Abdillah Imron Nasution
Dentistry Study Program, Faculty of Medicine, Syiah Kuala University

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Surface Structure Study of Crystal Hydroxy-Apatite from Fluorosis Enamels Nasution, Abdillah Imron; Gunawan, Harun Asyiq; Soekanto, Sri Angky
Journal of Dentistry Indonesia Vol 16, No 3 (2009): December
Publisher : Faculty of Dentistry, University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4944.685 KB) | DOI: 10.14693/jdi.v16i3.100

Abstract

Fluorosis is a condition due to ingestion of excessive amounts of fluor which can cause the change in tooth structure and strength. However, there is still lack of explanation on the surface structure of crystal hydroxyapatite that influences the microscopic characteristic of fluorosis enamel. Objectives: To investigate the surface structure of crystal hydroxy-apatite in fluorosis enamel. Materials and Methods: Determination of fluor concentration and the surface structure of normal and fluorosis enamel specimen were carried out by using Scanning Electron Microscopy/Energy Disperse X-Ray (SEM/EDX). Results: Fluor concentration of fluorosis enamel was significantly higher with increased surface roughness and porosity than normal enamel. SEM observation also showed gaps areas between enamel rods and visible aprismatic zone in some regions. Conclusion: High level of fluor concentration on fluorosis enamel indicated the subtitution of OH- by F- increasing the surface roughness of enamel surface.DOI: 10.14693/jdi.v16i3.100
Gambaran Tingkat Pengetahuan Anak Terhadap Makanan Dan Minuman Kariogenik Pada Siswa Kelas 3, 4 Dan 5 Sekolah Dasar Negeri 47 Banda Aceh ., Mustaqim; ., Herwanda; Nasution, Abdillah Imron
Journal Caninus Dentistry Vol 2, No 1 (2017): februari 2017
Publisher : Journal Caninus Dentistry

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Abstract

ABSTRAKPengetahuan anak mengenai tindakan pencegahan karies seperti menjaga pola makan dapat secara signifikan mempengaruhi perilaku anak dalam mencegah terjadinya karies dikarenakan pengetahuan mendasari seseorang dalam berperilaku dan perilaku yang didasari oleh pengetahuan akan lebih bertahan lama apabila didasari oleh pengetahuan. Tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan siswa kelas 3, 4 dan 5 Sekolah Dasar Negeri 47. Penelitian ini merupakan penelitian deskriptif. Pengambilan sampel dilakukan secara total sampling. Penilaian tingkat pengetahuan dilakukan dalam tiga kategori yaitu baik (> 75%), Sedang (56–74%) dan kurang (55%) yang dianalisis secara deskriptif dan diinterpretasikan ke dalam grafik dan tabulasi.Hasil penelitian menunjukkan bahwa tingkat pengetahuan anak terhadap makanan dan minuman kariogenik pada siswa kelas 3, 4 dan 5 Sekolah Dasar Negeri 47 Banda Aceh adalah kurang, dengan siswa yang tingkat pengetahuannya berkategori kurang berjumlah 49 (61,3%) siswa dari total sampel penelitian.Kata kunci: siswa sekolah dasar, pengetahuan, makanan dan minuman kariogenik.
SCANNING ELECTRON MICROSCOPY OF CANDIDA ALBICANS CELL WALL ON TOOTH SURFACE AFTER FLUCONAZOLE-TREATED AND INCUBATED WITH GUAVA (PSIDIUM GUAJAVA L) Nasution, Abdillah Imron; Basri, Basri
250-20412
Publisher : Dentistry Faculty

