Rini Riyanti
Fakultas Kedokteran Universitas Jember
Articles
8
Documents
Uji Aktivitas Antiplatelet Ekstrak Etanol Kubis Merah (Brassica oleracea var. capitata L.) Antiplatelets activity of red cabbage ethanolic extract (Brassica oleracea var. capitata L.)

Pustaka Kesehatan Vol 2, No 1 (2014)
Publisher : Pustaka Kesehatan

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Abstract

Antiplatelet aggregation effect of red cabbage ethanolic extract (Brassica oleracea var. capitata L.) was measured by bleeding time on Balb-C mice. The test substances given orally during the period of 8 days. Bleeding time was measured on first day and 9th day. Red cabbage ethanolic extract were divided into 3 doses: wich are 9.69 mg/kg body weight; 19,38 mg/kg body weight, and 38,76 mg/kg body weight. After getting the percentage of bleeding time increase, data were analyzed by analysis of variance test (Anova), followed by individual comparison within the groups by LSD test. The test substances above respectively increased bleeding time 58 ± 16%; 70,7 ± 8,9 %, and 113 ± 12%. As the conclusion, red cabbage ethanolic extract doses 38,76 mg/kg body weight could increase bleeding time as well as positive controle 129 ± 8,2%. Keywords: antiplatelets, Brassica oleracea red cabbage, bleeding time.

Pengaruh Pemberian Ekstrak Tauge (Vigna radiata (L)) terhadap Kadar Serum Trigliserida pada Tikus Wistar Jantan yang Diinduksi Kuning Telur (The Effect of Mungbean (Vigna radiata (L)) Sprout on Triglyceride Serum Levels of Male Wistar Rats Induced by Eg

Pustaka Kesehatan Vol 4, No 1 (2016)
Publisher : Pustaka Kesehatan

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Abstract

Dyslipidemia is a condition of abnormal blood lipid profiles, including hypertriglyceridemia. One of antidislipidemia agent is niasin, that can be found in mungbean (Vigna radiata (L)) sprout. This study aimed to determine the difference in triglyceride serum after treatment with mungbean sprout extract on male wistar rats induced by egg yolk. This was an experimental study with randomized Post-test Only Control Group Design. Twenty five male wistar rats aged 2-3 months, divided into 5 groups: K(-), K(+), P1, P2 and P3. K(-) was treated with standard diet. The other four groups were injected with 0,006 mg/ 200 gram weight IV adrenalin on the first day followed by egg yolk diet for six weeks. P1, P2, and P3 group were treated with 50, 100, and 200 mg/ 200 g/day of mungbean sprout extract simultaneously with the diet. At the end of the treatment, the serum was taken to examine the triglyceride serum. Average levels of triglycerides serum in group K(-) 69,2±15,9; K(+) 92±14,9; P1 63,2±14,1; P2 53±6,9; P3 84,8±23,9. There was significant different of triglyceride serum means between group K(+) and P2 (p=0,014). In conclusion, 100 mg of mungbean sprout extract showed a significant difference in triglyceride serum with control group of male wistar rats induced with egg yolk.   Keywords: Mungbean sprout, egg yolk, triglyceride

CORRELATION OF CD4 WITH TOTAL LYMPHOCYTE COUNTS IN HIV PATIENTS

UNEJ e-Proceeding 2016: Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UNEJ e-Proceeding

