Herlyani Khosama
Faculty of Medicine, University of Indonesia

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GAMBARAN PENOLAKAN MASYARAKAT TERHADAP PUNGSI LUMBAL DI BAGIAN NEUROLOGI BLU RSUP. PROF. DR. R.D. KANDOU MANADO Pasomba, Selvyani; Khosama, Herlyani; Sampoerno, Junita M.P.
e-CliniC Vol 1, No 1 (2013)
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Abstract: The examination of cerebrospinal fluid obtained by a lumbar puncture is important in the diagnosis of CNS infection. There have been no reports of refusals of lumbar punctures in Manado. This study is a descriptive preliminary using interviews and questionnaires. The subjects were all patients or families of patients in the inpatient unit at the Department of Neurology BLU. Prof. Dr. R. D. Kandou Manado in November 2012. The results showed that of the total number of 60 respondents, 27 (45%) under advice, agreed to undergo lumbar punctures; 30 (50%) refused, and 3 (5%) were not able to decide and thus abstained. While 93.3% of respondents knew the definition and indications of lumbar puncture, 86.7% refused eventhough they knew that the lumbar puncture procedure was important in the management of the disease; 86.7% assumed that the lumbar puncture was a dangerous procedure; 80% felt unsure enough to refuse; and 86.7% were afraid to have the lumbar puncture procedure done. All respondents knew that lumbar puncture had complications. Conclusion: nearly all respondents who refused knew that the lumbar puncture procedure is important in the management of the disease, yet they assumed the lumbar puncture was dangerous, uncomfortable, and felt fearful. Keywords: lumbar puncture, neurology, refusal description, society. Abstrak: Pemeriksaan cairan serebrospinal yang diperoleh melalui tindakan pungsi lumbal penting untuk mendiagnosis infeksi susunan saraf pusat. Meskipun demikian, sering terjadi penolakan terhadap pemeriksaan ini. Sampai saat ini belum ada laporan tentang gambaran penolakan pungsi lumbal di Manado. Penelitian ini bersifat deskriptif dengan wawancara menggunakan kuesioner. Subjek penelitian ialah semua pasien atau keluarga pasien di ruang rawat inap Bagian Neurologi BLU RSUP. Prof. Dr. R.D. Kandou Manado bulan November 2012. Hasil penelitian memperlihatkan jumlah responden sebanyak 60 orang, 27 (45%) setuju jika seandainya disarankan untuk menjalani pungsi lumbal, 30 (50%) menolak, dan tiga (5%) tidak dapat memutuskan setuju atau menolak (abstain). Sebanyak 93,3% responden mengetahui definisi dan indikasi pungsi lumbal, 86,7% responden yang menolak menganggap pungsi lumbal penting dalam penatalaksanaan penyakit, 86,7% menganggap pungsi lumbal merupakan tindakan yang berbahaya, 80% responden merasa tidak nyaman, dan 86,7% takut terhadap pungsi lumbal. Simpulan: hampir seluruh responden yang menolak mengetahui bahwa tindakan pungsi lumbal penting dalam penatalaksanaan penyakit, dan menganggap pungsi lumbal sebagai tindakan berbahaya, tidak nyaman dan merasa takut pada tindakan ini. Kata kunci: pungsi lumbal, neurologi, gambaran penolakan, masyarakat.