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Abstract

The Candida albicans cell wall is a target of fluconazole. The content of guava (Psidium guajava L) known have contribute factors to resistance of fluconazole. Objective: characterize the surface alterations and the general shape changes of candida cells after in vitro exposure to fluconazole and guava. Material and Methods: six tooth specimen groups: Cells exposed without fungicidal doses (Negative Control), Positive Cells exposed to maximal fungicidal doses of Fluconazole (100µg/ml) (Control), Guava (G), Guava+Fluconazole susceptibility (GFS), Guava+Fluconazole Susceptible-Dose Dependent (GFSDD), Guava+Fluconazole dose Resistance (GFR). Each group mixed with 10 ml artificial saliva, 2 ml glucose 2%, and 2 ml C. albicans. Fluconazole doses based on NCCLS approved M27-A. Scaninng Electron Microscopy conducted after 15 days incubation at Faculty of Veterinary University of Syiah Kuala and Faculty of Engineering University of Indonesia. Results, SEM of Negative Control presented smooth of blastospores; small clusters of interconnected cells, spherical to elongate in shape, lying down, polar buds, and hyphae on dental surface. SEM of Positive Control and Guava generally presented: wrinkled of blastospores, rough surfaces, cells fewer than Negative Control, and lying apart. Positive Control showed spherical to elongate in shape and Guava with spherical in shape presented more wrinkled than Positive Control. SEM of GGF and Guava+Fluconazole Susceptible-Dose Dependent presented wrinkled of blastospores, rough surfaces, decreased in number, spherical to elongate in shape, lying apart, and hyphae on surface. SEM of Guava+Fluconazole dose Resistance presented wrinkled of blastospores but more smooth than others, elongate in shape; bud’s orientations penetrate to dental tissue. Conclusion: Guava improving the integrity of cell wall of Candida albicans and contributed to resistance of Candida albicans to fluconazole. Keywords: Candida albicans, Guava, Fluconazole, Scanning Electron Microscopy
Kemampuan Air Rebusan Daun Salam (Eugenia Polyantha Wight) Terhadap Jumlah Makrofag Pada Gambaran Histologi Periodontitis Agresif (Penelitian Pada Tikus Model) Andayani, Ridha; Nasution, Abdillah Imron; Rahimi, Afini
Cakradonya Dental Journal Vol 8, No 2 (2016): Desember 2016
Publisher : FKG Unsyiah

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Abstract

Aggregatibacter actinomycetemcomitans merupakan bakteri dominan pada periodontitis agresif. Daun salam (Eugenia polyantha w) bersifat sebagai anti-inflamasi, antimikroba, analgesik dan antibakteri. Saat ini, belum banyak penelitian potensi daun salam dalam respon inflamasi yang diperankan oleh makrofag. Tujuan penelitian ini untuk mengetahui kemampuan air rebusan daun salam dengan konsentrasi 20%, 40%, dan 80% terhadap jumlah sel makrofag pada gambaran histologi periodontitis agresif. Penelitian ini merupakan penelitian eskperimental laboratoris yang menggunakan tikus putih rattus norvegiccus dibagi empat kelompok, tiga kelompok perlakuan air rebusan daun salam dengan konsentrasi 20%, 40%, dan 80%, dan satu kelompok kontrol akuades.Pada hari pertama kelompok perlakuan dan kelompok kontrol diinokulasi bakteri Aggregatibacter actinomycetemcomitans sampai hari ketujuh. Hari kedelapan sampai kesepuluh kelompok perlakuan diaplikasikan air rebusan daun salam dan kelompok kontrol diaplikasikan akuades. Hari kesebelas tikus dieuthanasi, selanjutnya dilakukan pengambilan sampel histologi jaringan periodontal tikus diamati secara mikroskopik. Hasil penelitian menunjukkan perbandingan jumlah makrofag kelompok perlakuan dengan kelompok kontrol menunjukkan perbedaan yang bermakna (p≤0,05). Dapat disimpulkan, kandungan air rebusan daun salam dapat membantu respon inflamasi yang diperankan oleh sel makrofag.
GAMBARAN MORFOLOGI Candida albicans SETELAH TERPAPAR EKSTRAK SERAI (Cymbopogon citratus) PADA BERBAGAI KONSENTRASI ., Afrina; Nasution, Abdillah Imron; Sabila, Cut Iryanti
Cakradonya Dental Journal Vol 9, No 2 (2017): Desember 2017
Publisher : FKG Unsyiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.509 KB) | DOI: 10.24815/cdj.v9i2.9748

