Heri Nugroho
Staf pengajar bagian Ilmu Penyakit Dalam Fakultas Kedokteran UNDIP Semarang

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Artemisia annua Leaf Extract Increases GLUT-4 Expression in Type 2 Diabetes Mellitus Rat Kartikadewi, Arum; Prasetyo, Awal; Budipradigdo, Lisyani; Nugroho, Heri; Tjahjono, Kusmiyati; Lelono, Arthur
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.531

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BACKGROUND: The depletion of glucose transporter 4 (GLUT-4) affects blood glucose level in the type 2 diabetes mellitus (T2DM) patient. Herbals supplementation such as Artemisia annua is known to posses an antidiabetic potency, but its effect on long term glucose control marker, glicated hemoglobin (HbA1C) and muscle GLUT-4 expression still has not been investigated.METHODS: Twenty Wistar rats were divided into four groups (five rats per group). The C1 group was consist of healthy control rats and C2 group was consist of diabetic control rats. Diabetic condition was induced by giving high lard fat diet for 28 days, followed with 30 mg/kgBW of Streptozotocin injection at the 29th day. Meanwhile, T1 and T2 group were consist of diabetic rats, which were supplemented with 50 mg/kgBW and 100 mg/kgBW of Artemisia annua leaf extract, respectively. GLUT-4 expression and HbA1C level were measured at the 14th day post-treatment.RESULTS: The GLUT-4 was expressed 1.8 and two times higher in T1 and T2 group, respectively, compared to C2 group. Meanwhile, HbA1C level in C2 group was two times higher than C1 group (11.95±2.52 compared to 5.61±2.69, p<0.01). Further, the administration of 100 mg/ kgBW Artemisia annua extract caused a slight reduction of HbA1C (11.95±2.52 compared to 8.18±3.53, p>0.05)CONCLUSION: Muscle cell’s GLUT-4 in T1 and T2 group was expressed increasingly and significantly different compared to the C2 group. HbA1C level in T2 was slightly reduced although no significant different compared to C2 group.KEYWORDS: Artemisia annua, GLUT-4, HbA1C, type 2 diabetes mellitus
PENGARUH PENGGUNAAN BROQUET PADA PRESTASI MESIN SEPEDA MOTOR Arijanto, Arijanto; Nugroho, Heri
ROTASI "JURNAL TEKNIK MESIN" VOLUME 13, NOMOR 1, JANUARI 2011
Publisher : ROTASI "JURNAL TEKNIK MESIN"

