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THE INFLUENCE OF 10% TRICHLOROACETIC ACID ON COVERING OF TYMPANIC MEMBRANE PERFORATION WITHOUT BRIDGE Martono, Wahju Budi; -, Jogjahartono; Pramono, Noor
PROSIDING SEMINAR NASIONAL Vol 1, No 1 (2008): CONTINUING MEDICAL AND HEALTH EDUCATION (CMHE) | Peran Biomolekuler dalam Pen
Publisher : Universitas Muhammadiyah Semarang

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Background: Up to now, the covering of tympanic membrane perforation on human either or without operation has always been using the bridge. The covering of tympanic membrane perforation without operation by attempting epithelization of perforation edge which initially perform by injuring the perforation edge. The material that can be used to make the injuring is 10% trichloroacetic acid (TCA). The covering of perforation without bridge was conductive on guinea pig and proven that spontaneous covering take place. And there for the covering of tympanic membrane perforation without bridge can also happened on human being, by making the injuring on the perforation edge using 10% TCA.Objective: The objective of the research to prove that application of 10% TCA on the edge of tympanic membrane perforation can cause the perforation covering although without using the bridge.Method: This is the experimental research using pre and post test design. The chronic tympanic membrane perforation patiens without infection with normal Eustachii tube function, the size of tympanic membrane perforation 25% were treated with 10% TCA application on their perforation edge every 2 weeks until the covering take place or maximal 5 times application if no covering take place. Measurement of perforation size was conducted prior to first application and after the treatment.Result: From 36 ears suffering chronic tympanic membrane perforation with normal Eustachii tube function and without infection with the size of perforation 25% were selected to the sample of the research. The perforation that can be covered after the treatment of 10% TCA application were higher in number than those were not covered (63,9%:39,1%).Conclusion: The application of 10% TCA on the edge of tympanic membrane perforation can cause perforation covering although without the use of bridge.Keywords: Tympanic membrane perforation, Trichloroacetic acid
Respons Histopatologik Karsinoma Serviks Uteri Setelah Pemberian Kemoradiasi Iskandar, T Mirza; Mexitalia, Maria; Sarjadi, Sarjadi; Dharmana, Edi; Pramono, Noor
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTFactors associated with histopathologic responses of cervical cancer after chemoradiation therapyIntroduction: Cervical carcinoma is the second most common women cancer in the world. A combined of surgical, radiation and chemotherapy is the main cervical carcinoma treatment. The histopathological response is one performance to assess the result of the treatment. The purpose of the study is to analyze the factors of cervical cancer which contributes to the histopathological response after chemoradiation treatment.Methods: The design of the study was a case control, done at Dr. Kariadi Hospital Semarang in 2008. Patients with biopsy-proven cervical carcinoma were entered into the study. The variables of risk factors included the stage of the cancer by FIGO staging, the type and differentiation of the tumour, the anemia and the history of the transfusion and the immunotherapy by BCG vaccine. The histopathological response was assessed after the chemoradiation treatment. Chi-square was used to analyze the risk factors and logistic regression was used for the multivariate analysis.Results: Between April-August 2008, 77 patients finished the chemoradiation treatment. The type of the cancer was squamous cell carcinoma (71.4%) and the stage was III B (81.8%). The staging, type and differentiation of the tumor, and the history of transfusion did not contributes to the histopathological response. After adjustment of other factors, the contribution of anemia to poor histopathological response were 6.25 times (95% CI 1.12-34.90; p=0.037) higher than good histopahological response.Conclusion: Anemia is the risk factor of poor histopathological response of cervical carcinoma after chemoradiation therapy.Keywords: Cervical carcinoma, chemoradiation, histopahological responseABSTRAKPendahuluan: Karsinoma serviks uteri (KSU) merupakan kanker kedua terbanyak pada wanita di seluruh dunia. Sampai saat ini terapi pilihan utama KSU adalah operasi, radiasi dan kemoterapi. Salah satu penilaian keberhasilan terapi adalah dengan respon histopatologik. Tujuan penelitian ini adalah menilai faktor-faktor yang berperan terhadap respons histopatologik setelah terapi kemoradiasi.Metode: Desain penelitian adalah kasus kontrol. Penelitian dilakukan di RSUP Dr. Kariadi Semarang. Kriteria inklusi adalah KSU yang