Abstract

Candida albicans merupakan jamur oportunisik dan termasuk salah satu flora normal dalam rongga mulut manusia yang dapat berubah menjadi patogen dan menyebabkan kandidiasis oral. Salah satu mekanisme adaptasi yang dilakukan C. albicans untuk mempertahankan hidupnya dari senyawa antifungal ekstrak serai (Cymbopogon citratus) adalah perubahan morfologi. Penelitian ini bertujuan untuk mengetahui gambaran morfologi C. albicans setelah terpapar serai pada berbagai konsentrasi yang dilakukan pada kelompok perlakuan yang terdiri dari konsentrasi 6,25%, 12,5%, 25%, 50%, 75%, dan 100%, kelompok kontrol negatif (akuades) dan tiga kelompok kontrol flukonazol berdasarkan dosis CLSI minimum, optimum, dan maksimum. C. albicans yang digunakan adalah ATCC 10231 yang telah disensitisasi dengan Cigarette Smoke Condensate (CSC). Gambaran morfologi C. albicans dilihat menggunakan mikroskop elektrik dengan pembesaran 1000x dan dibedakan menjadi bentuk blastospora, sel budding, pseudohifa, dan hifa. Gambaran morfologi C. albicans kemudian dianalisis secara deskriptif dan tabulasi. Hasil menunjukkan bahwa morfologi C. albicans setelah terpapar ekstrak serai pada semua konsentrasi didominasi oleh blastospora, dengan jumlah sel budding dan hifa paling sedikit terdapat di konsentrasi 25%.Kata Kunci: Candida albicans, kandidiasis oral, serai
Perbandingan Jumlah Koloni Streptococcus Sp, Lactobacillus Sp Dan Candida Sp Di Dalam Rongga Mulut Pasien Skizofrenia Rumah Sakit Jiwa Banda Aceh Andayani, Ridha; Nasution, Abdillah Imron; Qadri, Muhammad
Cakradonya Dental Journal Vol 6, No 1 (2014): Juni 2014
Publisher : FKG Unsyiah

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Abstract

Pasien skizofrenia dapat mengalami masalah gigi dan mulut yang sama dengan orang normal sebagai populasi umum. Namun bukti menunjukkan bahwa mereka memiliki resiko lebih besar mengalami penyakit di rongga mulut dan lebih membutuhkan perawatan rongga mulut. Terjadinya penyakit di rongga mulut sangat erat kaitannya dengan peningkatan jumlah koloni mikroorganisme seperti Streptococcus sp, Lactobacillus sp dan Candida sp. Peningkatan jumlah koloni mikroorganisme dapat meningkatkan status mikroorganisme tersebut menjadi patogen yang menyebabkan suatu penyakit di rongga mulut. Penelitian ini bertujuan untuk mengetahui perbandingan jumlah koloni Streptococcus sp, Lactobacillus sp dan Candida sp di rongga mulut. Penelitian ini adalah penelitian deskriptif dengan pendekatan eksperimental laboratoris yang dilakukan di Rumah Sakit Jiwa Banda Aceh. Subjek penelitian sebanyak 47 pasien skizofrenia laki-laki dan perempuan. Pada subjek dilakukan pengambilan sampel di rongga mulut dengan menggunakan cotton wooden steril yang kemudian dibawa ke laboratorium untuk dikultur dan dihitung jumlah koloni mikroorganismenya. Berdasarkan hasil penelitian menunjukkan jumlah koloni Streptococcus sp yang dikultur pada media selektif TYS20B sebanyak 93,2 x 106 CFU/ml, Lactobacillus sp yang dikultur pada media selektif MRSA sebanyak 0,6 x 106 CFU/ml, dan Candida sp yang dikultur pada media selektif SDA sebanyak 30,5 x 106 CFU/ml. Streptococcus sp merupakan mikroorganisme paling dominan pada rongga mulut pasien skizofrenia Rumah Sakit Jiwa Banda Aceh sehingga dapat dikatakan karies gigi sangat rentan terjadi di rongga mulut pasien tersebut.
The pH changes of artificial saliva after interaction with oral of artificial saliva after interaction with oral micropathogen Gani, Basri A.; Soraya, Cut; Sunnati, Sunnati; Nasution, Abdillah Imron; Zikri, Nurfal; Rahadianur, Rina
Dental Journal (Majalah Kedokteran Gigi) Vol 45, No 4 (2012): (December 2012)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v45.i4.p234-238