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Jumlah mobil di Indonesia telah mencapai 10 juta unit, bertambah 500 ribu unit per tahun dan sepeda motor lebih dari 25 juta unit dan bertambah 5 juta unit per tahun akan makin mencemari lingkungan serta memacu pemanasan global. Untuk mengurangi dampak emisi gas buang salah satu alat penghemat bahan bakar adalah katalisator Broquet. Katalis ini terbuat dari palladium campuran berbentuk kasa direndam dalam bahan bakar, sehingga oktan bahan bakar bertambah dan pembakaran menjadi lebih sempurna. Pengujian akan mengkaji efek penggunaan Broquet pada mesin sepeda motor Honda CS-1 125 cc terhadap perubahan performa mesin yang meliputi daya, torsi, konsumsi bahan bakar dan efisiensi. Dari hasil pengujian didapatkan torsi maksimal meningkat 18,8 % dari 11,44 Nm menjadi 13,60 Nm, setelah menggunakan broquet. Demikian juga terjadi peningkatan daya pengereman maksimal 22 % dari 0,92 kW menjadi 1,14 kW, selain itu juga diperoleh penghematan bahan bakar sebesar 13 % yang semula 1,14 liter/jam menjadi lebih hemat yaitu 1,01 liter/jam, Ditinjau dari prestasi mesin broquet layak digunakan sebagai penghemat bahan bakar alternatif bahkan dari hasil pengujian emisi gas buang penggunaan broquet juga lebih ramah lingkungan
NILAI DIAGNOSTIK KARAKTERISTIK KLINIS DIBANDINGKAN DENGAN BIOPSI PATOLOGI ANATOMI DALAM MENDIAGNSOSIS KARSINOMA TIROID Dona, Yohanes; Nugroho, Heri; Hapsari, Rebriarina
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background : Thyroid malignancy is the most commonly found among the endocrine glands malignancies. Generally, thyroid carcinoma has a good prognosis if it is detected as soon as possible. It is very important to diagnose it earlier because the thyroid cancer progression is slow and survival rate can be longer if therapy is given early. Clinical examination, consists of anamnesis and physical examination, becomes the first, the easiest, the fast, and the cheapest step to do in order to know the clinical characteristics of the patient to make an early detection and to help diagnosing and directing to the thyroid malignancy.Objective : To explain diagnostic value and combination of clinical characteristic variables compared with histopathology biopsy to diagnose thyroid carcinoma in patients of RSUP Dr. Kariadi in January 2008 until December 2011.Method : Subject of this study were patients of RSUP Dr. Kariadi who had thyroid nodules which had been clinically examined, had been registered in the medical record, and had been examined with histopathology biopsy. Data of clinical examination and histopathology biopsy from each sampel were collected to be analized according to formula to get sensitivity value, specifity value, positif predictive value, and negative predictive value.Result : Total subject of this research was 120. In this study, result of clinical examination are tumor size more than 4 cm and history of progressive enlargement has sensitivity, specifity, positive predictive value , and negative predictive value of 82,35%, 85,71%, 82,35%, and 85,71%, respectively.Conclusion : Clinical characteristic have high sensitivity and specifity to diagnose thyroid carcinoma. Clinical characteristic combination which can give a suspicion to a thyroid carcinoma are tumor size more than 4 cm and history of progressive enlargement.Keywords : Diagnostic value, clinical characteristic, thyroid carcinoma
FAKTOR – FAKTOR RISIKO OSTEOPOROSIS PADA PASIEN DENGAN USIA DI ATAS 50 TAHUN Wardhana, Wisnu; Nugroho, Heri; Hapsari, Rebriarina
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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ABSTRACTBackground: Osteoporosis becomes a global issue because the prevalence has been raising, and so does in Indonesia. Beside can decrease quality of life, osteoporosis can also increase health cost because of fractures. One of steps that can decrease the prevalence of osteoporosis is by knowing and avoiding the risk factors of osteoporosis.Objective: To describe the risk factors of osteoporosis in patients in RSUP Dr. Kariadi Semarang.Methods: Subject of this study were patients of RSUP Dr. Kariadi Semarang that their bone density had been examined by using Dual Energy X – ray Absorptiometry (DEXA). This study used case-control study. The data consisted of primary data from interview and secondary data by looking at the patients’ medical record.Result: Total of respondents that had been studied was 50 patients,consisted of 25 patients with ostoeporosis as the case and 25 patient without osteoporosis as the control. Variabels that was proven to be risk factors of osteoporosis were woman, age over than 65, early menopause, and diabetes mellitus. Body mass index, history of fracture, long period steroid consumption, alcohol consumption, smoking habit, hepatic chirosis, hyperthyroid, and chronic kidney disease were not proven to be risk factors of osteoporosis.Conclusion: Woman, age, early menopause, and diabetes mellitus are the risk factors of osteoporosis in patients of RSUP Dr. Kariadi Semarang.Keywords: Risk factor, Osteoporosis
UJI DIAGNOSTIK FNAB (FINE NEEDLE ASPIRATION BIOPSY) DIBANDINGKAN DENGAN BIOPSI PATOLOGI ANATOMI DALAM MENDIAGNOSIS KARSINOMA TIROID Prasetyo, Zen Ary; Nugroho, Heri; Hapsari, Rebriarina
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background : There were estimated 0.5 to 10 cases per 100,000 people suffering from thyroid nodules. Malignant thyroid nodules that require immediate treatment, whereas benign could be therapeutically treated. FNAB is the initial diagnostic step of thyroid nodules. FNAB technique is safe, inexpensive, reliable and has minor risk of complications.Objective : To describe the diagnostic value of FNAB compared with histopathological biopsy in the diagnosis of thyroid carcinoma in RSUP Dr. Kariadi SemarangMethod : The study subjects were patients in RSUP Dr. Kariadi Semarang who had thyroid nodules and had been examined using FNAB and histopathological biopsy. Data of FNAB and histopathological biopsy examination of each sample were collected to calculate sensitivity, specificity, positive predicted value, and negative predicted value.Result : There were 34 samples obtained. Sensitivity, specificity, positive predicted value, and negative predicted value of FNAB were 100%, 84%, 69,2%; and 100% respectively.Conslusion : FNAB has a good diagnostic value to diagnose thyroid carcinoma.Keyword : Disagnostic test, FNAB, thyroid carcinoma
Faktor Risiko Penyakit Ginjal Kronik Diabetes (PGK-DM) pada Diabetes Mellitus Tipe-2 (Studi di RSUD DR Soedarso Kota Pontianak Provinsi Kalimantan Barat) Rini, Sulistio; Hadisaputro, Suharyo; Lestariningsih, Lestariningsih; Nugroho, Heri; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v3i2.4029