Plasmin for Enhanced Improvement in Acute Ischaemic Stroke: A Multicentre Randomized Placebo-Controlled Trial Misbach, Jusuf; Jannis, Jofizal; Kustiowati, Endang; Umbas, David Gunawan; Nurimaba, Nurjaman; Suratno, Suratno; Kotambunan, Siwi; Yamanie, Nizar; Soertidewi, Lyna; Octaviana, Fitri; Khosama, Herlyani
Journal of the Indonesian Medical Association Vol. 59 No. 5 May 2009
Publisher : Journal of the Indonesian Medical Association

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Plasmin® (rongshuan jiaonans) is a medicine from China - which has gone through a high technology of biochemical extraction - that has thrombolitic effect, fibrinolytic effect, anticoagulant, antiplatelet and anti-inflamation effect. The purpose of this study was to evaluate Plasmin® in acute ischemic stroke patients in a randomized, double-blind, placebo-controlled trial using some assessments of functional outcome and vascular as well as labarotary parameter such as Barthel Index (BI) and Modified Rankin Scale (MRS), mini mental state examination (MMSE), transcranial Doppler’s (TCD) performance, and measurement of blood analysis including fibrinogen level, INR, platelet aggregation, total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride level. An 84-day randomized double-blind placebo-controlled study was conducted. Participants were recruited from six academic hospitals that had been diagnosed as ischaemic stroke for the first time after 2 hours and before 2 weeks of onset. Patients were randomly assigned to plasmin® or placebo control (1:1 ratio). Sixty patients of ichaemic stroke who fulfilled inclusion criteria were enrolled in the study over 84 days period, with 44 participants completing the study (21 plasmin and 23 placebo). The increasing of BI score at 84th day compare to 14th day was significantly more in plasmin group than in placebo. Eighteen participants (85.7%) of plasmin showed improvement in MRS score, while in placebo group only 12 participants (52.2%) showed improvement (p =0.018). Motor strength of upper extremity was seen improving significantly in plasmin after 14 days of treatment compare to placebo, while lower extremity was significantly improved after 28 days of treatment. Administration of plasmin® in the acute ischaemic stroke patient between 2 hours and 2 weeks of onset showed significant improvement in motor strength, BI score, and MRS score. Further study with larger number of participants is recommended to confirm the benefit of plasmin® in management of acute ischaemic stroke.Keywords: acute ischaemic stroke, Barthel Index, Modified Rankin Scale, plasmin, randomized controlled trial
PROFIL CARPAL DAN CUBITAL TUNNEL SYNDROME PADA NELAYAN PESISIR PANTAI MANADO DI MAASING Linda, Amanda V; Mahama, Corry N; Khosama, Herlyani
Jurnal Kedokteran Klinik Vol 3, No 1 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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AbstractCarpal tunnel syndrome is a collection of symptoms that occur when the median nerve trapped in the carpal tunnel. Whereas cubital tunnel syndrome is an event of trapping the ulnar nerve in the cubital tunnel and Guyon’s canal. Both syndromes are at the top of the list of cumulative trauma disorders, namely types of musculoskeletal and nervous system injuries due to repetitive work. There had not been much research on carpal and cubital tunnel syndrome, especially in repetitive movements such as fishermen in North Sulawesi. This was a descriptive study that aimed to obtain the profile of carpal and cubital tunnel syndrome in fishermen at Manado coastal specifically in Maasing by using a cross-sectional method. Typical symptoms were assessed based on subjective symptoms; tingling, numbness, pain, or waking up at night. Additional for carpal tunnel syndrome was objective symptoms found in examination of thumb opposition tests, pinprick test, Tinel’s Test, Phalen’s Test, and carpal compression test, and for cubital tunnel syndrome was of Froment sign, elbow flexion test, and Tinel’s test, and whether or not there was sign of Wartenberg. Subjects consisted of 45 persons and the typical symptoms of the syndrome were found in 24 persons; carpal tunnel syndrome in 47% of subjects and cubital tunnel syndrome in 27% of subjects. Typical symptom of carpal and cubital tunnel syndrome mostly found on subject under the age of 50 and work for more than 10 years. Both syndroms showed that paresthesia was the most common symptom.Keywords: carpal tunnel syndrome, cubital tunnel syndrome, fishermen.AbstrakCarpal tunnel syndrome adalah kumpulan gejala yang terjadi saat N. medianus mengalami kompresi di dalam terowongan karpal. Sedangkan cubital tunnel syndrome adalah peristiwa terperangkapnya N. ulnaris di cubital tunnel dan Guyan’s canal. Kedua sindrom ini menempati urutan teratas dalam daftar cumulative trauma disorders yakni jenis cedera muskuloskeletal dan sistem saraf akibat pekerjaan berulang. Belum banyak dilakukan penelitian mengenai carpal dan cubital tunnel syndrome khususnya pada pekerjaan dengan gerakan repetitif seperti pada nelayan di Sulawesi Utara. Metode: Penelitian ini bertujuan untuk mengetahui profil carpal dan cubital tunnel syndrome pada nelayan pesisir pantai Manado di Maasing dengan menggunakan metode potong lintang dan bersifat deskriptif. Gejala khas dinilai berdasarkan gejala subjektif; kesemutan, mati rasa, nyeri, atau terbangun pada malam hari akibat kesemutan di tangan serta gejala objektif hasil pemeriksaan tes oposisi ibu jari, pinprick test, Tinel’s Test, Phalen’s Test, dan carpal compression test untuk carpal tunnel syndrome dan pemeriksaan tes provokasi Froment sign, elbow flexion test, dan Tinel’s test, dan ada maupun tidak ada gejala tambahan berupa Wartenberg sign untuk cubital tunnel syndrome. Subjek yang diteliti berjumlah 45 orang dan sebanyak 24 orang ditemukan adanya gejala khas sindrom; carpal tunnel syndrome pada 47% subjek dan cubital tunnel syndrome pada 27% subjek. Gejala khas carpal dan cubital tunnel syndrome ditemukan lebih banyak pada subjek berusia di bawah 50 tahun dan sudah bekerja selama lebih dari 10 tahun.. Pada carpal dan cubital tunnel syndrome, keluhan yang paling banyak ditemukan adalah kesemutan.Kata kunci: carpal tunnel syndrome, cubital tunnel syndrome, nelayan.