telah menyelesaikan kemoradiasi. Faktor-faktor yang dinilai berperan terhadap respons histopatologi adalah tipe histologis dan diferensiasi tumor, stadium tumor berdasarkan FIGO, anemia dan riwayat transfusi serta pemberian imunoterapi dengan BCG. Analisis statistik menggunakan kai-kuadrat dan regresi logistik.Hasil: Selama periode April-Agustus 2008 terdapat 77 penderita yang menyelesaikan kemoradiasi. Sebagian besar penderita berada pada stadium IIIB (71,4%) dan mempunyai tipe histologi karsinoma sel skuamosa (81,8%). Stadium tumor, tipe histologi dan diferensiasi tumor, riwayat transfusi serta imunoterapi BCG tidak berperan pada respons histopatologik. Setelah memperhitungkan faktor perancu, risiko anemia terhadap respons histopatologi yang jelek adalah 6,25 kali (95% CI 1,12-34,90; p=0,037).Simpulan: Anemia merupakan faktor risiko terjadinya respon histopatologik yang jelek pada penderita karsinoma serviks uterisetelah mendapatkan terapi kemoradiasi.
Effect of clomiphene citrate or letrozole of follicles, endometrial and cervical mucus (clinical trials on infertile women with ovulation disorders WHO II) Dewantiningrum, J.; Pramono, Noor; Tjahjanto, H.
Indonesian Journal of Obstetrics and Gynecology Vol. 33. no. 3 July 2009
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Objective: To compare the follicle diameter, the number of mature follicle, quality of endometrium, quality of mucus cervix and a success rate of ovulation between clomiphene citrate (CC) and letrozole.Mterial and methods: Randomized controlled double blind trial was done parallel design non matching from September 1st, 2007 until January 31st, 2008 in Dr. Kariadi General Hospital Semarang. Fourty infertile women with an ovulation WHO II were eligible as subject, divided into 20 subject each according block randomisasion. Dependent variables were CC (50mg/day) and letrozole (2.5mg/day) given on day 3-7 of the menstrual cycle. Independent variable were the follicle diameter, the number of mature follicle, quality of endometrium, quality of mucus cervix and a success rate of ovulation that comparable between groups. Analysis was done using chi square, t test and Mann Whitney comparing independent sample test and Lambda and Spearman correlation with statistically significance if p<0.05.Result: The patient’s characteristics were the same between two group. The follicle diameter were the same between two group CC group is 21.65 (3.58) mm and letrozole group is 19.8 (7.03) mm. Eighteen subject on CC group had mature follicle, 4 had multiple mature follicle. Single mature follicle was found in 13 subject on letrozole group. The number of mature follicle were the same between the two group (p=0.09). Quality of endometrium (p=0.03) dan quality of mucus cervix (p=0.03) were significantly better on letrozole group than CC group (good quality of endometrium and good quality of mucus cervix were 14 vs 6). All subject on CC group and 18 subject on letrozole group had ovulation (p=0.49).Conclusion: There were no significant difference on the follicle diameter, the number of mature follicle and the success rate of ovulation, but the quality of endometrium and mucus cervix were better on letrozole group than CC group.Keywords: clomiphene citrate, letrozole, mature follicle, quality of endometrium, Moghissi’s score and quality of mucus cervix
DARK CHOCOLATE’S EFFECT ON MENSTRUAL PAIN IN LATE ADOLESCENTS Maharani, Sandy Isna; Pramono, Noor; Wahyuni, Sri
Belitung Nursing Journal Vol 3, No 6 (2017): November-December 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.564 KB) | DOI: 10.33546/bnj.292

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Background: Menstrual pain can be severe enough to interfere with everyday activities for a few day every month, particualrly in activities in homes and schools for late adolescents. Dark chocolate is considered effective in reducing menstrual pain. However, little is known about its effect.Objective: This study aimed to examine the effect of dark chocolate on menstrual pain in late adolescents.Methods: This was a true experiment study with randomized pretest-posttest with control group design. This study was conducted from September to November 2016 at the Bhakti Husada Boarding School of Poltekkes Kemenkes Semarang. There were 50 samples recruited by simple random sampling, with 25 randomly assigned to the experiment and control group. Numeric Rate Scale (NRS) was used to measure pain. Independent t-test and Mann-whitney were used to examine the effect of intervention. Results: There were significant differences in menstrual pain (p <0.001) before and after treatment. The mean of menstrual pain in the treatment group (2.76 ) was lower than the menstrual pain in the control group (5.36) with p <0.001.Conclusion: Dark chocolate could reduce menstrual pain significantly in the late adolescents.
