Niken Puruhita
Program Studi Ilmu Gizi Fakultas Kedokteran Universitas Diponegoro

Published : 41 Documents
Articles

EFEK PEMBERIAN EKSTRAK KLOROFIL DAUN PEPAYA (CARICA PAPAYA, LINN.) TERHADAP KADAR AST DAN ALT SERUM Damayanti, Kusmadewi Eka; Wijayahadi, Noor; Puruhita, Niken
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 1 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.446 KB) | DOI: 10.14710/jgi.4.1.63-66

Abstract

Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day. Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05).Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats. 
FAKTOR – FAKTOR RISIKO KEJADIAN GIZI BURUK PADA BALITA YANG DIRAWAT DI RSUP Dr. KARIADI SEMARANG Novitasari A, Dewi; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

Background : Malnutrition can cause the longer healing duration. The objective of this research is analyze the risk factors under five year old children’s malnutrition who are hospitalized in Kariadi hospital.Method : This research is observational research with case control approach. The total subjects of the research are 80 persons. The case of research is the number of under five year old children with malnutrition status,while the control is the number of under five year old children with good nutrition status. The data were taken from medical record in Kariadi hospital 2007-2011. The data analyze which is used is X2 test.Result : The most of under five year old children’s malnutrition are female 64,1%. Some demography characteristic constitute risk factor of malnutrition, that are social economic status (OR= 21,000; CI 95%= 6,459-68,279), mother education (OR=16,333; CI95%=5,143 – 51,872), comorbid disease (OR=35,286; CI 95%= 7,390-168,476), mother’s breast milk (OR= 9,471; CI 95%=3,067-29,242), low birth weight (OR= 21,000; CI95%= 4,451-99,082), and complete of imunization (OR=12,000; CI95%=4,180-34,454)Conclusion : Sosial economic status, education of mother, comorbid disease, mother’s breast milk, low birth weight, and the completeness of imunization constitute risk factor of malnutrition incident under five year old children. The most dominant risk factor of malnutrition is under five year old children’s comorbidities disease.Keywords : Demography characteristic, malnutrition, under five year old children
PERBEDAAN DURASI PENYEMBUHAN DIARE DEHIDRASI RINGAN-SEDANG BALITA YANG DIBERIKAN ASI DAN SENG PERMATASARI, DEVINA PUTRI; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

BACKGROUND : The incidence of diarrhea increased every year. Breast-feeders and zinc can reduced duration of diarrhea in some research. However, granting at the same time didn’t know yet.AIM : Analyzing difference of healing duration between the children who are breastfed and received zinc in diarrhea with mild-moderate dehydration at Kariadi hospital in 2011-2012.METHODES : This research was analityc research with case control approach. 45 subject age 6-12 month in diarrhea with mild-moderat dehydration. Subject obtained from medical record at Kariadi Hospital Semarang. The subjects divided into three groups and received treatment breastfed, zinc supplementation, breastfed and zinc supplementation. Kruskal wallis and Mann WhitneyU was used to analyze the difference of duration diarrhea between three groups.RESULT : Difference of healing duration diarrhea with mild-moderate dehydration interracial groups p=0.011. Difference of healing duration diarrhea with mild-moderate dehydration between breastfed and zinc groups (p=0.172), zinc compared breastfed and zinc (p=0.078),breastfed compared breastfed and zinc groups (p=0.003).CONCLUSSION : The groups who received zinc and breastfed had shorter duration of diarrhea.There were significant difference between three groups (3,0±1,18 days). The groups who received breastfed compared breastfed and zinc have significant difference.KEYWORDS : Breastfed, zinc, healing duration diarrhea with mild-moderate dehydration
PENGARUH LATIHAN SENAM AEROBIK TERHADAP PERUBAHAN BERAT BADAN PADA PESERTA KLUB KEBUGARAN Sientia, Fathirina; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