Abstract

Backgorund: Saliva contains several protein elements, exocrine proteins and antibodies, such as lactoferrin, sIgA, peroxidase, albumin, polypeptides, and oligopeptides that contribute to the defense of oral mucosa and dental pellicle to prevent infection caused by oral micropathogen, such as Candida albicans, Streptococcus mutans and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). Those micropathogens have a role to change salivary pH as an indicator of oral disease activities. Purpose: This study was aimed to analyze the changes of artificial saliva pH after interaction with S. mutans, C. albicans, and A. Actinomycetemcpmitans. Methods: The materials used in this study consist of S. mutans (ATCC 31987), C. albicans (ATCC 10231), A. actinomycetemcomitans (ATTC 702 358), and artificial saliva. To examine the pH changes of artificial saliva, those three microbiotas were cultured and incubated for 24 hours. Results: The results showed that the interactions of S. mutans, C. albicans, and A. actinomycetemcomitans in the artificial saliva can change the salivary on neutral. There were no significant difference with the control treatment salivary pH 4, 5, 6, 8, and 9 (p>0.05). Similarly, there was also no significant difference when those three microorganism interacted each other in the artificial saliva (p<0.05). Conclusion: It can be concluded that the biological activity of S. mutans, C. albicans, and A. actinomycetemcomitans in artificial saliva can change the salivary pH into neutral. It indicates that those microbiotas mutually supported and cooperated in influencing the biological cycle of the oral cavity with salivary pH as an indicator.Latar belakang: Saliva merupakan cairan eksokrin yang mengandung unsur protein dan antibodi seperti sIgA laktoferin peroksidase, albumin, polipeptida dan oligopeptida yang berperan pada pertahanan mukosa rongga mulut dan gigi guna mencegah infeksi oral mikropatogen seperti C. albicans, S. mutans, dan A. actinomycetemcpmitans. Patogenesis ketiga oral mikropatogen tersebut diawali dengan mempengaruhi perubahan pH saliva sebagai langkah invasi dan infeksi pada mukosa oral dan pelikel gigi. Tujuan: Penelitian ini bertujuan untuk untuk mengetahui perubahan pH saliva buatan setelah diinteraksikan dengan S. mutans, C. albicans, dan A. Actinomycetemcpmitans. Metode: Materi penelitian ini berupa Streptococcus mutans strain ATCC 31987, Candida albicans strain ATCC 10231, Aggregatibacter actinomycetemcomitans strain ATTC 702358, dan saliva buatan. Untuk mengetahui perubahan pH saliva, maka ketiga mikrobiota tersebut dikultur dan untuk menguji perubahan pH saliva dilakukan uji interaksi ketiga mikroorganisme tersebut dalam saliva buatan selama 24 jam dengan pengaturan pH saliva sebagai indikator hasil penelitian. Hasil: Hasil penelitian menunjukkan interaksi S. mutans, C. albicans, dan A. actinomycetemcomitans dalam saliva buatan mampu mereduksi perubahan pH saliva mengarah ke pH netral dengan kontrol perlakuan pH saliva 4, 5, 6, 8, dan pH 9 secara statistik tidak tidak menunjukkan perbedaan bermakna (p>0,05), begitu juga ketika dilakukan interakasi diantara masing-masing mikroorganisme tersebut dalam saliva buatan menunjukkan adanya perbedaan bermakna (p<0,05). Kesimpulan: Dapat disimpulkan bahwa aktivitas biologi S. mutans, C. albicans, dan A. actinomycetemcomitans dalam saliva buatan mampu merubah pH Saliva sekaligus mempertahankan pH netral. Hal ini menggambarkan bahwa mikrobiota tersebut saling mendukung dan bekerjasama dalam mempengaruhi siklus biologi rongga mulut dengan pH saliva sebagai indikator.
Potential of Jatropha multifida sap against traumatic ulcer Gani, Basri A.; Nasution, Abdillah Imron; Nazaruddin, Nazaruddin; Sartika, Lidya; Alam, Rahmat Kurniawan
Dental Journal (Majalah Kedokteran Gigi) Vol 48, No 3 (2015): (September 2015)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v48.i3.p119-125

