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STATUS KESEHATAN LANJUT USIA GEREJA RAWAMANGUN JAKARTA TIMUR Mawi, Martiem; Tandean, Reza; Abikusno, Nugroho
E-Journal Widya Kesehatan dan Lingkungan 2005
Publisher : E-Journal Widya Kesehatan dan Lingkungan

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Abstract

To determine the health status of older persons living in the community. A cross-sectional observational study was done of 59 older persons of a Catholic church in Rawamangun, east Jakarta, who volunteered in the study through informed consent. Data collected were physical, blood pressure, lipid profile, ECG, VEP1, weight, height knee height and food frequency. Older persons with hypertension (>140/90) were 14 (23.7%). The lipid profile of older persons were 31 (52.5%) subject had hypercholesterolemia (200 mg/L), 5 (8.5%) subject had hypertriglyceridemia (200>mg/L) 13 (22.0%) subjects had hypo-high-density-lipoproteinemia (<45 mg/L), and 12 (20.3%) subjects had hyper-low-density-lipoproteinemia (>150 mg/L). Older persons with abnormal ECG were 16 (27.1%), 2 (3.4%) subjects had less than normal VEP1 and 37 (62.7%) subjects exercised >= 3 times weekly. Body Mass Index of older persons were 12 (20.3%) subjects BMI below 20.27 (45.8%) BMI between 20-25, 18 (30.5%) between 25-30, and 2 (3.3%) subjects BMI above 30(obesity).
Serum estradiol levels and bone mineral density in postmenopausal women Mawi, Martiem
Universa Medicina Vol 29, No 2 (2010)
Publisher : Faculty of Medicine, Trisakti University

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Abstract

Postmenopausal women are at high risk of disease, such as coronary heart disease, stroke, malignancies, dementia and osteoporosis. This is due to decreased levels of estrogen/estradiol, produced mainly in the ovaries, leading to reduced bone mineral density (BMD), which is the gold standard for diagnosis of osteoporosis. The purpose of the present study was to determine the relationship between serum estradiol levels and BMD in postmenopausal women. The study, which was of cross-sectional design, involved 184 postmenopausal women meeting the inclusion criteria, viz. healthy postmenopausal women aged between 47 and 60 years having taken no hormonal medications in the previous 3 years. The subjects were assessed for anthropometric and biochemical characteristics, including BMD and serum estradiol levels. BMD was measured at the lumbar spine, right femoral neck and at the distal radius by the dual-energy X-ray absorptiometry (DXA) instrument. The mean serum estradiol concentration was 7.54 ± 4.65 pg/ml, while in 49.5% of the subjects the estradiol concentration was £ 5 pg/ml. In postmenopausal women with estradiol concentrations of > 5 pg/ml, a significant positive relationship was found between BMD and the T-scores for the femoral neck. Thus the higher the serum estradiol levels, the higher the BMD values for femoral neck region. In conclusion, the results of this study point to estradiol levels as a major factor in determining the BMD values in postmenopausal women.
Effect of aerobic exercise on blood lipid levels in postmenopausal women Mawi, Martiem
Universa Medicina Vol 28, No 1 (2009)
Publisher : Faculty of Medicine, Trisakti University

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Abstract

High blood total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), and low concentrations of high-density lipoprotein cholesterol (HDL-C) are related to risk for coronary heart disease (CHD) development. Growing evidence indicates that physical exercise can prevent at least some of the negative effects on health associated with post. The purpose of this study was to evaluate the effect of regular aerobic exercise for 12 weeks on the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. An experimental study was conducted comprising 62 postmenopausal women, aged 50-70 years, not on hormonal therapy, consuming a regular diet, living in East and South Jakarta, and willing to perform aerobic exercises regularly. The results of this study showed that all four lipid levels differed significantly between the control group and the intervention group, the respective mean levels ± SD for TC being 228.0 ± 39.7 mg/dL vs. 171.6 ± 18.4 mg/dL, (p = 0.000); for LDL-C 149.0 ± 36.9 mg/dL vs. 97.7 ± 17.8 mg/dL, (p = 0.000); for HDL-C 50.9 ± 3.9 mg/dL vs. 71.5 ± 6.7 mg/dL, (p = 0.000); and for triglycerides 150.5 ± 67.5 mg/dL vs. 95.0 ± 37.8 mg/dL (p = 0.000). Thus practitioners recommending exercise for coronary artery disease risk reduction in postmenopausal women.
Higher triglyceride serum level increases atherosclerotic index in subjects 50-70 years of age Mawi, Martiem; Chondro, Fransisca; Chudri, Juni
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

