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RESIDU PESTISIDA PIRETROID PADA BAWANG MERAH DI DESA SRIGADING KECAMATAN SANDEN KABUPATEN BANTUL Narwanti, Iin; Sugiharto, Eko; Anwar, Chairil Anwar
PHARMACIANA Vol 2, No 2: November 2012
Publisher : PHARMACIANA

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Abstract

Telah dilakukan penelitian terhadap residu pestisida piretroid pada sampel bawang merah di Desa Srigading, Kecamatan Sanden, Kabupaten Bantul. Penelitian ini bertujuan untuk menganalisis, mengidentifikasi dan mengevaluasi residu pestisida piretroid pada bawang merah. Sampel bawang merah diekstraksi menggunakan alat homogenizer dengan pelarut aseton. Clean-up dilakukan dengan kolom kromatografi menggunakan florisil dan selanjutnya kadar residu pestisida ditentukan dengan kromatografi gas yang dilengkapi dengan detektor tangkapan elektron (Electron Capture Detector/ECD). Hasil penelitian menunjukkan bahwa sampel bawang merah terdeteksi adanya residu pestisida piretroid (_-sipermetrin dan _-sihalotrin). Kisaran residu pestisida pada sampel bawang merah untuk _-sipermetrin (98,8-245,6 ppb) dan _-sihalotrin (14,4-120,0 ppb). Terdapat sampel bawang merah yang melebihi Batas Maksimum Residu (BMR).
Pengembangan Produk Tablet Oral Disintegrasi Piroksikam Rohmiati, Rohmiati; Wahyuningsih, Iis; Guntarti, Any; Narwanti, Iin; Putri, Hilma; Anwar, Shinta Desy; Rahmadani, Firda; Rustandi, Tedi; Islamy, Muhammad Rido
Media Farmasi: Jurnal Ilmu Farmasi Vol 15, No 1 (2018)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.351 KB) | DOI: 10.12928/mf.v15i1.12307

Abstract

Piroksikam digunakan sebagai analgetik dan antiinflamasi yang sering dialami oleh kalangan lansia yang mempunyai kesulitan menelan. Salah satu upaya yang dapat dilakukan untuk mengatasi masalah tersebut yaitu dengan sediaan Orally Disintegrating Tablet (ODT). Avicel PH 102 merupakan bahan disintegran yang biasa digunakan sebagai penyusun ODT, karena mempunyai daya disintegran yang sangat baik. Tujuan penelitian ini untuk mengembangkan piroksikam menjadi bentuk sediaan ODT. Metode pembuatan ODT dilakukan dengan metode kempa langsung. Variasi konsentrasi Avicel PH 102 yang digunakan untuk formula 1 sebesar 15% dan formula 2 sebesar 20%. Tablet hasil formulasi diperiksa karakteristik fisik yang meliputi identifikasi tablet, kerapuhan, kekerasan, ketebalan, waktu hancur, bentuk dan ukuran tablet, laju disolusinya serta dilakukan penetapan kadar. Metode analisa kadar piroksikam baik pada penentuan disolusi maupun pada penentuan kadar, dilakukan verifikasi metode spektrofotometri UV-Vis terlebih dahulu meliputi spesifisitas, presisi, dan akurasi. Formula terbaik selanjutnya dilakukan uji hedonik. Hasil verifikasi untuk ketiga uji memenuhi persyaratan sehingga dikatakan metode uji valid. Hasil uji fisik tablet dikatakan memenuhi syarat kecuali untuk uji kerapuhan. Data laju disolusi dan penetapan kadar tablet piroksikam memenuhi syarat FI V yaitu laju disolusi tidak kurang dari 75%(Q + 5%) dan hasil penetapan kadar F1 dan F2 berturut-urut sebesar 95,22 ± 3,09% dan 95,14 ± 4,26%. Dari penelitian ini dapat disimpulkan bahwa piroksikam dapat dibuat dalam bentuk sediaan ODT karena menghasilkan sediaan tablet dengan sifat fisik yang baik kecuali pada uji kerapuhan. Formula yang dipilih yaitu formula 2, karena waktu hancur dan disolusi tablet lebih baik dibandingkan dengan formula 1.
UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO Nurani, Laela Hayu; Utami, Dwi; Widyaningsih, Wahyu; Narwanti, Iin; Nurwening, Eti; Jumina, Jumina
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.12 KB) | DOI: 10.12928/pharmaciana.v4i2.1575

