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PENGARUH PARASETAMOL DOSIS ANALGESIK TERHADAP KADAR SERUM GLUTAMAT PYRUVAT TRANSMINASE TIKUS WISTAR JANTAN Kusuma, Indra; Witjaksono, Witjaksono
MEDIA MEDIKA MUDA Vol 2, No 1 (2013): MEDIA MEDIKA MUDA
Publisher : MEDIA MEDIKA MUDA

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Abstract

Latar belakang: Dalam dunia kedokteran penggunaan parasetamol sebagai analgesik semakin banyak digunakan di bidang anestesi terutama sebagai pereda nyeri akut paskaoperasi derajat ringan hingga sedang karena parasetamol dianggap lebih aman dan efektif. Namun, dibalik keunggulan tersebut, parasetamol juga memiliki efek samping. Dewasa ini terdapat beberapa pustaka dan penelitian yang menjelaskan mengenai efektifitas dan efek hepatotoksik parasetamol namun masih belum jelas mengenai efek parasetamol sebagai obat analgesik terhadap Serum Glutamat Pyruvat Transaminase (SGPT) yang merupakan indikator kerusakan fungsi hati.Tujuan: Mengetahui pengaruh prasetamol dosis analgesik (1000 mg) terhadap kadar Serum Glutamat Pyruvat Transaminase tikus wistar jantan.Metode:Penelitian ini menggunakan true experimental dengan post test only with control group design. Sampel menggunakan tikuswistarjantan sebanyak 21 tikus. Tikus wistar dibagi secara simple random sampling menjadi 3 kelompok. Kelompok kontrol yang tidak diberi parasetamol. Perlakuan 1 yang diberi parasetamol peroral 1000mg 4x sehari selama 2 hari. Perlakuan 2 yang diberi parasetamol peroral 1000mg 4x sehari selama 4 hari. Data diujinormalitasdenganShapiro Wilks. Data dianalisisadenganOne Way Anovayang kemudiandilanjutkandenganujiPost Hoc (LSD).Hasil:Terdapatkenaikannilaireratakadar SGPT dari kontrolterhadapperlakuan 1 danperlakuan 2. UjiAnovadidapatkanperbedaan yang bermakna (p = 0.025). UjiPost Hoc didapatkanperbedaan yang bermaknapada kontrolterhadapperlakuan 1 (p = 0.010), danterhadapperlakuan 2 (p = 0.042).Kesimpulan:Pemberianparasetamoldosisanalgesik selama 2 dan 4 hari dapat menyebabkan terjadinya kenaikan kadar SGPT yang bermakna. 
Acalypha indica root extract increases post-hypoxic rat hippocampal tissue culture cell viability via phospholipase A2 inhibition Yolanda, Sophie; Andraini, Trinovita; Kusuma, Indra
Medical Journal of Indonesia Vol 22, No 3 (2013): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.528 KB) | DOI: 10.13181/mji.v22i3.581

Abstract

Background: Phospholipase A2 (PLA2) is involved in inflammation and cell death following stroke, and inhibition of its activity may promote neuroregeneration. This study aimed to observe the influence of Acalypha indica Linn root extract towards relative cell viability and PLA2 enzyme level in post-hypoxic hippocampal tissue culture.Methods: Experimental in vitro study using 24 primary neuronal cell cultures obtained from Sprague Dawley rat exposed to hypoxia with 5% O2 / 5% CO2 / N2 balanced gas for 24 hours. Post-hypoxia, Acalypha indica Linn root extract was added at doses of 10, 15, and 20 mg/mL to three treatment groups. No treatment was given to the control group. Each group consists of six samples. After 72 hours of incubation, relative cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) examination, and phospholipase A2 enzyme level was determined using ELISA.Results: PLA2 enzyme level of rat hippocampal tissue culture treated with Acalypha indica Linn root extract at 10, 15, and 20 mg/mL were significantly lower than that of control (5.55 ng/mL, 6.85 ng/mL, and 7.42 ng/mL vs 7.96 ng/mL, p < 0.05).Conclusion: Acalypha indica Linn root extract increases the relative cell viability and decreases the PLA2 enzyme level of post-hypoxic mouse hippocampal tissue with the optimal dose of the extract at 10 mg/mL. (Med J Indones. 2013;22:136-40 doi: 10.13181/mji.v22i3.581)Keywords: Acalypha indica Linn, cell viability, hypoxia, neurogenesis, phospholipase A2
BIMBINGAN KELOMPOK DENGAN TEKNIK DISKUSI UNTUK MENINGKATKAN MINAT BERWIRAUSAHA PESERTA DIDIK KELAS X JURUSAN PEMASARAN SMK N 1 MAGETAN TAHUN AJARAN 2014/2015 Kusuma, Indra
Counselium Vol 1, No 3 (2014): Jurnal Counselium
Publisher : Universitas Sebelas Maret

