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All Journal Jurnal Biologi Papua
Aditya K. Karim
Jurusan Biologi FMIPA Uncen

Published : 9 Documents
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Patofisiologi Bisa Ular dan Aplikasi Terapi Tumbuhan Obat Antiophidia (Antibisa) Karim, Aditya K.; Indrayani, Ervina; Hanum, Laila
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Publisher : Jurnal Biologi Papua

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Abstract

Venomous snakebite is an important cause of morbidity and mortality, and is one of the major health problems in many regions of the world. Medicinal Plant which are effectively inhibitor and neutralize the snake venom and it is considered as a valuable source of natural products for development of medicines against venomous snake bite. The biomedical value of these natural inhibitors can lead to the development of new therapeutics for an assortment of diseases as well as contributing to efficient antivenoms for the treatment of ophidic accidents.Key words: pathophysiology, snake bite, envenomation, medicinal plant, therapeutic
Review: Senyawa Bioaktif Herpetofauna pada Penderita Diabetes Mellitus dan Hipertensi: Tinjauan Secara Patofisiologi Karim, Aditya K.; Eprilurahman, Rury; Fitria, Laksmindra; Kawatu, Paul J.
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Publisher : Jurnal Biologi Papua

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Abstract

Amphibians and reptiles (herpetofauna groups) produced of many compounds. The herpetofauna and their chemical compounds have been the subject of intense research interest for many years due to their potential in medical application and in lead compound development for new drugs. A number of different types of compounds have been identified from the glandular skin secretions of amphibians and venom or saliva of reptiles. These compounds have been shown to be active against gram-negative and gram-positive bacteria, fungi, enveloped viruses, diabetes mellitus, hypertension and cardiovascular disorder.Key words: Herpetofauna, diabetes mellitus, hypertension, drugs, pathophysiology
Antiproliferatif Ekstrak Metanol Daun Dianella nemorosa Lam. (Liliaceae) terhadap Sel Kanker MKN45 dengan Menggunakan Metode WST-1 Karim, Aditya K.; Sismindari, Sismindari
JURNAL BIOLOGI PAPUA Vol 3, No 2 (2011)
Publisher : JURNAL BIOLOGI PAPUA

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Dianella nemorosa Lam. was known containing alkaloids, terpenoid, phenolic compouds and tanin. Antiproliferative effect of D. nemorosa leaves methanol exctract, which demonstrated to have an in vitro cytotoxic effect on cancer cell line. The aim of research was examined the effect antiproliferative methanol extract of D. nemorosa leaves against MKN45 (gastric cancer) cell line. Leaves powder extracted using methanol. Antiproliferative effect was determined by Cell Proliferation Reagents WST-1 ((2-(4-iodophenyl)-3-(4-nitro-phenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt). Test for 1h, 2h, and 4h after incubated for 72h was done. The result of this research showed that methanol exctract from D. nemorosa possessed remarkable no had antiproliferative activity against MKN45 cell line. The result indicated methanol extract of D. nemorosa leaves selective inhibitory effect or antiproliferative against cell line. Key words: Dianella nemorosa, Antiproliferative, MKN 45, and WST-1
Senyawa Bioaktif Herpetofauna pada Penderita Diabetes Mellitus dan Hipertensi: Tinjauan Secara Patofisiologi Karim, Aditya K.; Eprilurahman, Rury; Fitria, Laksmindra; Kawatu, Paul J.
JURNAL BIOLOGI PAPUA Vol 5, No 1 (2013)
Publisher : JURNAL BIOLOGI PAPUA

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Abstract

Amphibians and reptiles (herpetofauna groups) produced of many compounds. The herpetofauna and their chemical compounds have been the subject of intense research interest for many years due to their potential in medical application and in lead compound development for new drugs. A number of different types of compounds have been identified from the glandular skin secretions of amphibians and venom or saliva of reptiles. These compounds have been shown to be active against gram-negative and gram-positive bacteria, fungi, enveloped viruses, diabetes mellitus, hypertension and cardiovascular disorder. Key words: Herpetofauna, diabetes mellitus, hypertension, drugs, pathophysiology
Kapasitas Reproduksi Mencit Betina (Mus musculus L.) Setelah Pemberian Infus Batang Tabat Barito (Ficus deltoidea Jack.) Karim, Aditya K.
JURNAL BIOLOGI PAPUA Vol 3, No 1 (2011)
Publisher : JURNAL BIOLOGI PAPUA