Abstract

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme. Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)- 1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide and chloroquine by successively are 0,571±0,071; 25,498±1,876 mg/mL. The result showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide hadn’t the heme polymerization inhibitory activity.
TLC-Bioautography Profile of Ethyl Acetate Extract of 5 Bacteria Isolated from Ficus carica L Rhizosphere Narwanti, Iin; Sulistyani, Nanik
International Journal of Public Health Science (IJPHS) Vol 4, No 2: June 2015
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v4i2.7263

Abstract

Research has been conducted on the 5 isolates of bacteria isolated from the rhizosphere of Ficus carica L as a producer of antibiotics. The previous study showed they have NRPS gene profiles that differ from each other. This study aims to determine the TLC Rf spots having inhibition activity against the growth of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The study was conducted using the 5 bacteria isolates, namely T19, T24, T25, T37 and T41. All isolates were fermented at room temperature for 14 days. Further the each broth culture was filtered and extracted using ethyl acetate. Components in the extract were separated by thin layer chromatography (TLC) with the mobile phase of chloroform-methanol (7: 3), followed by bioautography test against the S. aureus and E. coli to determine the chromatogram spots containing antibiotics. TLC results showed all isolates had different chromatogram profiles. The bioautography results showed that only isolate T25 can produce antibiotics against S. aureus. The antibiotic spot was at Rf 0.9 in the use of chloroform-methanol (7: 3) solvent system.
PEMBINAAN KESADARAN PANGAN THOYIB YANG AMAN PENGAWET SINTETIS PADA PENGURUS CABANG ‘AISYIYAH WIROBRAJAN Khairi, Amalya Nurul; Juwitaningtyas, Titisari; Narwanti, Iin
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 2, No 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v2i2.446

Abstract

Ibu-ibu anggota PCA Wirobrajan sebagian besar adalah pengusaha makanan dan minuman yang terampil dalam pengolahan panganan basah tradisional maupun street food. Kondisi ini merupakan akibat dari banyaknya jumlah sekolah dan adanya Pasar Klitihikan yang khusus menjual makanan jenis camilan di Kecamatan Wirobrajan. Pengabdian ini bertujuan untuk meningkatkan kesadaran Ibu-ibu anggota PCA Wirobrajan terhadap bahaya penggunaan pengawet sintetis sekaligus membekali dengan keterampilan membuat pengawet dari bahan alami dan deteksi sederhana kandungan formalin. Metode yang dilakukan adalah dengan pelatihan dan pemaparan materi. Kegiatan tersebut dilaksanakan dalam tiga kali sesi. Dari hasil pembinaan yang dilakukan diperoleh hasil antusiasme keikutsertaan Ibu-ibu PCA Wirobrajan dan semangat mereka untuk memperbaiki proses pengolahan pangan dengan meminimalisir penggunaan bahan tambahan pangan (BTP) sintetis yang berbahaya. 
Culture Broth Activity of Antibiotic Producer Bacteria (P301 Isolate) Against Staphylococcus aureus ATCC 25923 and Time Optimization of Secondary Metabolite Production SULISTYANI, NANIK; NARWANTI, IIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Isolate P301 is an antibiotic producer bacteria isolated from rice plant ryzospher. This study was intended to identify the antibacterial activity of its culture broth againts Staphylococcus aureus ATCC 25923 and to identify the time optimization profileof secondary metabolite production from isolate P301 as producer antibiotics. Antibacterial activity was carried out using cup plate method by measuring the inhibitory zone around the wells. Optimization profile of production time of secondary metabolite was determined by plotting of the inhibition zone diameter versus incubation time. The result showed that isolate P301 culture broth inhibited the growth of S. aureus. According to the activity assay againts S. aureus, the optimum time for antibiotic production is after doing incubation for at least 11 days.
Optimation of NaOH Catalyst Consentration on 1,3-Diphenyl-2-propen-1-on Synthesis Using Microwave-Assisted Organic Synthesis (MAOS) Method Narwanti, Iin; Kusumajati, Narendra Bagus
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 4, No 1 (2019): JKPK ( Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v4i1.25790