UJI NEUROLOGICAL DEPRESSION DISORDERS INVENTORY FOR EPILEPSY (NDDI-E) PADA PASIEN EPILEPSI DI POLIKLINIK SARAF RSUP PROF. DR. R. D. KANDOU Lengkoan, Joshua; Khosama, Herlyani; Sampoerno, Maja
e-CliniC Vol 3, No 2 (2015): Jurnal e-CliniC (eCl)
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Abstract: Depression is a comorbid symptom that often occurs in epileptic patients. This study aimed to obtain the occurence of depression among epileptic patients at the Neurology Department Prof. Dr. R. D. Kandou Hospital Manado. This study used a cross-sectional design for diagnostic test. Respondents were all patients that came to the Neurology clinic at Neurology Department Prof. Dr. R. D. Kandou Hospital Manado. There were 30 epileptic cases during the period of October to November 2014 that fulfilled the inclusion and exclusion criteria. Based on the outcome of questionnaires distributed to respondents and the manual calculation with standardized score of Neurological Depression Disorders Inventory for Epilepsy (NDDI-E) >15, diagnosis of depression was confirmed. There were 10 depression cases among the 30 respondents. Conclusion: Neurological Depression Disorders Inventory for Epilepsy Indonesian Version could be used to detect depression disorders among epileptic patients.Keyword: epilepsy, depression, NDDI-EAbstrak: Depresi adalah salah satu gejala komorbid yang sering terjadi pada pasien epilepsi. Penelitian ini bertujuan untuk mengetahui gambaran depresi pada pasien epilepsi di Poliklinik Saraf RSUP Prof. Dr. R. D. Kandou Manado. Penelitian dilakukan menggunakan desain potong lintang untuk uji diagnostik dengan mengambil sampel semua pasien epilepsi yang datang ke Poliklinik Saraf BLU RSU Prof. Dr. R. D. Kandou Manado. Terdapat 30 pasien epilepsi yang berobat ke poliklinik saraf RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober sampai November 2014 yang memenuhi kriteria inklusi dan ekslusi. Dari hasil kuesioner yang dibagikan kepada responden dan melalui hasil perhitungan manual dengan standar skor Neurological Depression Disorders Inventory for Epilepsy (NDDI-E) >15 diagnosis mengalami depresi ditetapkan. Hasil penelitian menunjukkan 10 dari 30 responden mengalami depresi. Simpulan: Neurological Depression Disorders Inventory for Epilepsy (NDDI-E) versi Bahasa Indonesia dapat digunakan dalam mendeteksi gangguan depresi pada pasien epilepsi.Kata kunci: epilepsi, depresi, NDDI-E
GAMBARAN KUALITAS TIDUR PADA PERAWAT DINAS MALAM RSUP PROF. DR. R. D. KANDOU MANADO Thayeb, Ricky R. T. A.; Kembuan, Mieke A. H. N.; Khosama, Herlyani
e-CliniC Vol 3, No 3 (2015): Jurnal e-CliniC (eCl)
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Abstract: Sleep is one of the primary needs of the basic requirement for human survival. Sleep disorders can cause some effects in humans. It is estimated that 60-80% of workers with shift work system have impaired sleep quality. This results in a decrease in work productivity and an increase in the occurence of accidents. This study aimed to obtain the sleep quality of nurses in Prof. Dr. R. D. Kandou Hospital Manado in 2013. This was a descriptive and observational study by using questionnaires. The study population was nurses in the Neurology Department and the Emergency Department (ED) with samples of 52 people. The results showed that the subjective sleep qualities as perceived by the nurses themselves were as follows: good enough (44.23%) and poor (36.54%). Respondents that had sleep disturbance less than once a week were 30.77%, and respondents