Abstract

Background: Traumatic ulcer is a lesion in oral mucosa as a result of physical and mechanical trauma, as well as changes in salivary pH. Jatropha multifida sap can act as antimicrobial, anti-inflammatory and re-epithelialization, and can also trigger the healing process of ulcers. Purpose: Research was aimed to determine the potential of Jatropha multifida sap against traumatic ulcer base on clinical and histopathological healing process. Method: This research was conducted laboratory experimental model, with rats (Rattus norvegicus) as the subject as well as Jatropha multifida sap for ulcer healing. Those subjects were divided into four groups: two treatment groups administrated with pellet and Jatropha multifida sap, one group as the positive control group administrated with 0.1% triamcinolone acetonide, and one group as the negative control group administrated with 0.9% NaCl. Ulcer manipulation was used 30% H2O2, and evaluation of ulcer healing was used clinical and histopathological approach. Result: Clinically, the healing process of ulcers in the treatment group with Jatropha multifida sap was faster than that in the positive control group with 0.1% triamcinolone acetonide, indicated with the reduction of the ulcer size until the missing of the ulcers started from the third day to the seventh one (p≤0.05). Histopathologically inflammatory cells (lymphocytes, and plasma cells) declined started from the third day, and the formation of collagen and re-epithelialization then occurred. On the seventh day, the epithelial cells thickened, and the inflammatory cells infiltrated. Statistically, those groups were significant (p≤0.05). Conclusion: Jatropha multifida sap has a significant potential to cure traumatic ulcers on oral mucosa clinically and histopathologically.
The correlation between pH and flow rate of salivary smokers related to nicotine levels labelled on cigarettes Saputri, Dewi; Nasution, Abdillah Imron; Surbakti, Mutiara Rizki Wardarni; Gani, Basri A.
Dental Journal (Majalah Kedokteran Gigi) Vol 50, No 2 (2017): (June 2017)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v50.i2.p61-65

Abstract

Background: Saliva is a biological fluid in oral cavity that plays a role in maintaining the environmental balance and oral commensal. Nicotine of cigarettes has been reported as a predisposing factor for changing of pH and salivary flow rate, thereby changing in biological salivary components. Purpose: This study aimed to analyze the correlation between salivary pH and salivary flow rate in smokers with nicotine levels labeled on cigarettes. Methods: Purposive sampling was conducted involving 40 male smokers. Before participating, they filled a questionnaire related to the history of their smoking habit. Using a spitting method for 5 minutes their saliva was collected. Results: Result of Pearson correlation test showed that there was a significant correlation between smoking intensity and salivary flow rate of those smokers (r = -0.486 and p<0.001). The results also indicated that there was a significant correlation between smoking intensity and salivary pH (r = -0.376 and p<0.017). On the other hand, there was no significant correlation between nicotine levels levels labeled on cigarettes with salivary pH of those smokers (r = -0.107, p>0.512). There was no correlation between nicotine levels labeled on cigarettes and salivary pH of those smokers (r = -0.216, p>0.181). Nevertheless, there was a significant correlation between salivary flow rate and salivary pH of those smokers (r= 0.686, p<0.00,). Conclusion: There is a strong correlation between the intensity of smoking with salivary flow rate and its pH. However, there is no correlation between nicotine levels labeled on cigarettes and both salivary flow rate as well as salivary pH.
Perubahan Potential of Hydrogen (pH) Saliva Sebelum dan Sesudah Berkumur Air Rebusan Jahe Merah (Z. Officinale Var Rubrum) Pada Mahasiswa Fakultas Kedokteran Gigi Universitas Syiah Kuala Angkatan 2016 Harahap, Rani Nurzaini; Andayani, Ridha; Nasution, Abdillah Imron
Journal Caninus Dentistry Vol 2, No 3 (2017): Agustus 2017
Publisher : Journal Caninus Dentistry

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Abstract

The potential of Hydrogen (pH) is a measure of hydrogen ion concentration of the solution which shows whether the solution is acidic, alkaline or neutral. Factors that affect the pH of saliva are chemical and mechanical stimuli. One of the herbal ingredients that are known to increase the pH of saliva was red ginger. Red ginger (Z. officinale var rubrum)  in the form of the decoction is one example of herbal beverages. The purpose of the study is to examine changes in the pH of saliva of students of the Faculty of Dentistry, Class of 2016, University of Syiah Kuala, before and after rinsing with red ginger (Z. officinale var rubrum) decoction. The population in this study was students of the Faculty of Dentistry, Class of 2016, University of Syiah Kuala. Subjects included in the inclusion criteria were 37 people. The study used experimental laboratory research with an analytic experimental design with pre-test and post-test. Data were analyzed by using T-Test. The result showed that the red ginger (Z. officinale var rubrum) decoction could increase the pH of saliva p <0.05. Differences between the pH of saliva before and after rinsing with red ginger decoction and the pH of saliva before and after rinsing with mineral water were also significant. Based on these results it can be concluded that the red ginger (Z. officinale var rubrum) decoction can increase the pH of saliva. Keywords : Water of boiled red ginger (Z. officinale var rubrum), The pH of saliva.