Purwantyastuti Purwantyastuti
Departemen Farmakologi Fakultas Kedokteran UI

Published : 16 Documents
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The Relation of Tempeh Consumption and Plasma Lipid Peroxides in the Elderly Purwantyastuti, Purwantyastuti
Journal of the Indonesian Medical Association Vol. 57 No. 10 October 2007
Publisher : Journal of the Indonesian Medical Association

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The objective of the study is to analyze the relationship between tempeh consumption and lipid peroxidation. Subjects, 365 men and women were selected by a multistage sampling procedure followed by random sampling from members of elderly groups in health centers in Jakarta. Data were collected through interview using 26 items semi–quantitative food frequency questionnaire. Nutrition intakes were computed using World Food 2 Dietary Assessment System Program. Lipid peroxides and profile was measured in the fasting blood collected in the morning. The results showed that average total cholesterol and LDL cholesterol was higher than recommended. Low HDL cholesterol was found only in 28,6 % of women and most triglyceride levels were still below 200 mg/dL. Similar mean value of plasma lipid peroxides were found in men and women (± 0.2700 nmol/mL). Energy intake was 56-56% lower than RDA, total protein intake was 85-87% lower than RDA. Total and saturated fat intakes were more than the recommendation. The unsaturated fat intakes were lower than the recommendation. Cholesterol intake was less than 300 mg/day. There were significant differences in lipid peroxides level between tempeh consumption of 350 g or more/week and less than 350 g/week. The increased intake of tempeh is inversely correlated with level of lipid peroxides. Statistical analysis showed significant negative correlation between the amount of tempeh consumption and plasma LDL level in the elderly (p=0.05; r=-0.117). This study showed that consuming tempeh at least 7 pieces of the household size in a week is associated with low lipid peroxides and LDL cholesterol.Keywords: tempeh, lipid peroxides, LDL
Efficacy and Safety Review of "Grey Area" between the Food and Drugs: How the Truth Spoken? Purwantyastuti, Purwantyastuti
Journal of the Indonesian Medical Association Vol. 59 No. 6 June 2009
Publisher : Journal of the Indonesian Medical Association

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If you wish to receive the full text of this article, as well as other articles published in Journal of the Indonesian Medical Association, please email us at yapenidi@yahoo.com*All articles requested are subject to translational fee from our certified Indonesian-English medical translator
Stakeholders’ Perception About Medical Doctors’ Competency in Primary Health Care Adisasmito, Wiku; Purwantyastuti, Purwantyastuti; Djuwita, Ratna; Thabrany, Hasbullah; Iljanto, Sandi; Kamso, Sudijanto; Vidiawati, Dhanasari
Journal of the Indonesian Medical Association Vol. 60 No. 1 January 2010
Publisher : Journal of the Indonesian Medical Association

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Phycisians graduated from Faculty of Medicine are expected to fulfill the required competences by the community in providing medical services in the primary health care. This study aimed at exploring the need, competence, and perfomance of phycisian graduated from Indonesian Faculty of Medicine in primary health care based on stakeholder perception. The study conducted in six cities in South Jakarta, Bandar Lampung, Pontianak, Makasar, Denpasar, and Ternate between July and October 2008. This qualitative study employed in-depth interview and focus group discussion (FGD) for data collection. Informants were stakeholders from local health centers, private clinics, medical doctor association, local government office and district dealth office. There were 67 informants and 11 FGDs. Interview guideline was developed using 7 areas of the phycisian standard of competence developed by the Indonesian Medical Council. In general, the stakeholders’ perceptions of the physician competence in providing medical services in the primary health care were in line with the standard of competence. Self-introspection and self-improvement were perceived very good. Effective communication and the use of information technology were perceived low. The primary health care institutions did not provide sufficient effort to improve these two competences. Phycisians’ clinical competence, basic medical knowledge, public health management, ethics, moral, medicolegal, and patient safety were considered good. Education improvement in communication and technology information for medical students are expected. In general, the quality of medical education supporting clinical competence and basic medical knowledge are acceptable and need to be maintained to follow the new development of medical sciences.Keywords: Indonesia, Indonesian medical council, medical doctors’ competency, primary care institution
Monitoring the Drugs Side Effects Purwantyastuti, Purwantyastuti
Journal of the Indonesian Medical Association Vol. 60 No. 4 April 2010
Publisher : Journal of the Indonesian Medical Association

