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Combination of Doxorubicin and Areca Ethanolic Extract Induces Apoptosis by Increasing Caspase-3 Level on Breast Cancer (T47D) Cells Rahmi, Fitria; Meiyanto, Edy; Susidarti, Ratna Asmah
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

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Abstract

Despite causing many side effects, doxorubicin (Dox) is still one of breast cancer drug of choice. Thus, combination of chemotherapy is developed in order to decrease doxorubicin regimen dose. The aim of this research is to examine the combination effect of doxorubicin (dox) and areca extract (AE) on T47D human breast cancer cells. The cytotoxic activity was determined using MTT assay. The combination index (Cl) of the combination treatment was calculated to determine the effects (synergistic, additive or antagonistic). The combination application of dox (6-22nM) and AE (8-30μg/ml) on T47D cells showed synergistic (Cl<0.9) or addictive effect )Cl =0.9-I.I). The effective combincation of dox-AE was 6nM-8μg/ml on Cl<0.5. Apoptosis induction of AE solely and its combination with dox was the observed using double staining method. Moreover, expression of Bax and caspase-3 protein which mediated apoptosis, were observed using immunocytochemistry. Combination of AE and Dox increased expression of Caspase-3 but did not increase expression of Bax. This result showed AE increase the effectiveness of doxorubicin against T47D cells.Keyword : Breast cancer, doxorubicin, areca extract, T47D cells
Pengaruh Prokrastinasi Akademik Terhadap Perilaku Menyontek Pada Siswi Sma Di Pesantren X Khairat, Ummul; Maputra, Yantri; Rahmi, Fitria
Jurnal RAP Vol 5, No 2 (2014): Vol 5 No 2 Nopember 2014
Publisher : Universitas Negeri Padang

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Abstract

ABSTRAK: The influence of academic procrastination towards cheating behavior on high school students of “X” boarding school. This Research testing effect of academic procrastination on the students’s behavior cheat on sma at Pesantren X. Subjects were 104 respondents. The sampling technique used sampling saturated. Collecting data using a scale of academic procrastination Rothblum Solomon (1984) and the scale of cheating behavior based on the theory Cizek (1999) as modified by the researcher. Data analysis technique used a simple regression analysis. Results of this study, the academic procrastination have a significant effect on the behavior of cheating visible from significance value of 0.008 (P <0.05). Results obtained R2 is 0.066, which means that the influence of academic procrastination to cheat on student behavior amounted to 6.6%.Keywords: Academic procrastination, cheating behavior, boarding schoolABSTRAK: Pengaruh prokrastinasi akademik terhadap perilaku menyontek pada siswi sma di pesantren x. Penelitian menguji pengaruh prokrastinasi akademik terhadap perilaku menyontek pada siswi sma di Pesantren X. Subjek adalah 104 orang responden. Teknik pengambilan sampel yang yang dipakai adalah sampling jenuh. Pengumpulan data menggunakan skala prokrastinasi akademik Solomon dan Rothblum (1984) dan skala perilaku menyontek berdasarkan teori Cizek (1999) yang dimodifikasi oleh peneliti. Teknik analisa data yang digunakan adalah analisis regresi sederhana. Hasil penelitian ini didapatkan prokrastinasi akademik memiliki pengaruh yang signifikan terhadap perilaku menyontek terlihat dari nilai signifikansi sebesar 0,008 (P<0,05). Hasil R2 yang didapat adalah 0,066 yang berarti bahwa besarnya pengaruh prokrastinasi akademik terhadap perilaku menyontek pada siswi adalah sebesar 6,6%.Kata Kunci: prokrastinasi Akademik, perilaku menyontek, pesantren
Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