Latar Belakang: Pada dekade terakhir ini kegemukan merupakan masalah di negara maju dan negara berkembang. Kegemukan dapat berhubungan dengan berbagai macam penyakit. Saat ini di klub kebugaran menawarkan progam latihan senam aerobik yang dapat menurunkan berat badan.Tujuan: Menganalisis perubahan berat badan pada peserta senam sebelum dan setelah mengikuti latihan senam aerobik selama 12 minggu di klub kebugaran.Metode: Penelitian ini menggunakan rancangan quasi experimental dengan pendekatan pre dan post test design dengan sampel wanita yang mengikuti latihan senam aerobik selama 12 minggu di klub kebugaran. Besar sampel yaitu 20 peserta senam aerobik dengan tekhnik pengambilan sampel secara non random yaitu metode consecutive sampling.Hasil: Terdapat perubahan berat badan bermakna (p= 0,000) pada peserta senam aerobik sebelum dan setelah mengikuti latihan senam aerobik selama 12 minggu di klub kebugaran dengan rerata berat badan awal peserta 59,8 ± 9,49 dan rerata berat badan akhir peserta 56,9 ± 8,72. Terdapat perbedaan bermakna rerata penurunan berat badan (p=0,022) pada peserta senam aerobik dengan tingkat aktivitas fisik yang berbeda dan asupan makan tidak berpengaruh (p= 0,427) terhadap berat badan peserta setelah mengikuti latihan senam aerobik selama 12 minggu di klub kebugaran.Kesimpulan: Terdapat penurunan berat badan pada peserta senam serobik setelah mengikuti latihan senam aerobik selama 12 minggu di klub kebugaran.Kata Kunci : Latihan senam aerobik, berat badan, aktivitas fisik 
PERBEDAAN ASUPAN ENERGI, PROTEIN DAN STATUS GIZI PADA REMAJA PANTI ASUHAN DAN PONDOK PESANTREN Susanti, Dyah Ayu; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

Background : Adolescents is one of vulnerable group which is lack of nutrition. In general nutrition intake of female adolescents in the orphanage is less than in the moslem boarding school.Aim : Knowing the differences of energy intake, protein, and nutrition status at female adolescents in the orphanage and moslem boarding school.Methods : Kinds of this research is observational research which is use cross sectional approach. Amount of subject in this research is 46 adolescents, which is 23 adolescents live in Darul Khadlonah Orphanage dan another 23 adolescentds live in Baitul Muqodas Moslem Boarding School. Analysis of data using independent T – test and Mann Whitney U Test with the SPSS program for windows.Results : There were differences of energy intake significantly (P=0,00) between female adolescent of orphanage and moslem boarding school. There were differences of protein intake significantly (P=0,00) between both of subject group. There were not differences of MUAC significantly (P=0,074) between female adolescent group of orphanage and moslem boarding school. There were differences of BMI significantly (P=0,008) at both of subject group.Conclusion : Most of the adequacy energy and protein level of female adolescent at orphanage and moslem boarding school is included in low category. MUAC at female adolescent group of orphanage was not different if being compare with moslem boarding school group. There are 13 subjects in the orphanage and 7 subjects in the moslem boarding scholl which is in a bad nutrition status. However, BMI between both of subject group are different significantly.There are 7underweight subjects in the orphanage and 2 subjects in the moslem boarding school.Keywords : Energy intake, Protein intake, BMI, MUAC
FAKTOR RISIKO KEJADIAN HEMORRHOID PADA DEWASA USIA 21-30 TAHUN Ulima, Bifirda; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

BACKGROUND: Some risk factors for hemorrhoids at an adult age has not been widely publicized. The aim of this study are to find out that constipation, rectal tumor, physical activity, family history, and sitting position and time during defecation as risk factors of hemorrhoids among 21-30 old year age adult.METHOD: This was an observational study with case-control design. A total subjects of 54 peoples were recruited in the study. Cases were hemorrhoid’s patients obtained from medical records of Dr. Kariadi hospital Semarang while controls were those who do not suffer from hemorrhoids. Analysis of data using chi square and odds ratio.RESULTS: The mean age of cases 24.9±3.77 years old (cases) and 22.1±1.92 years old (control), female 55.5% (cases) and female 61.1% (control). In the data analysis with odds ratio obtained that constipation (OR=2.125; CI95%=0.715-6.315; p=0.172), rectal tumor (OR=2.080; CI95%=0.177-24.405, p=0.552), physical activity (OR=1.000; CI95%=0.059-16.854, p=1.000), family history (OR=2.059; CI95%=0.622-6.816, p=0.233), the sitting position during defecation (OR=0.308; CI95%=0.95-1.002, p=0.46) and time during defecation (OR=1.360; CI95%=0.458-4.042, p=0.580).CONCLUSIONS: Constipation, rectal tumor, family history, and sitting positions and time during defecation are risk factors of hemorrhoids among 21-30 old year age adult. While physical activity is not risk factor of hemorrhoids among 21-30 old year age adult.KEYWORDS: Constipation, physical activity, family history, defecate position, hemorrhoids.
PERBEDAAN ASUPAN ENERGI, PROTEIN, AKTIVITAS FISIK DAN STATUS GIZI ANTARA LANSIA YANG MENGIKUTI DAN TIDAK MENGIKUTI SENAM BUGAR LANSIA Akmal, Hilda Fauzia; Puruhita, Niken
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Abstract

