Mujinah Mujinah
Center for Radioisotopes and Radiopharmaceuticals, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia

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OPTIMASI KONDISI SPEKTROMETER ALFA DENGAN DETEKTOR ION-IMPLATED SILIKON DI PUSAT PRODUKSI RADIOISOTOP Kadarisman, Kadarisman; Mutalib, Abdul; Gunawan, Adang Hardi; Lubis, Hotman; Lestari, Enny; Mujinah, Mujinah; Hafid, Dadang
Jurnal Radioisotop dan Radiofarmaka Vol 1, No 1 (1998): Jurnal PRR 1998
Publisher : Jurnal Radioisotop dan Radiofarmaka

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OPTIMASI KONDISI SPEKTROMETER ALFA DENGAN DETEKTOR ION­IMPLATED SILIKON DI PUSAT PRODUKSI RADIOISOTOP. Telah dilakukan penetapan kondisi optimum spektrometer alfa yang dibubungkan dengan detektor silikon yang diimplantasi ion dengan standar sumber radiasi alfa campuran 239Pu, 241Am dan 244Cm.Pengamatan meliputi penetapan jarak antara cuplikan dengan detektor, tingkat kevakuman, batas deteksi alat dan penetapan efisiensi pencacahan dari masing-masing radionuklida. Dari percobaan diperoleh hasil kondisi optimum yaitu, jarak antara detektor dengan standar 1- 2 cm, tekanan kevakuman -1050 mbar, batas deteksi 5,1 dpm dan efisiensi pencacahan masing-masing untuk 239Pu (5157 keV) 10.6%, 241Am(5486 keV) 10,3% dan 244Cm(5805 keV) 9,9%. OPTIMIZATION OF ALPHA SPECTROMETER COUPLED TO ION-IMPLANTED SILICON DETECTOR IN RADIOISOTOPE PRODUCTION CENTER. The optimization of alpha spectrometer coupled to an ion-implanted silicon detector was carried out using an alpha radiation mixed standard source containing radionuclides of 239Pu, 241Am and 244Cm. This experiment involved the determination of the optimum distance between a radiation source and the detector surface, the pressure of the vacuum chamber, and the detection limit and the efficiency of the detector. The results show that the optimum distance between the radiation source and the detector is 1-2 cm; the pressure is -1050 mbar; the detection limit is 5.1 dpm, and the efficiencies for 239Pu ( 5157 keV), 24lAm (5486 keV) and 244Cm(5805 keV) are 10.6%, 10.3% and 9.9%, respectively.
PROSES UJI KUALITAS PRODUK Mo-99 HASIL BELAH U-235 DI PUSAT PRODUKSI RADIOISOTOP PERIODE 1995 -1996 Kadarisman, Kadarisman; Komala, Imas; Gunawan, Adang Hardi; Suparman, Ibon; Sayad, M.; Djoharly, Djoharly; Sovilawati, Evi; Ramli, Martalena; Ritonga, Togar M.; Tahyan, Yayan; Hafid, Dadang; Herlina, Herlina; Karyadi, Karyadi; Lestari, Enny; Sarmini, Endang; Mujinah, Mujinah; Kurniasih, Dede
Jurnal Radioisotop dan Radiofarmaka Vol 1, No 2 (1998): JURNAL PRR 1998
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ROSES UJI KUALIT AS PRODUK 99Mo HASIL BELAH 235U DI PUSAT PRODUKSI RADIOISOTOP PERIODE 1995 -1996. Telah dilakukan evaluasi kualitas produk 99Mo hasil belah 235U. Konsentrasi radioaktivitas, kemurnian radionuklida, pengotor radionuklida pemancar gamma dan alfa telah dibahas. Sebanyak 44 buah cuplikan produk 99Mo yang diproses dari Januari 1995 sampai dengan Juni 1996 di Pusat Produksi Radioisotop - BATAN, telah diperiksa dan dievaluasi memenuhi persyaratan kualitas sesuai yang ditetapkan oleh Medy-Physics Inc dan layak digunakan untuk pembuatan generator 99Mo - 99mTc. Konsentrasi radioaktivitas produk 99Mo berkisar dari 280 mCi/mL sampai dengan 4500 mCi/mL pada saat kalibrasi. Konsentrasi radioaktivitas total pengotor radionuklida pemancar alfa yang ditetapkan dengan pencacah alfa Eberlin berkisar antara 0,04 x 10-7 µCi/mCi 99Mo sampai dengan 4,55x10-7 µCi/mCi 99Mo, yang menunjukkan semua produk 99Mo yang dianalisis memenuhi persyaratan yang telah ditetapkan, maksimum 1,0 x 10-6 µCi/mCi 99Mo. Demikian juga konsentrasi radioaktivitas pengotor radionuklida pemancar gamma tidak ada yang melampaui persyaratan yang telah ditetapkan, yaitu 131I < 0,05 µCi/mCi 99Mo, 103Ru < 0,05 µCi/mCi 99Mo dan total nuklida pemancar gamma yang lain < 0,1 µCi/mCi 99Mo. Konsentrasi radioaktivitas nuklida pengotor 131I terbesar adalah 0,0125 µCi/mCi 99Mo, untuk 103Ru 0,032 µCi/mCi 99Mo, dan untuk total nuklida lainnya 0,08031 µCi/mCi 99Mo. Nuklida pemancar gamma yang paling dominan mengotori produk 99Mo