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Abstract

BackgroundAtherosclerosis, the underlying cause of heart attack, stroke and peripheral disease, is a main cause of morbidity and mortality worldwide. Hypercholesterolemia and hypertriglyceridemia are independent factors in the development and progression of atherosclerosis. The atherosclerotic index (AI) is a strong indicator of cardiovascular heart disease. The objective of this study was to determine the relationship between lipid serum level and AI in subjects 50-70 years of age. Methods A study of cross-sectional design was conducted among male and female subjects 50-70 years of age. The inclusion criteria were: healthy, and capable of active communication. The exclusion criteria were: subjects not completing the study, currently consuming antihyperlipidemic drugs. Lipid profile comprising total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, and malondialdehyde (MDA), was analyzed using commercial kits. Systolic and diastolic blood pressure and body mass index was measured in all subjects. Atherogenic index was calculated from (total cholesterol – HDL cholesterol) / HDL cholesterol. Multiple linear regression was used to analyze the data.Results Mean age of the subjects was 60.6 ± 3.30 years and there was a significant relationship of LDL cholesterol and triglycerides with AI (b=0.009; p=0.000 and b=0.008; p=0.000, respectively). Triglyceride level was the most influencing factor for AI (b=0.008; Beta=0.616; p=0.000)ConclusionsHigher triglyceride levels increase AI in subjects 50-70 years of age. Subjects with high serum triglyceride level but without symptoms of cardiovascular disease should be examined for the development of coronary artery blockage.
High free testosterone index increases lung function in adult males Mawi, Martiem; Nirmalasari, Rully Ayu
Universa Medicina Vol 31, No 2 (2012)
Publisher : Faculty of Medicine, Trisakti University

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BackgroundIncreasing age and decreased testosterone concentrations in males influence muscle strength and muscle mass, particularly in skeletal muscle. There have been few studies on decreased lung function resulting from reduced mass and strength of respiratory muscles. The aim of the present study was to investigate the existence of an association between free testosterone index (FTI) and lung function in males aged between 40 and 80 years.MethodsThis cross-sectional study involved 167 males aged between 40 and 80 years in Cilandak subdistrict, South Jakarta. Total serum testosterone and sex hormone-binding globulin (SHBG) concentrations were determined by electrochemiluminescence immunoassay (ECLIA) using Roche Elecsys Reagent Kit Cat 11776061 and Elecsys 2010 reagent (Cobas e601), respectively FTI was calculated using the formula free testosterone/SHBG x 100%. Forced expiratory volume in 1 second (VEP1) was assessed by means of an AS 500 spirometer. ResultsMean age of the subjects was 53.32 ± 8.26 years, mean total serum testosterone concentration was 532.59 ± 206.92 ng/dL, mean SHBG concentration 41.26 ± 21.14 nmol/L, mean FTI 48.22 ± 14.34 %, and mean VEP1 was 1.63 ± 0.54 L. There was a significant association between both SHBG and FTI on the one hand and VEP1 on the other, with Pearson correlation coefficients of -0.199 (p=0.010) and 0.271 (p=0.000), respectively. Linear multiple regression analysis indicated that FTI was the most influential variable on lung function (VEP1), higher FTI values indicating higher VEP1 (â=0.008: p=0.004).ConclusionIn males aged 40-80 years, higher FTI values indicate better lung function as determined by means of VEP1.
High blood pressure tends to increase carotid intima-media thickness in adult females Imran, Yudhisman; Prawiroharjo, Pukovisa; Mawi, Martiem
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

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Abstract

BackgroundAtherosclerosis is initiated by endothelial dysfunction, as a result of increasing degradation of nitrit oxide by reactive oxygen species, thereby increasing oxydative stress. Dyslipidemia is one of the risk factors of endothelial dysfunction. The aim of this study was to evaluate the relationship of blood pressure and serum lipid level with carotid intima-media thickness (CIMT) in subjects aged between 55-65 years.MethodsA cross sectional study was carried out in 52 male and female subjects aged between 55-65 years. Age, gender, body mass index (BMI), blood pressure, lipid profile, and CIMT were assessed in all subjects. The independent t-test was used to to analyze the relationship between all variables and CIMT. The level of statistical significance was set at p<0.05ResultsMean age was 59.19 ± 3.68 years, prevalence of thickened CIMT was 66.5%, and plaques were found in 9 subjects. There wwre no significant differences in age, BMI, systolic and diastolic blood pressure, and lipid profile between normal and thickened CIMT (p>0.05). However, there was a significant difference in gender between the two groups (p=0.011). In females, mean systolic and diastolic blood pressure were higher in the thickened CIMT group than in the normal CIMT group, but the difference was not significant (p>0.05). ConclusionsOur findings suggest that high blood pressure tends to increase CIMT in female adults. An increasing value of CIMT should be considered as a sign of cerebrovascular disease.