Mudasir Mudasir
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281

Published : 44 Documents
Articles

Isolasi Kitin dari Cangkang Kepiting Laut (Portunus pelagicus Linn.) serta Pemanfaatannya untuk Adsorpsi Fe dengan Pengompleks 1,10-fenantrolin

VALENSI Vol 3, No 1 (2013): Jurnal Kimia Valensi Volume 3//No.1//Mei 2013
Publisher : Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

Show Abstract | Original Source | Check in Google Scholar | Full PDF (519.832 KB)

Abstract

Abstrak Telah dilakukan isolasi kitin dari cangkang kepiting laut (Portunus pelagicus Linn.) yang digunakan sebagai fasa padat dalam Adsorpsi kompleks tris(1,10-fenantrolin)besi(II). Optimasi berat kitin dan penentuan eluen yang sesuai telah dipelajari dalam penelitian ini dengan tujuan untuk meningkatkan recovery kompleks yang optimum. Hasil penelitian menunjukkan bahwa spektra Inframerah dari kitin hasil isolasi memberikan bilangan gelombang yang hampir sama dengan kitin standar. Penentuan kadar abu, kadar nitrogen dan kadar karbon serta derajat deasetilasi dari hasil analisis kitin hasil isolasi memberikan hasil yang memenuhi syarat kitin standar. Berat kitin optimum untuk adsorpsi kompleks [Fe(phen)3]2+ 0,4 ppm adalah 0,2 g yang memberikan % recovery sekitar 55,56% dan eluen yang sesuai adalah campuran etanol : HCl (6 : 4, v/v). Kata Kunci: Isolasi kitin, Adsorpsi, Besi, 1,10-fenantrolin dan Eluen. Abstrack The isolated crab shell chitin from the sea crab (Portunus pelagicus Linn.) for solid-phase extraction  [Fe(1,10-phenantroline)3]2+complex based. The weight optimized of chitin and searched of eluent were compatible. The result showed that infrared spectra of the isolated chitin has similar characteristic absorption with that of the standard chitin. The measurement of ash contents, nitrogen contents, and carbon contents and de-acetylated degrees from analysis result of the isolated chitin up to the standard chitin. The weight optimized of chitin used for solid-phase extraction of 0.4 ppm trace(1.10-phenanthroline)iron(II) complex are 0.2 g with % recovery 55,56% and the eluent compatible are the mixed ethanol: HCl (6:4, v/v).   Keywords: Chitin isolation, Adsorption, Iron, 1,10-phenantroline and Eluent.

EVALUATION OF LEAD LEVEL IN VARIOUS TISSUES OF PIGEONS (Columbia livia) IN YOGYAKARTA

Jurnal Sain Veteriner Vol 18, No 1&2 (2000)
Publisher : Fakultas Kedokteran Hewan

Show Abstract | Original Source | Check in Google Scholar

Abstract

Lead is one of major air pollutants. Lead is a dangerous poison for human and animals. Pigeon meat is one of popular food consumed by many people in Yogyakana. The aim of this research was to evaluate whether the lead concentration in the pigeon in Yogyakarta is considered safe for human consumption or not Forty birds 3-4 months old were collected from 4 locations in Yogyakarta, Group I (10 birds) were collected from people who sole fried birds around UripBumodibflTjo, C. Simanjuntak, Kaliurang, Gcjayan, Johanes streets, and North Ringroad. Group II (10 birds) were collected from the bird markets (Ngasem, Terban, Lempuyangan), group III (10 birds) were collected from the bird owners who raised the birds extensivelly (not in cages). Group IV (10 birds) were obtained from the bird owners who raised tho birds imeosivdly (in cages). All experimental animals were euthanized by chloroform then necropsied. Kidney, liver and breast muscle were collected for lead examination using atomic absorption spectrophotorneter {AAS). The results of the experiment showed that lead concentrations in the kidneys, liver and breast muscle of pigeons obtained from several locations in Yogyakarta were higher than the recommended standard value from WHO (0,1 ppm).

KITIN DARI LIMBAH CANGKANG UDANG SEBAGAI MEDIA UNTUK BAKTERI KITINOLITIK YANG DIISOLASI DARI LUMPUR SAWAH

Jurnal Manusia dan Lingkungan (Journal of People and Environment) Vol 16, No 2 (2009)
Publisher : Pusat Studi Lingkungan Hidup Universitas Gadjah Mada

Show Abstract | Original Source | Check in Google Scholar

Abstract

Limbah cangkang udang dimanfaatkan untuk memproduksi kitin sebagai media pertumbuahn bakteri kitinolitik. Enam isolat yang diperoleh dari lumpur sawah semuanya menunjukkan aktivitas kitinolitik. Hasil analisis selama 5 hari inkubasi menunjukkan bawah jumlah sel dan kadar protein diproduksi paling besar pada hari ke empat oleh isolat TNH23. Aktivitas kitinase tertinggi ditunjukkan oleh isolat TNH54 pada hari kedua sebesar 0,331 U/mL dan aktivitas spesifik 0,721 U/mg. isolat TNH23 dan TNH54 diduga mempunyai genus yang berbeda yaitu Aeoromonas hydrophyla dan Burcholderia pseudomallei.