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Abstract

The aim of this study is to know the effectiveness of a group guidance by using discussion technique to improve the entrepreneurshipinterest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.This research is an experimental quasi study by applying the nonequivalent control group design. The population of this study is all the tenth grade students marketing major of SMKN 1 Magetan. While the sample is the tenth grade students marketing 2 as the experiment group with the total number of 31 students. Meanwhile, for the control group is taken from 32 students of tenth grade from marketing 2 class. The sample is taken by using purposive random sampling technique. The treatment is a group guidance by using discussion technique which is given to the students four times. The data of this research is entreprenurship interest. The source of the primary data is coming from the tenth grade students marketing major of SMK N 1 Magetan in the 2014/2015 academic year. The instrument used is the questionnaire of entreprenurship interest. The data is analyzed by calculating the formula of Independent Samples T test along with SPSS Statistic 17.    The result of the research show that (1) there is a significant difference between experiment group which has accepted the treatment of a group guidance by using discussion technique and the control group which has not accepted any treatment, as the value of thitung  0,573< ttabel1,67, with the significance value is 0,569 > 0,05. (2) there is a significant difference between the experiment group before and after the treatment has been given to them. It can be seen by the result of thitung3,806> ttabel 1,67. With the significance value is 0,000 < 0,05.Based on the result of this study, it can be concluded that a group guidance by using discussion technique are effective in improving the entrepreneurship interest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.  Key words : a group guidance, discussion, entrepreneurship interest
BIMBINGAN KELOMPOK DENGAN TEKNIK DISKUSI UNTUK MENINGKATKAN MINAT BERWIRAUSAHA PESERTA DIDIK KELAS X JURUSAN PEMASARAN SMK N 1 MAGETAN TAHUN AJARAN 2014/2015 Kusuma, Indra; Abdat, Chadidjah
Counselium Vol 1, No 3 (2014): Jurnal Counselium
Publisher : Universitas Sebelas Maret

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Abstract

The aim of this study is to know the effectiveness of a group guidance by using discussion technique to improve the entrepreneurshipinterest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.This research is an experimental quasi study by applying the nonequivalent control group design. The population of this study is all the tenth grade students marketing major of SMKN 1 Magetan. While the sample is the tenth grade students marketing 2 as the experiment group with the total number of 31 students. Meanwhile, for the control group is taken from 32 students of tenth grade from marketing 2 class. The sample is taken by using purposive random sampling technique. The treatment is a group guidance by using discussion technique which is given to the students four times. The data of this research is entreprenurship interest. The source of the primary data is coming from the tenth grade students marketing major of SMK N 1 Magetan in the 2014/2015 academic year. The instrument used is the questionnaire of entreprenurship interest. The data is analyzed by calculating the formula of Independent Samples T test along with SPSS Statistic 17.    The result of the research show that (1) there is a significant difference between experiment group which has accepted the treatment of a group guidance by using discussion technique and the control group which has not accepted any treatment, as the value of thitung  0,573< ttabel1,67, with the significance value is 0,569 > 0,05. (2) there is a significant difference between the experiment group before and after the treatment has been given to them. It can be seen by the result of thitung3,806> ttabel 1,67. With the significance value is 0,000 < 0,05.Based on the result of this study, it can be concluded that a group guidance by using discussion technique are effective in improving the entrepreneurship interest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.  Key words : a group guidance, discussion, entrepreneurship interest
BIMBINGAN KELOMPOK DENGAN TEKNIK DISKUSI UNTUK MENINGKATKAN MINAT BERWIRAUSAHA PESERTA DIDIK KELAS X JURUSAN PEMASARAN SMK N 1 MAGETAN TAHUN AJARAN 2014/2015 Kusuma, Indra; Abdat, Chadidjah
Counselium Vol 1, No 3 (2014): Jurnal Counselium
Publisher : Universitas Sebelas Maret

