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Journal : Jurnal Medika Planta

EFFECT OF ETHANOL EXTRACT SAMBILOTO LEAF (Andrographidis folium) AGAINST BLOOD GLUCOSE LEVEL IN MALE Swiss Webster MICE INDUCED BY ALOXAN COMPARED TO JAMU D -, Rosnaeni; Ratnawati, Hana; Kastilani, Sarah
Jurnal Medika Planta Vol 1, No 1 (2010)
Publisher : Jurnal Medika Planta

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 Introduction: Jamu D is Indonesian traditional medicine containing ethanol extract of sambiloto leaf (EESL) which can be used as diabetes mellitus alternative drug. The aim of this study is to know the effect of EESL in lowering blood glucose levels comparde to Jamu D. Methods :The real prospective experimental comparative with complete randomized design was done. Twenty four aloxan induced diabetic male Swiss Webster mice was divided into 6 groups of treatment i.e. EESL dose 1 (29.25 mg/ kgBW), EESL dose 2 (58.5 mg/ kgBW), EESL dose 3 (117 mg/ kgBW),  control (CMC 1% suspension), comparator (Glibenklamid 0.65 mg/ kgBW), Jamu D (195 mg/ kgBW) for 7 days. The fasting blood glucose level was examined at the eight day and blood glucose level decrease percentage was analyzed with ANOVA, continued with Tukey HSD, a = 0.05. Results: showed that the decrease of blood glucose level in EESL dose1(65.93 %), dose (66.66 %), was same with Jamu D (59.82 %)(p >0,05) while the decrease percentage in dose 2 was significant different with Jamu D (p < 0,01). Conclusions :  EESL dose 1 and dose 3 were as effective as Jamu D in decreasing blood glucose level while dose 2 was not effective 
EFFECT OF ETHYL ACETATE AND BUTANOL FRACTIONS OF VELVET BEAN SEED (Mucuna Pruriens L.) TO IMPROVE LIPID PROFILE IN DYSLIPIDEMIC RATS Ratnawati, Hana; Widowati, Wahyu; Chakravitha, Clarissa
Jurnal Medika Planta Vol 1, No 1 (2010)
Publisher : Jurnal Medika Planta

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Introduction: Nowadays many people had dyslipidemic, affected by dietery habits and unhealthy lifestyle. High blood lipid can increase the risk of atherosclerosis and coronary heart disease (CHD). The CHD mortality rate are increasing and known as first leading cause of death in Indonesia. Objective: to find out the effect of ethyl acetate and butanol fractions of velvet bean seed (M. pruriens L.) to improve lipid profile in dyslipidemic rats. Methods: laboratory experimental prospective design, in vivo  preclinical test used dyslipidemic rats, which given ethyl acetate and butanol fractions in concentration at 15, 30, 60mg/kgBW/day, simvastatine 27mg/kgBW/day during ten days. The parameters used respectively are HDL, LDL, triglyceride, and total cholesterol level on dyslipidemic rats. Data were  analysed  with  Anava  and continued Post Hoc Duncan with level of significancy  95%. Results : Ethyl acetate fraction 15mg/kgBW/day significantly decreased total cholesterol level (56.667mg/dL) compared to positive control (70.667mg/dL), and ethyl acetate fraction 60mg/kgBW/day significantly decreased LDL level (7.333mg/dL) compared to positive control (14.333mg/dL), butanol fraction 60mg/kgBW/day significantly decreased  triglyceride level (65.667mg/dL) compared to positive control (112.333mg/dL) and significantly  increased HDL level (30.333g/dL) compared to positive control (24.333g/dL). Conclusion:  Ethyl acetate and butanol fractions of M. pruriens L. improve lipid profile such as decrease LDL, triglyceride, total cholesterol level and increase HDL level in dyslipidemic rats.
The Comparison Effect of Aloe vera L., Psidium guajava Linn, Curcuma domestica Val to Colitis Ulcerative Mice Models Histopatology Kurniawati, Dewi; Jasaputra, Diana Krisanti; Ratnawati, Hana; Tiono, Hartini; Sujatno, Muchtan; Dewi, Aprilin Krista; Mayestica S., Putu; Arifin, Samuel
Jurnal Medika Planta Vol 1, No 2 (2010)
Publisher : Jurnal Medika Planta

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Introduction: Ulcerative colitis (UC) is an inflammatory disease limited to the mucosal and submucosal layers of the colon. UC treatments was aimed to decrease inflammation and oxidation process on colon. Nowadays people start using hermal medicine to attentuate inflammation and oxidation process in ulcerative colitis, e.g. Aloe vera, Psidium guajava Linn, Curcuma domestica Val.Objective: to compare the effect of Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract on histopatology of ulcerative colitis.Methods: experimental comparative research with completely randomized design. Mice were divided on 5 groups (n=6) which were given Aloe vera ethanol extract 700 mg/kgBB and DSS 2,5%; Psidium guajava Linn ethanol extract 1.591,2 mg/kgBB and DSS 2,5%; Curcuma domestica Val ethanol extract 180.816 mg/kgBB and DSS 2,5%; aquadest and DSS 2,5% (positive control); aquadest (negative control). Data were analyze with ANOVA followed by Tukey HSD test with a=0.05.Results: there were a decrement percentage of crypt loss on Aloe vera ethanol extract group (10.5 +- 4,64681%), Psidium guajava Linn ethanol extract group (11 +- 2,09762%), Curcuma domestica Val ethanol extract group (9 +- 3,09839%) compared with positive control group (26.8 +- 1,72240%)(p<0.05). Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract had same effectivity (p>0.05).Conclusion: Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract had same effectivity on decreasing percentage of crypt loss on colitis ulcerative histopatology of mice induced by DSS 2.5%.