Reno Rudiman
Consultant Digestive Division of Surgery Department, Faculty of Medicine, University of Padjadjaran Dr. Hasan Sadikin Hospital - Bandung Indonesia.

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Korelasi Ekspresi Protein Deleted in Colorectal Cancer (DCC) dengan Keganasan Kolorektal Stadium II dan III Suraya A., Ida Bagus Budhi; Rudiman, Reno
Majalah Kedokteran Bandung Vol 1, No 42 (2010)
Publisher : Majalah Kedokteran Bandung

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Abstract

Gen deleted in colorectal cancer (DCC) merupakan salah satu gen supresor tumor yang memegang peranan untuk terjadinya keganasan kolorektal. Mutasi gen DCC didapatkan pada 70% kasus dan tidak adanya ekspresi protein DCC ini memberikan prognosis buruk pada kasus keganasan kolorektal. Tujuan penelitian ini adalah untukmengetahui apakah ekspresi protein DCC berhubungan dengan kemungkinan metastasis keganasan kolorektal. Penelitian ini merupakan penelitian cross–sectional, data diambil secara retrospektif. Data didapatkan dari sediaan blok parafin di Bagian Patologi Anatomi RS Hasan Sadikin Bandung periode bulan Mei sampai Agustus 2007. Dari 38 sampel, terdiri dari 19 sampel untuk stadium II dan 19 sampel stadium III, kemudian dilakukan pemeriksaan imunohistokimia. Hasil penelitian menunjukkan, usia termuda 18 tahun dan tertua 83 tahun. Berdasarkan jenis kelamin terdapat 18 sampel (47,4%) pria dan 20 sampel (52,6%) wanita. Sampel dengan stadium II memberikanekspresi protein DCC, sedangkan pada stadium III, didapatkan 5 sampel (13,16%) yang tidak memberikan ekspresi DCC. Dari uji statistik didapatkan nilai chi kuadrat sebesar 5,758 dengan p=0,016 (p<0,05). Dapat disimpulkan bahwa terdapat hubungan yang bermakna antara stadium keganasan kolorektal dan ekspresi protein DCC.Correlation Between Deleted in Colorectal Cancer (DCC) Protein Expression and Stage II – III of Colorectal CancerDeleted in colorectal cancer (DCC) gene is one of the tumor supressor genes which play a role in colorectal pathogenesis. Mutation of this DCC gene was found in approximately 70% cases and the absence of DCC protein expression give the poor prognosis. The aim of the study was to evaluate whether the expression of DCC protein hada correlation with metastasis probability of the stage II and III colorectal cancer. This was a cross-sectional study and data were obtained retrospectively. The data consisted of 38 colorectal carcinoma samples in second and third stadium, 19 samples in each stadium, during the period of May to August 2007. We perfomed imunohistochemistryexamination. On this study, the youngest was 18 years old and the oldest was 83 years old. According to gender, 18 samples (47.4%) were male and 20 samples (52.6%) were female. All samples in stage II stadium gave expression of the DCC protein and there were 5 samples (13.16%) with stadium III didn´t give expression. From statisticalanalysis, chi square 5.758 and the p-value was 0.016 (p < 0.05). We can conclude that there is a correlation between the colorectal carcinoma stadium and the expression of DCC protein. 
Efek Oksigen Konsentrasi Tinggi Pascaoperasi Laparotomi pada Peritonitis terhadap Tingkat Infeksi Luka Operasi Djaya, Wildan; Rudiman, Reno; Lukman, Kiki
