Siti Aliyah Pradono
Department of Oral Medicine, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430

Published : 12 Documents
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Valacyclovir in the Management of Recurrent Intraoral Herpes Infection

Journal of Dentistry Indonesia Vol 21, No 1 (2014): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Infection by Herpes Simplex Virus (HSV) type I and II cause a worldwide medical problems. HSV-I infections are common in oral and perioral area. After primary infection, HSV becomes latent in the dorsal root ganglia and recurrences are caused by many stimuli. Antiviral agents, prevention of transmission, suppression of recurrences are current management of HSV infection. Objective: to discuss the management of Recurrent Intraoral Herpes (RIH) infection. Case report: a 21 years old female patient came to hospital with irregular painful ulcers in her mouth preceded by prodrome, followed with eruption and outbreak of vesicles. The first laboratory examination confirmed high titer of reactive Immunoglobulin M (IgM) and IgG of anti HSV-I and HSV-II. She was diagnosed to have RIH and treated with oral Acyclovir, multivitamins, immune stimulant and 0.2% chlorhexidine gargle with good healing. Oral Valacyclovir was given after she had another recurrence, with the result of low episodes of RIH and continuous titer improvement of reactive IgM and IgG of anti HSV-I and HSV-II. Conclusion: Oral administration of Valacyclovir as a the oral prodrugs of Acyclovir is effective prophylactic and therapeutic option with many advantages against HSV infection.

The Use Of Acyclovir And Phyllanthusniruri Supplement as Medication For Recurrent Intraoral Herpes Infections

Journal of Dentistry Indonesia Vol 17, No 2 (2010): August
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Recurrent intraoral herpes infection (RIH) is one of the recurrent herpes simplex virus type-1 infections (HSV-1). It presents as single or clustered painful ulcers occur mainly on the keratinized mucosa, with the size of one to five millimeter. The Onset of RIH is considered to be associated with various endogenous and exogenous triggers. Therefore, it is important to recognize each individual triggers to prevent and to minimize and the infection for recurring. This report will describe three cases of RIH associated with emotional and physical stress. All patients have experienced continous recurrence of the disease for almost a year. Symptoms included painful multiple minute ulcers on oral mucosa initiated with fever. Serology investigation on antibody against HSV-1 confirmed a reactive elevation in these patients. Treatment consisted of acyclovir per oral 1000 mg daily per oral, counseling on stress condition and intake of nutritional supplementation. Nevertheless, stress conditions were difficult to overcome, therefore long-term medications were recommended to prevent recurrence episodes. One patient was taken a long-term acyclovir therapy and the other two patients were taken long-term acyclovir therapy with Phyllanthusniruri (Meniran) supplementation. Follow-ups on three cases showed the benefit of taking Phyllanthusniruri (Meniran) supplementation as reduction in RIH symptoms, shorten healing time and prolonged recurrence interval.DOI: 10.14693/jdi.v17i2.47

TERAPI KORTIKOSTEROID PADA PEMPHIGOID MEMBRAN MUKOSA MULUT DAN EFEK SAMPINGNYA (LAPORAN KASUS)

Journal of Dentistry Indonesia Vol 10, No 1 (2003): APRIL
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Mucous membrane pemphigoid (MMP), also known as cicatrical pemphigoid, is a chronic, autoimmune, subepithelial blistering disease primarily affecting people over 50 years old. MMP may affect any mucosal surface, which is particularly oral mucosa, conjuctiva, esophagus, or larynx is involved. MMP rarely occurs in children and adolescents, but several cases of MMP affecting 2 to 18 years old patients old male patient who had been diagnosed with oral mucous membrane pemphigoid by anamnesis, clinical feature, histopathology. The patient was treated with systemic corticosteroid, topical corticosteroid, oral rinse and multivitamins. Until recently corticosteroid remains as the most effective and the drug of choice to treat pemphigoid lesions. Clinicians need to pay attention in using this drug because of its potential side effect.

