Wiryawan Permadi
Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

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Embryo Quality: The Most Critical Factor for Pregnancy Rates after day-2, day-3, and day-5 of Embryo Transfer Djuwantono, Tono; Permadi, Wiryawan; Harlianto, Harris; Ritonga, Mulya Nusa Amrulah; Halim, Danny; Achmad, Tri Hanggono; Faried, Ahmad
Indonesian Journal of Obstetrics and Gynecology Vol. 34. No. 4. October 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Objective: To determine the most critical factor on day-2, day-3, and day-5 of embryo transfer in correlation with pregnancy rates.Method: This research is a retrospective study in Aster Fertility Clinic, IVF program- Dr. Hasan Sadikin Hospital, Bandung, Indonesia. One hundred ninety five women enrolled in an IVF program conducted from March 2006 through November 2009 at the Aster Fertility Clinic. Effect of embryo-transfer day and any other factors (including quality of embryo, oocyte quantity, difficulty of embryo transfer technique, and blood or mucus contamination on the catheter) on pregnancy rate in IVF.Results: The mean age of the pregnant group was 34.65 (SD = 3.91), and the mean of the infertility period was 7.25 years (SD = 3.54). There were no siginificant differences in pregnancy rates in the day-2, day-3, and day-5 groups. The most critical factor influencing pregnancy was the total score for the quality of embryos [p = 0.001; OR (CI 95%) = 1.94 (0.91 - 4.08)]. Otherwise, the day of embryo transfer, oocyte quantity, and difficulties in embryo transfer did not affect the pregnancy rate (p > 0.05).Conclusion: Our study suggests that the total score for the quality of the embryos was the most critical factor for the success rate of pregnancy rather than the day of embryo transfer, oocyte quantity, difficulty of embryo transfer technique, or contamination of blood and mucus on the catheter.[Indones J Obstet Gynecol 2010; 34-4: 175-9]Keywords: day of embryo transfer, in vitro fertilization, quality of embryo total score, oocytes quantity, catheter contaminationTujuan: Untuk menentukan faktor yang terpenting pada keberhasilan kehamilan setelah transfer embrio hari ke-2, ke-3 dan ke-5.Metode: Penelitian ini adalah studi retrospektif di klinik Fertilitas Aster, Program IVF- Rumah Sakit Dr. Hasan Sadikin, Bandung, Indonesia. Penelitian ini melibatkan seratus sembilan puluh lima perempuan yang mengikuti program IVF sejak Maret 2006 hingga Nopember 2009. Efek dari waktu (hari) transfer embrio dan faktorfaktor lainnya (termasuk kualitas embrio, jumlah oosit, kesulitan dalam teknik transfer embrio, dan kontaminasi darah atau mukus dalam kateter) terhadap angka keberhasilan kehamilan pada IVF.Hasil: Rata-rata usia perempuan hamil pada penelitian ini 34,65 (SD = 3,91), dan rata-rata periode infertilitas 7,25 (SD = 3,54). Tidak terdapat perbedaan bermakna pada angka kebehasilan kehamilan setelah transfer embrio baik pada hari ke-2, -3 dan -5. Faktor terpenting yang mempengaruhi keberhasilan kehamilan adalah skor total dari kualitas embrio [p = 0,001; OR (CI 95%) = 1,94 (0,91 - 4,08)]. Dilain fihak, waktu transfer embrio, jumlah oosit, kesulitan dalam teknik transfer embrio tidak mempengaruhi kebehasilan kehamilan (p > 0,05).Kesimpulan: Hasil studi kami menunjukkan bahwa faktor terpenting yang mempengaruhi keberhasilan kehamilan adalah skor total dari kualitas embrio dibandingkan dengan waktu transfer embrio, jumlah oosit, kesulitan dalam teknik transfer embrio, atau kontaminasi darah dan mukus dalam kateter.[Maj Obstet Ginekol Indones 2010; 34-4: 175-9]Kata kunci: hari setelah transfer embrio, fertilisasi in vitro, skor total dari kualitas embrio, jumlah oosit, kontaminasi kateter
The Rise of Inhibin A Serum Level in Preterm Labor Haribudiman, Oky; Effendi, Jusuf S; Permadi, Wiryawan
Indonesian Journal of Obstetrics and Gynecology Vol. 35. No 3. July 2011
Publisher : Indonesian Journal of Obstetrics and Gynecology