that had sleep disturbance 1-2 times a week were 59.62%. Most nurses (69.24%) did not use sleeping pills. Respondents that experienced some disruption of their activities during the day over the past 1 month as many as 1-2 times a week were 55.77%. Conclusion: The quality of sleep of night shift nurses in Prof. Dr. R. D Kandou Hospital Manado belonged to poor quality.Keywords: night shift nurse, sleep qualityAbstrak: Tidur merupakan salah satu kebutuhan primer yang menjadi syarat dasar bagi kelangsungan hidup manusia. Gangguan tidur dapat menimbulkan beberapa efek pada manusia. Salah satu hal yang menjadi perhatian adalah 60-80% pekerja dengan system kerja shift mengalami gangguan kualitas tidur. Hal ini mengakibatkan penurunan produktivitas kerja dan dapat menyebabkan kecelakaan. Penelitian ini bertujuan untuk mengetahui gambaran kualitas tidur perawat di RSUP. Prof. Dr. R. D. Kandou Manado tahun 2013. Penelitian ini menggunakan metode deskriptif observasional dan pemberian kuesioner. Populasi ialah perawat Instalasi inap neurologi dan Instalasi gawat darurat (IGD dengan sampel berjumlah 52 orang. Hasil penelitian memperlihatkan kualitas tidur subjektif menurut persepsi perawat itu sendiri ialah cukup baik (44,23%) dan kurang baik (36,54%); gangguan tidur kurang dari sekali dalam seminggu (30,77%); dan gangguan tidur 1-2 kali dalam seminggu (59,62%). Mengenai penggunaan obat tidur, sebagian besar perawat (69,24%) tidak menggunakan obat tidur. Mengenai perawat yang mengalami gangguan beberapa aktifitas di siang hari selama 1 bulan terakhir sebanyak 1-2 kali dalam seminggu yaitu sebesar 55,77%. Simpualn: Kualitas tidur perawat dinas malam di RSUP Prof. Dr. R. D Kandou Manado tergolong kualitas tidur yang buruk.Kata kunci: perawat dinas malam, kualitas tidur
Karateristik perawat di Irina F RSUP Prof. Dr. R. D. Kandou Manado yang mengalami keluhan nyeri punggung bawah Goni, Naftalia T.S.; Khosama, Herlyani; Tumboimbela, Melke J.
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
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Abstract: Low back pain is a clinical syndrome characterized by major symptoms of pain or other uncomfortable feelings in the lower spine. Low back pain is the leading cause of activity limitation and work absence world-wide. This study aimed to obtain the characteristics of nurses in Irina F Prof. Dr. R. D. Kandou Hospital Manado who had low back pain. This was a prospective descriptive study with a cross sectional design. Samples were 43 respondents. The results showed that of 50 respondents there were 43 respondents who suffered from low back pain. Of 43 respondents there were 14 male nurses (32.5%), and 29 female nurses (67.5%). Low back pain was suffered by 16 nurses (37,2%) aged 23-29 years, 19 nurses (44.2%) aged 30-39 years, two nurses (4.6%) aged 40-49 years, and six nurses (14%) aged 50-57 years. There were 16 nurses (37.2%) who had worked less than 5 years, and 27 nurses (72.8%) who had worked more than 5 years. There were seven nurses (16.3%) who had working time <8 hours a day, and 36 nurses (83.7%) who had working time >8 hours a day. Keywords: low back pain, nurse Abstrak: Nyeri punggung bawah (NPB) adalah sindroma klinik yang ditandai dengan gejala utama nyeri atau perasaan lain yang tidak enak di daerah tulang punggung bagian bawah. NPB merupakan penyebab utama dari keterbatasan aktivitas dan absen pekerjaan di sebagian besar dunia. Penelitian ini bertujuan untuk mengetahui karakteristik perawat di Irina F RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif prospektif dengan desain potong lintang. Sampel diperoleh sebanyak 43 responden. Hasil penelitian menunjukkan bahwa dari 50 responden terdapat 43 responden (86%) yang pernah mengalami keluhan NPB. Dari 43 responden terdapat 14 perawat laki-laki (32,5%) dan 29 perawat perempuan (67,5%). NPB dialami oleh 16 perawat (37,2%) berusia 23-29 tahun, 19 perawat (44,2%) berusia 30-39 tahun, 2 perawat (4,6%) berusia 40-49 tahun, dan 6 perawat (14%) berusia 50-57 tahun. Terdapat 16 perawat (37,2%) yang memiliki masa kerja <5 tahun, dan 27 perawat (62,8%) memiliki masa kerja >5 tahun. Terdapat 7 perawat (16,3%) yang memiliki lama kerja <8 jam sehari, dan 36 perawat (83,7%) memiliki lama kerja >8 jam sehari.Kata kunci: nyeri punggung bawah, perawat
Perbedaan Skor INA-MOCA pada Pemain Catur dan Bukan Pemain Catur Pauran, Scivo V.; P.S, Junita Maja; Khosama, Herlyani
e-CliniC Vol 5, No 1 (2017): Jurnal e-CliniC (eCl)
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Abstract: Aging is progressive declining process of many body functions, including cognitive function. Cognitive function is a conscious mental activity such as thinking, memory, learning, as well as language, and can be evaluated by using INA-MoCA. Chess is a popular game that requires intelligence. Some researchers believe that there is a close relation between cognitive function and chess. This study was aimed to determine whether there was any difference between the cognitive function of chess players and non-chess player. This was an analytic study with a cross-sectional study. Primary data were obtained from INA-MoCA score of the chess players and non-chess players. The results showed that in non-elderly category, the average score of INA-MoCA indicated that chess players had higher cognitive functions than non-chess players (p=0.43). In elderly category, the average score of INA-MoCA indicated that the chess players had better cognitive function than the non-chess players by 2.77 (p=0.03). Conclusion: Either elderly or non-elderly, chess players had higher cognitive function than non-chess players.Keywords: cognitive function, elder, chess, INA-MoCA Abstrak: Menua adalah proses penurunan banyak fungsi tubuh yang progresif, termasuk penurunan kognitif. Fungsi kognitif adalah aktivitas mental secara sadar seperti berpikir, mengingat, belajar, dan bahasa. Salah satu evaluasi fungsi kognitif dengan menggunakan INA-MoCA. Permainan catur merupakan permainan yang populer dan memerlukan kecerdasan. Beberapa peneliti percaya bahwa ada hubungan yang erat antara fungsi kognitif dan permainan catur. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan fungsi kognitif antara pemain catur dan bukan pemain catur. Jenis penelitian ialah analitik dengan desain potong lintang. Data primer ialah skor INA-MoCA pemain catur dan bukan pemain catur. Hasil penelitian pada kelompok bukan lansia, rerata skor INA-MoCA mengindikasikan pemain catur memiliki fungsi kognitif yang lebih tinggi daripada yang bukan pemain catur (p=0,43). Pada kelompok lansia, rerata skor INA-MoCA menunjukan pemain catur memiliki fungsi kognitif yang lebih baik daripada bukan pemain catur dengan selisih 2,77 (p=0,03). Simpulan: Fungsi kognitif pemain catur baik pada lansia maupun bukan lansia lebih baik daripada bukan pemain catur.Kata kunci: fungsi kognitif, lansia, pemain catur, INA-MoCA
Gambaran gangguan pemusatan perhatian pada remaja gamers di Manado periode November 2014 – Desember 2014 Kaseger, Kevin A.; Khosama, Herlyani; Mahama, Corry N.