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Metode sederhana untuk menambah tekanan oksigen secara adekuat pada perfusi jaringan yaitu dengan menambah konsentrasi oksigen yang diinspirasi pada penderita pascalaparotomi. Untuk melihat efektivitas oksigen konsentrasi tinggi tersebut dilakukan uji klinis di Rumah Sakit Dr. Hasan Sadikin Bandung. Dilakukan uji klinis secara random pada 102 penderita yang menjalani laparotomi karena peritonitis lokal atau difus serta membagi penderita dalam dua grup masing-masing 51 penderita untuk mendapatkan oksigen 30% dan 80% selama 2 jam pascaoperasi. Oksigen 30% didapat dari nasal kanul dengan oksigen 3 liter, sedangkan oksigen 80% diperoleh dari nonrebreathing mask dengan oksigen 10 liter. Penanganan anestesi dilakukan standar dan semua penderita mendapat antibiotik profilaksis. Dengan menggunakan protokol single blind, luka dievaluasi saat penderita pulang atau hari ke-7 jika masih dirawat dan 2 minggu pascaoperasi. Uji klinis dilakukan di subbagian Bedah Digestif RSHS selama periode Oktober 2009–Mei 2010. Dari 51 penderita yang diberi oksigen 80%, terdapat 2 (4%) penderita mengalami infeksi luka operasi dibandingkan dengan 9 dari 51 penderita (18%) yang diberi 30% oksigen. Durasi perawatan di rumah sakit sama pada kedua grup penderita. Simpulan, pemberian terapi oksigen konsentrasi tinggi pascaoperasi dapat menurunkan insidensi infeksi luka operasi. [MKB. 2012;44(3):165–9].Kata kunci: Infeksi luka operasi, laparotomi, oksigen, peritonitisEffect of Laparotomy Post-Operative High Concentration Oxygen in Peritonitis to Surgical Wound Infection Level A simple method to improve oxygen pressure to tissue perfusion adequately is by increasing the concentration of inspired oxygen.We therefore tested the hypothesis that the supplemental administration of oxygen during the post-operative period decreases the incidence of wound infection.We randomly assigned 102 patients at Dr. Hasan Sadikin Hospital who underwent exploratory laparotomy due to local and diffuse peritonitis to receive 30 percent or 80 percent inspired oxygen for two hours post-operation. The 30% oxygen was obtained from the nasal canule and 3 litres of oxygen whereas 80% oxygen was obtained from non-rebreathing mask and 10 litres of oxygen. Using the single-blind protocol, wounds were evaluated before the patients were discharged or 7 days post-operative and then two weeks after surgery. The clinical trial was performed at Dr. Hasan Sadikin Hospital Bandung between October 2009–May 2010. From the 51 patients who received 80% oxygen, 2 (4%) had surgical-wound infections, whereas from the 51 patients given 30 percent oxygen, 9 (18%) had surgical-wound infections. The length of hospital stay for both groups were the same. In conclusion that post-operative administration of high concentration ofoxygen can reduce the incidence of surgical-wound infections. [MKB. 2012;44(3):165–9]. Key words: Laparotomy, oxygen, periotonitis, surgical wound infection DOI: http://dx.doi.org/10.15395/mkb.v44n3.83
Ekspresi Protein Deleted in Colorectal Cancer (DCC) dan p53 pada Keganasan Kolorektal Suraya Adnyana, Ida Bagus Budhi; Rudiman, Reno
Majalah Kedokteran Bandung Vol 49, No 3 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v49n3.1125