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AbstractObjective: The purpose of this study was to measure inhibin A serum level in women with preterm delivery, thus determining any correlation between inhibin A serum and gestational age in preterm delivery.Method: The design of our study was cross sectional with 36 subjects who came to Dr. Hasan Sadikin Hospital, Bandung and six satellite hospitals in July-August 2011 and met inclusion-exclusion criteria. Inhibin A serum level was measured with ELISA. Inhibin A serum level in preterm labor and was compared using independent t test, and correlation between inhibin A serum level and gestational age in patients with preterm labor was calculated using Pearson correlation test.Result: Characteristics test in both groups showed that both are homogeneous and comparable. The mean inhibin A serum level in preterm labor was higher (845.733 pg/ml) compared with preterm gestation (568.203 pg/ml) (p = 0.025). There was a significant correlation between inhibin A serum level and gestational age in preterm labor (p = 0.023) with a correlation coefficient of 0.38, indicating a moderate positive relationship.Conclusion: Inhibin A serum level in preterm labor was higher than preterm pregnancy. In preterm labor, inhibin A serum level increases with gestational age.[Indones J Obstet Gynecol 2011; 35-3: 110-4]Keywords: preterm delivery, inhibin A serum level
Total Serum Level of Calcium and Ion Calcium is Lower in Hypotonic Uterine Inertia Wattimury, Josef; Permadi, Wiryawan; Armawan, Edwin
Indonesian Journal of Obstetrics and Gynecology Vol. 1 No. 3 July 2013
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Objectives: To know the correlation between total and ion serum calcium level with the uterine contractility of laboring patient.Methods: This is a cross-sectional analytic correlative study measuring the strength of correlation of total and ion calcium serum level between groups with hypotonic uterine inertia - and normal labor. Each group consists of 20 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital in August - September 2012. Statistical analysis was performed by using Eta (η) coefficient.Results: Mean total calcium serum level on hypotonic uterine inertia is 6.66 mg/dl, while mean of total calcium serum level on normal labor is 8.56 mg/dl, with Eta (η) correlation coefficient 0.721. Mean ion calcium serum level on hypotonic uterine inertia is 4.14 mg/dl, while mean of total calcium serum level on normal labor is 4.92 mg/dl, with Eta (η) correlation coefficient 0.802.Conclusion: Total serum level of calcium and ion calcium in hypotonic uterine inertia is lower than the level of which in normal labor. There is a strong correlation between total and ion serum calcium level with uterine contractility, the Eta (η) correlation coefficient are 0.721 and 0.802 respectively.Keywords: hypotonic uterine inertia, ion serum calcium level, normal labor, total serum calcium level
Efek Olive Oil dan Virgin Coconut Oil terhadap Striae Gravidarum Pratami, Evi; Permadi, Wiryawan; Gondodiputro, Sharon
Majalah Kedokteran Bandung Vol 46, No 1 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.%v46n1.%220