hasil belah 235U adalah radioiodium yang terdiri dari isotop 133I(dalam 42 batch), 132I(dalam 37 batch) dan isotop 133I (dalam 39 batch). Sedangkan yang paling sedikit adalah nuklida 140Ba dan 132Tc, masing­ masing dalam 1 batch dari jumlah 44 batch. QUALITY CONTROL PROCESS OF 99Mo FISSION PRODUCT IN RADIOISOTOPE PRODUCTION CENTER 1995 - 1996. Quality evaluation of 99Mo fission was carried out. Radioactive concentration, impurities of gamma and alpha emitting radionuclides were investigated. Fourty four batches of 99Mo were processed from January 1995 to June 1996 in Radioisotope Production Center - BATAN, were investigated for the agreement with the quality requirement set out by Medy-Physics Inc. and their suitability for 99mTc generator production. Radioactive concentration of 99Mo solutions were found between 280 mCi/mL to 4500 mCi/mL at calibration time. Radioactive concentration of total alpha emitting impurities were between 0,04 x 10-7 µCi/mCi 99Mo to 4,55 x 10-7 µCi/mCi 99Mo which complied with the impurity limit of 1.0 x 10-6 µCi/mCi 99Mo at calibration time. Radioactive concentration of gamma emitting impurities of all 44 99Mo solutions complied with quality requirements set out by Medy-Physics Inc. i.e. 131I < 0.05 µCi/mCi 99Mo, 103Ru <0.05 µCi/mCi 99Mo and others gamma emitter < 0.1 µCi/mCi 99Mo. The highest radioactive concentartion of impurities observed were 0.0125 µCi 131I/mCi 99Mo, 0.032 µCi 103Ru/mCi 99Mo and other was 0.0803 µCi/mCi 99Mo. Major gamma enitting impurities were radioiodine, i.e: 131I in 42 batches, 132I in 37 batches and 133I in 39 batches, while 140Ba and 132Te were only observed in one batch.
PEMBUATAN NANOPARTIKEL EMAS SEBAGAI STUDI AWAL PEMBUATAN KOMPOSIT NANOPARTIKEL EMAS-DENDRIMER RADIOAKTIF Mahardika, Pratiti; Oktavia, Ratri; Mujinah, Mujinah
Jurnal Radioisotop dan Radiofarmaka Vol 13, No 1 (2010): Jurnal PRR 2010
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ABSTRAKPEMBUATAN NANOPARTIKEL EMAS SEBAGAI STUDI AWAL PEMBUATANKOMPOSIT NANOPARTIKEL EMAS-DENDRIMER RADIOAKTIF.Telah dilakukan pembuatan nanopartikel emas sebagai bahan baku pembuatan komposit nanopartikel emas-dendrimer radioaktif untuk nanobrakiterapi kanker prostat. Pada penelitian yang dilakukan oleh Khan Mohamed K.. et al. telah terbukti bahwa nanopartikel emas radioaktif efektif mengurangi pertumbuhan kanker prostat. Nanopartikel emas diinjeksikan ke sel kanker dengan media pembawa dendrimer. Penelitian pendahuluan pembuatan komposit nanopartikel emas-dendrimer radioaktif ini dilakukan dengan melarutkan foil cmas dalam aqua regiq dan mengeringkannya. melakukan pembentukan HAuCl1 kemudian melakukan pcnambahan stabilizer untukpenbentukan partikel berukuran nano. Oari hasil percobaan diperoleh nanopartikel emas terkecil berukuran 44,3 nm dengan ukuran rerata 204.3 nm.Kata kunci: nanopartikel emas, nanobrakiterapi, dendrimerABSTRACTPREPARATION OF GOLD NANOPARTICLE AS A FIRST STEP OF MAKING ARADIOACTIVE GOLD NANOPARTICLE-DENDRIMER COMPOSITE.Preparation of gold nanoparticle as a raw material for making radioactive gold nanoparticle-dendrimer composite for nanobrachytherapy prostate cancer was carried out. Khan Mohamed K.. et al.. reported that radioactive gold nanoparticle effectively reduced prostate cancer growth. Gold nanoparticle was injected to cancer cell withdendrimer as the carrier. A preliminary research of making radioactive gold nanoparticle-dendrimer composite was started with dissolving gold foil in aqua regia and dried, forming gold chloride then stabilizer was added to form nanometer size particle. The experiment resulted in gold nanoparticle with smallest size of 44.3 nm and average size of 204.3 nm.Key words: gold nanoparticle, nanobrachytherapy
Synthesis and Characterization of Poly(Amidoamine) Dendrimers Encapsulated 198Au Nanoparticles Ritawidya, R.; Pujiyanto, A.; Mujinah, Mujinah; Witarti, Witarti; Setiawan, Setiawan; Ramli, M.; Kurniasih, D.; Yanuar, A.; Mutalib, A.; Kardono, L.B.
Atom Indonesia Vol 38, No 3 (2012): December 2012
Publisher : PPIKSN-BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (460.081 KB) | DOI: 10.17146/aij.2012.176