Abstract

Angka kejadian keganasan kolorektal pada usia muda semakin meningkat, tetapi belum ada data yang cukup menjelaskan mengenai hal tersebut, termasuk mutasi gen yang berperan. Tujuan penelitian mengetahui apakah ekspresi protein DCC dan p53 berperan pada keganasan kolorektal usia kurang dari 40 tahun. Dilakukan pemeriksaan imunohistokimia di Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran/ Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung periode Januari sampai Mei 2011 untuk melihat ekspresi protein DCC dan p53 pada sediaan blok parafin penderita keganasan kolorektal kelompok usia <40 tahun dan usia >40 tahun.  Bahan pemeriksaan dikumpulkan mulai bulan Januari sampai Mei 2011. Hasil penelitian menunjukkan bahwa pada keganasan kolorektal usia <40 tahun lebih banyak yang tidak didapatkan ekspresi kedua protein tersebut, 9 kasus pada kelompok usia >40 tahun, sedangkan pada usia lebih dari 40 tahun hanya ditemukan pada 2 kasus.  Simpulan, pada sebagian besar kasus keganasan kolorektal usia <40 tahun, protein DCC dan p53 sudah tidak terekspresi. [MKB. 2017;49(3):186–91]Kata kunci: Ekspresi DCC, ekspresi p53, keganasan kolorektal, usia  Deleted in Colorectal Cancer (DCC) and p53 Protein Expressions in Colorectal Cancer The incidence of colorectal cancer in young patients is currently increasing; however, no adequate data available to explain the increase, including the gene mutation involved in these cancer. This study aimed to discover the DCC and p53 protein expressions that play a role in colorectal cancer in people under 40 years old. Immunohistochemical examination was performed at the Department of Anatomy Pathology Faculty of Medicine of Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung in the period of January to May 2011 to look into DCC and p53 expressions in paraffin blocks of colorectal malignancy patients in the age group of <40 and >40 years old. The examination specimens were collected in the period of January to May 2011. The results of the study showed that in colorectal malignancy in <40 years old patients, the expression of the two proteins was rarely found while in the age group of 40 years old, the expressions were only found in 2 cases. It is concluded in most cases of colorectal cancer in the <40 years old group, the DCC and p53 are already not expressed. [MKB. 2017;49(3):186–91]Key words: Age, colorectal cancer, DCC expression, p53 expression
Lactate Clearance: Predictor for Mortality and Therapeutic Response on Severe Sepsis Patient Siregar, Edwin Saleh; Purnama, Andriana; Rudiman, Reno
BALI MEDICAL JOURNAL Vol 5, No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Severe sepsis and septic shock are at high mortality rate. This high mortality persists as important aspect in the term of patient treatment which take account in determining aggressiveness of relevant therapy. Lactate level consideration was considered important among patient under shock, septicemia, post-operative, acute lung injury, and critical condition. Lactate concentration in static blood was widely studied and suggested as prognostic value among severe sepsis and septic shock patient due to the nature of lactate as the result of anaerobic metabolism. Several study documented the use of lactate as prognostic indicator for shock condition. The increase of lactate concentration could be useful as the indicator of inadequate oxygen delivery and the existence of anaerobic metabolism. Lactate clearance investigation is more superior therapeutic target compared with others oxygen derivate variables. Methods: This research is a cohort observational study involving secondary data which was collected from laboratory examination results of study subjects. The research held from August 2015 to December 2015 in Digestive Division, Surgery Department, Hasan Sadikin Hospital. 42 patient involved in this study. Results: Comparative test results revealed significant lactate clearance based on mortality in LCH (6) (p = 0.000) and H (24) (p =0.000) as well. The level of LC H (6) and H (24) seemed lower in died patient compared with life patient. Conclusion: This study concluded that lactate clearance in died patient was lower in comparison with life patient.
Ekspresi Protein Deleted in Colorectal Cancer (DCC) dan p53 pada Keganasan Kolorektal Suraya Adnyana, Ida Bagus Budhi; Rudiman, Reno
Majalah Kedokteran Bandung Vol 49, No 3 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v49n3.1125