Abstract

Prevalensi striae gravidarum (SG) pada ibu hamil berkisar 50% sampai 90%. Efek SG menyebabkan rasa gatal, panas, dan kering serta gangguan emosional sehingga menimbulkan masalah kosmetik pada sebagian besar ibu. Saat ini banyak ibu hamil menggunakan olive oil untuk mencegah SG, namun minyak ini relatif sukar didapat dan harganya mahal. Di Indonesia dikenal minyak lain yaitu virgin coconut oil (VCO) yang memiliki kandungan efektif untuk menjaga elastisitas kulit, minyak ini mudah didapat dan murah. Penelitian ini bertujuan menganalisis perbedaan dan korelasi efek olive oil dan VCO terhadap SG. Penelitian ini dilaksanakan pada bulan Maret−Juli 2012. Rancangan penelitian ini merupakan penelitian klinis melalui pendekatan eksperimental. Subjek penelitian adalah 80 ibu hamil di wilayah Dinas Kesehatan Kota Surabaya dan dikelompokkan menjadi 2 kelompok dengan menggunakan random permuted blocks. Hasil penelitian menunjukkan tidak terdapat perbedaan SG berdasarkan jumlah garis dan tingkat eritema antara kelompok yang menggunakan olive oil dan VCO (p=0,156 dan 1,00). Selanjutnya terdapat korelasi kuat antara kelompok olive oil dan VCO dengan jumlah garis (r=-0,576 dan -0,560) dan tingkat eritema (r=-0,699 dan -0,586). Simpulan, tidak ada perbedaan efek olive oil dengan VCO terhadap SG. [MKB. 2014;46(1):1–5]Kata kunci: Olive oil, striae gravidarum, virgin coconut oilEffects of Olive Oil and Virgin Coconut Oil against Striae GravidarumThe prevalence of striae gravidarum (SG) in pregnant women ranges from 50% to 90%. Effects of SG include itchy and hot feeling as well as dry skin. This situation also causes emotional disturbances that poses a cosmetic problem for most pregnant women. Nowadays, many pregnant women use olive oil to prevent SG, but it is relatively difficult to find and costly. In Indonesia, a similar oil, virgin coconut oil (VCO), has been used by many pregnant women for the same reason. The aim of this study was to analyze the differences and correlation between effects of olive oil and VCO against SG. The study was conducted in March−July 2012. An experimental study was performed on 80 pregnant women in Surabaya Municipality and they were divided into 2 groups using random permuted blocks. The results of this study showed that there was no difference in SG appearance based on the number of lines and levels of erythema between groups (p=0.156 and 1.00). Furthermore, there was a strong negative correlation between the effect of olive oil or VCO on the number of lines (r=-0.576 and -0.560) and the level of erythema (r=-0.699 and -0.586). In conclusion, there is no difference in the effect of olive oil and VCO against SG. [MKB. 2014;46(1):1–5]Key words: Olive oil, striae gravidarum, virgin coconut oil DOI: 10.15395/mkb.v46n1.220
Total Serum Level of Calcium and Ion Calcium is Lower in Hypotonic Uterine Inertia Wattimury, Josef; Permadi, Wiryawan; Armawan, Edwin
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.642 KB) | DOI: 10.32771/inajog.v1i3.354