Fenomena Pelaksanaan Ujian Nasional Tingkat Madrasah Aliyah Se-Provinsi Riau

Tadris: Jurnal Keguruan dan Ilmu Tarbiyah Vol 1, No 1 (2016): Tadris: Jurnal Keguruan dan Ilmu Tarbiyah
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Original Source | Check in Google Scholar

Abstract

Tujuan penelitian ini adalah untuk mengetahui bagaimanakah Kualitas pelaksanaan Ujian Nasional (UN) serta apakah ada fenomena lain yang muncul dalam pelaksanaan Ujian Nasional (UN) di Madrasah Aliyah Negeri (MAN) se- Provinsi Riau. Pendekatan penelitian yang digunakanyakni kombinasi kuantitatif-kualitatif, maka metode penelitian ini mengkombinasikan teknik pengumpulan data kuntitatif dan dianalisa dengan kualitatif prosentase. Penelitian ini dilakukan di MAN Rengat, MAN Bengkalis, dan MAN 2 Model Pekanbaru. Berdasarkan analisa data, Peneliti telah menyimpulkan bahwa terdapat fenomena dalam pelaksanaan Ujian Nasional di tingkat Madrasah Aliyah Negeri se- Propinsi RiauThe aim of the research is to know how the quality of National Test application (UN) also whether is there any phenomenon that appears in National Test application (UN) on Madrasah Aliyah Negeri (MAN) surround the Riau Province. The research procedure that used is quantitative and qualitative combination, so the research method combined the quantitative data gathering and analyzed by qualitative percentage. This research has been done in MAN Rengat, MAN Bengkalis, and MAN 2 Model Pekanbaru. According to data analyzed, the researcher has concluded that there is a phenomenon in applying National Test in Madrasah Aliyah Negeri surround Riau Province. 1994.Kata kunci: fenomena dalam UN, UN madrasah aliyah, UN madrasah aliyah Riau.

Desain Senyawa Turunan Karbamat Sebagai Insektisida Baru Menggunakan Metoda In Silico

Elkawnie Vol 3, No 1 (2017)
Publisher : Elkawnie

Show Abstract | Original Source | Check in Google Scholar | Full PDF (170.423 KB)

Abstract

Linear equation of QSAR model of insecticidal activity of carbamate derivatives based on atomic charge and hydrofobic, electronic and steric descriptors has been investigated. The descriptors were calculated by semiempirical PM3 method and biological activities of the compound were taken from experiment. The relationship between descriptors and their biological activities was analyzed with multilinear regression analysis.The best linier equation resulted from that analysis is : Log 1/LD 50 = 12,651 + (2,467 qC2) + (2,832 qC4) - (14,089 qC6) - (0,24 qO7) + (0,293 μ) - (0,08 SA (grid)) +(0,041 V)+ (0,141 EH) - (0,303 log P) n = 39 ; r = 0,839 ; adjusted r2 = 0,612 ; SE = 0,355; Fhit/Ftable = 3,443 PRESS=5,188 Based on that model, a new carbamate derivative has been designed which show better predicted activity (log 1/LD50 = 9,79) while the old one (log 1/LD50 = 8,81). This new carbamate insecticide derivative can be synthesized laboratoriccally for the next prove. Key Word:QSAR, Insecticides carbamate, PM3.

Analisis Hubungan Kuantitatif Struktur Dan Aktivitas Senyawa Turunan Triazolopiperazin Amida Menggunakan Metode Semiempirik AM1

Elkawnie Vol 1, No 2 (2015)
Publisher : UIN Ar-Raniry

Show Abstract | Original Source | Check in Google Scholar | Full PDF (615.152 KB)

Abstract

QSAR studies had done on derivatives of triazolopiperazine amide as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies had began by modeling the structures of the derivatives of triazolopiperazine amide and calcutating the descriptors of QSAR by semiempirical AM1 method which available on HyperchemÒprogram. QSAR analysis had done by multilinear regression method analysis which is available on SPSSÒ program using electronic and molecular parameters. The best QSAR equation model for method of semiempirical AM1: -log IC50 =  152.252 + (18,.295*qC1) + (2.343*qC5) + (2263.448*qC9) +  (1662.252*qC10) – (350.806*qC15) + (639.687*qO25)+ (6.515*EH) n = 18; r2 = 0.712; adjusted r2 = 0.510; Fhit/Ftab = 1.124; PRESS = 0.006 The main side of the compound can be determined through the equation. It can be used to study in preventing the disease of DM2 by inhibiting of enzyme DPP IV.

