Henny Maulani
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Ekspresi Protein HER-2/neu, Status Reseptor, Estrogen dan Progesteron pada Berbagai Yuwono Derajat Keganasan Karsinoma Payudara Duktal Invasif Wanita Usia Muda EP, Ika Kartika; Maulani, Henny; Sulastri, Henny; ., Yuwono
Indonesian Journal of Pathology Vol. 18 No. 1 January 2009
Publisher : Indonesian Journal of Pathology

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Background. According to the 2001 report of the committee for cancer registry of the Indonesian Association of Pathologists (BRK-IAPI), in Indonesia breast cancer is a second rank malignant disease (19,88%) of all malignancies following cervical cancer. The HER-2/neu expressions, estrogen and progesterone receptor status in women ≤ 40 years with invasive duct carcinoma of the breast has not been done. A diagnostic test has been done at Departement of Anatomy Pathology with total sample was 31. The aim of this study is to find out the expressions of HER-2/neu, estrogen and progesterone receptor status in young women with invasive duct carcinoma of the breast on various grade.Method.Using formalin fixed, paraffin embedded tissues block archives, women with invasive duct carcinoma of the breast, whose age ≤ 40 years were performed immunostaining  to determine HER-2/neu expressions, estrogen and progesterone receptor status.  Furthermore the study asses the correlation between histologic grading with HER-2/neu expressions and estrogen and progesteron receptor status.Results.Among 31 patients, this study found high grade tumor (64,52%), diameter tumors > 5 centimeters (48,4%0), and the majority is           in 36-40 year age group.  HER-2/neu were overexpressed in 13 patients (41,9%), estrogen receptor positive in 13 patients (41,9%), and progesterone receptor positive in 14         patients (45,1%).  Statistic analysis revealed there is no significant correlation between histologic grading and HER-2/neu expressions, estrogen and progesterone receptors respectively.Conclusion.HER-2/neu overexpressions were commonly found in high grade tumor, while positivity of estrogen and progesterone receptor more common in grade II tumor. There is no significant correlation was found between histologic grading, and HER-2/neu expressions, as well as estrogen and progesterone receptors status.Key words: HER-2/neu, estrogen receptor, progesterone receptor, histologic grading, breast carcinoma
Angka Kejadian Karsinoma Urothelial di Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang Periode Tahun 2009-2013 Syafa’ah, Aini Nur; Maulani, Henny; Suciati, Tri
Majalah Kedokteran Sriwijaya Vol 47, No 1 (2015): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Kanker kandung kemih merupakan kanker yang paling umum ke-4 terjadi pada pria dan ke-12 pada wanita. Karsinoma urothelial merupakan salah satu jenis kanker kandung kemih yang sering ditemukan di negara berkembang. Penelitian ini bertujuan untuk mengetahui angka kejadian karsinoma urothelial di Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang periode tahun 2009-2013. Jenis penelitian yang digunakan adalah metode deskriptif dengan pendekatan serial kasus. Data diambil dari rekam medik Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang. Terdapat 66 kasus karsinoma urothelial dari 29.175 kasus yang diperiksa secara histopatologi di Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang. Angka kejadian karsinoma urothelial di Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang adalah 0,23%. Pria lebih banyak daripada wanita yaitu sebanyak 80,3% dengan rasio pria:wanita sebesar 4:1. Karsinoma urothelial paling banyak terdiagnosis pada usia 61-70 tahun. Diagnosis mikroskopik terbanyak adalah invasive high grade urothelial carcinoma yaitu sebesar 66,7%. Angka kejadian karsinoma urothelial di Bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang pada tahun 2009-2013 adalah 0,23% dan diagnosis mikroskopik terbanyak adalah invasive high grade urothelial carcinoma.