Diah Krisnansari
Jurusan Kedokteran Fakultas Kedokteran dan Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman, Jl. Dr. Gumbreg No. 1, Purwokerto

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Suplementasi Vitamin E dan Profil Lipid Penderita Dislipidemia: Studi pada Pegawai Rumah Sakit Profesor Dokter Margono Soekarjo Purwokerto Krisnansari, Diah; Kartasurya, Martha Irene; Rahfiludin, M. Zen
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.198 KB)

Abstract

ABSTRACT Vitamin E supplementation and lipid profile in patients with dislipidemia Background: The prevalence of dislipidemia in Indonesia increase lately. Vitamin E has important role in cholesterol metabolism and protecting low density lipoprotein cholesterol against oxidation. This study was to investigate the effect of vitamin E supplementation on lipid profile.Method: The study was a randomised controlled clinical trial. Subjects were the employees of Professor Doctor Margono Soekarjo hospital aged 30-50 years who suffered from dislipidemic. The supplementation groups received 400 IU vitamin E and the control group received placebo once a day for 30 days. Lipid profile was examined using vitros system chemistry analyser 250 dan 350. Nutritional intake were gathered using food recall method and processed with nutrisurvey. Analyses were conducted using T-test, Mann Whitney, Wilcoxon and Chi square tests.  Result: There were no differences in total (p=0.910), LDL (p=0.457) and HDL cholesterol levels (p=0.809) as well as trigliseride level (p=0.687) between the two groups before suplementation. There were differences in total (p=0.004) and LDL (p=0.002), there were no differences in HDL cholesterol level (p=0.332) and trigliseride level (p=0.940) between the two groups after supplementation. There were differences on the changes in total cholesterol (p=0.001) and LDL cholesterol (p=0.000) and no differences on the changes in HDL cholesterol level (p=0.197) as well as trigliserida level (p=0.438). There was no difference in nutritional intake between the two groups. Conclusion: That supplementation of vitamin E 400 IU once daily for 30 days improve lipid profile. Keywords: Dislipidemia, vitamin E, total cholesterol, LDL cholesterol, HDL cholesterol, trigliseride   ABSTRAK Latar belakang: Angka kejadian dislipidemia di Indonesia semakin meningkat. Vitamin E merupakan antioksidan penting dalam metabolisme kolesterol, melindungi kolesterol LDL terhadap oksidasi dan meningkatkan kolesterol HDL. Penelitian ini bertujuan mengetahui pengaruh suplementasi vitamin E terhadap profil lipid penderita dislipidemia. Metode: Desain studi adalah acak buta ganda terkontrol dengan subyek 42 orang karyawan RS Profesor Dokter Margono Soekarjo penderita dislipidemia yang berusia 30-50 tahun, dibagi menjadi dua kelompok yaitu 22 orang memperoleh vitamin E 400 IU dan 20 orang memperoleh placebo sekali sehari selama 30 hari. Karakteristik subyek diperoleh melalui wawancara, berat badan dan tinggi badan diperoleh melalui pengukuran. Profil lipid diukur sebelum dan sesudah suplementasi dengan vitros system chemistry analyser 250 dan 350. Asupan gizi diperoleh melalui food recall dan dianalisis dengan program nutrisurvey. Data dianalisis dengan uji T, Mann Whitney, Wilcoxon dan Chi square. Hasil: Tidak ada perbedaan kolesterol total (p=0,910), kolesterol LDL (p=0,457), kolesterol HDL (p=0,809) dan trigliserida (p=0,687) antara kedua kelompok sebelum suplementasi. Ada perbedaan kolesterol total (p=0,004) dan kolesterol LDL (p=0,002), tidak ada perbedaan kolesterol HDL (p=0,332) dan trigliserida (p=0,940) antara kedua kelompok sesudah suplementasi. Ada perbedaan perubahan kolesterol total (p=0,001) dan kolesterol LDL (p=0,000), tidak ada perbedaan perubahan kolesterol HDL (p=0,197) dan trigliserida (p=0,438) antara kedua kelompok. Tidak ada perbedaan asupan gizi antara kedua kelompok. Simpulan: Suplementasi vitamin E 400 IU sekali sehari 30 hari dapat memperbaiki kolesterol total dan kolesterol LDL penderita.  
High serum iron and zinc decrease glutathione S-transferase among women with breast cancer Roestijawati, Nendyah; Ernawati, Dwi Arini; Krisnansari, Diah
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.25-30

