Samsul Mustofa
Fakultas Kedokeran Universitas YARSI

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Peran Kromosom Seks Terhadap Perkembangan Otak Mustofa, Samsul
Majalah Kesehatan Pharmamedika Vol 1, No 2 (2009)
Publisher : Majalah Kesehatan Pharmamedika

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Abstract

Otak adalah organ yang paling penting dalam tubuh manusia. Organ inilah yang mengontrol seluruh kerja tubuh. Awal pembentukan susunan saraf pusat atau otak dimulai setelah kehamilan 3 - 4 minggu kehamilan. Diferensiasi dan perkembangan otak pada tahap awal dipengaruhi oleh kromosom seks (kromosom X dan Y). Perbedaan perkembangan pada jenis kelamin laki-laki dan perempuan dipengaruh oleh faktor hormonal yang mengakibatkan perbedaan secara fisik maupun psikis. Abnormalitas kromosom seks, berupa kelainan jumlah maupun struktur kromosom dan dapat menyebabkan terjadinya kelainan genetik atau kelainan kongenital. Tulisan ini bertujuan mengetahui peranan gen yang terdapat kromosom seks (X dan Y) terhadap perkembangan otak pada jenis kelamin laki-laki dan wanita. Penulisan ini berdasarkan data yang diambil dari jurnal maupun literatur yang ada kaitannya. Kesimpulan. Abnormalitas pada struktur kromosom Y mengakibatkan terjadinya gangguan hormonal pada individu yang dapat menyebabkan ketidak jelasan jenis kelamin. Abnormalitas kromosom X baik jumlah maupun struktur berpengaruh terhadap perkembangan amygdala yang terdapat di dalam forebrain, dan dapat menyebabkan gangguan kecerdasan  Kata kunci: diferensiasi otak, X-linked, kromosom seks, penyakit genetik, gangguan kecerdasan
Sindrom Metabolik dan Defisiensi Testosteron Mustofa, Samsul
Majalah Kesehatan Pharmamedika Vol.2 No.2 2010
Publisher : Majalah Kesehatan Pharmamedika

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Metabolic syndrome (Mets) is a disease associated with metabolic disorders. This syndrome is known by a description such as low HDL-cholesterol, high triglycerides, increased blood sugar, signs of insulin resistance, the discovery of overweight (which is characterized by increased waist circumference or body mass index), and increased blood pressure. Mets prevalence increases with the addition of age. Some researchers report that low levels of testosterone and SHBG were significantly correlated with the Mets. Other researchers showed that 19% of men with the Mets (WHO criteria) had a lower total testosterone, free testosterone 11% lower, and 18% lower SHBG than controls. Total testosterone to be negatively correlated with insulin levels, insulin resistance, and BMI in male patients with the Mets. This paper aims to examine more deeply about the relationship between Metabolic Syndrome with Testosterone Deficiency based on the source of the article or journal-related. Metabolic Syndrome impact inconvenience for patients. Provision of exogenous testosterone can improve the condition of the patient.
Prevalensi bayi lahir cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI Mustofa, Samsul; Susmiarsih Panjiasih, Tri; Wikaningrum, Riyani
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

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Congenital Malformations was instrumental in perinatal morbidity and infant mortality. Patients with severe disorders are classified to be affected physically, mentally, and socially and require special attention. Prevalence data from various types of congenital malformations may be useful to plan primary prevention measures for such disorders. The purpose of this study was to examine the prevalence of congenital malformations at the teaching hospitals, Faculty of Medicine, YARSI University. In this study, data were obtained from medical records in four teaching hospitals i.e. Abdul Muluk Hospital in Bandar Lampung, Lampung, Serang General Hospital in Serang, Banten, Garut General Hospital in Garut, and Gunung Jati General Hospital in Cirebon, West Java, within a period of three years i.e. 2005 to 2007. Based on ICD-10 codes, eight groups involving 18 types of birth defects were recorded. Among 25,276 babies born in four previously mentioned hospitals, 283 babies were born with congenital malformation. The prevalence of congenital malformations in Abdul Muluk Hospital was 11.31% with the frequency of 5.961/1,000 live birth, Serang Hospital was 13.78% with the frequency of 7.163/1,000 live birth, Garut Hospital was 33.92% with the frequency of 9.777/1,000 live birth and Gunung Jati Hospital was 40.99% with the frequency of 24.98/1000 live birth. Various disorders were noted, being the most common was disorder in the digestive system (25.80%), followed by the musculoskeletal system (20.49%), and the nervous system (16.61%). In conclusion, the total prevalence of congenital malformations in the teaching hospital, Faculty of Medicine, YARSI University was 1.12% with the frequency of 11.2/1000 live births. Congenital malformations were particularly prominent in Gunung Jati General Hospitals Cirebon, West Java.