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Abstract

Worldwide estimates of people living with HumanImmunodeficiency Virus was approximately 32million in 2007 with thousands of people gettinginfected every day therapy (Obirikorang et.al,2012). Globally, 34 million people were living withhuman immunodeficiency virus (HIV) at the end of2011 (Chen et.al, 2013). Most people living withHIV are from developing countries with less than5% receiving antiretroviral therapy (Obirikoranget.al, 2012).A CD4 count is a laboratory test that measures thenumber of CD4 T lymphocytes (CD4 cells) in asample of blood. In HIV patients, it is the mostimportant laboratory indicator of how well theimmune system is working and the strongestpredictor of HIV progression. Once a person isinfected with HIV, the virus begins to attack anddestroy the CD4 cells of the person’s immunesystem. HIV uses the CD4 cells to multiply andspread throughout the body. This is the HIV lifecycle.The associated immune deficiency in humanimmunodeficiency virus (HIV) patients leading toinfection by opportunistic pathogen is ascribed todepletion of CD4. CD4 count can therefore beregarded as the accurate measurement of therobustness and functionality of the immunecapability to protect the body against generalinfection. CD4 T lymphocyte cell depletion is one ofthe hallmarks of progression of HIV infection and amajor indicator of the stage of the disease in HIVinfected individuals. World Health Organizationrecommended that most treatment initiationdecisions be guided by CD4 measurement andclinical staging.AIDS is the stage of HIV infection that occurs whenthe immune system is badly damaged and it isbecome vulnerable to opportunistic infections.When the number of your CD4 cells falls below 200cells/mm3, these are considered to haveprogressed to AIDS. (In a healthy immune system,CD4 counts are between 500 and 1,600cells/mm3.)The initiation of antiretroviral therapy is based onCD4 counts of less than 350 cells/mm3 according tothe World Health Organization (WHO) and Centrefor Disease Control (CDC). The determination ofCD4 count however in resource-limited localities isdifficult.In April 2002, the World Health Organization(WHO) suggested that total lymphocyte count(TLC) could serve as a surrogate for CD4+cell countbecause TLC is easily obtained from routinecomplete blood cell counts by multiplying thepercentage of lymphocytes by the white-blood-cellcount (Chen et.al, 2013).Total lymphocyte count(TLC) is a derived immunological marker calculatedfrom white blood cell count and relativelymphocyte count. For instance, if a patient has atotal white blood cell count of 10.0 × 10⁹/L andrelative lymphocyte count of 30% obtained fromdifferential leukocyte count, total lymphocytecount of such patient would be 3 × 10⁹/L.The aim of this study was therefore to ascertainexisting relationships between CD4 count and TLCand to further ascertain if TLC could be used as asurrogate markerfor CD4 counts.

The Effectivenes of Red Rice to Decrease Total Cholesterol in Type 2 DM Patients

Journal of Agromedicine and Medical Sciences Vol 3, No 1 (2017)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Diabetes mellitus (DM) is a group of metabolic diseases with hyperglycemia characteristic that happens because anomaly of insulin secretion or insulin activity. Insulin deficiency in type 2 DM caused dislipidemia. Red rice are contain fiber, essential fatty acid and Gamma Amino Butiric Acid (GABA). This research intended to know the effectiveness of red rice to decrease total cholesterol levels of patient with type 2 DM. Clinical test with quasi experimental and research design non randomized control-group pretest-postest design was used for the research method. Total samples of this research are 36 samples. The treated group was given the red rice during 6 days on breakfast and dinner, while the control group did not have any intervention. The research showed that average cholesterol levels in the beginning and finale of treated group was 235,69 mg/dL and 198,56 mg/dL, while average cholesterol levels in the beginning and finale of control group was 235,72 mg/dL and 256,50 mg/dL. From this research, red rice has effective to decrease  total cholesterol levels of patients with type 2 DM.Keywords: Diabetes mellitus, Red Rice, Cholesterol total levels

Uji Aktivitas Antiplatelet Ekstrak Etanol Kubis Merah (Brassica oleracea var. capitata L.) Antiplatelets activity of red cabbage ethanolic extract (Brassica oleracea var. capitata L.)

Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (59.127 KB)

Abstract

Antiplatelet aggregation effect of red cabbage ethanolic extract (Brassica oleracea var. capitata L.) was measured by bleeding time on Balb-C mice. The test substances given orally during the period of 8 days. Bleeding time was measured on first day and 9th day. Red cabbage ethanolic extract were divided into 3 doses: wich are 9.69 mg/kg body weight; 19,38 mg/kg body weight, and 38,76 mg/kg body weight. After getting the percentage of bleeding time increase, data were analyzed by analysis of variance test (Anova), followed by individual comparison within the groups by LSD test. The test substances above respectively increased bleeding time 58 ± 16%; 70,7 ± 8,9 %, and 113 ± 12%. As the conclusion, red cabbage ethanolic extract doses 38,76 mg/kg body weight could increase bleeding time as well as positive controle 129 ± 8,2%. Keywords: antiplatelets, Brassica oleracea red cabbage, bleeding time.