Latar Belakang: Senam bugar lansia merupakan bentuk olahraga yang gerakannya mudah diikuti oleh lansia untuk meningkatkan status kesehatan dan kebugaran jasmani. Penelitian ini bertujuan menganalisis perbedaan asupan energi, protein, aktivitas fisik dan status gizi antara lansia yang mengikuti dan tidak mengikuti senam bugar lansia.Metode: Penelitian ini adalah penelitian observasional dengan pendekatan cross sectional. Subjek adalah 30 lansia rawat jalan di Instalasi Geriatri RSUP Dr. Kariadi Semarang yang telah memenuhi kriteria inklusi dan eksklusi, dibagi secara merata menjadi 2 kelompok, yaitu lansia yang mengikuti dan tidak mengikuti senam bugar lansia. Analisis data menggunakan uji Independent T Test dan Mann Whitney U dengan program SPSS for windows versi 17.0.Hasil: Terdapat perbedaan bermakna pada aktivitas fisik (p=0,045) dan status gizi (p=0,004) kedua kelompok subjek. Namun, tidak terdapat perbedaan bermakna pada asupan energi (p=0,2378) dan protein (p=0,110).Simpulan: Aktivitas fisik dan status gizi pada kelompok yang mengikuti dan tidak mengikuti senam bugar lansia berbeda secara bermakna. Namun, asupan energi dan protein antara kedua kelompok subjek tidak berbeda.Kata kunci: Senam Bugar Lansia, asupan energi, asupan protein, aktivitas fisik
PERBEDAAN KADAR KOLESTEROL LDL DAN HDL ANTARA WANITA VEGETARIAN TIPE VEGAN DAN NON-VEGAN Edyanto, Ermia; Puruhita, Niken
Journal of Nutrition College Vol 1, No 1 (2012): Journal of Nutrition College
Publisher : Nutrition Science Department

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Abstract

ABSTRACTBackground: Studies which investigated different risk for cardiovascular disease in vegetarian reported that each vegetarian diet type had different lipid serum level. Elevated LDL cholesterol level and reduced HDL cholesterol level are independent risk factors for coronary heart disease. This study was aimed to compare levels on LDL and HDL cholesterol between vegetarian vegan and non-vegan.Methods: Two groups of vegetarian women, 23 people in each group of vegan and non-vegan, participated in this cross-sectional study. The data taken of each subject were nutrient intakes (total fat, PUFA, MUFA, SFA, cholesterol, and total fiber), physical activity, body weight, height, LDL and HDL cholesterol serum levels. Data were analyzed by Shapiro-Wilk test, independent-t test, Mann-Whitney test and ANACOVA test.Results: There were no significant differences on LDL and HDL cholesterol serum levels between vegetarian vegan and non-vegan, both before and after variables i.e age, physical activity, body mass index (BMI), amount of total fat, PUFA, MUFA, SFA, cholesterol, and total fiber adjusted (p &gt; 0,05). LDL cholesterol levels for vegetarian vegan and non-vegan were respectively: 97,8 ± 54,87 mg/dl and 112,6 ± 36,03 mg/dl, while for HDL cholesterol, those levels were 54,9 ± 11,15 mg/dl and 55,2 ± 10,82 mg/dl. In multivariant analysis, the most influential variables on LDL cholesterol serum level were age (p = 0,001) and physical activity (p = 0,010), while for HDL serum cholesterol were BMI (p = 0,010) and total fat (p = 0,012). This study also found the significant difference of BMI between vegetarian vegan and non-vegan (p = 0,011), whose for each of groups’ BMI, were respectively: 20,9 ± 3,08 kg/m2 and 23,5 ± 3,53 kg/m2. Conclusion: LDL and HDL cholesterol serum levels are not different between vegetarian vegan and non-vegan. BMI of both groups is different. Age and physical activity affect on LDL serum cholesterol level, while BMI and total fat affect on HDL serum cholesterol level. LDL cholesterol serum level and BMI in vegetarian vegan  are lower than non-vegan. Key words: Vegetarian diet, vegan, non-vegan, LDL cholesterol, HDL cholesterol
PERBEDAAN KADAR KOLESTEROL LDL DARAH TIKUS SPRAGUE DAWLEY PADA PEMBERIAN KOPI FILTER DAN TANPA FILTER Sari, Raysa Tanjung; Puruhita, Niken
Journal of Nutrition College Vol 1, No 1 (2012): Journal of Nutrition College
Publisher : Nutrition Science Department