Abstract

BACKGROUNDBreast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.METHODSAn observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.RESULTSThe results showed that there was a significant relationship of serum iron with GST (r=-0.487; p<0.05) and serum zinc with GST (r=-0.409; p<0.01).CONCLUSIONOur study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.
Hepatoprotective Potential of Propolis toward Hepar Injury Rats (Rattus norvegicus) Induced by Carbon Tetrachloride Krisnansari, Diah; Sulistyo, Hidayat; Kusdaryantoi, Wahyu Dwi
Jurnal Ners Vol 9, No 2 (2014): VOL. 9 NOMOR 2 OKTOBER 2014
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.V9I22014.270-278

Abstract

Introduction: The prevalence of chronic liver disease continues to increase. One potentially hepatotoxic substances that cause chronic liver disease is carbon tetrachloride. The process of liver damage can be prevented by the antioxidant role of propolis. The aims of this research was to study the hepatoprotective potential of propolis toward hepar injury rats induced by carbon tetrachlorida. Method: This was an experimental study with pre-post test. Twenty five male Wistar rats aged 12–16 week old, weighing 125–200 gr were allocated into 5 groups. Group I: standard meal + aquadest-gavage; group II: standard meal + CCl4 1% 1 mL + aquadest-gavage, group III: standard meal + CCl4 1% 1 mL + 0,054 gr propolis-gavage, group IV: standard meal + CCl4 1% 1 mL + 0,108 gr propolis-gavage and group V: standard meal + CCl4 1% 1 mL + sylimarin 50 mg/kg-gavage. IL-6, SOD, NAS score+fibrotic were measured after treatment. Analysed of IL-6 and NAS score+fibrotic with Kruskal Wallis to Mann Whitney and analysed of SOD with One-Way ANOVA to LSD. Results: The study showed that there were significant differences in IL-6, SOD and NAS score + fibrotic between groups. Discussion: Provision of 0,054 gr and 0,108 gr have hepatoprotective potential toward hepar injury rats induced by carbon tetrachlorida. Further research need to identify antioxidants and hepatoprotective potential of propolis on human with liver disease.Keywords: IL-6, SOD, fibrotic, propolis
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN ASUPAN CAIRAN DAN NATRIUM PADA PASIEN GAGAL GINJAL KRONIK (Studi Kasus pada Pasien yang Menjalani Hemodialisis di RSUD Prof. Dr. Margono Soekarjo Purwokerto) fitriani, eka; Krisnansari, Diah; Winarsi, Hery
Jurnal Gizi dan Pangan Soedirman Vol 1 No 01 (2017): Jurnal Gizi dan Pangan Soedirman
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jgps.2017.1.01.344

Abstract

ABSTRACT This observational study using cross sectional design. Sampling method using purposive sampling and got 35 participants who were CKD patients undergoing hemodialysis in Prof. Dr. Margono Soekarjo Hospital, Purwokerto. The data of participant characteristic, length of time since the initiation of hemodialysis therapy, knowledge, attitude, and social support were collected by using questionnares. Patient’s compliance to fluid and natrium intake was collected by calculating fluid and natrium intake level. Data were analyzed using Fisher test. Most participants did not comply with fluid restriction, but complied with natrium restriction. All factors that have been analized had no correlation to fluid and natrium intake compliance (p > 0,05), except gender and social support factor that had correlation to fluid intake compliance (p < 0,05). Male patients needed an intensive assistance so that fluid intake compliance increased. Moreover, social support from family and others needed to achieve this goal.   Keywords: Fluid and natriumi intake compliance, gender, hemodialyss, social, support  ABSTRAK  Penelitian observasional ini menggunakan desain cross sectional. Metode pengambilan sampel menggunakan purposive sampling dan didapatkan 35 peserta penderita CKD yang menjalani hemodialisis di Rumah Sakit Prof. Dr. Margono Soekarjo, Purwokerto. Data karakteristik peserta, lamanya waktu sejak dimulainya terapi hemodialisis, pengetahuan, sikap, dan dukungan sosial dikumpulkan dengan menggunakan kuesioner. Ketaatan pasien terhadap asupan cairan dan natrium dikumpulkan dengan menghitung tingkat asupan cairan dan natrium. Data dianalisis dengan menggunakan uji Fisher. Sebagian besar peserta tidak mematuhi pembatasan cairan, namun sesuai dengan batasan natrium. Semua faktor yang telah dianalisis tidak memiliki korelasi dengan kepatuhan asupan cairan dan natrium (p> 0,05), kecuali faktor pendukung gender dan sosial yang memiliki korelasi terhadap kepatuhan asupan cairan (p <0,05). Pasien laki-laki membutuhkan bantuan intensif agar kepatuhan asupan cairan meningkat. Apalagi dukungan sosial dari keluarga dan orang lain perlu untuk mencapai tujuan ini.  Kata kunci: Kepatuhan cairan dan natrium, jenis kelamin, hemodialisis, dukungan sosial