Valentino Rangga
Mahasiswa program pendidikan S-1 kedokteran umum FK UNDIP

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PERBANDINGAN PEMBERIAN HEPARIN SUBKUTAN DAN INTRAVENA TERHADAP KADAR FIBRINOGEN PADA PENCEGAHAN DEEP VEIN THROMBOSIS

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

ABSTRACTBackground: Deep vein thrombosis (DVT) is a condition where thrombus is formed in a deep vein especially in the lower limbs and inguinal. Blood clots can obstruct blood flow from lower limbs to the heart. DVT is an often occured disease and can be fatal and deathly if it is not get diagnosed and treated effectively. Giving anticoagulants such as heparin either intravenously or subcunaneosly can prevent thrombus formation. Fibrinogen levels is directly proportional to the risk of a thrombus generation.Methods: An observational study with cross-sectional approach. Data were derived from secondary data with total sample of 20 which divided into two groups. Group 1 was an ICU patient who given intravenous heparin and Group 2 given subcutaneous heparin. Fibrinogen levels were recorded and compared before and after one day heparin administration.Results: There is no significant differences (p=0,226) between fibrinogen levels before and after intravenous heparin administration (388,56209,31 mg/dl vs 468,93178,38 mg/dl). In subcutaneous heparin group there is a significant (p=0,006) increase in levels of fibrinogen before and after heparin administration (265,2790,67 mg/dl vs 453,93112,49 mg/dl). After comparing pre-post fibrinogen levels in both groups (60,37228,85 mg/dl vs 188,66169,19 mg/dl), we obtained no significant difference between two groups (p=0,171).Conclusions: No significant differences between administering heparin intravenously and subcutaneously against fibrinogen levels as a prophylactic of deep vein thrombosis in ICU.Key words: Intravenous heparin, subcutaneous heparin, fibrinogen levels, deep vein thrombosis