progression of diabetic nephropaty.
Advanced Glycation End Products (AGEs) Antibody Protects Against AGEs-induced Apoptosis and NF-ĸB p65 Subunit Overexpression in Rat Glomerular Culture Adianingsih, Oktavia Rahayu; Lyrawati, Diana; Samsu, Nur
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

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Abstract

Advanced glycation end products (AGEs) have been thought to be a major cause of diabetic nephropathy (DN). The mechanisms underlying the involvement of AGEs antibody in diabetic nephropathy are not fully understood. The present study was designed to investigate the protective effect of AGEs antibody on AGEs-induced glomerular damage. Isolated glomeruli were pre-incubated either with 10 µg/mL polyclonal anti-AGEs antibody (AGE-pAb) or monoclonal anti-Nɜ -carboxymethyl-lysine antibody (CML-mAb) as a model of AGEs antibody to block interaction of AGEs with receptor for AGEs (RAGE) and incubated afterwards either with 100 µg/mL bovine serum albumin (BSA) or AGE-modified bovine serum albumin (AGE-BSA) for 48 h. Annexin V/nephrin doublestaining was performed to determine apoptosis. Using immunofluorescence, we found that administration of AGE-BSA not only significantly increased glomerular cells apoptosis and nuclear factor kappa B (NF-ĸB) p65 expression, but also reduced expression of nephrin, an important structural and signal molecule of podocytes slit diaphragm. Blocking the interaction of AGE-RAGE with AGEs antibody significantly protected glomerular cells from AGEs-induced apoptosis and NF-ĸB p65 overexpression. We found that AGE-pAb conferred superior protective effect compared with CmL-mAb for the same reduction in apoptosis and NF-ĸB p65 expression. In sharp contrast, CmL-mAb led to preserve expression of podocytes nephrin better than AGE-pAb. These results demonstrate that the antibody against AGEs may be beneficial for preventing the glomerular damage in DN.
ANALISIS COMMON-SIZE UNTUK MENILAI KINERJA KEUANGAN PERUSAHAAN PADA PT INDOSAT TBK. DAN PT TELKOMUNIKASI TBK. (Tahun 2014-2016) Zuhri, Mohammad harisudin; Satriyono, Gandung; Samsu, Nur
JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Vol 1, No 2 (2018): Desember 2018
Publisher : Fakultas Ekonomi Universitas KAdiri

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Abstract

Penelitian ini bertujuan untuk mengetahui kinerja keuangan dengan menggunakan common size pada perusahaan PT Indosat, Tbk. dan PT Telekomunikasi, Tbk. yang terdaftar di Bursa Efek Indonesia selama tahun 2014-2016 ditinjau dari neraca dan laporan laba rugi. Penelitian ini merupakan penelitian deskriptif kuantitatif. Data dikumpulkan dengan metode dokumentasi dan analisis data yang digunakan yaitu analisis persentase per komponen atau common size. Hasil penelitian menunjukkan bahwa common size ditinjau dari neraca, PT Indosat, Tbk. yang mengalokasikan dana untuk aktiva sebagian besar dari utang PT Telekomunikasi, Tbk. mengalokasikan dana untuk aktiva dari modal sendiri sehingga meningkatkan margin of safety bagi kreditur dan menguatkan posisi keuangan perusahaan. Common size ditinjau dari laporan laba rugi, PT Indosat, Tbk. dan PT Telekomunikasi, Tbk.mengalami peningkatan pada laba bersihnya pada tahun 2016 sehingga kinerja keuangan perusahaan semakin baik dan tahun 2014-2015 kinerja keuangan kurang baik karena mengalami penurunan pada laba bersihnya. Kata kunci: common size, kinerja keuangan, laporan laba rugi, neraca.
Pengaruh Word Of Mouth (WOM) Dan Brand Image Terhadap Keputusan Penggunaan Jasa Foto Pada Studio Foto 4 Warna Photography Kota Kediri Kusuma, Yeziga Enggar; Satriyono, Gandung; Samsu, Nur
JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Vol 2, No 1 (2019)
Publisher : Fakultas Ekonomi Universitas KAdiri

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Abstract

The research aims to analyze and determine the effect of Word of Mouth and Brand Image on the decision to use photo services on 4 colors of Kediri City Photography. This research uses quantitative methods. The type of research used is the correlation with sampling techniques. The research sample was 60 respondents in number. The multiple linear regression analysis techniques is tested for validity and reliability first. The conclusion of this study is (1) Word of Mouth has a significant effect on the decision to use photo services on 4 colors of photography. (2) Brand image has a significant effect on the Decision of Using Photo Services on 4 Colors of Photography. (3) Simultaneously or together with two independent variables consisting of word of mouth, brand image has a significant effect on service use decisions. Penelitian bertujuan menganalisis dan mengetahui pengaruh Word Of Mouth dan Brand Image terhadap Keputusan Penggunaan Jasa foto pada 4 Warna Photography Kota Kediri. Penelitian ini menggunakan metode kuantitatif. Jenis penelitian yang digunakan penelitian adalah korelasi dengan teknik pengambilan sampel. Sampel penelitian 60 responden jumlahnya. Teknik analisis regresi linier berganda dengan terlebih dahulu di uji validitas dan reliabilitas.Kesimpulan penelitian ini adalah (1) Word Of Mouth berpengaruh signifikan terhadap Keputusan Penggunaan Jasa Foto pada 4 Warna Photography. (2) Brand image berpengaruh signifikan terhadap Keputusan Penggunaan Jasa Foto pada 4 Warna Photography. (3) Secara simultan atau bersama – sama dua variabel bebas yang terdiri dari word of mouth, brand image berpengaruh signifikan terhadap keputusan penggunaan jasa.