Abstract

Objectives: To know the correlation between total and ion serum calcium level with the uterine contractility of laboring patient. Methods: This is a cross-sectional analytic correlative study measuring the strength of correlation of total and ion calcium serum level between groups with hypotonic uterine inertia - and normal labor. Each group consists of 20 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital in August - September 2012. Statistical analysis was performed by using Eta (η) coefficient. Results: Mean total calcium serum level on hypotonic uterine inertia is 6.66 mg/dl, while mean of total calcium serum level on normal labor is 8.56 mg/dl, with Eta (η) correlation coefficient 0.721. Mean ion calcium serum level on hypotonic uterine inertia is 4.14 mg/dl, while mean of total calcium serum level on normal labor is 4.92 mg/dl, with Eta (η) correlation coefficient 0.802. Conclusion: Total serum level of calcium and ion calcium in hypotonic uterine inertia is lower than the level of which in normal labor. There is a strong correlation between total and ion serum calcium level with uterine contractility, the Eta (η) correlation coefficient are 0.721 and 0.802 respectively. [Indones J Obstet Gynecol 2013; 1-3: 145-8] Keywords: hypotonic uterine inertia, ion serum calcium level, normal labor, total serum calcium level
Correlation between Sperm Motility and Morphology in the Success Rate of in Vitro Fertilization Procedure Ramadhan, Praditya Virza; Rezano, Andri; Permadi, Wiryawan
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Background: In vitro fertilization (IVF) is one of the assisted reproductive technology that has been used in treating infertility. Unfortunately, not every IVF procedure achieves 100% success in fertilizing the oocyte. It has been studied that the percentage of normal motile sperm and percentage of normal sperm morphology play a key role in this process. This study was conducted to evaluate correlation between sperm motility and morphology in the success rate of IVF. Methods: This study was an observational analytic involving medical records of infertile couples who were treated by IVF procedure in Dr.Hasan Sadikin General Hospital Bandung in 2009–2014. The variables that were used in this study were percentage of sperm motility, percentage of sperm morphology and fertilization rate.The collected data was analyzed using nonparametric Mann Whitney test and Spearman correlation test.Result: This study showed that there was a significant difference between the fertilization rate group and sperm motility (p=0,048) but there was no significant correlation between motility and the entire fertilization rate (p=0,319). This study also indicated that there was no significant difference between fertilization rate group and sperm morphology (p=0,232) and there was no significant correlation between sperm morphology and fertilization rate (p=0,720).Conclusions: Motility might has a role in determining the success rate of in vitro fertilization; meanwhile morphology does not have any role in determining the success rate of in vitro fertilization. [AMJ.2016;3(4):520–5] DOI: 10.15850/amj.v3n4.957
Apakah Kadar β-hCG Praevakuasi dan Gambaran Proliferasi Sel Trofoblas secara Mikroskopik dapat digunakan untuk Prediksi Transformasi Keganasan pada Mola Hidatidosa? Mantilidewi, Kemala Isnainiasih; Zulvayanti, Zulvayanti; Permadi, Wiryawan
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstrakTujuan: Meneliti perbedaan karakteristik umur, paritas, besar uterus, kadar β-hCG, dan hiperproliferasi pada mola hidatidosa (MH) dengan regresi spontan dan pada MH dengan transformasi keganasan di RS Dr.Hasan Sadikin Bandung. Metode: Penelitian cross sectional deskriptif restrospektif mengambil data umur, paritas, besar uterus, kadar β-hCG pre-evakuasi, dan hiperproliferasi dari rekam medis pasien MH periode 2007-2016. Data diolah menggunakan program SPSS versi 20.0 for Windows. Nilai p<0,05 dianggap signifikan. Hasil: Dari 400 rekam medis yang dianalisis, 233 dengan data lengkap dapat dianalisis. Mayoritas pasien usia reproduktif 20-35(53,6%) tahun, paritas 1-2 (n=90, 38,6%), dan besar uterus rata-rata 19,12±4,633 (~minggu kehamilan). Kadar β-hCG <100000 mIU/mL sebanyak 78(33,5%), ≥100000 mIU/mL sebanyak 155(66,5%). Pasien dengan hiperproliferasi sebanyak 83(35,6%) sedangkan pasien tanpa hiperproliferasi sebanyak 150(64,4%). Terdapat 219(94,0%) dengan komplit MH, dan 14(6,0%) HM parsial (tidak dipublikasi). Pasien kemudian dikategorikan menjadi kelompok transformasi keganasan dan kelompok remisi spontan. Tidak terdapat perbedaan umur, paritas, dan besar uterus diantara dua kelompok (p>0,05). Perbedaan kadar βhCG (mIU/mL) dan tingkat proliferasi menunjukkan hasil signifikan (p<0.05). Kesimpulan: Kadar β-hCG preevakuasi dan status hiperproliferasi dapat digunakan sebagai prediktor transformasi keganasan pasien MH. Kata kunci: Mola hidatidosa, faktor risiko, remisi, transformasi keganasanCan Preevacuation Level β-hCG and Microscopic Trophoblast ProliferationPredict Malignant Transformation in Hydatidiform Mole?AbstractObjective: To describe differences among age, parity, size of uterus, level of β-hCG, and hyperproliferation state in HM with spontaneous remission and in that with malignancy transformation at dr.Hasan Sadikin General Hospital Bandung. Methods: This a cross sectional descriptive restrospective study of HM cases analyzing data on age, parity, size of uterus, pre-evacuation level of β-hCG, and hyperproliferation state taken from medical record of HM patients between 2007-2016. Data were statistically analyzed using SPSS version 20.0 for Windows. Result p<0.05 was considered significant.  Results: Out of 400 cases, 233 cases were selected. Those with incomplete data were not included in the analysis. Majority of patients were in reproductive age 20-35(53.6%) years old, has parity 1-2(n=90, 38.6%), and the size of uterus has mean 19.12±4.633 (~week of pregnancy). The level of β-hCG <100000 mIU/mL was 78(33.5%), ≥100000 mIU/mL was 155(66.5%). Patients with hyperproliferation were 83(35.6%) while without hyperproliferation were 150(64.4%). There were 219(94.0%) with complete HM, and 14(6.0%) partial HM (unpublished data). There were no significant differences in age, parity, size of uterus between the two groups (p>0.05). Differences on level of βhCG (mIU/mL) and proliferation state showed significant result (p<0.05). Conclusion: Preevacuation level of β-hCG and histopatology (proliferation state) may predict malignancy transformation in HM.Keywords: Hydatidiform mole, risk factors, remission, malignancy transformation
Pengaruh Pijat Punggung dan Memerah ASI terhadap Produksi ASI pada Ibu Postpartum dengan Seksio Sesarea Astuti, Retno Puji; Rusmil, Kusnandi; Permadi, Wiryawan; Mose, Johanes C; Effendi, Jusuf Sulaeman; Herawati, Dewi M.D
Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care Vol 2, No 1 (2015): Maret
Publisher : Program Studi Magister Kebidanan FK UNPAD

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.007 KB) | DOI: 10.24198/ijemc.v2i1.7