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Background: Prevalence of type-2 diabetes mellitus have increased significantly. The increasing number of people with diabetes has a major impact on the development of chronic diabetic kidney disease. The research was aimed to clarify several risk factors of chronic diabetic kidney disease on type-2 diabetes mellitus (CDK-DM).Method: The research was based on case control study design. The number of respondents was 140 respondents consisting 70 cases and 70 controls that met the criteria of inclusion and exclusion. The cases were patients with type-2 chronic diabetic kidney disease stadium 2-5. The controls were patients with type-2 chronic diabetic kidney disease with blood sugar levels ≥ 200 mg / dL. The data were then analyzed using logistic regression.Results: The result shows that risk factors of chronic diabetic kidney disease in type-2 diabetes mellitus are diabetes in family (OR = 6,732; 95% CI = 2,623- 17,276), high blood pressure (OR = 6,760; 95% CI = 2,190- 20,867), lack of physical activities (OR = 4,367 95% CI = 1,823-10,462) and lack of family support (OR = 4,203; 95% CI = 1,437-12,295). The probability of chronic diabetic kidney disease occurrence in type-2 diabetes mellitus when four risk factors exist are 96,71%.Conclusion: The host factors have important role of chronic diabetic kidney disease in type 2 diabetes mellitus . The factors proven to be risk factors for occurrence of chronic diabetic kidney disease in type 2 diabetes mellitus were diabetic in the family, Hipertension, poor physical exercise and family Support. 
PENGARUH MODEL PEMBELAJARAN LEARNING CYCLE 5E TERHADAP HASIL BELAJAR MATEMATIKA Nugroho, Heri
HISTOGRAM: Jurnal Pendidikan Matematika Vol 2, No 1 (2018): Histogram
Publisher : STKIP Andi Matappa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.051 KB) | DOI: 10.31100/histogram.v2i1.112

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Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika pada materi teorema Pythagoras. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 2 Tuntang. Pengambilan sampel dilakukan dengan teknik Cluster Random Sampling dan diperoleh siswa kelas VIIIE sebagai kelas eksperimen dan VIIIG sebagai kelas kontrol. Uji beda rerata kemampuan awal siswa dengan menggunakan uji Mann-Whitney menghasilkan nilai signifikansi 0,851 (lebih dari 0,05), artinya kondisi awal kedua kelas seimbang. Hasil uji beda rata-rata mengahasilkan nilai signifikansi sebesar 0,024 (kurang dari 0,05). Hal ini berarti terdapat perbedaan yang signifikan antara rerata kedua kelas, maka disimpulkan terdapat pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika bagi siswa kelas VIII SMP Negeri 2 Tuntang.
Beberapa Faktor yang Berpengaruh terhadap Kejadian Diabetes Mellitus Tipe 2 pada Wanita Usia Subur (WUS) di RSUD Kota Madiun Ardiani, Hanifah; Hadisaputro, Suharyo; Lukmono, Djoko Trihadi; Nugroho, Heri; Suryosaputro, Antono
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v3i2.4026

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Background : Women of reproductive age with Diabetes Mellitus (DM) who were married having a risk complications of pregnancy, either on mother and her baby. Study on risk factors of DM in women of reproductive age was a rare, they have never done on women of reproductive age that married. The objective of this study was to prove some variables that influence to DM in women of reproductive age.Method : An observasional analytic was conducted with case-control study design. Populations in this study were women of reproductive age 20-49 years that check blood sugar at Madiun Regional Hospital. The samples in this study were 54 cases and 54 controls by consecutive sampling. Data were analyzed by chi-square and logistic regression.Results : Women of reproductive age with 2 and 3 quartile stress scores had risk 4,12 (95% CI=1,42-11,92) and 5,64 (95% CI=1,19-16,55) greater for DM than the comparison group. Women of reproductive age with physical activity <600 MET had risk 4,33 times greater for DM than ≥ 600 MET (95% CI = 1,71-10,96).Conclusion : Variables levels of carbohydrate and fat consumption were not associated with DM. Physical activity and stress levels were evident influece DM occurence in women of reproductive age.
Faktor Risiko yang Berpengaruh terhadap Terjadinya Hipertensi pada Penderita Diabetes Melitus Tipe II di Wilayah Puskesmas Kabupaten Pati Sari, Gracilaria Puspa; Chasani, Shofa; Pemayun, Tjokorda Gde Dalem; Hadisaputro, Suharyo; Nugroho, Heri
Jurnal Epidemiologi Kesehatan Komunitas Vol 2, No 2: Agustus 2017
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.003 KB) | DOI: 10.14710/jekk.v2i2.3996