Abstract

with a variation of NaOH catalyst concentration has been done. The purpose of this study was to determine the concentration of NaOH catalyst in the synthesis of 1,3-diphenyl-2-propen-1-on using MAOS method which produced optimal yield. The synthesis of 1,3-diphenyl-2-propen-1-on using benzaldehyde and acetophenone was carried out using the MAOS method with NaOH catalyst. The variation of NaOH catalyst concentration was 10%, 20%, 30%, and 40%. Microwave radiation was carried out at 140 watts for 20 seconds. The purity of the synthesized 1,3-diphenyl-2-propen-1-on was tested by melting point, TLC, and gas chromatography. The structure of the synthesized 1,3-diphenyl-2-propen-1-on was characterized by FTIR, GC-MS and NMR. The results showed that the compound 1,3-diphenyl-2-propen-1-on can be synthesized from benzaldehyde and acetophenone using MAOS method. The obtained yield at varying catalyst concentrations of 10, 20, 30 and 40% were (50.58±1.84%, (69.20±1.58)%, (84.55±1.50)% and (90.60±0.96)%, respectively. The concentration of 40% NaOH catalyst produces the most optimal yield of synthesis products. 
SINTESIS SENYAWA ANTIMALARIA BARU TURUNAN FENANTROLIN N-(2-NITROBENZIL)-1,10-FENANTROLINIUM IODIDA DAN (1) N-(4-NITROBENZIL)-1,10-FENANTROLINIUM IODIDA Utami, Dwi; Narwanti, Iin; Jumina, Jumina
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.53 KB) | DOI: 10.20884/1.jm.2014.9.1.153

Abstract

Malaria is a global health problem, especially in the tropics. Efforts to decrease the incidence of malaria plagued the plasmodium resistance to existing antimalarial drugs. Benzyl Phenanthrolium Iodide derivates have been proved has antimalarial activity. The aim of this study is synthesis the nitro benzyl phenanthrolium.The research that has been done was the synthesis of (1)-N-(2-nitrobenzyl) phenantrolium iodide and(1)-N-(4-nitrobenzyl)-1,10-phenantrolium iodide. Synthesis of (1)-N-(2-nitrobenzyl)-1,10-phenantrolium iodide through a two-steps reaction SN-2 is the reaction of (1)N-(2- nitrobenzyl) chloride and potassium iodide followed by reaction phenantroline 1:10 monohydrate, whether the second product was 4-nitrobenzil bromida as starting material. The reaction were started by reflucting the nitro subtituted benzil halida with potassium iodide for 1 hour, yielded nitro subtituted benzyl iodide. Then followed by reflucting nitro substituted benzyl iodide with 1,10-phenanthroline for 11 hours. The final product isolated and purificated by suitable solvent. The melting point was conducted by melting poin apparatus. The structures of product was characterized by IR and UV-Vis spectroscopy.Results obtained in the form of thick liquid light yellow with a melting point of 54.2-63.5oC. While the compound (1)-N-(4-nitrobenzyl)-1,10-phenantrolium iodide is synthesized from 4-nitrobenzylbromide and potassium iodide followed by reaction phenantroline 1:10 monohydrate. Synthesis results in the form of pale yellow crystals with a melting point of 221?225oC . The resulting yield of 32.87%. The interpretation of UV-Vis and Infra red spectras indicated that nitro benzyl iodide have been condensed with 1,10 phenantroline as the end of the product.