Pengaruh Pemberian Ekstrak Tauge (Vigna radiata (L)) terhadap Kadar Serum Trigliserida pada Tikus Wistar Jantan yang Diinduksi Kuning Telur (The Effect of Mungbean (Vigna radiata (L)) Sprout on Triglyceride Serum Levels of Male Wistar Rats Induced by Eg

Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (199.785 KB)

Abstract

Dyslipidemia is a condition of abnormal blood lipid profiles, including hypertriglyceridemia. One of antidislipidemia agent is niasin, that can be found in mungbean (Vigna radiata (L)) sprout. This study aimed to determine the difference in triglyceride serum after treatment with mungbean sprout extract on male wistar rats induced by egg yolk. This was an experimental study with randomized Post-test Only Control Group Design. Twenty five male wistar rats aged 2-3 months, divided into 5 groups: K(-), K(+), P1, P2 and P3. K(-) was treated with standard diet. The other four groups were injected with 0,006 mg/ 200 gram weight IV adrenalin on the first day followed by egg yolk diet for six weeks. P1, P2, and P3 group were treated with 50, 100, and 200 mg/ 200 g/day of mungbean sprout extract simultaneously with the diet. At the end of the treatment, the serum was taken to examine the triglyceride serum. Average levels of triglycerides serum in group K(-) 69,2±15,9; K(+) 92±14,9; P1 63,2±14,1; P2 53±6,9; P3 84,8±23,9. There was significant different of triglyceride serum means between group K(+) and P2 (p=0,014). In conclusion, 100 mg of mungbean sprout extract showed a significant difference in triglyceride serum with control group of male wistar rats induced with egg yolk.   Keywords: Mungbean sprout, egg yolk, triglyceride

Hubungan Kadar SGOT dengan Kadar Leukosit pada Pasien NSTEMI di ICCU RSD dr. Soebandi Jember (Correlation between SGOT Level and Leukocytes in NSTEMI Patients at ICCU dr. Soebandi Hospital, Jember)

Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Acute Coronary Syndrome (ACS) is a syndrome that occurs because of blockage of the coronary artery causing clinical symptoms due to unfulfilled oxygen supply. Atherosclerosis is suspected as the main cause of ACS. Inflammation is one pathophysiology of atherosclerosis characterized by leukocytosis. NSTEMI is one spectrum of ACS that diagnosed by anamnesis, ECG, and cardiac marker such as troponin. SGOT is also released into the circulation when there is myocardial damage. Studies has reported that SGOT increased from the normal range during a myocardial infarction. The purpose of this study was to determine the relationship between levels of SGOT and leukocytes in patients with NSTEMI. The sample included 10 patients with NSTEMI in July-December 2016 from ICCU RSD dr. Soebandi Jember. The data was collected from medical record. The result showed that the average of SGOT increased from the normal range, while the average levels of leukocytes were in normal range. Pearson correlation test showed that there was no significant relationship between the two variables with p=0.083>0.05. In conclusion, there was no relationship between the levels of SGOT and leukocytes in patients with NSTEMI at ICCU RSD dr. Soebandi Jember.   Keywords: NSTEMI, SGOT, Leukocyte  

Pengaruh Ekstrak Albumin Ikan Gabus (Chana striata) terhadap Kadar IFN-γ Pasien Tuberkulosis Paru dengan Pengobatan Fase Intensif (The Effect of Albumin Snakehead Fish (Chana striata) Extract on IFN-Y of Pulmonary Tuberculosis Patients during Intens

Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but not statistically signicant if compared with the decrease of control group (p=0.061). It can be concluded that albumin snakehead fish (Chana striata) extract in dose of 1500 mg/day had not able to decrease IFN-γ levels of pulmonary tuberculosis patients during intensive phase medication yet.   Keywords: tuberculosis, albumin, snakehead fish, IFN-γ