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Abstract

The aim of this study is to know the effectiveness of a group guidance by using discussion technique to improve the entrepreneurshipinterest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.This research is an experimental quasi study by applying the nonequivalent control group design. The population of this study is all the tenth grade students marketing major of SMKN 1 Magetan. While the sample is the tenth grade students marketing 2 as the experiment group with the total number of 31 students. Meanwhile, for the control group is taken from 32 students of tenth grade from marketing 2 class. The sample is taken by using purposive random sampling technique. The treatment is a group guidance by using discussion technique which is given to the students four times. The data of this research is entreprenurship interest. The source of the primary data is coming from the tenth grade students marketing major of SMK N 1 Magetan in the 2014/2015 academic year. The instrument used is the questionnaire of entreprenurship interest. The data is analyzed by calculating the formula of Independent Samples T test along with SPSS Statistic 17.    The result of the research show that (1) there is a significant difference between experiment group which has accepted the treatment of a group guidance by using discussion technique and the control group which has not accepted any treatment, as the value of thitung  0,573< ttabel1,67, with the significance value is 0,569 > 0,05. (2) there is a significant difference between the experiment group before and after the treatment has been given to them. It can be seen by the result of thitung3,806> ttabel 1,67. With the significance value is 0,000 < 0,05.Based on the result of this study, it can be concluded that a group guidance by using discussion technique are effective in improving the entrepreneurship interest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.  Key words : a group guidance, discussion, entrepreneurship interest
BIMBINGAN KELOMPOK DENGAN TEKNIK DISKUSI UNTUK MENINGKATKAN MINAT BERWIRAUSAHA PESERTA DIDIK KELAS X JURUSAN PEMASARAN SMK N 1 MAGETAN TAHUN AJARAN 2014/2015 Kusuma, Indra
Counselium Vol 1, No 2 (2013): Jurnal Counselium
Publisher : Universitas Sebelas Maret

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Abstract

The aim of this study is to know the effectiveness of a group guidance by using discussion technique to improve the entrepreneurshipinterest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.This research is an experimental quasi study by applying the nonequivalent control group design. The population of this study is all the tenth grade students marketing major of SMKN 1 Magetan. While the sample is the tenth grade students marketing 2 as the experiment group with the total number of 31 students. Meanwhile, for the control group is taken from 32 students of tenth grade from marketing 2 class. The sample is taken by using purposive random sampling technique. The treatment is a group guidance by using discussion technique which is given to the students four times. The data of this research is entreprenurship interest. The source of the primary data is coming from the tenth grade students marketing major of SMK N 1 Magetan in the 2014/2015 academic year. The instrument used is the questionnaire of entreprenurship interest. The data is analyzed by calculating the formula of Independent Samples T test along with SPSS Statistic 17.    The result of the research show that (1) there is a significant difference between experiment group which has accepted the treatment of a group guidance by using discussion technique and the control group which has not accepted any treatment, as the value of thitung  0,573< ttabel1,67, with the significance value is 0,569 > 0,05. (2) there is a significant difference between the experiment group before and after the treatment has been given to them. It can be seen by the result of thitung3,806> ttabel 1,67. With the significance value is 0,000 < 0,05.Based on the result of this study, it can be concluded that a group guidance by using discussion technique are effective in improving the entrepreneurship interest of the Marketing Major students grade tenth of SMK Negeri 1 Magetan in the 2014/2015 Academic Year.  Key words : a group guidance, discussion, entrepreneurship interest
Pengembangan Model Perencanaan Himpunan Data dan Aplikasi Instrumentasi Berbasis Pola Tujuh Belas Plus Kusuma, Indra
NADWA Vol 8, No 2 (2014)
Publisher : NADWA

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Abstract

This paper describes the development of a set of data and planning models based instrumentation applications seventeen plus patterns in BK teachers SMP / MTs in Bondowoso. The results of this study indicate that counselling activity plan-ning model using the approach pattern seventeen plus becomes very necessary. B.K. teachers in SMP/MTs of Bondowoso still do not have a wide range of data that should be held for the provision of counselling services. The teachers feel it is important to have variety of data sets and instrumentation applications for the smooth running of counselling services (score = 3.23). The evaluation of the implementation of set of data and applications instrument was still very low (score = 1.14). The planning model development activities and application in-strumentation data set found that B.K. teachers desperately need (score = 4.28). The assessment model development planning activities data set and instrumenta-tion applications that are promoted rated excellent (score = 4.47).Keywords: planning, data set, application instrumentation
RANCANG BANGUN ANTENA PLANAR MONOPOLE MIKROSTRIP UNTUK APLIKASI ULTRA WIDEBAND (UWB) Kusuma, Indra; Haryadi, Tommi; _, Mukhidin
ELECTRANS Vol 13, No 2 (2014): Volume 13, Nomor 2, Tahun 2014
Publisher : Universitas Pendidikan Indonesia

