Iesje Martiza
Department of Pediatrics, Medical Faculty of Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung

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Surveillance of Rotavirus Diarrhea in Dr. Hasan Sadikin General Hospital Bandung Prasetyo, Dwi; Martiza, Iesje; Soenarto, Yati
Majalah Kedokteran Bandung Vol 42, No 4 (2010)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

The diarrhea morbidity in Indonesia has increased, however, all the reports had not been done carefully, so that accurate surveillance are essential for improving quality of morbidity data. To determine the prevalence and clinical manifestations of rotavirus diarrhea and to characterize the circulating rotavirus strains, children below 5 years old who were admitted to Hasan Sadikin Hospital, Bandung because of diarrhea, from January 2006 through March 2007 were enrolled in a surveillance study and had stool specimens tested for the presence of rotavirus using enzyme immunoassay (EIA). The strains of rotavirus were determined using reverse transcriptase-polymerase chain reaction (RT-PCR). Rotavirus were detected in 47.8% analyzed samples (87/184), G and P-genotype of rotavirus were G[1] (37.5%) and P[6] (53.5%). Most subjects were males (56%), 6–11 months of age (35%). Most common clinical manifestations besides diarrhea were dehydration (72.7%) and vomiting (50%). Subjects with positive rotavirus more common had dehydration (72% vs 28%) and vomiting (61% vs 39%). In conclusion, vomiting and dehydration are the prominent clinical manifestations of diarrhea with positive rotavirus infection. G1 and P6 are the most common genotype of rotavirus. [MKB. 2010;42(4):155–60].Key words: Clinical manifestations, diarrhea, genotype, prevalence, rotavirus Surveilans Diare Rotavirus di Rumah Sakit Dr. Hasan Sadikin BandungMorbiditas diare di Indonesia meningkat, tetapi semua laporan belum dilakukan secara cermat, sehingga surveilans yang akurat penting untuk memperbaiki kualitas data. Penelitian ini dilakukan untuk menentukan prevalensi dan manifestasi klinis diare rotavirus serta karakteristik strain rotavirus, anak usia di bawah 5 tahun yang dirawat karena diare di RS Hasan Sadikin, Bandung, dari Januari 2006 sampai Maret 2007, diikutsertakan dalam suatu penelitian surveilans dan spesimen fesesnya diperiksa untuk mendeteksi adanya rotavirus dengan menggunakan enzyme immunoassay (EIA). Strain rotavirus diperiksa dengan reverse transcriptase-polymerase chain reaction (RT-PCR). Rotavirus terdeteksi pada 47,8% sampel analisis (87/184), genotipe-G dan P adalah G[1] (37,5%) dan P[6] (53,5%) dari strain. Kebanyakan subjek adalah laki-laki (56%) usia 6–11 bulan (35%). Manifestasi klinis terbanyak adalah dehidrasi (72,7%) dan muntah (50%). Subjek dengan rotavirus positif lebih sering mengalami dehidrasi (72% vs 28%) dan muntah (61% vs 39%). Simpulan, muntah dan dehidrasi adalah manifestasi klinis terbanyak pada diare dengan infeksi rotavirus. Genotipe G1 dan P6 merupakan genotipe rotavirus yang paling sering ditemukan. [MKB.2010;42(4):155–60].Kata kunci: Diare, genotipe, manifestasi klinis, prevalensi, rotavirus DOI: http://dx.doi.org/10.15395/mkb.v42n4.29
Association between hepatitis C infection and number of screened blood unit transfusions in thalassemic children Wulandari, Diah Asri; Martiza, Iesje; Alfa, Yasmar; Prasetyo, Dwi
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.182-6

Abstract

Background Donor blood screening test for antibody againsthepatitis C virus (HCV) by third generation ELISA is widely used.However, there is still a window period during which a donor mayalready be infected despite a negative screening test.Objectives To determine the prevalence of hepatitis C infection inthalassemic children who had received screened donor blood andto seek the association between HCV infection and the number ofblood unit transfusions received.Methods This was an analytic cross-sectional study. Sixty-sevenchildren who had received third generation ELISA screened donorblood were examined for HCV antibody. The study was conductedin Hasan Sadikin General Hospital, Bandung, from January toMarch 2004. The prevalence of hepatitis C was presented in per-centage. The association between HCV infection and sex, age,interval between transfusions, and the number of blood unit trans-fusions received was determined by univariate analysis and logis-tic regression analysis.Results In univariate analysis, significant difference between HCV-infected and uninfected subjects was found in the mean age andmean number of blood units transfused (P<0.001). In logistic re-gression analysis, we found a significant association between thequantity of transfused blood with positive HCV antibody (P<0.001).The odds ratio for positive HCV antibody was 1.08 for each bloodunit transfusion received (95%CI 1.02;1.14). The prevalence ofhepatitis C in thalassemic children who received third generationELISA screened blood was 22.4% (95%CI 12.4%;32.4%). Thisprevalence is lower than that in a previous study of thalassemicchildren receiving unscreened blood (50.8%).Conclusions The prevalence of HCV infection in thalassemic chil-dren who had received screened donor blood is 22.4%. HCV in-fection is significantly associated with the number of screened bloodunit transfusions
Perbedaan Manifestasi Klinis dan Laboratorium Kolestasis Intrahepatal dengan Ekstrahepatal pada Bayi Prasetyo, Dwi; Ermaya, Yudith Setiati; Martiza, Iesje
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v48n1.733