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Abstract

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay – to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) – was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 µg/m) for 48 h caused 13-84% growth inhibition (IC 5077 µg/mL) of the cells, while arecoline (ARE) treatment (10-500 µg/mL) showed 8-73% inhibition (IC50 180 µg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferative 
PENGAWASAN CAMAT DALAM PENATAAN PEMUKIMAN KUMUH DI KECAMATAN RUMBAI PESISIR KOTA PEKANBARU Rahmi, Fitria; ", Zulkarnaini
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 2: WISUDA OKTOBER 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Growth and development of an area of town is not always a positive affect. High population growth resulted in increased population density and an increased in the density of buildings for residential as well as an increased need of infrastructure to carry out activities in an effort to make ends meet. The increase in space requirements is almost always coupled with the growth and development of slums and squatter settlements in a region.Tassel coastal districts is one district that has slums, the residential area is located in one of the villages Meranti Pandak subdistrict coastal fringe. Villages that cannot escape the problem of untidiness. If it is left without treatment improvements will expand the existing slums. Efforts taken by the government to address this is through the implementation of the restructuring program of slums that have been implemented since the first approach taken by various coastal fringe districts, including mutual cooperation program of activities that include physical, environmental, and infrastructure there.One of the government programs in addressing the slum is a slum arrange evenly and thorough quality improvement in a very seedy area.This study aims to determine how much oversight arrangement slum districts on the fringe of society in the coastal city of Pekanbaru. The method used to achieve the purpose of the research is qualitative method.Keywords : Seedy, Structuring, Regulation, Supervision, Slums.
PENGARUH KARAKTERISTIK PEKERJAAN TERHADAP PERILAKU KEWARGAAN ORGANISASI DENGAN MEDIATOR NILAI-NILAI KUALITAS KEHIDUPAN KERJA Rahmi, Fitria; Riyono, Bagus
Jurnal Psikologi Undip Vol 15, No 1 (2016): April 2016
Publisher : Fakultas Psikologi, Universitas Diponegoro

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Abstract

Organizational Citizenship Behavior (OCB) can be formally defined as a discretionary work behaviour of the employees that is not recognized by the formal reward or the sanction system of their organization. OCB can be seen as a voluntary behavior of the employees, which is out of the job description of their obligation, it is not directly related to the formal reward, but useful in improving the efficiency and effectiveness of the organization.Previous research found four aspects of the job characteristic (variety skill, task identity, task significance and autonomy) positively effected on OCB of employee. The objective of this study was to look effect of job characteristic to OCB which mediated by values of Quality of Work Life (QWL). This values as a foundation to display OCB. The subjects of this research were 65 employees from PT. X. Regression analysis showed that job characteristic significant toward OCB through the mediating of QWL values. In another word QWL had a mediator role between job characteristic and OCB. This finding were usefull to improve the OCB in company, with more attention to job characteristic that promote employees’ QWL. The results and benefits of the research were further discussed in the discussion.
KEMATANGAN KARIR DITINJAU DARI JENIS KELAMIN DAN JENIS SEKOLAH DI KOTA PADANG Rahmi, Fitria; Puspasari, Dwi
Jurnal RAP Volume 8, Nomor 1, Tahun 2017
Publisher : Universitas Negeri Padang

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Abstract

Penelitian ini bertujuan untuk mengetahui perbedaan kematangan karir pada siswaditinjau dari jenis kelamin dan jenis sekolah di Kota Padang. Teknik sampling yangdigunakan yaitu kluster random sampling. Pengumpulan data menggunakan skala yangdiadaptasi dari skala Career Development Inventory Australia Short-Form (CDI-A-SF).Hasil pengujian hipotesis menggunakan ANAVA dua jalur diperoleh bahwa terdapatperbedaan kematangan karir pada siswa ditinjau dari jenis kelamin, dan terdapat perbedaankematangan karir pada siswa ditinjau dari jenis sekolah. Lebih lanjut hasil penelitian danpembahasan akan dijelaskan dalam diskusi.
RELIGIUSITAS DAN KESEPIAN PADA LANSIA PWRI CABANG KOPERINDAG SUMATERA BARAT rahmi, fitria
Jurnal Antropologi: Isu-Isu Sosial Budaya Vol 17, No 2 (2015): (December)
Publisher : Universitas Andalas

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Abstract

Indonesia merupakan salah satu negara dengan penduduk berstruktur aging, dimana dari tahun ke tahun terjadi peningkatan jumlah lansia. Meningkatnya jumlah lansia diikuti dengan meningkatnya permasalahan kesehatan dan permasalahan psikologis. Salah satu permasalahan psikologis yang muncul yaitu perasaan kesepian. Rasa kesepian akan semakin dirasakan lansia yang sebelumnya aktif bekerja. Kesepian akan memicu tingkat stress, depresi dan bunuh diri pada lansia. Religiusitas yang rendah diyakini menyebabkan perasaan kesepian pada lansia. Penelitian ini dilakukan untuk mengetahui hubungan antara religiusitas dan kesepian pada lansia Persatuan Wredatama Republik Indonesia (PWRI), cabang Koperindag Sumatera Barat. Sampel dipilih dengan menggunakan teknik purposive sampling dengan jumlah 40 orang lansia. Data yang dianalisa dengan menggunakan korelasi Product Moment menunjukkan bahwa terdapat hubungan negatif yang signifikan antara religiusitas dan kesepian pada lansia PWRI, terlihat dari nilai r = -0,709 (dengan p < 0,01.). Ini berarti semakin tinggi religiusitas semakin rendah kesepian yang dialami lansia.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS PELANGGAN JASA PENERBANGAN LION AIR KOTA PADANG Arima, Sesria Iidh; Rahmi, Fitria; Sari, Septi Mayang
Jurnal RAP Vol 9, No 1 (2018)
Publisher : Universitas Negeri Padang