GAMBARAN KLINIK DAN LATAR BELAKANG PASIEN DENGAN DIAGNOSIS KLNIK SEBAGAI LICHEN PLANUS DI POLI PENYAKIT MULUT RSCM DAN RSGM

Journal of Dentistry Indonesia Vol 7, No 2 (2000)
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Lichen planys is disorder of the skin and mucous membrane that presenting pruritic, purple and polygonal papules. Oral lesions may persist for years and with clinical appearance that sometimes very ocnfusing. In most cases, oral lesions are present as white, reticulated or natelike areas involving the mucosa. These lesions are characteristic and called Wickhams striae. This paper presented some cases with lesions that resembled oral lichen planus.

LESI ULSERASI RONGGA MULUT YANG SERING DIJUMPAI BERHUBUNGAN DENGAN INFEKSI VIRUS

Journal of Dentistry Indonesia Vol 10, No 2 (2003): AUGUST
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

The oral mucosa is the target of a number of infectious processes caused by a range of organism. Viruses is one of the organism which is considered in oral mucosal damage. Recently, the main viruses causing oral mucosal infections are the large herpes group. This article discuss herpes simplex virus and varicella zoster virus that cause herpetic stomatitis and herpes zoster, with particular attention to the typical oral manifestations, current treatmetn options. Dentists should recognize the clinical appearances of the diseases, so the appropriate therapy can be done.

Daylong Effect of Rinsing with Water Diluted Antiplaque®Toothpaste Combined with Toothbrushing on Volatile Sulphur Compound Levels

Journal of Dentistry Indonesia Vol 16, No 2 (2009): August
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Halitosis, complained by most adult population, is a common oral condition. About 8%% of the cases happened because of the microbia activity in the oral cavity that produces Volatile Sulphur Compound (VSC) which has unpleasant odour. Daily oral prophylaxis can reduce the oral VSC levels. Objective: to determine the daylong effect of Antiplque® toothpaste in daily oral prophylaxis: as dentrifice for tooth brushing and, in modified way, as oral rinse; on the VSC level. Methods: a double blind, clinical experimental study, involving 120 subjects with or without halitosis complain, divided in 2 treatment groups (oral rinse group and the combination of tooth brushing and oral rinse group, using Antiplaque® toothpaste) and 2 control groups (same procedure using placebo toothpaste). The daylong VSC levels measure with halimeter were taken twice, in the afternoon day I and day II. Results: there are significant reduction of daylong VSC levels (Wilcoxon signed rank test P<0.0%), but not in the treatment groups using the placebo toothpaste. The result on conbination of tooth brushing and oral rinse using Antiplaque® toothpaste are significant compared to the oral rinse treatment using Antiplaque® toothpaste alone (Mann Whitney, P<0.05). Conclusion: tooth brushing with Antiplaque® toothpaste combined with oral rinse using the modified Antiplaque® toothpaste can significantly reduce daylong VSC levels.DOI: 10.14693/jdi.v16i2.94

Uji Klinik Efektifitas Pasta Gigi Antiplaque™ terhadap Kesembuhan Lesi dan Rekurensi Sariawan (Stomatitis Aftosa Minor)

Journal of Dentistry Indonesia Vol 5, No 2 (1998): August
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Treatment of Recurrent Aphthous Stomatitis (RAS) often becomes a problem until now. It is because of the RAS characteristic that has a high recurrence, unclear etiology and has a lot of predisposing factors. Antiplaque™ tooth paste with active ingredients of Sodium monophosphate, Arnica tincture, Cloxiphenol and Oleum cariofill, has been used in this study to accelerate healing and to reduce the recurrence of RAS. Ninety one students and employees of Faculty of Dentistry, University of Indonesia who have minor RAS as subjects were divided into study group and control group. Regarding of healing the results of 58.7% from study group compared to 35.9% from control group, implies that the lesions healed faster. RAS recurrence of 83.3% from study group compared to 42.9% from control group states that recurrence had decreased.

Xerostomia akibat Terapi Radiasi Leher dan Kepala pada Penderita Kanker Tiroid

Journal of Dentistry Indonesia Vol 9, No 1 (2002): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

Saliva is essential for preservation of oral health. It aids in preparation of the initial food bolus, assist in taste and swallowing, and lubricates the oral mucosa. In addition it has antiviral, antifungal, and antibacterial properties. Consequently, salivary gland dysfunction can lead to complaints of oral dryness (xerostomia). Diseases of the thyroid gland, hyperthyroidism and hypothyroidsm, and their treatment have also been suggested to cause salivary gland dysfunction. In addition head and neck radiation therapy, treatment for head and neck cancers can cause irreversible salivary gland function. This case study, reported on patient with thyroid cancer in which the thyroid gland has been removed and received head and neck radiation therapy.  