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Abstract

Pada penelitian ini dirancang antena mikrostrip monopole planar untuk aplikasi UWB yang bekerja pada frekuensi 3,1-10,6  GHz. Penelitian ini dilakukan dalam dua tahap. Pada tahap pertama dilakukan optimasi rancangan antena melalui simulasi menggunakan perangkat lunak 3D Electromagnetic Simulator. Pada tahap kedua dilakukan fabrikasi dengan menggunakan bahan dasar substrat Roger RT-58880 dengan konstanta dielektrik 2,2 dan ketebalan 1,6 mm. Dari hasil simulasi didapatkan  frekuensi kerja antena antara 2,8 – 9 GHz dengan nilai return loss <-10 dB dan VSWR kurang dari 2, dan Bandwidth sebesar 6,3 GHz. Antena memiliki pola radiasi omnidireksional dengan gain pada frekuensi 3,1 GHz MHz sebesar 2,2 dBi dan impedansi input pada frekuensi 3,1 GHz sebesar 50,231Ω. Dari hasil pengukuran didapatkan rentang frekuesi kerja antena antara 2,6 – 9,5 GHz dengan nilai return loss di bawah -10 dB dan VSWR kurang dari 2, dan Bandwdith sebesar 6,9 GHz. Antena memiliki pola radiasi omnidireksional dengan gain  pada frekuensi 3,1 GHz sebesar 2,1 dBi dan impedansi input pada frekuensi 3,1 GHz sebesar 51,031  Ω. Dari hasil simulasi dan pengukuran dapat disimpulkan bahwa antenna ini dapat digunakan untuk aplikasi UWB.
PENGEMBANGAN MODEL PERENCANAAN HIMPUNAN DATA DAN APLIKASI INSTRUMENTASI BERBASIS POLA TUJUH BELAS PLUS PADA GURU BK/KONSELOR SMP DI KABUPATEN BONDOWOSO Kusuma, Indra; Budiyanto, Sapto Mei
Jurnal Pendidikan Ilmu Sosial Vol 25, No 2: DESEMBER 2015
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

The main target of the research is to show that planning is the most important stages of management function, mainly to face exsternal environment that changed dynamically. The main topic on this research was focused on the certain elements from planning process and the process that have very closed relation with the problem solving and also the program development of counseling service at school. The Planning model for counceling activity by using seventeen plus  pattern approach to be very urgent to be done by guiding and counceling teachers in order the implantation is in line with the students’ need at the field.From the introduction study can be concluded that in general the Bk/guiding and counceling teachers at Junior High School/SMP at Bondowoso is still having not variant data that should be owned for conducting guiding and counceling service at school. In general, the guiding and counceling teachers SMP/Jumior High School at Bondowoso felt important and even very important for having data collection and instrumentation application for running on the duty for conducting guiding and counceling service at school, with average score: 3,23.Besides that, it can be explained that conducting evaluation of data collecting and the existing of instrumentation application nowadays, it can be concluded that it was still very low in general with the average score = 1,14. While, it was linked with the need of model development for data compilation activity planning and instrumentation application were found that guiding and counceling’s teachers very needed in general with the average score = 4,28. While it was linled with the assessment of model development of data compilation activity planning and instrumentation application that were promoted, it was found that guiding and counceling’s teachers gave very good assessment in general with the average score = 4,47.
Pengembangan Model Perencanaan Himpunan Data dan Aplikasi Instrumentasi Berbasis Pola Tujuh Belas Plus Kusuma, Indra
Nadwa: Jurnal Pendidikan Islam Vol 8, No 2 (2014): Pendidikan Berbasis Masyarakat
Publisher : FITK UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/nw.2014.8.2.595

Abstract

This paper describes the development of a set of data and planning models based instrumentation applications seventeen plus patterns in BK teachers SMP / MTs in Bondowoso. The results of this study indicate that counselling activity planning model using the approach pattern seventeen plus becomes very necessary. B.K. teachers in SMP/MTs of Bondowoso still do not have a wide range of data that should be held for the provision of counselling services. The teachers feel it is important to have variety of data sets and instrumentation applications for the smooth running of counselling services (score = 3.23). The evaluation of the implementation of set of data and applications instrument was still very low (score = 1.14). The planning model development activities and application instrumentation data set found that B.K. teachers desperately need (score = 4.28). The assessment model development planning activities data set and instrumentation applications that are promoted rated excellent (score = 4.47). Abstrak Makalah ini menjelaskan pengembangan model perencanaan himpunan data dan aplikasi instrumentasi berbasis pola tujuh belas plus pada guru B.K. SMP/MTs di Bondowoso. Hasil penelitian ini menunjukkan bahwa model perencanaan kegiatan konseling dengan menggunakan pendekatan pola tujuh belas plus menjadi sangat perlu dilakukan agar implementasinya sesuai dengan kebutuhan siswa. Guru BK SMP/MTs di Bondowoso masih banyak yang belum memiliki berbagai data untuk penyelenggaraan layanan konseling. Guru-guru tersebut sangat memerlukan himpunan data dan aplikasi instrumentasi untuk kelancaran menjalankan tugasnya (rerata = 3,23). Sementara evaluasi pelaksanaan himpunan data dan aplikasi instrumennya ternyata masih sangat rendah (rerata = 1,14. Guru-guru BK juga sangat membutuhkan (rerata = 4,28). Penilaian pengembangan model perencanaan kegiatan himpunan data dan aplikasi instrumentasi yang dipromosikan dinilai sangat baik (rata = 4,47)