EFFECT OF COMBINATION OF OXYTOCIN MASSAGE AND HYPNOBREASTFEEDING ON UTERINE INVOLUTION AND PROLACTIN LEVELS IN POSTPARTUM MOTHERS Nor Aini, Yuni; Hadi, Hadi; Rahayu, Sri; Pramono, Noor; Mulyantoro, Donny Kristanto
Belitung Nursing Journal Vol 3, No 3 (2017): May-June 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.122 KB) | DOI: 10.33546/bnj.102

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Background: The absence of contractions after childbirth can lead to a slow-running uterine involution process. Thus, the effort to maintain and accelerate the process is needed. Oxytocin massage and hypnobreastfeeding are considered as an alternative treatment, but the effect of the combination of the two treatments have not yet been examined.Objective: To examine the effect of combination of oxytocin massage and hypnobreastfeeding on uterine involution and prolactin levels in post partum.Methods: A Quasy experimental study with pretest posttest control group design. a total of 40 respondents were recruited using simple random sampling, with 20 respondents assigned in the treatment and control group. Metline and ELISA methods were used to measure uterine involution prolactin levels. Paired t-test and independent t-test were used to analyze the data.Results: There was a significant decrease of uterine involution in the experiment group and control group after intervention with p-value 0.000 (<0.05), and it can be seen that the uterine involution in the experiment group (6.05) was faster than uterin involution in the control group (7.00).  Findings also showed that the prolactin level in the experiment group (273.53) was higher than the prolactin level in the control group (209.37).Conclusion: There was statistically significant effect of the combination of oxytocin massage and hypnobreastfeeding on the uterine involution and prolactin level in postpartum mothers in the General Hospital of Semarang. It is expected that the combination of oxytocin massage and hypnobreastfeeding can be used as consideration and references in providing postpartum midwifery care.
EFFECT OF MULTI MICRONUTRIENT SUPPLEMENTATION ON HEMOGLOBIN LEVELS IN PREGNANT WOMEN WITH ANEMIA Sari, Rati Purnama; Pramono, Noor; Wahyuni, Sri; Udji Sofro, Muchlis Achsan; Widyawati, Melyana Nurul
Belitung Nursing Journal Vol 3, No 6 (2017): November-December 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.918 KB) | DOI: 10.33546/bnj.291

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Background: The coverage of 90 Fe tablets in Semarang in 2015 was 26.619 of 29.490 pregnant women (97%) but the incidence of anemia in pregnant women was still quite high. One important factor which influences the levels of hemoglobin is multi micronutrient.Objective: This study aims to analyze the changes in hemoglobin levels with multi micronutrient supplementation in pregnant women with anemia.Methods: A Quasy experimental study with randomized control group pre-post test design. The study samples were 40 pregnant women with gestational age of 20 ± 1 weeks divided into two groups, the intervention group (multi micronutrient supplementation) and the control group (Fe supplementation) for 6 weeks. The study was conducted from November 2016 to January 2017. The levels of hemoglobin were measured using cyanmethohemoglobin. Paired t test and independent t test were used for data analyses.Results: The mean increase in hemoglobin levels after multi micronutrient supplementation was 1.545 (1.292) g/dl, whereas the mean increase in hemoglobin levels after Fe supplementation was 0.757 (0.742) g/dl. The difference in hemoglobin levels before and after multi micronutrient supplementation was significantly different (p=0.049). Cohen’s d effect size test showed value of 0.748.Conclusion: Multi micronutrient supplementation could improve hemoglobin levels. Increase in the levels of hemoglobin with multi micronutrient supplementation was higher than Fe supplementation. 