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Background: The prevalence of hypertension in type 2 diabetic patients is 1,5-3 times higher than it is in nondiabetic individuals This chronic condition accelerates macrovascular complications. Research about risk factors of hypertension in type 2 diabetic patients is still rare because its causes multifactorial. The objectives of this research is to explain the risk factors affecting hypertension in type 2 diabetic patients.Methods: An observational studies with case-control study design in Primary Healthcare Centers patients in Pati District. Patients with hypertension in type 2 diabetes are the case, while the type 2 diabetes patients without hypertension are the control. There were 57 cases and 57 controls included. Data were obtained from medical records and qualitative interviews. Chi-square test in bivariate and multiple logistic regression in multivariate analysis.Results: Factors that influence hypertension in type 2 diabetic patients were physical activity (OR=6,4; 95% CI: 2,18 - 18,77; p=0,001), diabetes duration ≥ 5 years (OR=5,4; 95% CI: 1,97 - 14,704; p=0,001), and medication adherence (OR=3,6; 95% CI: 1,32 - 9,83; p=0,012). Other risk factors i.e age ≥45 years, male, diet compliance, history of hypertension, smoking, salt consumption, coffee consumption, and sleep duration were not significantly influenced.Conclusion: In this study, physical activity, diabetes duration, and DM medication adherence are risk factors that influence of hypertension in type 2 diabetic patients. 
Faktor Risiko yang Berpengaruh Terhadap Status Kontrol Glikemik pada Kehamilan dengan Diabetes Melitus (Studi Kasus Kontrol Pasien di Beberapa RS di Kota Semarang) Meiwarnis, Resna; Soejoenoes, Ariawan; Nugroho, Heri; Hadisaputro, Suharyo; Setyawan, Henry
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 2: Agustus 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.292 KB) | DOI: 10.14710/j.e.k.k.v1i2.3947

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Background : The number of diabetes patients was higher in women than men. The high prevalence in women occurs in pregnant women because of the increasing age of childbearing. Commonly, pregnancy in women with diabetes was associated with morbidity and mortality.  Data obtained from Diabetic  Department  King’s  College  Hospital mentioned that  during  pregnancy, a good control of maternal diabetes cause a progressive decline in blood glucose control. The purpose of this research is to explain some risk factors related to glycaemic control status in pregnancy with diabetes mellitus. Methods : This research was an observational study using case control design by using retrospective approach. The population of this study is all cases of pregnancy with diabetes with  the number of sample was 62 people, consist of 31 cases and 31 control with consecutive  sampling. In this research, cases sample selection was chosed from pregnant women with diabetes who come to Tugurejo Hospital, Semarang City Hospital and Roemani Hospital during 2015. Control sample selection was chosed from non pregnant women with diabetes who come to Tugurejo Hospital, Semarang City Hospital and Roemani Hospital during 2015. Results : The pattern of taking medications that was not good (p= 0,002; aOR= 7,2; 95%CI= 1,9-17,2) was risk factors of poor glycaemic control status with probability event amounted was 70,0%. Conclusion : The risk factors to glycaemic control status in pregnancy with diabetes was the pattern of taking medications that was not good. Background  :Thenumber  ofdiabetes  patients  washigher  inwomen  thanmen.Thehigh prevalence   in   women   occurs   in   pregnant   women   because   of   the   increasing   age   of childbearing.  Commonly,  pregnancy  inwomen  withdiabetes  wasassociated  withmorbidity andmortality.  Dataobtained  fromDiabetic  Department  King’s  College  Hospital  mentioned that  during  pregnancy,  agood  control  ofmaternal  diabetes  cause  aprogressive  decline  in bloodglucosecontrol.Thepurposeof thisresearchisto explainsomeriskfactorsrelatedto glycaemiccontrolstatusinpregnancywithdiabetesmellitus.Methods  :Thisresearch  wasanobservational  studyusingcasecontrol  design  by  using  a retrospective  approach.  Thepopulation  ofthisstudyisallcasesofpregnancy  withdiabetes with  the  number  of  sample  was  62  people,  consist  of  31  cases  and  31  control  with consecutive  sampling.  In  this  research,  cases  sample  selection  was  chosed  from  pregnant women   with   diabetes   who   come   to  Tugurejo   Hospital,   Semarang   City   Hospital   and Roemani  Hospital  during  2015.  Control  sample  selection  was  chosed  from  non  pregnant women   with   diabetes   who   come   to  Tugurejo   Hospital,   Semarang   City   Hospital   and RoemaniHospitalduring2015.Results:Thepatternoftakingmedications  thatwasnotgood(p=0,002;aOR=7,2;95% CI=1,9-17,2)was   risk  factors   of  poor  glycaemic   control   status  with  probability   event amountedwas70,0%.Conclusion  :Theriskfactorstoglycaemiccontrolstatusinpregnancywithdiabeteswasthe patternoftakingmedicationsthatwasnotgood.