Is it herpes or aphthae lesions?

Padjadjaran Journal of Dentistry Vol 20, No 1 (2008): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

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Abstract

Is it herpes or aphthae lesions?

Unidentified angular recurrent ulceration responsive to antiviral therapy

Dental Journal (Majalah Kedokteran Gigi) Vol 46, No 1 (2013): (March 2013)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

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Abstract

Background: Recurrent ulcer on angular area is usually called stomatitis angularis. It is caused by many factors such as vertical dimension reduce, vitamin B12, and immune system deficiency, C. albicans and staphylococcus involvement. Clinically is characterized by painful fissure with erythematous base without fever. Purpose: to describe an unidentified angular ulcer proceeded by recurrent ulcers with no response of topical therapy. Case: An 18-years old male came to Oral Medicine clinic in RSCM who complained of angular recurrent ulcers since 3 years ago which developed on skin and bleed easily on mouth opening. Patient had fever before the onset of ulcers. Large, painful, irregular ulcers covered by red crustae on angular area bilaterally. Patient has been treated with various drugs without improvement and lead to mouth opening limitation. Intra oral shows herpetiformtype of ulcer and swollen of gingival. Case management: Provisional diagnosis was established as viral infection thus acyclovir 200 mg five times daily for two weeks and topical anti inflammation gel were administered. Blood test for IgG/IgM of HSV1 and HSV2 were non reactive, however ulceration showed a remarkable improvement. The ulcers healed completely after next 2 weeks with acyclovir. Conclusion: The angular ulceration on above patient failed to fulfill the criteria of stomatitis angularis or herpes labialis lesion. However it showed a good response to antiviral. Therefore, unidentified angular ulceration was appointed, as the lesion might be triggered by other type of human herpes virus or types of virus that response to acyclovir.Latar belakang: ulser rekuren pada sudut mulut biasanya disebut stomatitis angularis. Kelainan ini disebabkan oleh banyak faktor seperti berkurangnya dimensi vertikal, defisiensi vitamin B12 dan sistem kekebalan tubuh, infeksi C. albicans serta staphylococcus. Secara klinis kelainan ini ditandai dengan fisur sakit pada sudut mulut dengan dasar eritematus tanpa disertai demam. Tujuan: Melaporkan kasus ulser sudut mulut rekuren yang tidak biasa, tanpa respon terhadap terapi topikal yang biasa diberikan. Kasus: Seorang lakilaki berusia 18 tahun datang ke klinik Penyakit Mulut RSCM dengan keluhan ulser rekuren pada sudut mulut yang meluas ke kulit sekitarnya sejak 3 tahun yang lalu. Ulser mudah berdarah saat pasien membuka mulut dan demam sebelum lesi timbul. Ulser membesar, bilateral, sakit, tepi tidak teratur, ditutupi oleh krusta merah. Pasien telah diobati dengan berbagai obat, namun tidak menunjukkan perbaikan. Intra oral tampak ulser jenis herpetiformis pada gingiva disertai dengan pembengkakan. Tatalaksana kasus: Diagnosis awal ditegakkan sebagai infeksi virus, oleh karena itu pasien diberikan acyclovir 200 mg lima kali sehari selama dua minggu dan gel anti radang topikal. Walaupun hasil darah IgG/IgM HSV1 dan HSV2 non reaktif, namun ulserasi menunjukkan penyembuhan yang luar biasa dengan anti virus yang diberikan. Ulser sembuh sempurna setelah pemakaian acyclovir 2 minggu berikutnya. Kesimpulan: ulserasi sudut mulut pada pasien di atas gagal memenuhi kriteria stomatitis angularis atau herpes labialis. Namun ulser menunjukkan respon yang amat baik terhadap antivirus. Diagnosis ditetapkan sebagai ulserasi sudut mulut yang tidak teridentifikasi. Kemungkinan lesi dipicu oleh virus herpes manusia jenis lain atau jenis virus yang memberikan respon terhadap asiklovir.