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Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits α or β particle with a proper energy. 198Au (99% β max = 0.96 MeV and t1/2 = 2.69 days) is one of radionuclides that has been considered to be effective for the above-mentioned purpose. The purpose of this research was to synthesis and characterize poly(amidoamine) (PAMAM) G3.0 dendrimers encapsulated 198Au nanoparticles as a new brachytherapy agent. PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles was successfully synthesized by a bottom-up method using sodium borohydride as a reductor. Purification was then performed by a size exclusion chromatography in order to separate large Au nanoparticles that were formed outside the cavity of PAMAM G3.0 dendrimers. Prior to the synthesis of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles, the synthetic procedure was first established by using a non-radioactive Au. The PAMAM G3.0 dendrimers encapsulated Au nanoparticles produced was then characterized by using an UV-Vis spectroscopy, a transmission electron microscopy (TEM), particle size analyzer (PSA), and an atomic absorption spectroscopy (AAS). Characterization results revealed that PAMAM G3.0 dendrimers encapsulated Au nanoparticles that were prepared from a reaction mixture of PAMAM G3.0 dendrimers and Au HAuCl4 with mol ratio of 2.8, was found to be a proper formula. It produced PAMAM G3.0 dendrimers encapsulated Au nanoparticles with diameter of 1.743 nm, spheris, uniform and drug loading value of 26.34%. This formula was then used in synthesis using radioactive Au, 198Au. Characterization results of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles gave a radiochemical purity of 99.4% and zero charge. Received: 04 December 2012; Revised: 18 December 2012; Accepted: 20 December 2012
PENENTUAN PROFIL ELUSI IODIUM-125 SEBAGAI PERUNUT UNTUK TUJUAN RADIOIMMUNIASSAY (RIA) Maiyesni, Maiyesni; Mujinah, Mujinah; Kurniasih, Dede; Witarti, Witarti; Triyatno, Triyatno; S, Herlan
Jurnal Sains dan Teknologi Nuklir Indonesia Vol 17, No 2 (2016): Agustus 2016
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.899 KB) | DOI: 10.17146/jstni.2016.17.2.2404