Abstract

Ikterus fisiologis sering didapatkan pada bayi dan kebanyakan gejalanya ringan. Gejala ikterik biasanya akan menghilang dalam 2 minggu setelah lahir. Pada ikterus yang terkonjugasi terjadi defek produksi intrahepatal, transpor transmembran dari empedu, yaitu kolestasis intrahepatal (IH) atau obstruksi kolestasis ekstrahepatal (EH) yang mengakibatkan hambatan empedu. Penelitian ini dilakukan untuk melihat perbedaan manifestasi klinis dan laboratorium kolestasis IH dengan EH pada bayi. Studi potong lintang dilakukan pada 72 bayi dengan kolestasis yang datang ke Rumah Sakit Dr. Hasan Sadikin Bandung, periode Januari 2014–Desember 2015. Analisis data dilakukan dengan uji Pearson Chi-kuadrat dan Mann-Whitney. Subjek terdiri atas 43 (60%) laki-laki dan 29 (40%) perempuan, kolestasis IH sebanyak 61 orang (85%), dan EH sebanyak 11 (15%). Pada penelitian ini didapatkan perbedaan bermakna manifestasi klinis asites antara kolestasis IH dan EH (p=0,047), sedangkan venektasi, hepatomegali, dan splenomegali tidak didapatkan perbedaan bermakna. Pada pemeriksaan warna feses tidak didapatkan perbedaan bermakna (p=0,936), demikian juga hasil laboratorium bilirubin total, bilirubin direk, glutamat oksaloasetat transaminase, glutamat piruvat transaminase, alkali fosfatase, dan gama glutamil transferase serum tidak berbeda bermakna. Simpulan, didapatkan perbedaan manifestasi klinis asites, sedangkan manifestasi klinis yang lain dan hasil laboratorium tidak didapatkan perbedaan antara kolestasis IH dan EH. [MKB. 2016;48(1)45–50]Kata kunci: Kolestasis ekstrahepatal, kolestasis intrahepatal, laboratorium, manifestasi klinisDifferences of Clinical Manifestation and Laboratory Findings in Intra-Hepatic and Extra-Hepatic Cholestasis in InfantsAbstractPhysiological jaundice found in infants and most symptoms are often mild. Jaundice symptoms usually disappear within 2 weeks after birth. In conjugated jaundice defects in intra-hepatic production, transmembran transport from bile, i.e. cholestasis intra hepatic (IH), or extra-hepatic (EH) obstruction/cholestasis occur, resulting in bile barriers. This study was conducted to look at the differences in the clinical and laboratory manifestations of IH and EH cholestasis in infants. A cross-sectional study was performed on 72 infants with cholestasis who came to Dr. Hasan Sadikin General Hospital Bandung, during the period of January 2014–December 2015. Data analysis was performed with Pearson Chi-square test and Mann-Whitney. Subjects consisted of 43 (60%) infant boys and 29 (40%) infant girls, IH cholestasis were 61 (85%) and EH cholestasis were 11 (15.3%). Significant differences in the clinical manifestations of acites with IH and EH cholestasis were found (p=0.047), whereas insignificant differences in venectation, hepatomegaly and splenomegaly were observed. On examination of stool color, no significant difference was found (p=0.936). The same was true for laboratory results of total bilirubin, direct bilirubin, serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma glutamyl transferase. In conclusion, we found differences in clinical manifestation of acites, while for other clinical manifestations and laboratory results no differences were found between IH and EH cholestasis. [MKB. 2016;48(1)45–50]Key words: Clinical manifestation, extra-hepatic cholestasis, intra-hepatic colestasis, laboratory
Prevalence of HBsAg positive among non- immunized junior high school students in Bandung K., Lia Marlia; Alfa, Yasmar; Martiza, Iesje; Prasetyo, Dwi
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.974 KB) | DOI: 10.14238/pi47.6.2007.252-5