LAVENDER (LAVANDULA ANGUSTIFOLIA) AROMATHERAPY AS AN ALTERNATIVE TREATMENT IN REDUCING PAIN IN PRIMIPAROUS MOTHERS IN THE ACTIVE FIRST STAGE OF LABOR Karo Karo, Hilda Yani; Pramono, Noor; Wahyuni, Sri; Mashoedi, Imam Djamaluddin; Latifah, Leny
Belitung Nursing Journal Vol 3, No 4 (2017): July-August 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.074 KB) | DOI: 10.33546/bnj.159

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Background: Labor and childbirth is an extremely painful process. Aromatherapy is considered as one of the nonpharmacological methods to reduce labor pain.Objective: To determine the effect of Lavender (Lavandula Angustifolia) aromatherapy on the level of pain in primipara in the first stage of labor.Methods: A quasy-experimental research with pretest and posttest design with control group conducted between October until November 2016. Forthy respondents selected using consecutive sampling, which 20 assigned in each group. a Numerical Rating Scale (NRS) pain scale was used. Paired and independent t-test were used for data analyses.Results: The results showed that the p-value of labor pain after intervention was 0.000 (<0.05), which indicated that there was statistically mean difference of labor pain between intervention (6.10) and control group (4.05) in primipara in the first active stage of labor.Conclusion: The women in the lavender aromatherapy group reported lower intensity of labor pain. The intervention study could be practiced in the community health centers for pregnant women in order for them to apply this healing method.
THE IMPACT OF COMBINATION OF ROLLING AND OKETANI MASSAGE ON PROLACTIN LEVEL AND BREAST MILK PRODUCTION IN POST-CESAREAN SECTION MOTHERS Yuliati, Nia Dwi; Hadi, Hadi; Rahayu, Sri; Pramono, Noor; Mulyantoro, Donny Kristanto
Belitung Nursing Journal Vol 3, No 4 (2017): July-August 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.636 KB) | DOI: 10.33546/bnj.150

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Background: Normal childbirth or cesarean section has an effect on the initiation of early breastfeeding. Thus, rolling massage and oketani massage are considered helpful for milk production. However, little is known about the combination of rolling and oketani massage.Objective: To examine the effect of combination of rolling and oketani massage on the levels of prolactin and milk production in post-cesarian section mothers.Methods: A quasy-experimental study with pretest-posttest control group design. Thirty six samples were selected using consecutive sampling, with 18 each assigned to an experiment and control group. Breast milk production was measured based on the baby's weight, while prolactin levels were measured using ELISA method. Data were analyzed using univariate and bivariate analysis.Results: Results showed that there was a statistically significant difference of prolactin levels after intervention in the experiment and control group with p-value 0.035 (<0.005), and significant difference in breast milk production in both groups in posttest 1 and posttest 2 with p-value 0.000 (<0.05).Conclusion: There was statistically significant effect of the combination of rolling and oketani massage on the increase of prolactin levels and breast milk production. It is suggested that this intervention can be applied in midwifery care in post-cesarean section mothers.