Abstract

Manfaat iodium-125 (125-I) sudah banyak diketahui. 125-I  dapat digunakan antara lain sebagai perunut dalam teknik Radioimmunoassay (RIA) untuk deteksi dini berbagai penyakit kanker, menentukan kesuburan hewan ternak serta cemaran mikotoksin di dalam pangan secara invitro.  125-I  yang dibutuhkan dalam teknik ini disamping harus mempunyai kemurnian radiokimia > 95%,  konsentrasi radioaktifitas   juga tinggi, sehingga volume  125-I  haruslah sekecil mungkin. Dengan demikian perlu dipelajari profil elusi 125-I dari kolom reduktor Jones saat proses peningkatan kemurnian  radiokimia. Penelitian ini bertujuan untuk menentukan volume optimal  eluat dengan efisiensi dan kemurnian radiokimia yang dapat diterima. Pada penelitian ini kondisi kolom yang dipilih adalah kolom dengan pH basa. Kolom reduktor Jones yang mengandung  125-I dielusi dengan larutan  NaOH 0,01N secara  fraksinasi volume 1 ml. Radioaktifitas  masing-masing fraksi diukur menggunakan  dose calibrator. Penentuan kemurnian radiokimia dilakukan pada fraksi yang memiliki radioaktifitas  tertinggi dan fraksi gabungan  dengan  metode kromatografi kertas. Radioaktifitas  tertinggi ditunjukkan pada  fraksi kedua  yaitu  16,59  mCi dengan efisiensi 33,95% dan fraksi gabungan yaitu 50,19 mCi dengan efisiensi 92,26%. Kemurnian radiokimia 125-I bulk, fraksi kedua dan fraksi gabungan berturut-turut adalah 41,50, 97,5  dan  98,50%.  Volume optimal eluat adalah 7 ml serta  pH 125-I sebelum dan sesudah fraksinasi adalah 10 -11.  Determination of  Elution Profile the Iodine-125 as a tracer for Radioimmunoassay (RIA). The benefits of the Iodine-125 (125I ) isotope was well known. 125I are used as radiotracer in Radioimmunoassay (RIA) technique for early detection of cancer, determine of hormone content which related with fertility of livestock and also for contamination detection of mycotoxins on food by in vitro.  125I which is needed in this technique not only must have high radiochemical purity above 95% but also high radioactivity concentration, so that  125I volume which is use must as little as possible. Therefore, 125I elution profile for increasing radiochemical purity using a reductor Jones column should be studied. Aim of this study is to determine the optimum volume of eluate which have efficiency and radiochemical purity that can be accepted. The preliminary study was conducted to determine the optimal conditions of reductor Jones  column. Reductor Jones column is conditioned on neutral and alkaline pH. At this elution study, the columns conditions selected is alkaline pH. Reductor Jones column which containing 125I eluted with NaOH 0,01 N solution by fractionated in 1mL. The radioactivity of each fraction is measured with dose calibrator.  Determination of the radiochemical purity of carried out on the fraction which have the highest radioactivity and the combined fractions using paper chromatography. Highest radioactivity is shown in the second fraction at 16,59 mCi with efficiency 33,95%  and combined fractions at 50,19 mCi with efficiency 92,26%. The radiochemical purity of 125-I bulk, second fraction and combined fractions are 41,50%, 97,5 % dan  98,50%, respectively.  Optimum fraction is 7 mL and pH of 125-I before and after fractination are 10-11. By studying the elution profile can be known that the optimal volume is the smallest total volume of eluent with efficiency and radiochemical purity level that can be accepted. 
PENINGKATAN KEMURNIAN RADIOKIMIA IODIUM-125 PRODUKSI PRR DENGAN NATRIUM METABISULFIT DAN REDUKTOR JONES Maiyesni, Maiyesni; Mujinah, Mujinah; Witarti, Witarti; Dede K, Dede K; Triani W, Triani W; Trianto, Trianto
Jurnal Kimia Valensi Jurnal Valensi Volume 3, No.1, Mei 2013
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Syarif Hidayatullah State Islamic Uni