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
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Abstract: Attention deficit disorders (ADD) is a medical disorder that has its own characteristics and tends to be hereditary. Generally, there are three types of behavior associated with this disorder, namely: lack of surrounding attention (inattentiveness), easily distracted (distractibility), and impulsive attitude (impulsiveness). This study was aimed to obtain the prevalence of ADD among adolescent gamers. This was a descriptive-quantitative study with a cross-sectional design. This study was carried out on regular gamers aged 12-15 years who were students of junior high schools. The total respondents in this study were 30 regular gamer teenagers. The digit span, backward digit span, and the stroop test were performed on all respondents. The results showed that among teenagers who played video games more than 1 time per week there were 36.67% with attention deficit disorders.Keywords: ADD, videogames, adolescents, digit span, backward digit span, stroop test Abstrak: Gangguan pemusatan perhatian (GPP) adalah suatu kelainan medis yang memiliki ciri tersendiri dan cenderung merupakan keturunan. Secara umum terdapat tiga jenis perilaku yang dikaitkan dengan kelainan ini, yaitu: sikap kurang memperhatikan sekeliling (inattentiveness), mudah terganggu (distractibility), dan sikap menurutkan kata hati (impulsiveness). Penelitian ini bertujuan untuk mendapatkan prevalensi GPP di kalangan remaja gamers. Jenis penelitian ialah deskriptif-kuantitatif dengan desain potong lintang. Penelitian ini dilakukan pada remaja regular gamers berusia 12-15 tahun yang masih duduk di bangku SMP dengan total 30 remaja regular gamers sebagai responden. Pada responden dilakukan pemeriksaan digit span, backward digit span, dan stroop test. Hasil penellitian memperlihatkan bahwa dari ketiga macam pemeriksaan tersebut yang dilakukan pada remaja yang bermain videogame lebih dari 1 kali per minggu didapatkan GPP rata-rata 36,67%. Kata kunci: GPP, videogame, remaja, digit span, backward digit span, stroop test.
RASIO NEUTROFIL LIMFOSIT DAN LUARAN CEDERA KEPALA Kastilong, Merlin; I, Irene Subrata; Tangkudung, Gilbert; Khosama, Herlyani
Jurnal Sinaps Vol 1 No 2 (2018): volume 1 Nomor 2, Juni 2018
Publisher : Neurologi Manado

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Pendahuluan: Luaran cedera kepala dapat dipengaruhi oleh beberapa faktor, salah satunya inflamasi. Rasio neutrofil limfosit  (RNL) adalah salah satu penanda inflamasi yang mudah dilakukan dan diaplikasikan, namun jarang diteliti. Tujuan: Mengetahui apakah terdapat hubungan RNL dengan luaran cedera kepala. Metode: Penelitian potong lintang terhadap pasien cedera kepala sedang–berat (CKS-B) yang dirawat di RSUP Prof. R.D Kandou bulan November 2017–Februari 2018. Subjek dilakukan pemeriksaan laboratorium hitung jenis leukosit dan dihitung RNL. Skala Luaran Glasgow (SLG) dinilai saat keluar rumah sakit dan dibagi menjadi luaran buruk (SLG <4) dan baik (SLG  ≥4). Analisis data menggunakan chi square. Hasil: Terdapat 60 subjek penelitian, dengan proporsi terbanyak laki-laki (70%). Nilai median RNL lebih tinggi pada luaran buruk (6,82) dibandingkan luaran baik (4,16). Nilai cut off point RNL adalah 3,62. Subjek dengan RNL ≥3,62 memiliki luaran buruk dibandingkan subjek dengan RNL  <3,62 , secara statistik bermakna (p=0,04). Diskusi: Terdapat perbedaan bermakna luaran pasien cedera kepala diihat dari RNL. Pasien dengan RNL rendah memiliki luaran lebih baik dibandingkan pasien dengan RNL tinggi.   