Abstract

Background Sero-epidemiologic survey of hepatitis B is used todetermine the prevalence of hepatitis B infection in community,particularly among population which has not been covered byhepatitis B immunization program.Objective To determine the prevalence of HBsAg positive amongjunior high school’s students in Bandung.Methods A cross-sectional study was conducted on junior high school(SMP) students. Subjects were selected randomly using stratifiedcluster sampling of 4 junior high schools in Bandung. The inclusioncriteria were students of first and second grade, lived in Bandungarea, without history of hepatitis B immunization. Subjects wereinterviewed and were screened for HBsAg using Reverse PassiveHemagglutination technique.Results There were 341 subjects consisted of 201 girls and 140boys. None of the subjects had any sexual intercourse or intravenousdrugs, while 261 subjects (76.5%) had shared personal care. Historyof blood transfusion was found in 13 subjects (3.8%), tattooing in2 (3.8%), body piercing in 28 (8.2%), and contact with chronicliver disease patients in 16 (4.7%). Based on HBsAg serologic test,3 subjects (2 boys and 1 girl) were found to be positive, thus HBsAgpositive prevalence was 0.9% (95%CI -0.001;0.019). Two of themhad shared personal care with their relatives or friends. None ofthem had tattoo, body pierce, blood transfusion, or contact withchronic liver disease patients. Their physical condition were withinnormal limit. One of them refused to do further laboratory testsbecause no permission from his parents. Liver function of thosestudents were normal, anti-HBc IgM were negative, and total anti-HBc were positive in two of them.Conclusion The prevalence of HBsAg positive in junior highschool students in Bandung is low and there is no obvious riskfactor for the transmission of the disease.
Perbedaan Manifestasi Klinis dan Laboratorium Kolestasis Intrahepatal dengan Ekstrahepatal pada Bayi Prasetyo, Dwi; Ermaya, Yudith Setiati; Martiza, Iesje
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v48n1.733

Abstract

Ikterus fisiologis sering didapatkan pada bayi dan kebanyakan gejalanya ringan. Gejala ikterik biasanya akan menghilang dalam 2 minggu setelah lahir. Pada ikterus yang terkonjugasi terjadi defek produksi intrahepatal, transpor transmembran dari empedu, yaitu kolestasis intrahepatal (IH) atau obstruksi kolestasis ekstrahepatal (EH) yang mengakibatkan hambatan empedu. Penelitian ini dilakukan untuk melihat perbedaan manifestasi klinis dan laboratorium kolestasis IH dengan EH pada bayi. Studi potong lintang dilakukan pada 72 bayi dengan kolestasis yang datang ke Rumah Sakit Dr. Hasan Sadikin Bandung, periode Januari 2014–Desember 2015. Analisis data dilakukan dengan uji Pearson Chi-kuadrat dan Mann-Whitney. Subjek terdiri atas 43 (60%) laki-laki dan 29 (40%) perempuan, kolestasis IH sebanyak 61 orang (85%), dan EH sebanyak 11 (15%). Pada penelitian ini didapatkan perbedaan bermakna manifestasi klinis asites antara kolestasis IH dan EH (p=0,047), sedangkan venektasi, hepatomegali, dan splenomegali tidak didapatkan perbedaan bermakna. Pada pemeriksaan warna feses tidak didapatkan perbedaan bermakna (p=0,936), demikian juga hasil laboratorium bilirubin total, bilirubin direk, glutamat oksaloasetat transaminase, glutamat piruvat transaminase, alkali fosfatase, dan gama glutamil transferase serum tidak berbeda bermakna. Simpulan, didapatkan perbedaan manifestasi klinis asites, sedangkan manifestasi klinis yang lain dan hasil laboratorium tidak didapatkan perbedaan antara kolestasis IH dan EH. [MKB. 2016;48(1)45–50]Kata kunci: Kolestasis ekstrahepatal, kolestasis intrahepatal, laboratorium, manifestasi klinisDifferences of Clinical Manifestation and Laboratory Findings in Intra-Hepatic and Extra-Hepatic Cholestasis in InfantsAbstractPhysiological jaundice found in infants and most symptoms are often mild. Jaundice symptoms usually disappear within 2 weeks after birth. In conjugated jaundice defects in intra-hepatic production, transmembran transport from bile, i.e. cholestasis intra hepatic (IH), or extra-hepatic (EH) obstruction/cholestasis occur, resulting in bile barriers. This study was conducted to look at the differences in the clinical and laboratory manifestations of IH and EH cholestasis in infants. A cross-sectional study was performed on 72 infants with cholestasis who came to Dr. Hasan Sadikin General Hospital Bandung, during the period of January 2014–December 2015. Data analysis was performed with Pearson Chi-square test and Mann-Whitney. Subjects consisted of 43 (60%) infant boys and 29 (40%) infant girls, IH cholestasis were 61 (85%) and EH cholestasis were 11 (15.3%). Significant differences in the clinical manifestations of acites with IH and EH cholestasis were found (p=0.047), whereas insignificant differences in venectation, hepatomegaly and splenomegaly were observed. On examination of stool color, no significant difference was found (p=0.936). The same was true for laboratory results of total bilirubin, direct bilirubin, serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma glutamyl transferase. In conclusion, we found differences in clinical manifestation of acites, while for other clinical manifestations and laboratory results no differences were found between IH and EH cholestasis. [MKB. 2016;48(1)45–50]Key words: Clinical manifestation, extra-hepatic cholestasis, intra-hepatic colestasis, laboratory