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v3i1.331

Abstract

Radioisotop 125iodium cukup dikenal luas manfaatnya, diantaranya adalah sebagai perunut (tracer) kit RIA/IRMA untuk deteksi in-vitro berbagai penyakit, sebagai sumber radiasi dalam brachytherapy penyakit kanker, sebagai perunut binding assay dalam berbagai penelitian bioteknologi. Beberapa tahun lalu untuk memenuhi kebutuhan dalam negeri 125I masih diimpor. BATAN, telah memiliki fasilitas produksi radioisotop 125I, tetapi sampai dua tahun terakhir selain efisiensi produksi belum optimal, kualitas produk belum memenuhi persyaratan untuk banyak keperluan di atas. 125I yang digunakan pada bidang kesehatan  dalam bentuk larutan Na125-I harus memiliki kemurnian radiokimia tinggi (>95 %) agar mendapatkan hasil penandaan yang baik. Dengan demikian perlu dilakukan peningkatan kemurnian radiokimia 125I- dengan mengurangi pengotor radiokimia yang berasal pengotor ion iodat dan ion periodat. Pada penelitian ini digunakan Na2S2O5 dan reduktor Jones untuk mereduksi ion iodat dan ion periodat menjadi ion iodida. (Na125-I) produksi PRR-BATAN sampai batas yang diharapkan. Pada percobaan ini diperoleh kemurnian radiokimia 125I- 91,49 % dengan penambahan Na2S2O5 0,1 N volume 6 uL, dan 95,16% dengan volume 8 uL. Penggunaan Na2S2O5 dengan konsentrasi 0,3 N volume 2 uL diperoleh kemurnian radiokimia 99 % sedangkan volume 4 uL, 6 uL, dan 8 uL menghasilkan kemurnian radiokimia 100 %. Sedangkan penggunaan reduktor Jones menghasilkan kemurnian radiokimia 125I- yaitu 99,83 %. Kata Kunci: iodium-125, kemurnian radiokimia, Na2S2O5, reduktor Jones, iodat.
Preparasi Radiofarmaka 99mTc-Etambutol Untuk Deteksi Tuberkulosis R., Anna; Witarti, Witarti; Mujinah, Mujinah; Jakaria, Jakaria; K., Dede; W., Widyastuti
Prosiding Seminar Nasional Teknik Kimia "Kejuangan" 2019: PROSIDING SNTKK 2019
Publisher : Prosiding Seminar Nasional Teknik Kimia "Kejuangan"

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Preparation Of 99mTc- ETAMBUTOL Radiopharmaceutical For Detection Of Tuberculosis. Radiopharmaceutical is a radioactive compound used for health services in nuclear medicine. Most of radiopharmaceutical was used for diagnosis of various abnormalities of organs, such as for the detection of tuberculosis. Tuberculosis (TB) is an infection disease caused by mycobacterium tuberculosis and can attack various organs of the body, which can lead to death. By using nuclear technology Batan has been developing ethambutol radiopharmaceutical labeled with 99mTc for detection of extra lung tuberculosis with results more sensitive and accurate that are not easily detected by methods and equipment used today and the aims to fulfil radiopharmaceuticals for hospital because there is no availability of ethambutol kits on the market. The etambutol kit produced by dry lyophilized method in sterile room, therefore has to fulfil requirements as a radiopharmaceutical. The Quality Control was performed by using several parameters including sterility , endotoxin and radiochemical purity. The results of quality control showed that Etambutol was sterile, endotoksin requirments and radiochemical purity on average >85 %. Result of clinical test from hospital showed that the image was very clear and contrast , 99mTc-ethambutol was uptake with Mycobacterium tuberculosis and accumulated in organs infected of TB.