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Abstract

Background : Coffee contains cafestol and kahweol which can increase LDL cholesterol levels. Effect of cafestol and kahweol with chlorogenic acids are antagonist in coffee. Chlorogenic acids is strong antioxidant in coffee. Unfiltered coffee contains more chlorogenic acids and cafestol than filtered coffee. The study aims to determine the differences of LDL cholesterol levels of Sprague Dawley rats in giving filtered and unfiltered coffee. Methods : a laboratory experimental study, with randomized pre-post test control group design, with a simple random sampling to 28 Sprague Dawley rats were divided into 3 groups. The first treatment was given unfiltered coffee 4x2.7 ml, the second treatment was given filtered coffee 4x2.7 ml and the control was given water 4x2.7 ml for 28 days. LDL cholesterol levels were determined by the homogenous enzyme method. Data were analyzed by paired t-test and Oneway ANOVA test at 95% confident level. Results : Changes levels of LDL cholesterol in filtered coffee (0.85 mg/dl) are higher than unfiltered coffee (0.15 mg/dl). However statistical test shows there is no significant difference of LDL cholesterol in filtered and unfiltered coffee (p&gt;0.05). Conclusion : There is no significant difference of LDL cholesterol levels of Sprague Dawley rats in filtered and unfiltered coffee.
STUDI KUALITATIF PROSES ASUHAN GIZI TERSTANDAR DI RUANG RAWAT INAP RS ST. ELISABETH SEMARANG Wijayanti, Tania; Puruhita, Niken
Journal of Nutrition College Vol 2, No 1 (2013): Journal of Nutrition College
Publisher : Nutrition Science Department

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Latar Belakang: Banyaknya kejadian malnutrisi pada pasien di rumah sakit sering tidak teratasi dengan baik. Menurut penelitian tahun 2002, terjadi penurunan status gizi pada pasien sebesar 28,2% selama dirawat di rumah sakit. Proses Asuhan Gizi Terstandar sebagai bentuk pelayanan gizi merupakan hal yang berperan dalam penyembuhan pasien sehingga diperlukan penelitian terhadap subjek penelitian. Metode: Penelitian deskriptif dengan metode kualitatif. Pengumpulan data dilakukan dengan indepth interview, observasi partisipasi dan data sekunder. Keabsahan data dilakukan dengan triangulasi data, penguraian detail hasil penelitian, auditing dengan pembimbing, dan konfirmasi hasil penelitian pada subjek penelitian. Hasil: Proses asuhan gizi terstandar (PAGT) belum dilakukan secara optimal. Dietisien mengharapkan PAGT dapat disederhanakan. Saat assessmen gizi, dietisien belum secara detail mengumpulkan data fisik pasien, penentuan diagnosis gizi belum tepat, di beberapa ruangan diagnosis gizi tidak dilakukan oleh dietisien, intervensi gizi dan monitoring-evaluasi sudah dilakukan dengan baik. Faktor internal yaitu pengetahuan PAGT dietisien baik tapi motivasi yang mereka miliki belum cukup mampu untuk menjadikan dietisien menerapkan matriks pada diagnosis gizi. Faktor eksternal yaitu kebijakan rumah sakit tentang penegakkan diagnosis gizi belum dicantumkan dan kolaborasi antar tenaga kesehatan sudah berjalan. Kesimpulan: Pelaksanaan PAGT harus didukung dari kebijakan rumah sakit atau lembaga berwenang lainnya, profesi kesehatan lain dan pemahaman dietisien tentang metode PAGT.