Dwi Prasetyo
Department of Pediatrics, Medical Faculty of Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung
Articles
29
Documents
Clinical Aspects Disparities of Resistant and Non Resistant Nephrotic Syndrome in Children

Journal of the Indonesian Medical Association Vol. 60 No. 12 December 2010
Publisher : Journal of the Indonesian Medical Association

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Abstract

Histopathologically diagnosed nephrotic syndrome (NS) consists of minimal and nonminimal lesions. Minimal lesion nephrotic syndrome (MLNS) is usually called as sensitive steroid nephrotic syndrome (SSNS), and nonminimal lesion nephrotic syndrome (NMLNS) is the same as steroid resistant nephrotic syndrome (SRNS). Histopathologic feature is a gold standard in diagnosing NS, but it is not possible for every patient due to its invasive nature. This study aimed to elucidate the association between several clinical and laboratory manifestations such as nonalbumin protein, cholesterol, hypertension, haematuria, and the response towards SRNS and SSNS. An analytic study was carried on to find out the response of steroid therapy. The sample consisted of two groups with 38 subjects each, collected from the Outpatient and Inpatient setting of the Department of Child Health Hasan Sadikin General Hospital, Bandung, since January 2008 up to September 2009, all of whom were diagnosed with SSNS or SRNS according to the medical records data. Further analysis was done using X2. Logistic regression analysis was done simultaneously to find out the association of several variables, and odds ratio was used to calculate the strength between the variables. There was no difference in nonalbumin protein (p=0.139) and hypertension (p=0.247) of all subjects from both groups. The cholesterol rate was lower in SRNS group compared to those in SSNS group (p<0.05). Both groups showed difference in the incidence of haematuria (p=0.054). Multivariate analysis found out the association between sex, cholesterol rate and nonalbumin protein response towards steroid therapy in NS.Keywords: cholesterol, SRNS, SSNS, nonalbumin protein

Scoring System for Helicobacter pylori Infection in Children with Recurrent Abdominal Pain

Journal of the Indonesian Medical Association Vol. 62 No. 8 August 2012
Publisher : Journal of the Indonesian Medical Association

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Abstract

Introduction: Helicobacter pylori (H. pylori) infection is estimated to strike half the world’s population. However, the diagnostic tool for H. pylori infection remains expensive and scarce. Thus, a simple diagnostic method is required in places with limited resources. This study aims to assess the diagnostic values of scoring system for H. pylori infection in children presenting with recurrent abdominal pain (RAP). Methods: This is a diagnostic study with a cross sectional design on 196 children aged 6-18 years who presented with RAP. This study was conducted in Bandung, January-November 2009. The scoring system was developed based on a questionnaire on complaints related to H. pylori infection. As the gold standard, a non-invasive examination with high accuracy was used, a serological kit BioM pylori (Mataram local antigen).The diagnostic values were assessed by the area under the receiver operating characteristic (ROC) curve. Result: The prevalence of H. pylori infection in children presenting with RAP is 54.6% (95% CI: 47.6 - 61.6%). After performing bivariate and multivariate analyses, 11 questions were used on the final questionnaire. Based on the ROC curve, a cut-off point of score > 30 was obtained, with a  88.5% sensitivity and 88.2% specificity. Conclusion: The scoring system can be used to predict H.pylori infection in children aged 6-18 years who presented with RAP. Key words: Helicobacter pylori, recurrent abdominal pain, scoring system, children