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Produksi ASI yang sedikit pada hari-hari pertama setelah melahirkan menjadi kendala dalampemberian ASI secara dini pada tindakan seksio sesarea. Pengaruh anestesi pada ibu pasca seksio sesarea menyebabkan terhambatnya pengeluaran hormon oksitosin. Perlu dilakukan stimulasi reflek oksitosin dengan pijat punggung dan memerah ASI. Tujuan penelitian ini untuk menganalisis pengaruh pijat punggung dan memerah ASI terhadap produksi ASI pada ibu Postpartum dengan seksio sesarea. Penelitian ini menggunakan metode quasi experiment dengan rancangan posttest only design with nonequivalent groups. Populasi penelitian ini adalah ibu Postpartum dengan seksio sesarea di RSIA Buah Hati Pamulang, Tangerang Selatan. Pengambilan sampel ini dilakukan dengan teknik non- random sampling dengan metode consecutive sampling. Jumlah sampel 60 responden yang dibagi menjadi 30 responden kelompok intervensi dan 30 responden kelompok kontrol. Pengolahan dan analisis data menggunakan uji chi-Square dan uji exact fisher. Hasil penelitian ini menunjukkan adanya pengaruh pijat punggung dan memerah ASI terhadap produksi ASI pada ibu postpartum dengan seksio sesarea dengan nilai Number Needed to Treat (NNT) = 3,3 dan nilai RR sebesar 2,8 serta nilai p = 0,012 menunjukkan adanya perbedaan yang signifikan produksi ASI antara kelompok intervensi dan kelompok kontrol. Besarnya pengaruh pijat punggung dan memerah ASI berdasarkan karakteristik Ibu, ditinjau dari usia 20-34 tahun pada kelompok intervensi dengan produksi ASI yang lancar nilai p = 0,011. Paritas dengan multiparitas nilai p = 0,013. Pendidikan dengan tamat SMA nilai p = 0,016. Pekerjaan dengan status tidak bekerja nilai p = 0,023. Simpulan dalam penelitian ini adalahtindakan pijat punggung dan memerah ASI berpengaruh baik terhadap produksi ASI yang lancar pada ibu postpartum dengan seksio sesarea. Selain itu, usia 20 – 34 tahun, paritas dengan multiparitas, pendidikan tamat SMA dan ibu yang tidak bekerja berpengaruh baik pada produksi ASI yang lancar. Saran untuk bidan dapat melakukan pijat punggung dan memerah ASI pada ibu postpartum dengan seksio sesarea maupun spontan dalam meningkatkan produksi ASI
Korelasi antara Kadar Vitamin D dengan Kejadian Preeklamsi Retnosari, Ekadewi; Permadi, Wiryawan; Setiawati, Elsa Pudji; Husin, Farid; Mose, Johanes Cornellius; Sabarudin, Udin
Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care Vol 2, No 4 (2015): Desember
Publisher : Program Studi Magister Kebidanan FK UNPAD

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.877 KB) | DOI: 10.24198/ijemc.v2i4.34

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Program Pembangunan Kesehatan di Indonesia dewasa ini masih diprioritaskan pada upaya peningkatan derajat kesehatan ibu dan anak, terutama pada kelompok yang paling rentan kesehatannya yaitu ibu hamil, ibu bersalin dan bayi pada masa perinatal. Hal ini ditandai dengan tingginya Angka Kematian Ibu (AKI). Menurut Survei Demografi Kesehatan Indonesia (SDKI) tahun 2012, AKI tahun 2007 sebesar 228/100.000 Kelahiran Hidup (KH) meningkat menjadi 359 /100.000 KH. Penyebab langsung kematian ibu adalah faktor yang berhubungan dengan komplikasi kehamilan, persalinan dan nifas seperti perdarahan, preeklamsi/eklamsi dan infeksi. Preeklamsi  merupakan gangguan multifaktorial. Beberapa penelitian memperlihatkan adanya bukti yang mendukung tentang kadar vitamin D yang berperan untuk terjadinya komplikasi kehamilan. Sumber vitamin D berasal dari sintesis endogen (matahari) dan sintesis eksogen (makanan). Sinar ultraviolet dapat mengubah pre vitamin D menjadi  vitamin D3. Indonesia terletak didaerah tropis yang kaya akan sinar ultraviolet, tetapi masih banyak ibu hamil yang menderita preeklamsi, sehingga tujuan dari penelitian ini adalah menganalis hubungan antara kadar vitamin D dengan kejadian preeklamsi. Populasi dalam penelitian ini adalah semua ibu hamil yang di diagnosis preeklamsi dan di diagnosis hamil normal yang melakukan pemeriksaan di RSUD H.M. Rabain dan  empat puskesmas di wilayah kabupaten Muara Enim. Total sampel 76 orang yang terdiri dari 38 orang kelompok kasus dan 38 orang kelompok kontrol. Rancangan penelitian dengan metode analitik yang dilakukan secara cross sectional. Analisis hasil dengan uji korelasi Point Biserial. Hasil penelitian dengan uji korelasi Point Biserial menunjukkan bahwa tidak terdapat hubungan antara kadar vitamin D dengan kejadian preeklamsi dengan nilai p  0,052. Simpulan dalam penelitian ini adalah tidak terdapat hubungan antara kadar vitamin D dengan kejadian preeklamsi awitan dini. Kadar vitamin D berkaitan  dengan awitan lanjut pada kejadian preeklamsi yang merupakan bagian dari faktor maternal, disamping itu kejadian preeklamsi sampai saat ini dipengaruhi oleh etiopatogenesis yang kompleks.
Perbandingan Kadar 25-(OH)-Vitamin D3 pada Serum Kelompok Mioma Uteri dan Non-Mioma Uteri Masoem, Aria Prasetya; Djuwantono, Tono; Ritonga, Mulyanusa A.; Effendi, Jusuf Sulaeman; Permadi, Wiryawan; Madjid, Tita Husnitawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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Abstract

