Dimas Erlangga Luftimas
Oncology and Stem Cell Working Group, Health Research Unit, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital

Published : 7 Documents
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Treatment Evaluation of Melasma Patients in Dr. Hasan Sadikin General Hospital Bandung in period of 2013–2014

Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Melasma is hyperpigmentation of the skin especially located on face exposed to the sunlight. This condition was characterized by brown to gray-brown macula with irregular border. Difficulties in treatment of melasma arise from high tendency for relapse, expensive cost, and high risk of side effects such as erythema, sores, scales, and acne eruption. Study about evaluation of melasma therapy in Dr. Hasan Sadikin General Hospital Bandung have not ever been done before. Therefore, this study was conducted to evaluate therapy of melasma in the Policlinic of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was retrospectively descriptive. Data were obtained from the new melasma patient medical records of Policlinic of Dermatology and Venereology of Dr. Hasan Sadikin General Hospital Bandung in period of January 2013–2014. Sampling method used in this study was total sampling. Treatments of melasma were evaluated by using Melasma Area Severity Index (MASI) score. Collected data were processed and presented in frequency distribution and percentage.Results: The most used topical drugs were combination of hydroquinone and tretinoin, and all of patients received sunblock. Most frequent time interval was two weeks (30.8%). The most common side effect was erythema (10 out of 22). Decreased MASI score was discovered in 48.1% and the most decreased category was mild (14 out of 25). Conclusions: The very common topical drugs used are hydroquinone and tretinoin. The side effect of the treatment is Erythema. The decreased MASI score is mild. [AMJ.2016;3(4):610–5]DOI: 10.15850/amj.v3n4.947

Akt–the Mammalian Target of Rapamycin (mTOR) Pathway Inhibition Increases Cervical Cancer Cell Chemosensitivity to Active Form of Irinotecan (SN-38)

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24–72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103

Treatment Evaluation of Melasma Patients in Dr. Hasan Sadikin General Hospital Bandung in period of 2013–2014

Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Original Source | Check in Google Scholar

Abstract

Background: Melasma is hyperpigmentation of the skin especially located on face exposed to the sunlight. This condition was characterized by brown to gray-brown macula with irregular border. Difficulties in treatment of melasma arise from high tendency for relapse, expensive cost, and high risk of side effects such as erythema, sores, scales, and acne eruption. Study about evaluation of melasma therapy in Dr. Hasan Sadikin General Hospital Bandung have not ever been done before. Therefore, this study was conducted to evaluate therapy of melasma in the Policlinic of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was retrospectively descriptive. Data were obtained from the new melasma patient medical records of Policlinic of Dermatology and Venereology of Dr. Hasan Sadikin General Hospital Bandung in period of January 2013–2014. Sampling method used in this study was total sampling. Treatments of melasma were evaluated by using Melasma Area Severity Index (MASI) score. Collected data were processed and presented in frequency distribution and percentage.Results: The most used topical drugs were combination of hydroquinone and tretinoin, and all of patients received sunblock. Most frequent time interval was two weeks (30.8%). The most common side effect was erythema (10 out of 22). Decreased MASI score was discovered in 48.1% and the most decreased category was mild (14 out of 25). Conclusions: The very common topical drugs used are hydroquinone and tretinoin. The side effect of the treatment is Erythema. The decreased MASI score is mild. [AMJ.2016;3(4):610–5]DOI: 10.15850/amj.v3n4.947

Upaya Meningkatkan Deteksi Dini Kanker Payudara di SMKN 1 Cijulang Kabupaten Pangandaran

Jurnal Pengabdian Pada Masyarakat Vol 3 No 2 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

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Abstract

EFFORTS TO IMPROVE EARLY DETECTION OF BREAST CANCER IN CIJULANG 1 VOCATIONAL HIGH SCHOOL, PANGANDARAN REGENCY. The high mortality rate of breast cancer (BC) patients in Indonesia is associated with conditions of most patients come to doctor in an advanced stage of BC. This is due to the low BC awareness of Indonesian women. This community service program (PPM) is intended to increase knowledge of adolescent women about early detection of BC. This action was conducted by BC awareness workshop to 114 female students of Vocational High School (SMK) 1 Cijulang, Pangandaran district, West Java. The profile of participants showed that 64% of participants are 17 years old and mostly from Cijulang and Cimerak sub-districts. In addition, the majority of participants were not aware of BC, indicated by lack of knowledge of BC signs and symptoms (97%), and low confident of doing breast self-examination (BSE) (30%). Moreover, there were 7% of the participants were smoking which is known to be one of the major risk factors for BC. These findings point out conducting a program for increasing BC awareness among students. The program was managed by mini-lecture that focuses on BC risk factors, BC early detection and BSE (SADARI) using videos and simulation on a mannequin. This program was expected to have an impact on their families, indirectly. Ultimately, this will increase the finding of new cases of BC which will increase their life expectancy.