Kata Kunci: cedera kepala, luaran, RNL   ABSTRACT Introduction : The outcome of traumatic brain injury (TBI) can be affected by several factors, one of which is inflammation. Neutrophyl lymphocyte ratio (NLR) is an easy and applicable inflammatory markers but rarely studied in TBI. Aims: Determining if there is difference in the outcome of traumatic brain injury based on NLR. Methods : a cross sectional study of moderate-severe TBI patients admitted at RSUP Prof. R.D Kandou from November 2017-Februari 2018.The subjects were performed differential count and calculated NLR. Glasgow Outcome Scale (GOS) at hospital discharge was assessed and classified as poor (GOS<4) and good outcome (GOS ≥4). Data was analyzed using chi-square test. Results :there were 60 subjects with the largest proportion is male (70%. NLR median score was higher in the poor outcome group (6.82) than in the good one (4.16). Cut off point of NLR was 3,62. Subjects with RNL ≥3,62 had poor outcomes compared to subjects with RNL <3,62, statistically significant (p=0.04). Discussion: There was a significant difference in TBI outcome based on RNL. Patients with low RNL have better outcomes than patients with high RNL.   Keyword :NLR, outcome, traumatic brain injury
NEUROLOGICAL DEPRESSION DISORDERS INVENTORY FOR EPILEPSY (NDDI-E) di POLIKLINIK SARAF RSUP PROF. DR. R. D. KANDOU MANADO Juwita, Angelina; Dompas, Aprillia; Khosama, Herlyani; Mahama, Corry
Jurnal Sinaps Vol 1 No 3 (2018): volume 1 Nomor 3, September 2018
Publisher : Neurologi Manado

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Abstract

Latar belakang: Depresi adalah salah satu gejala komorbid yang sering terjadi pada penderita epilepsi. Tujuan: Penelitian ini bertujuan untuk mengetahui sebaran depresi pada penderita epilepsi di poliklinik saraf RSUP Prof. Dr. R. D. Kandou Manado. Metode: Penelitian ini merupakan penelitian potong lintang. Penderita epilepsi yang datang berobat ke Poliklinik Saraf RSUP Prof. Dr. R. D. Kandou Manado bulan April sampai Juni 2017 yang telah memenuhi kriteria inklusi dan eksklusi dilakukan anamnesis, pemeriksaan fisik, pemeriksaan EEG, dan diminta mengisi kuesioner NDDI-E (Neurological Depression Disorders Inventory For Epilepsy). Hasil dianalisis menggunakan perangkat lunak SPSS versi 22. Diagnosis depresi ditegakkan menggunakan skor NDDI-E versi bahasa Indonesia yang telah divalidasi. Hasil penelitian: Terdapat 30 subjek pada penelitian ini, perempuan lebih banyak (53,33%). Median usia adalah 25 (16-53) tahun. Median lamanya menderita epilepsi adalah 5 (1-30) tahun. Mayoritas subjek menderita epilepsi lobus temporal (76,67%) dan sisanya epilepsi lobus frontal. Sebanyak 83,67% penderita epilepsi mempunyai komorbid depresi. Diagnosis depresi mayor (depresi yang dinilai berdasarkan NDDI-E ≥11) didapatkan sebanyak 26 orang (86,67%). Depresi terdapat pada 86,96% epilepsi lobus temporal dan 85,71% epilepsi lobus frontal. Kesimpulan: Penderita epilepsi di poliklinik saraf RSUP Prof. Dr. R. D. Kandou Manado mempunyai komorbid depresi yang tinggi.                                           Kata kunci: epilepsi, depresi, Manado, NDDI-E.   ABSTRACT Background: Depression is one of the common comorbid symptoms in epilepsy patients. Objective: This study aims to determine the distribution of depression of epilepsy patients of neurology clinic in RSUP Prof. Dr. R. D. Kandou Manado. Method: This study is a cross sectional study. Epilepsy patients who came to neurology clinic in RSUP Prof. Dr. R. D. Kandou Manado from April to June 2017 who have met the inclusion and exclusion criteria, anamnesis, physical examination, EEG examination, and asked to fill out the NDDI-E (Neurological Depression Disorders Inventory For Epilepsy) questionnaire. The results were analyzed using SPSS software version 22. Diagnosed depression is enforced using the score of NDDI-E validated Indonesian version.  Result: There are 30 subjects in this study, more women (53.33%). The median age is 25 (16-53) years. Median duration of epilepsy is 5 (1-30) years. The majority of subjects suffered temporal lobe epilepsy (76.67%), and the rest of the frontal lobe epilepsy. As many as 83.67% of epilepsy patients have comorbid depression. Major depression (depression assessed by NDDI-E Test ≥11) was found as many as 26 people (86,67%). Depression is present in 86.96% temporal lobe epilepsy and 85.71% frontal lobe epilepsy. Conclusion: Epilepsy patients of neurology clinic in RSUP Prof. Dr. R. D. Kandou Manado have a high comorbid depression.   Keyword: epilepsy, depression, Manado, NDDI-E.