Abstract

Angka kejadian keganasan kolorektal pada usia muda semakin meningkat, tetapi belum ada data yang cukup menjelaskan mengenai hal tersebut, termasuk mutasi gen yang berperan. Tujuan penelitian mengetahui apakah ekspresi protein DCC dan p53 berperan pada keganasan kolorektal usia kurang dari 40 tahun. Dilakukan pemeriksaan imunohistokimia di Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran/ Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung periode Januari sampai Mei 2011 untuk melihat ekspresi protein DCC dan p53 pada sediaan blok parafin penderita keganasan kolorektal kelompok usia <40 tahun dan usia >40 tahun.  Bahan pemeriksaan dikumpulkan mulai bulan Januari sampai Mei 2011. Hasil penelitian menunjukkan bahwa pada keganasan kolorektal usia <40 tahun lebih banyak yang tidak didapatkan ekspresi kedua protein tersebut, 9 kasus pada kelompok usia >40 tahun, sedangkan pada usia lebih dari 40 tahun hanya ditemukan pada 2 kasus.  Simpulan, pada sebagian besar kasus keganasan kolorektal usia <40 tahun, protein DCC dan p53 sudah tidak terekspresi. [MKB. 2017;49(3):186–91]Kata kunci: Ekspresi DCC, ekspresi p53, keganasan kolorektal, usia  Deleted in Colorectal Cancer (DCC) and p53 Protein Expressions in Colorectal Cancer The incidence of colorectal cancer in young patients is currently increasing; however, no adequate data available to explain the increase, including the gene mutation involved in these cancer. This study aimed to discover the DCC and p53 protein expressions that play a role in colorectal cancer in people under 40 years old. Immunohistochemical examination was performed at the Department of Anatomy Pathology Faculty of Medicine of Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung in the period of January to May 2011 to look into DCC and p53 expressions in paraffin blocks of colorectal malignancy patients in the age group of <40 and >40 years old. The examination specimens were collected in the period of January to May 2011. The results of the study showed that in colorectal malignancy in <40 years old patients, the expression of the two proteins was rarely found while in the age group of 40 years old, the expressions were only found in 2 cases. It is concluded in most cases of colorectal cancer in the <40 years old group, the DCC and p53 are already not expressed. [MKB. 2017;49(3):186–91]Key words: Age, colorectal cancer, DCC expression, p53 expression
Efek Oksigen Konsentrasi Tinggi Pascaoperasi Laparotomi pada Peritonitis terhadap Tingkat Infeksi Luka Operasi Djaya, Wildan; Rudiman, Reno; Lukman, Kiki
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Metode sederhana untuk menambah tekanan oksigen secara adekuat pada perfusi jaringan yaitu dengan menambah konsentrasi oksigen yang diinspirasi pada penderita pascalaparotomi. Untuk melihat efektivitas oksigen konsentrasi tinggi tersebut dilakukan uji klinis di Rumah Sakit Dr. Hasan Sadikin Bandung. Dilakukan uji klinis secara random pada 102 penderita yang menjalani laparotomi karena peritonitis lokal atau difus serta membagi penderita dalam dua grup masing-masing 51 penderita untuk mendapatkan oksigen 30% dan 80% selama 2 jam pascaoperasi. Oksigen 30% didapat dari nasal kanul dengan oksigen 3 liter, sedangkan oksigen 80% diperoleh dari nonrebreathing mask dengan oksigen 10 liter. Penanganan anestesi dilakukan standar dan semua penderita mendapat antibiotik profilaksis. Dengan menggunakan protokol single blind, luka dievaluasi saat penderita pulang atau hari ke-7 jika masih dirawat dan 2 minggu pascaoperasi. Uji klinis dilakukan di subbagian Bedah Digestif RSHS selama periode Oktober 2009–Mei 2010. Dari 51 penderita yang diberi oksigen 80%, terdapat 2 (4%) penderita mengalami infeksi luka operasi dibandingkan dengan 9 dari 51 penderita (18%) yang diberi 30% oksigen. Durasi perawatan di rumah sakit sama pada kedua grup penderita. Simpulan, pemberian terapi oksigen konsentrasi tinggi pascaoperasi dapat menurunkan insidensi infeksi luka operasi. [MKB. 2012;44(3):165–9].Kata kunci: Infeksi luka operasi, laparotomi, oksigen, peritonitisEffect of Laparotomy Post-Operative High Concentration Oxygen in Peritonitis to Surgical Wound Infection Level A simple method to improve oxygen pressure to tissue perfusion adequately is by increasing the concentration of inspired oxygen.We therefore tested the hypothesis that the supplemental administration of oxygen during the post-operative period decreases the incidence of wound infection.We randomly assigned 102 patients at Dr. Hasan Sadikin Hospital who underwent exploratory laparotomy due to local and diffuse peritonitis to receive 30 percent or 80 percent inspired oxygen for two hours post-operation. The 30% oxygen was obtained from the nasal canule and 3 litres of oxygen whereas 80% oxygen was obtained from non-rebreathing mask and 10 litres of oxygen. Using the single-blind protocol, wounds were evaluated before the patients were discharged or 7 days post-operative and then two weeks after surgery. The clinical trial was performed at Dr. Hasan Sadikin Hospital Bandung between October 2009–May 2010. From the 51 patients who received 80% oxygen, 2 (4%) had surgical-wound infections, whereas from the 51 patients given 30 percent oxygen, 9 (18%) had surgical-wound infections. The length of hospital stay for both groups were the same. In conclusion that post-operative administration of high concentration ofoxygen can reduce the incidence of surgical-wound infections. [MKB. 2012;44(3):165–9]. Key words: Laparotomy, oxygen, periotonitis, surgical wound infection DOI: http://dx.doi.org/10.15395/mkb.v44n3.83
The Analgesic Effect of Ethanol Extract Soursop (Annona muricata L.) Leaves in Wistar Rats Kuswinarti, Kuswinarti; Savira, Kendry; Rudiman, Reno
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v5n4.486