Akt–the Mammalian Target of Rapamycin (mTOR) Pathway Inhibition Increases Cervical Cancer Cell Chemosensitivity to Active Form of Irinotecan (SN-38)

International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24–72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103

The Profile of Dietary Patterns and Physical Activity in Preventing Metabolic Syndrome

JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Vol 4, No 1 (2019): Promote a More Active and Healthier lifestyle Through Physical Education
Publisher : Departemen of Physical Education-Indonesian University of Education

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Abstract

Indonesia merupakan negara yang mengalami kenaikan kejadian obesitas, hipertensi dan diabetes setiap tahunnya. Keadaan ini membuat meningkatnya prevalensi sindrom metabolik. Sindrom metabolik adalah kombinasi dari sejumlah kondisi, yaitu hipertensi, hiperglikemia, hiperkolesterolemia, hipertrigliserida dan peningkatan ukuran lingkar perut. Asupan energi dan pola makan yang berlebihan, peningkatan kejadian obesitas, aktivitas fisik sedentari dan riwayat risiko penyakit menjadi faktor resiko sejumlah kondisi penyebab terjadinya sindom metabolik. Kabupaten Pangandaran merupakan salah satu daerah pesisir pantai di Provinsi Jawa Barat yang secara demografis dimungkinkan tingginya konsumsi garam yang dapat memicu hipertensi. Pola makan dan aktivitas fisik yang tidak baik bagi kesehatan serta rendahnya tingkat pengetahuan dan kesadaran tentang bahaya sindrom metabolik memengaruhi jumlah kejadian sindrom metabolik. Pengabdian masyarakat ini dilakukan sebagai upaya preventif melalui pengisian kuisioner untuk mengetahui pola makan dan aktivitas fisik masyarakat kecamatan Cijulang Kabupaten Pangandaran serta pengukuran lingkar perut untuk mengetahui prevalensi resiko terjadinya sindrom metabolik. Dari 544 responden rata-rata berusia 30 tahun, 129 orang mempunyai lingkar perut yang tidak normal, 47% mengkonsumsi manis setiap hari 32% mengkonsumsi asin setiap hari dan 56% tidak olahraga setiap hari.

Exclusive and Non-Exclusive Breastfeeding among Stunted and Normal 6–9 Month-Old-Children in Jatinangor Subdistrict, Indonesia

Althea Medical Journal Vol 6, No 1 (2019)
Publisher : Althea Medical Journal

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Abstract

Background: Stunting has become a public health problem in Indonesia, with the prevalence of stunting is 37.2% nationally and 25.6% in West Java. One of the causes of stunting is malnutrition that may occur because of not giving exclusive breastfeeding on the first 1000 days of life (FDL). The purpose of this study was to determine whether there was difference between exclusive and non-exclusive breastfeeding among stunted and normal 6–9 month-old-children. Methods: This study was conducted using a cross-sectional analytic study during August-October 2018 with consecutive sampling method. This study involved 110 pairs of mothers and children aged 6-9 months who resided in villages which were within the work area of Jatinangor Public Health Center. Nutritional status was determined based on length-for-age z score according to WHO. The type of breastfeeding was known based on the questionnaire. Data was analyzed by chi square test. Result: There were 60 of 110 children (54.5%) who did not receive exclusive breastfeeding. The incidence of stunting in children was 12.7% (14 of 110), of whom 10 children had no exclusive breastfeeding (p>0.05).Conclusions: Although the incidence of stunting is higher in non-exclusive breastfeeding group, there is no difference in the proportion of stunting in children aged 6–9 months between those who are exclusively breastfed and those who are not, however, exclusive breastfeeding is encouraged.