EFFECT OF COMBINATION OF BREAST CARE AND OXYTOCIN MASSAGE ON BREAST MILK SECRETION IN POSTPARTUM MOTHERS Hesti, Kadek Yuli; Pramono, Noor; Wahyuni, Sri; Widyawati, Melyana Nurul; Santoso, Bedjo
Belitung Nursing Journal Vol 3, No 6 (2017): November-December 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.815 KB) | DOI: 10.33546/bnj.293

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Background: Optimal nutrition from an early age can be achieved through exclusive breastfeeding (ASI). Lack of milk production is one reason why mothers decide to give formula milk to their babies. Preliminary study at Public Health Center of Batealit Jepara indicated that 60% of mothers unable to breastfeed optimally, thus, breast care and oxytocin massage are proposed to increase milk secretion in postpartum mothers.Objective: To examine the effect of combination of breast care and oxytocin massage on breast milk secretion in postpartum mothers.Methods: This was a quasy experimental study with non-randomized control trial with pretest-posttest control group, conducted in the working area of the Community Health Center of Batealit of Jepara from December 5, 2016 to January 15, 2017. There were 44 postpartum mothers recruited in this study using purposive sampling, which 22 assigned in the experiment and control group. Data were analyzed using dependent t-test and Mann Whitney test.Results: There was a significant increase of breast milk secretion in the experiment and control group with p-value 0.000 (<0.05). In the experiment group, there was an increase of breast milk seceretion from 17.09 to 220.91 cc, and in the control group there was also an increase from 17.09 to 72.00 cc. The mean difference of breast milk secretion between pretest and posttest in the experiment group was 203.82 and in the control group was 54.90 with p-value 0.000 (<0.05)Conclusion: There was a significant increase of breast milk secretion in postpartum mothers after given the combination of oxytocin massage and breast care in the experiment group compared with the education and counseling about breast care in the control group. Thus, this result can be used as an evidence to perform oxytocin massage and breast care to increase the secretion of breast milk in postpartum mothers. 
SWEET POTATO (IPMOEA BATATAS L.) LEAF: ITS EFFECT ON PROLACTIN AND PRODUCTION OF BREAST MILK IN POSTPARTUM MOTHERS Kusuma, Ima Candra; Setiani, Onny; Umaroh, Umaroh; Pramono, Noor; Widyawati, Melyana Nurul; Kumorowulan, Suryati
Belitung Nursing Journal Vol 3, No 2 (2017): March-April 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.42 KB) | DOI: 10.33546/bnj.72

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Background: Sweet potato leaf is assumed to be one of alternative herbs that can increase breast milk production. However, there was no studies found in the literature that examine the sweet potato leaves to increase the levels of prolactin and milk production.Objective: To examine the effect of sweet potato (Ipomoea batatas L.) leaf on the levels of prolactin and milk production in postpartum mothers.Methods: This was a Quasy experimental study with pretest-posttest design with control group, conducted on November 2016 to December 2016 in the Health Center (Puskesmas) of Boyolali I. Thirty respondents were selected using consecutive sampling, which were divided to be 15 respodents in intervention group and 15 respondents in control group. Enzyme-linked immunosobent assay (ELISA) was used to measure prolactin levels, while breast milk production was measured based on the volume of breast milk and baby’s weight. Data were analzed using Independent t-test and paired t-test.Results: Finding showed that there was a significant difference in prolactin levels between the intervention (270.43) and control group (156.28) after intervention  with p-value 0.000, and a significant difference in breast milk production in terms of breast milk volume (intervention group 136.33; and control group 119) with p-value 0.028; and baby’s weight (intervention group 3030.3; and control group 2787.33) with p-value 0.000.Conclusion: There was  a significant effect of sweet potato (Ipomoea batatas L.) leaf on the levels of prolactin and breast milk production. Thus, it could be suggested that sweet potato leaves should be considered to be one of alternative treatements for health care providers, especially for midwives to help breastfeeding mothers in increasing their breast milk production and prolactin levels. Further research is needed to examine all factors affecting breast milk production.