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If you wish to receive the full text of this article, as well as other articles published in Journal of the Indonesian Medical Association, please email us at yapenidi@yahoo.com*All articles requested are subject to translational fee from our certified Indonesian-English medical translator
Systematic Review of the Effect of Vitamin D Supplementation on Immune Response Indrawati, Lili; Purwantyastuti, Purwantyastuti; Abikusno, Nugroho
Journal of the Indonesian Medical Association Vol. 61 No. 8 August 2011
Publisher : Journal of the Indonesian Medical Association

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The potential role for vitamin D and its active metabolite 1, 25-hydroxyvitamin D (1.25(OH)2D) in modulating the immune response was first recognized 25 years ago. The presence of adequate levels of vitamin D is required for the proper functioning of the bodys defense system such as barrier integrity, the production of antimicrobials, chemotaxis of other immune cells and regulation of inflammation in the innate and adaptive immune system. Sixty two studies on vitamin D and immune respons from 2000-2011 were identified. A total of 33 studies were excluded because it was not clinical trials, of the remaining 29, 21 were excluded because clinical trials were not randomized controlled trials and one was excluded because of using combined vitamin D and calcium, so the remaining seven clinical trials were reviewed to evaluate the clinical evidence for the role of vitamin D in the immune system. From the seven Randomized Controlled Trials (RCTs) reviewed in this paper, it is concluded that more research is needed to determine the beneficial effects of daily vitamin D in improving low level chronic inflammation and immune response. Side effects recognized in these studies were minimal and rare. J Indon Med Assoc. 2011;61:310-5.Keywords: Vitamin D, immune response modulator.
PENGARUH PENGOLAHAN KEDELAI MENJADI TEMPE DAN PEMASAKAN TEMPE TERHADAP KADAR ISOFLAVON (EFFECTS OF SOYBEAN PROCESSING BECOMING TEMPEH AND THE COOKING OF TEMPEH ON ISOFLAVONES LEVEL) Utari, Diah M; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Jurnal Penelitian Gizi dan Makanan Vol 33, No 2 (2010)
Publisher : Jurnal Penelitian Gizi dan Makanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | http://ejournal.litbang.depkes.go.id/index.php/pgm/article/view/3119

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ABSTRACT Background: Research over the past two decades has provided significant clinical trial and epidemiological evidence for health benefits of the consumption of soybean-based foods. A health claim indicating that high soybean consumption is associated with a lower risk of coronary heart disease (CHD). Compositions of nutrient and non-nutrient in soybean have been examination and give the contribution on lower risk of CHD especially on improve of lipid profile. Isoflavones is a non-nutrient that abundant in soybean. Tempeh is fermented soybean that popular as Indonesian traditional food and content of isoflavones is greater than soybean. Objective: to study effect of soybean processing becoming tempeh and the cooking of tempeh on isoflavones level. Methods: The samples of this study is raw tempeh and steamed tempeh. The analysis of isoflavones has used high performance liquid chromatography (HPLC). Results: During soybean processing becoming tempeh, twice boiling of soybean produce result isoflavones 47.4 percent greater than once boiling. Steaming tempeh result minimized isoflavones reduction (13.3%). Although there is no dietary recommendation for individual isoflavones, may be great benefit in increased consumption of tempeh. [Penel Gizi Makan 2010, 33(2): 148-153]   Keywords: tempeh, processing, isoflavones
Lipid peroxides level in the Indonesian elderly Purwantyastuti, Purwantyastuti; Kamso, Sudijanto; Suyatna, F. D.
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.299 KB) | DOI: 10.13181/mji.v14i2.174