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Tabat barito (Ficus deltoidea Jack.) is vastly used to induce sexual aroused (aphrodisiacs) and effect on female reproductive organ. The aim of this research was performed to examine the effects of bark tabat barito infuse on reproductive capacities female mice. Fifteen of female mice were devided randomly into 5 groups, respectively. The treatment dosages were control, placebo, 50%, 75% and 100%. Infuse and aquades administrated orally 0.5 ml/hari for 5 estrouse cycles. Female mice were mated (1:3). At the eighteen days of gestation, female mice were sacrificed and observed, covered the weight of mice, uterus, liver; the total number of fetus, their weight and length body. The statistical analysis was performed using ANOVA and DMRT test. The result of this study indicated that infuse of bark tabat barito (Ficus deltoidea Jack) increasing the reproductive capacities but no significant. The weight of mice, uterus, liver between control and treatment no different (P> 0.05) but for total number of fetus in control 8.00  1.00, whereas dosages 50, 75 and 100 were 8.67  0.58, 11.67  1.16 and 10.00  1.00, respectively. In total number of fetus different in 70% dosage to others, and total number of fetus in 100% dosage are significant different with control and 70% dosage. Key words: Tabat barito, aphrodisiacs, progesterone, reproductive capacities.
Skrining Fitokimia dan Uji Aktivitas Sitotoksik dari Tumbuhan Sarang Semut (Myrmecodia beccarii Hook.f.) Asal Kabupaten Merauke Mardany, Modustriarti P.; Chrystomo, Linus Y.; Karim, Aditya K.
JURNAL BIOLOGI PAPUA Vol 8, No 1 (2016)
Publisher : JURNAL BIOLOGI PAPUA

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Sarang semut (Myrmecodia beccarii Hook.f.) is a famous medicinal plant of Papua, which has traditionally potential in treating a wide variety of mild and severe illnesses, such as cancers and tumors, gout, coronary heart disease, hemorrhoids, tuberculosis, migraines, rheumatism, and leukemia. The purposes of this study were to determine the content of the active compound group and the cytotoxic activity of sarang semut plants from Merauke Region. The extraction was done by maceration using 96 % ethanol. The concentration of ethanolic extract were 0, 25, 50, 75, 100 ppm. The results of the study showed that the cytotoxic activity determine using BSLT (Brine Shrimp Lethality Test) method have a high cytotoxic activity with LC50 values of 22.86 ppm and containing the active compound namely flavonoids, tannins and saponins separately. The ethanolic extract of tuber of sarang semut (M. beccarii) has a high cytotoxic activity against larvae of Artemia salina Leach according BSLT method. Key words: Active compound, M. beccarii, cytotoxic activity, Merauke.
Patofisiologi Bisa Ular dan Aplikasi Terapi Tumbuhan Obat Antiophidia (Antibisa) Karim, Aditya K.; Indrayani, Ervina; Hanum, Laila
JURNAL BIOLOGI PAPUA Vol 6, No 2 (2014)
Publisher : JURNAL BIOLOGI PAPUA

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Abstract

Venomous snakebite is an important cause of morbidity and mortality, and is one of the major health problems in many regions of the world. Medicinal Plant which are effectively inhibitor and neutralize the snake venom and it is considered as a valuable source of natural products for development of medicines against venomous snake bite. The biomedical value of these natural inhibitors can lead to the development of new therapeutics for an assortment of diseases as well as contributing to efficient antivenoms for the treatment of ophidic accidents. Key words: pathophysiology, snake bite, envenomation, medicinal plant, therapeutic.
Peran Herpetofauna dalam Bidang Kesehatan: Peluang dan Tantangan Karim, Aditya K.; Wasaraka, Zainal A.; Chrystomo, Linus Y.; Indrayani, Ervina
JURNAL BIOLOGI PAPUA Vol 4, No 1 (2012)
Publisher : JURNAL BIOLOGI PAPUA

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Abstract

Skin secretions and venom from many species of amphibi (frogs and toads) and reptil (group of herpetofauna) from different famillies contain a wide range of unique physiological compounds with biological activity such as peptide, protein, non-protein, and enzyme. They are potent for drug development. The compounds, known as mode of action have practical application as pharmaceutical agents, diagnostic reagents or preparative tools. Peptides with potential anticancer, fibrinolityc, antibacterial, antifungal, antidiabetic activity play important roles in human health. This review introduces roles of herpetofauna for drugs development, potential therapeutic values and their application in human health and disease. Key words: Herpetofauna, skin secretion, venom, drugs development, health.
Tumbuhan Obat: Pendekatan Alternatif dalam Pengendalian Nyamuk Aedes aegypti dan Virus Dengue Penyebab Demam Dengue Suyono, Ign. Joko; Karim, Aditya K.
JURNAL BIOLOGI PAPUA Vol 4, No 2 (2012)
Publisher : JURNAL BIOLOGI PAPUA

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Dengue is the most important emerging tropical viral disease of humans in the world today. Aedes aegypti is a major mosquito vector responsible for transmitting many viral diseases and this mosquito that spreads major health problems like dengue fever. The resistance of Ae. aegypti to insecticides is already widespread and represents a serious problem for programmes aimed at the control and prevention of dengue in tropical countries. The search for compounds extracted from medicinal plant preparations as alternatives insecticide for mosquito control is in immediate need. Alternative approach for control Ae. aegypti dan virus dengue using the medicinal plant will be discussed in this paper. Key words: Medicinal plant, Aedes aegypti, dengue fever, dengue haemorragi fever, dengue shock syndrome.