CHOIRUL MUSLIM
Unknown Affiliation

Published : 3 Documents
Articles

Found 3 Documents
Search

A TYPE OF DWARFISM FOUND IN SOUTH BENGKULU TO BE AN X-LINKAGE

Jurnal Biologi Vol XII, No 2
Publisher : Jurnal Biologi

Show Abstract | Original Source | Check in Google Scholar

Abstract

We have reported here a specific human short stature population in Kedurang District, South Bengkulu. AH those are men, described as a mild dwarf (130-150 cm), detected after 5 to 10 years old, caused by the failure on lumbar backbone growth and development, and only found among the men. In this investigation, we examine the inheritance pattern of the dwarfism by using pedigree analysis, study the morphological comparison between the disorder and normal person, and finally we ascertain the variation among the disorder. We accomplished a survey on pedigree family to at least 3-4 generations related to the disorder. The data are then tested with Chi-square test, and transformed to tree families and pedigree analysis. To investigate morphological performance and their variation, we collected morphometric measurements to both disorder and normal group of sample; they are the height, the vertebral bones length, head measurement, the leg and arm length (upper and fore side), and their indexes. The data were analyzed descriptively. To find out the variation, the quantitative expression and penetrance, we evaluated the data according to normal distribution with Z test. The result showed all the dwarfisms in Kedurang are men, who inherited his gene from his carrier mother. As a result, the gene has tightly linked to X chromosome and supposedly belongs to Spondylo Epiphypeseal Dysplasia Tarda (SEDT). These were concluded from 32 related family of dwarfism. We found 19 dwarf persons, grouped into young, adult, and older persons. The their height were shorter than normal (136,5 cm), and the length of vertebrae was under normal value (51,5 cm). Their frontal extremity were shorter than the normal one, but they are in proportion with any part comprised them. Their feet were shorter, but the proportion of leg is longer than calf. The rest is as normally. Among the dwarf person, there are variations of the length. The phenotypic expressivity is varied in the vertebrae, leg, and calf; but the rest is relatively invariable. Their penetrance is strong, mostly in the height, length of vertebrae, and legs. Based on morphological data we concluded that the disorder in the Kedurang, South Bengkulu belongs to SEDT (Spondyloepiphyseal dysplasia tardd).

Beberapa Kejadian Cacat Bawaan Bayi Lahir Di Rumah Sakit M. Yunus Bengkulu Dalam Satu Dekade Terakhir

Prosiding Seminar Biologi Prosiding Seminar Nasional From Basic Science to Comprehensive Education
Publisher : Prosiding Seminar Biologi

Show Abstract | Original Source | Check in Google Scholar | Full PDF (349.815 KB)

Abstract

Untuk membandingkan jenis dan jumlah kejadian cacat bawaan pada bayi lahir, kami telah melakukan dua kali survey rekam medis, dan observasi langsung di RumahSakit M.Yunus dalam jarak lebih dari sepuluh tahun. Pada tahun 2000 kami mengolah data rekam medis periode Agustus 1998 s/d Juli 1999, dan mengamati setiap kelahiran bayi yang lahir di rumah sakit tersebut secara langsung selama bulan Juli 1999. Pada tahun 2013 kami sekali lagi mengolah yang sama pada periode Januari 2010 s/d Juli 2011, dan mengamati setiap kelahiran bayi selama bulan Juli 2011. Dari survey dan pengamatan langsung tersebut kami mencatat jenis-jenis cacat bawaan bayi lahir di Rumah Sakit M.Yunus Bengkulu, dan membandingkan jumlah dan jenisnya. Hasil penelitian menunjukkan ada 6 jenis cacat bawaan bayi lahir yang cenderung meningkat dari tahun ke tahun, ialah Atresia Ani, Hirschprung, Gastrochisis, Spina bifida, Hernia, dan Hydrocephalus. Peningkatan resiko cacat bawaan bayi lahir tersebut diduga berkaitan dengan semakin banyaknya penggunaan bahan kimia beresiko teratogenik, dan mutagenik di dalam asupan bahan makanan danobat-obatan di luar resep dokter. Kata kunci:   neonatus congenital, rekam medis, Atresia Ani, Hirschprung, Gastrochisis, Spina bifida, Hernia, Hydrocephalus, teratogenik

Pengaruh Pemberian Ekstrak Kijing (Pilsbryoconcha exilis) Pada Pemulihan Kualitas Sperma Mencit (Mus musculus)

PendIPA Journal of Science Education Vol 3, No 1 (2019): FEBRUARY
Publisher : FKIP University of Bengkulu

Show Abstract | Original Source | Check in Google Scholar | Full PDF (411.582 KB)

Abstract

ABSTRACT[Effect of Kijing Extract (Pilsbryoconcha exilis) on the Recovery of Sperm Quality in Mice (Mus musculus)]. This study aims to determine the effect of Pilsbryoconcha exilis extract on the quality of M. muscullus sperm. The approach used for the study was experiment with a complete randomized design model. In this study, 4 treatments and 5 replications were conducted, including treatment 1 which only administered aquades as control (P0), treatment 2 which only given paracetamol dose 250 mg / kg (P1), and treatment 3 given paracetamol dose 250 mg / kg and P. exilis extract dose 0,46 mg / g (P2) and treatment 4 given paracetamol 250 mg / kg and extract P. exilis 0,69 mg / g (P3). Technique of data analysis using qualitative descriptive and statistical test of One Way Annova parametry, and if obtained significant difference then continued statistic test of Smallest Real Difference. From the results of the study, it was found that P. exilis and paracetamol extract had no effect on sperm quality. Keywords: Sperm; M. muscullus; extract P. exilis; paracetamol.(Received August 14 , 2018; Accepted January 20, 2019; Published February 26, 2019) ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak Pilsbryoconcha exilis terhadap kualitas sperma M. muscullus yang diberi parasetamol. Pendekatan yang digunakan untuk penelitian adalah eksperimen dengan model rancangan acak lengkap (RAL). Pada penelitian ini menggunakan 4 perlakuan dan 5 ulangan meliputi perlakuan 1 yang hanya diberikan aquades merupakan kontrol (P0), perlakuan 2 yang hanya diberikan parasetamol dosis 250 mg/kg bb (P1), dan perlakuan 3 yang diberikan parasetamol dosis 250 mg/kg bb dan ekstrak P. exilis dosisi 0,46 mg/g bb (P2) dan perlakuan 4 yang diberikan parasetamol 250 mg/kg bb dan ekstrak P. exilis 0,69 mg/g bb (P3). Teknik analisa data menggunakan deskriptif kualitatif dan uji statistik parametri One Way Annova, dan jika didapatkan perbedaan yang bermakna maka dilanjutkan uji statistic Beda Nyata Terkecil (BNT). Dari hasil penelitian diketahui pemberian ekstrak P. exilis dan parasetamol berepengaruh tapi tidak signifikan terhadap kualitas sperma. Kata Kunci: Sperma; M. muscullus; ekstrak P. exilis; parasetamol.