ANALISIS HKSA SENYAWA ANTIDIABETIK TURUNAN TRIAZOLOPIPERAZIN AMIDA MENGGUNAKAN METODE SEMIEMPIRIK PM3

ALCHEMY Vol 5, No 4 (2017): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Original Source | Check in Google Scholar

Abstract

Analisis hubungan kuantitatif struktur dan aktivitas (HKSA) dilakukan untuk senyawa turunan triazolopiperazin amida untuk menghibisi enzim DPP IV penyebab diabetes melitus tipe 2. Analisis ini dilakukan dengan pemodelan molekul turunan triazolopiperazin amida dan perhitungan deskriptor HKSA menggunakan metode semiempirik PM3 dengan program HyperchemÒ. Analisis data menggunakan metode analisis regresi multilinear untuk parameter elektronik dan molekular dengan program SPSSÒ. Persamaan terbaik yang diperoleh adalah:-log IC50 = 79,955 - (11,635*qC1) - (2,094*qC2) - (34,6*qN11) + (797,684*qC15) + (0,288*m) n = 18; r = 0,714; adjusted r2 = 0,305; Fhit/Ftab = 1,239; PRESS = 0,017.Berdasarkan persamaan tersebut, senyawa dengan aktivitas terbaik yang diusulkan adalah:((2R)-4-Okso-4-[3-(Trifluorometil)-5,6-dihidro[1,2,4]triazolo[4,3-a]pirazin-7(8H)-il]-1-(2-fluoro-4,6-dihidroksofenil)butan-2-aminadengan harga –log IC50 = 8,601.

Characterization of Butanediol-Alginate Ester as Candidate of Hemodialysis Membrane

Indonesian Journal of Chemistry Vol 15, No 2 (2015)
Publisher : Universitas Gadjah Mada

Show Abstract | Original Source | Check in Google Scholar

Abstract

An ester of butanediol-alginate has been studied as a possible hemodialysis membrane. With 1,4-butanediol molar ratio of 0.1, 0.5, and 1.0, it showed that the membrane mechanical properties, stability, protein adsorption, platelet adhesion and performance for urea and creatinine clearance are better than that of unmodified alginate. The increase in 1,4-butanediol molar ratio causes hemodialysis ratio to improve, and causes protein adsorption and platelet adhesion at the membrane surface to decrease. In the case of protein adsorption and platelet adhesion, the membrane with the molar ratio of 1.0 has better hemocompatibility properties. In the hemodialysis test for 4 h, using 2.742 mg cm-2 h-1 of urea and 0.058 mg cm-2 h-1 of creatinine flux, this membrane showed that 48.5% of urea and 44.2% of creatinine were cleaned.

THE INFLUENCE OF PVA.cl.CITRIC ACID/CHITOSAN MEMBRANE HYDROPHICILITY ON THE TRANSPORT OF CREATININE AND UREA

Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Original Source | Check in Google Scholar

Abstract

The influence of cross-linking and membrane hydrophilicity on the transport rate had been studied using a membrane prepared from a mixture of chitosan/PVA cross-linked citric acid (PVA.cl.CA) for creatinine and urea transport. The optimum mole ratio of PVA:citric acid as well as the best composition of chitosan:PVA.cl.CA were determined using creatinine transport study. Using the optimum compositions, further study was done using different thickness of the membrane in transporting creatinine, urea and a mixture of 3 species (creatinine, urea and vitamin B12). Membrane characterization was done using FT-IR spectrophotometer, water absorption test, TG/DTG and SEM. The results showed that the optimum composition PVA:citric acid was obtained to be 90:1, having % WU of 113.74% and creatinine transport percentage of 18.16%. Meanwhile, the optimum composition of chitosan:PVA.cl.CA was found at 4:6 ratio having % WU and % transport of 136.67% and 24.26%, respectively. The optimum transport capacity was found for membrane thickness of 50 µm with WU% at 139.61% and the percent transport of creatinine and urea each was 38.93% and 60.36%. The presence vitamin B12 in the solution of is proved to disturb the transport of creatinine and urea through the membrane. Finally, hydrophilicity seemed to give substantial contribution in the transport process as well as the mechanical strength of the membrane.

Photocatalytic Decolorization Study of Methyl Orange by TiO2–Chitosan Nanocomposites

Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Original Source | Check in Google Scholar

Abstract

The photocatalytic decolorization of methyl orange (MO) by TiO2-chitosan nanocomposite has been studied. This study was started by synthesizing TiO2-chitosan nanocomposites using sol-gel method with various concentrations of Titanium(IV) isopropoxide (TTIP) as the TiO2 precursor. The structure, surface morphology, thermal and optical property of TiO2-chitosan nanocomposite were characterized by X-ray diffraction (XRD), fourier transform infra red (FTIR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and diffuse reflectance ultra violet (DRUV) spectroscopy. The photocatalytic activity of TiO2-chitosan nanocomposite was evaluated by photocatalytic decolorization of methyl orange as a model pollutant. The results indicate that the particle size of TiO2 increases with increasing ofthe concentration of TTIP, in which TiO2 with smallest particle size exhibit the highest photocatalytic activity. The highest photocatalytic decolorization was obtained at 5 h of contact time, initial concentration of MO at 20 ppm and at solution pH of 4. Using these conditions, over 90% of MO was able to be decolorized using 0.02 g of TiO2-chitosan nanocomposite under UV light irradiation. The TiO2-chitosan nanocomposite could be reused, which meant that the TiO2-chitosan nanocomposites can be developed as an effective and economical photocatalyst to decolorize or treat dye in wastewater.