AbstrakTujuan: Penelitian ini bertujuan untuk membandingkan perbedaan kadar 25-hidroksi-vitamin D3 pada serum kelompok mioma uteri dan non-mioma uteri. Metode: Penelitian ini merupakan penelitian analitik observasional dengan rancangan komparatif cross sectional. Subjek penelitian adalah wanita usia reproduksi yang menjalani prosedur laparatomi/laparaskopi yang memenuhi kriteria inklusi penelitian (n=42). Subjek penelitian dibagi menjadi dua kelompok, yakni kelompok mioma uteri (n=21) dan non-mioma uteri (n=21). Pada kedua kelompok dilakukan pemeriksaan kadar serum 25-hidroksi-vitamin D3 kemudian diperiksa dengan metode Electro-chemiluminescence Immunoassay (ECLIA). Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Juni−Agustus 2017. Hasil: Hasil penelitian menunjukkan kadar 25-hidroksi-vitamin D3 rata-rata pada kelompok mioma uteri adalah 6,70 (3,29) ng/ml, sementara pada kelompok non-mioma uteri 10,34 (2,79) ng/ml. Perbedaan kadar rata-rata 25-hidroksi-vitamin D3 pada kedua kelompok tersebut bermakna dengan nilai p<0,001. Namun, tidak didapatkan korelasi antara kadar 25-hidroksi-vitamin D3 dengan berat massa mioma uteri. Kesimpulan : Kadar 25-hidroksi-vitamin D3 pada kelompok mioma uteri lebih rendah dibandingkan dengan kelompok non-mioma uteri. Key words: Mioma uteri, vitamin D,  25-hidroksi-vitamin D3Abstract Objective: The aim of this study was to determine if there is any significant difference between serum levels of 25-hydroxy-vitamin D3 of uterine fibroid group and non-uterine fibroid group. Method: This was an observational analytic study with comparative cross-sectional method. Subjects were women in reproductive age who underwent laparotomy / laparoscopy procedures who met the study criteria (n=42). The subjects were divided into two groups, uterine fibroid group (n=21) and non-uterine fibroid (n=21). Measurement of serum 25-hydroxy-vitamin D3 was performed using Electro-chemiluminescence Immunoassay (ECLIA) method. The study was conducted at Dr. Hasan Sadikin hospital in June−August 2017. Result: The results showed the mean level 25-hydroxy-vitamin D3 on uterine fibroid group was 6.70 (3.29) ng / ml and non-uterine fibroid group 10.34 (2.79) ng/ml. There was significant difference between serum level of 25-hydroxy-vitamin D3 in uterine fibroid group and non-uterine fibroid with p value <0.001. But, there was no correlation between serum level of 25-hydroxy-vitamin D3 content and the weight of uterine fibroid mass. Conclusions: Serum level of 25-hydroxy-vitamin D3 is lower in uterine fibroid group than non-uterine fibroid group.Key words: Uterine fibroid, vitamin D, 25-hydroxy-vitamin D3