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Journal : Journal of the Indonesian Medical Association

The Role of of Red Fruit (Pandanus conoideus Lam) Oil towards Colitis Ulcerative Mice Model Khiong, Khie; Soeng, Sylvia; Ratnawati, Hana
Journal of the Indonesian Medical Association Vol. 62 No. 4 April 2012
Publisher : Journal of the Indonesian Medical Association

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Abstract

Introduction: Ulcerative colitis (UC) is chronic inflammation process in gut due to dysregulationof mucous immune systems. Oxidative stress caused by free radicals is believed to aggravate the degree of the disease. Red fruit (Pandanus conoideus Lam.) is indigenous plant from Papua that contains high level of antioxidants. The aim of this research were to examine the role of red fruit oil towards leukocytes proliferation and hystological feature of colon in colitis mice modelMethod: Colitis induced group were divides into 2 gropus; with and without red fruit oil treatment. Red fruit treated groups were given red fruit oil in various dosages of 0,1 ml; 0,2 ml and 0,4 ml respectively. At the end of experiment, all mice were sacrificed and the colons were removed and subjected to histopathological analysis by staining with HE. Lymphocytes were measured using MTT assay method.Result: From histopathological analysis results, 0,1 ml -red fruit oil treated group showed improving colon structure compared to untreated group. Red fruit oil of 0.1 ml and 0.4 ml groups showed increased of non-T leukocytes proliferation significantly compared to untreated group.Conclusion: Red Fruit extract can increase non-T leukocytes and T lymphocytes proliferationsignificantly. J Indon Med Assoc. 2012;62:142-8.Keywords: Red fruit extract, leukocytes and lymphocytes proliferation, Dextran Sulfate Sodium (DSS)