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Abstract

Penelitian ini bertujuan untuk melihat pengaruh kualitas pelayanan terhadap loyalitas pelanggan jasa penerbangan Lion Air di Kota Padang. Penelitian ini menggunakan metode kuantitatif dengan sampel 100 orang pengguna jasa penerbangan Lion Air dengan metode purposive sampling dan data ini dianalisis menggunakan analisis regresi sederhana. Hasil penelitian ini dianalisa dengan regresi linear sederhana menunjukan nilai F = 34.328 dengan signifikansi 0,000 (p<0,05) yang membuktikan bahwa kualitas pelayanan berpengaruh secara signifikan terhadap loyalitas pelanggan pengguna jasa penerbangan Lion Air di Kota Padang. Sedangkan nilai R2 sebesar 0,259 menunjukan bahwa kualitas pelayanan mempengaruhi loyalitas pelanggan sebesar 25,9%. Berdasarkan hasil tersebut maka hipotesis penelitian diterima.
Pengaruh Iklim Organisasi terhadap Organizational Citizenship Behavior pada Karyawan Bank X Fanis, Astria Tika; Rahmi, Fitria
Jurnal RAP Vol 7, No 1 (2016): Vol 7 No 1 Mei 2016
Publisher : Universitas Negeri Padang

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Abstract

Abstract: Effect of organization climate against civic organizations behavior of bank employees x. The purpose of this research is to explore the influence of organization climate on organizational citizenship behavior the Employee of Bank X. The design used in this research is quantitative research methods. The population of this research is the employee of Bank X with number of samples of 123 employees. The sampling technique Probability Sampling with sampling technique disproportionate stratified random sampling. The collecting data by using Organizational Climate Questionnaire (OCQ). The result of analysis regression shown significant value 0,000 (P<0.05), therefore climate organization as variable independent has a significant influence on organizational citizenship behavior as variable dependent. Keywords: Organizational citizenship behavior, climate organization, bank employee. Abstrak: Pengaruh iklim organisasi terhadap organizational citizenship behavior pada karyawan bank x. Tujuan dari penelitian ini adalah untuk mengeksplorasi pengaruh iklim organisasi terhadap perilaku kewargaan organisasional Karyawan Bank X. Desain yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif.  Populasi penelitian ini adalah karyawan Bank X dengan jumlah sampel 123 karyawan. Tekhnik pengambilan sampel Probablity Sampling dengan teknik penentuan sampel disproportionate stratified random sampling. Pengumpulan data dilakukan dengan menggunakan Organisasi Kuesioner Iklim (OCQ). Hasil analisis regresi menunjukkan nilai signifikan 0,000 (P<0,05), oleh karena itu iklim organisasi sebagai variabel independen memiliki pengaruh yang signifikan terhadap perilaku kewarganegaraan organisasional sebagai variabel dependen.Kata kunci: Organizational citizenship behavior, iklim organisasi, karyawan bank.
Combination of Doxorubicin and Areca Ethanolic Extract Induces Apoptosis by Increasing Caspase-3 Level on Breast Cancer (T47D) Cells Rahmi, Fitria; Meiyanto, Edy; Susidarti, Ratna Asmah
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

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Abstract

Despite causing many side effects, doxorubicin (Dox) is still one of breast cancer drug of choice. Thus, combination of chemotherapy is developed in order to decrease doxorubicin regimen dose. The aim of this research is to examine the combination effect of doxorubicin (dox) and areca extract (AE) on T47D human breast cancer cells. The cytotoxic activity was determined using MTT assay. The combination index (CI) of the combination treatment was calculated to determine the effects (synergistic, additive or antagonistic). The combination application of dox (6-22nM) and AE (8-30µg/ml) on T47D cells showed synergistic (CI<0.9) or additive effect (CI=0.9-1.1). The effective combination of dox-AE was 6 nM - 8 µg/ml on CI<0.5. Apoptosis induction of AE solely and its combination with dox was then observed using double staining method. Moreover, expression of Bax and caspase-3 protein which mediated apoptosis, were observed using immunocytochemistry. Combination of AE and Dox increased expression of Caspase-3 but did not increase expression of Bax. This result showed AE increase the effectiveness of doxorubicin against T47D cells.Keywords: Breast cancer, doxorubicin, areca extract, T47D cells