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A cross-sectional study was done to see the possible association of plasma lipid peroxides in the elderly with age and other factors. Plasma lipid peroxides is a product of free radical reactions which according to the latest theory of aging is the cause of aging process. Lipid peroxides were also found high in coronary heart disease. Four hundred forty relatively healthy elderly, age 55-85 years, were randomly chosen from free living elderly under guidance of health care centers (PUSKESMAS) in Jakarta. Anamnesis and physical examination were done in the morning in the health centers. Blood samples were taken in fasting conditions, plasma lipids and lipid peroxides were measured according to standard methods. There was an age difference of lipid peroxides level in the elderly, which increased with age up to 70 years old. Elderly 70 years old and over had low plasma lipid peroxides. The level was not related to high plasma lipids. Higher level was found when more chronic degenerative diseases were found. (Med J Indones 2005; 14: 71-7)Keywords: lipid peroxides, aging
Prevalensi dan Determinan Sindrom Metabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya Kamso, Sudijanto; Purwantyastuti, Purwantyastuti; Lubis, Dharmayati Utoyo; Juwita, Ratna; Robbi, Yull Kurnia; Besral, Besral
Jurnal Kesehatan Masyarakat Nasional Vol. 6 No. 2 Oktober 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.257 KB) | DOI: 10.21109/kesmas.v6i2.110

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Data tentang faktor-faktor yang berhubungan dengan sindrom metabolik pada kelompok eksekutif di Indonesia yang diperlukan untuk upaya pencegahan penyakit kardiovaskular sangat terbatas. Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan sindrom metabolik pada kelompok eksekutif. Penelitian dilakukan di Jakarta dan sekitarnyadengan menggunakan rancangan cross sectional. Jumlah responden yaitu 220 orang eksekutif laki-laki dan 68 orang eksekutif wanita. Pengumpulan data dilakukan dengan pengukuran antropometri, analisis biokimia darah, analisis asupan makanan, pengukuran angka stres, dan pengukuranindeks aktivitas. Analisis regresi logistik ganda dilakukan untuk mengetahui hubungan beberapa independen variabel dengan dependen variabel. Analisis ini menghasilkan indeks massa tubuh (overweight, odds ratio (OR) = 5,54; obesitas, OR = 7,44) dan rasio total kolesterol/high density lipoprotein (HDL)-kolesterol (OR = 8,83) sebagai determinan sindrommetabolik pada kelompok eksekutif. Penelitian ini menunjukkan bahwa pemeriksaan profil lipid dan pengukuran antropometri sederhana yang teratur pada kelompok eksekutif penting dilakukan untuk mendeteksi risiko sindrom metabolik.Kata kunci: sindrom metabolik, kelompok eksekutif, antropometriAbstractAvailable datas on metabolic syndrome among Indonesian executives are limited, despite the fact of the importance of these data for cardiovaskular prevention. The objective of this study was to assess prevalence of metabolic syndrome and its associations between anthropometric measures, lipid profiles, blood pressure, nutrient intakes, and life style in executive group. A cross sectional study was undertaken in some factoriesin Jakarta, using multistage random sampling. The respondents were 287 executives, 219 male and 68 female. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake, stress score, and activity index assessment. Multiple logistic regression analysis used to assess associations between independent variables and metabolic syndrome. This study showed that body mass index (overweight, odds ratio (OR) = 5,54; obesity, OR = 7,44) and ratio serum total cholesterol to high density lipoprotein (HDL)-cholesterol (OR = 8,83) were potential determinants of metabolic syndrome. This study shows the importance ofroutine check of lipid profile, blood pressure, and simple anthropometric assessment to detect the risk of metabolic syndrome in the elderly.Key words: metabolic syndrome, executive group, antropometric
Potensi Asam Amino pada Tempe untuk Memperbaiki Profil Lipid dan Diabetes Mellitus Utari, Diah M.; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Jurnal Kesehatan Masyarakat Nasional Vol. 5 No. 4 Februari 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.806 KB) | DOI: 10.21109/kesmas.v5i4.137