Abstract

Background: Pain is an emotional and sensory experience that is unpleasant and related to tissues damage. In the past, Soursop (Annona muricata L.) leaves have been believed to be able to relieve pain. This study aimed to explore the analgesic effect of soursop leaves and its effective dose in an animal model. Methods: Wistar rats (n=25) had been used in this experimental study, divided into 5 groups; consisting of a negative control group, experiment groups using extract soursop leaves with doses of 200mg/kgbw, 400 mg/kgbw and 600 mg/kgbw, and natrium diclofenac as a positive control. One hour after treatment, all groups of rats were induced by carrageenan-lambda in the feet. The basal retraction of rats’ legs was measured in 47oC water and repeated at two, four, and six hours. The data were analyzed using analysis of variance and Tukey’s test. Result: The dose of 200 mg/kgbw had no analgesic effect (p>0.05), while the dose of 600 mg/kgbw had the highest analgesic effect at 7.72 seconds on the 4th hour of induction. On the 6th hour, the dose of 400 mg/kgbw had the highest analgesic effect at 3.58 seconds.Conclusions: Extract soursop (Annona muricata L.) leaves in this study have been proven to have an analgesic effect.
PERAN RED CELL DISTRIBUTION WIDTH SEBAGAI PREDIKTOR MORTALITAS PADA PASIEN SEPSIS DAN SYOK SEPTIK DI RUMAH SAKIT UMUM PUSAT HASAN SADIKIN Silalahi, Fonda R.P; Rudiman, Reno; Rizky, Kiki A
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 2 No 2 (2019): Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Red cell Distribution Width (RDW) adalah parameter hematologis yang sederhana dan rutin diperiksa sebagai bagian pemeriksaan darah lengkap. Berbagai penelitian dan teori menghubungkan nilai RDW sebagai faktor prediktor mortalitas pada penyakit kritis dan juga sepsis. Tujuan dari penelitian ini adalah untuk mengetahui peran RDW sebagai prediktor kejadian mortalitas pada pasien sepsis dan syok septik. Penelitian dilakukan dengan metode prospektif terhadap 51 pasien dewasa dengan sepsis dan syok septik di Instalasi Gawat Darurat dan Instalasi Perawatan Intensif Rumah Sakit Umum Pusat (RSUP) Hasan Sadikin periode September 2017 sampai dengan Agustus 2018. Pemeriksaan RDW pada pasien diambil setelah diagnosis sepsis dan syok septik ditegakkan dan dilakukan observasi selama 30 hari. Terdapat 51 subyek penelitian dengan rerata usia 54,39 tahun. Rasio perbandingan pria : wanita adalah 1,55 : 1. Nilai median&nbsp; RDW adalah 19,1%. Nilai RDW tertinggi adalah 27,68% sedangkan nilai RDW terendah adalah 14,18%. Hasil analisis kurva Receiver Operating Characteristic (ROC) didapatkan cut off point pada nilai RDW 18,55% ( RDW&gt;18,55% dan RDW&lt;18,55%) mempunyai hubungan bermakna untuk memprediksi terjadinya mortalitas. RDW dapat dijadikan prediktor untuk kejadian mortalitas pada pasien sepsis dan syok septik.