Bulan G. Munthe
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Diabetes mellitus in β-thalassemia major patients

Medical Journal of Indonesia Vol 12, No 2 (2003): April-June
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

β-thalassemia major is a disease caused by β polypeptide chain synthesis disorder which is inherited as an autosomal recessive from both parents which is marked by little or no β globin chain synthesis. Medication for β thalassemia major patients is by repeated blood transfusions, which causes hemochromatosis. Hemochromatosis can occur in various organs including the pancreas. The aim of the study was to assess the alteration of plasma glucose concentration and the hemochromatosis prevalence. Fasting plasma glucose concentration and serum ferritin examination were measured in 115 β thalassemia major patients with ages between 10-23 years who were out-patients in the Thalassemia Centre, Department of Child Health, Medical School, University of Indonesia / Dr. Cipto Mangunkusumo General Hospital, Jakarta. The plasma glucose concentration examination was conducted by the GDH enzymatic method, with American Diabetes Association (ADA) criteria in the evaluation, while the serum ferritin examination was conducted with the microparticle enzyme immuno assay (MEIA) method. All patients had hemochromatosis, 14.8% of the patients had impaired fasting glucose level and 2.6% of the patients showed indications of diabetes mellitus. β thalassemia major patients who receive frequent transfusions will develop hemochromatosis that will in turn impair the pancreatic function. (Med J Indones 2003; 12: 87-93) Keywords : β thalassemia major, hemochromatosis, diabetes mellitus

Glucose-6-Phosphate Dehydrogenase Deficiency in the Dr. Cipto Mangunkusumo General Hospital

Paediatrica Indonesiana Vol 19 No 1-2 (1979): January 1979
Publisher : Indonesian Pediatric Society

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Abstract

The incidence of G-6-P-D deficiency in Indonesia is not yet known. So far only Inyo Luan Eng (1964) reported the incidence in some parts of Indonesia. Other data are only from case reports. This study which consisted of 3200 babies -- born in the Dr. Cipto Mangunkusumo General Hospital from September 1975 through October 1976 proved that the incidence is high enough that is 2.66% (85 out of 3200). The hemoglobin content of G-6-P-D deficient babies showed an average of 14.4 g%. This gives us an idea that there is slight anemia in these babies. The incidence of jaundice was 35 out of 85 (41%). Factors inducing jaundice were infection, hypoxia and sub-aponeurotic bleeding. Of 60 which could be examined quantitatively only 2 showed a G-6-P-D activity level of more than 120 mu/10^9 RBC, so that the screening method could be used for early detection of G-6-P-D deficiency.