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Prevalensi penyakit degeneratif dari tahun ke tahun meningkat akibat perubahan gaya hidup, khususnya perubahan pola makan. Walaupun tempe sebagai makanan tradisional Indonesia yang banyak dikonsumsi masyarakat karena mudah diperoleh dan harga terjangkau, tidak banyakyang mengetahui manfaat tempe bagi kesehatan. Tempe lama dikenal sebagai sumber protein yang dikonsumsi oleh kalangan masyarakat berpenghasilan rendah. Kajian lebih mendalam mengenai kandungan gizi dan manfaat tempe dan bagi kesehatan, khusus sebagai pencegah penyakit degeneratif perlu dilakukan. Proses fermentasi kedelai menjadi tempe mengakibatkan perubahan zat gizi dan non gizi yang mengakibatkan manfaat tempe jauh lebih baik dibandingkan kedelai. Protein tempe lebih mudah di cerna tubuh, sedangkan asam amino arginin yang meningkat hampir dua kali lipat pada tempe, sangat tinggi manfaatnya bagi kesehatan terutama dalam memperbaiki profil lipid dan diabetes mellitus. Mempertimbangkan hal tersebut tempe dapat dipertimbangkan sebagai pangan fungsional yangbermanfaat bagi kesehatan.Kata kunci: Tempe, protein, arginin, profil lipid, diabetes mellitusAbstractDegenerative diseases prevalence had been arining over years. One of the causes is the life style changes including eating pattern. Tempeh, an Indonesian soybean traditionally fermented food, was known and consumed by almost all Indonesian people. However, only a few know the health benefit of tempeh. Tempeh was also welknown and cheap protein source food affordable for the poor. Hence, there is a need to explore the nutritious content of tempeh and health benefit of it deeper such as in preventing degenerative diseases. Fermentation process of soybean to becometempeh had improved nutrient and non-nutrient contents that make tempeh better than soybean. Tempeh protein is more digestible than soybean and the arginine content increases twice, that could improve lipid profile and diabetes mellitus. Tempeh could be considered as functional food having health benefit.Key words: Tempeh, protein, arginine, lipid profile, diabetes mellitus
Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities) Kamso, Sudijanto; Purwantyastuti, Purwantyastuti; Rumawas, Yohanna S.P.; Lukito, Widjaja
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.283 KB) | DOI: 10.13181/mji.v14i2.184

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The objective of this study was to assess the nutritional status of hyperlipidemics elderly. A cross sectional study was undertaken in 4 big cities in Indonesia using multistage random sampling. The respondents were 656 hyperlipidemics and non hyperlipidemics elderly who were the subsample of 1261 sample of a larger population study. Data were collected through anthropometric measurements and biochemical blood analysis. To determine the nutritional status by Body Mass Index (BMI) the criteria used for elderly men and women are as follows, underweight BMI ≤ 18.5 kg/m2, normoweight BMI 18.5 - 24.9 kg/m2, overweight BMI 25 - 29.9 kg/m2, and obese BMI ≥ 30 kg/m2. To determine lipid status, the criteria used are as follows, hyperlipidemics elderly, those who had plasma total cholesterol ≥ 240 mg/dl and or triglycerides ≥ 200 mg/dl. Prevalence of hyperlipidemics in elderly women is higher then elderly men, 56.2% vs 47.0%. The BMI of hyperlipidemics is mostly overweight (60.4%) and obese (57.1%) for elderly men; and mostly normoweight (59.1%) and overweight (59.5%) for elderly women. The prevalence of hyperlipidemics among undernourished elderly men and women were also quite high, 38.7% and 31.6% respectively. (Med J Indones 2005; 14: 97-100)Keywords : BMI, hyperlipidemics, elderly